Details for: GRM3

Gene ID: 2913

Symbol: GRM3

Ensembl ID: ENSG00000198822

Description: glutamate metabotropic receptor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 210.3347
    Cell Significance Index: -53.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 42.5238
    Cell Significance Index: -52.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 5.7153
    Cell Significance Index: 252.8000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 5.1936
    Cell Significance Index: 196.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1280
    Cell Significance Index: 426.8700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.6523
    Cell Significance Index: 36.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.5192
    Cell Significance Index: 102.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.4690
    Cell Significance Index: 90.2900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2057
    Cell Significance Index: 833.9400
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 1.1539
    Cell Significance Index: 16.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3709
    Cell Significance Index: 684.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2792
    Cell Significance Index: 100.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1889
    Cell Significance Index: 170.5700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1815
    Cell Significance Index: 34.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1711
    Cell Significance Index: 263.4500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0847
    Cell Significance Index: 1.0500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0826
    Cell Significance Index: 1.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0039
    Cell Significance Index: -5.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0192
    Cell Significance Index: -36.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0498
    Cell Significance Index: -22.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0708
    Cell Significance Index: -51.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0762
    Cell Significance Index: -48.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0814
    Cell Significance Index: -61.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0829
    Cell Significance Index: -61.4200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0997
    Cell Significance Index: -54.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1096
    Cell Significance Index: -61.7900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1120
    Cell Significance Index: -11.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1149
    Cell Significance Index: -52.1700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1275
    Cell Significance Index: -20.7300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1489
    Cell Significance Index: -2.5800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1493
    Cell Significance Index: -42.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1625
    Cell Significance Index: -29.3000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1819
    Cell Significance Index: -1.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1867
    Cell Significance Index: -6.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2165
    Cell Significance Index: -42.9700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2270
    Cell Significance Index: -3.8900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2308
    Cell Significance Index: -7.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2339
    Cell Significance Index: -29.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2516
    Cell Significance Index: -36.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2572
    Cell Significance Index: -15.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2955
    Cell Significance Index: -62.2500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.3150
    Cell Significance Index: -34.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.3236
    Cell Significance Index: -39.7900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3313
    Cell Significance Index: -38.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.3478
    Cell Significance Index: -59.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3571
    Cell Significance Index: -9.9800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3660
    Cell Significance Index: -4.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3981
    Cell Significance Index: -51.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.4071
    Cell Significance Index: -55.9100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4140
    Cell Significance Index: -4.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4187
    Cell Significance Index: -18.9800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4346
    Cell Significance Index: -14.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4880
    Cell Significance Index: -50.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5286
    Cell Significance Index: -60.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.5350
    Cell Significance Index: -54.6500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5632
    Cell Significance Index: -14.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.5921
    Cell Significance Index: -17.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6566
    Cell Significance Index: -52.0000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.6714
    Cell Significance Index: -46.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6893
    Cell Significance Index: -51.3700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.7054
    Cell Significance Index: -17.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7269
    Cell Significance Index: -55.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7528
    Cell Significance Index: -24.1100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.7544
    Cell Significance Index: -10.7200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.7849
    Cell Significance Index: -47.1200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8368
    Cell Significance Index: -23.8800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.8447
    Cell Significance Index: -44.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8520
    Cell Significance Index: -21.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.8556
    Cell Significance Index: -48.0100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8698
    Cell Significance Index: -30.4700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.8734
    Cell Significance Index: -56.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.8897
    Cell Significance Index: -22.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9425
    Cell Significance Index: -59.4100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.9641
    Cell Significance Index: -25.3500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.9824
    Cell Significance Index: -20.3800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.0089
    Cell Significance Index: -52.9700
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.0571
    Cell Significance Index: -10.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.0659
    Cell Significance Index: -50.1000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -1.0794
    Cell Significance Index: -10.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.1410
    Cell Significance Index: -53.2000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.1609
    Cell Significance Index: -24.3000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -1.2407
    Cell Significance Index: -14.2000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.3284
    Cell Significance Index: -28.4000
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -1.3388
    Cell Significance Index: -10.5000
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -1.3389
    Cell Significance Index: -14.7700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.3584
    Cell Significance Index: -28.8300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.3658
    Cell Significance Index: -29.5900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.3673
    Cell Significance Index: -29.5400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.3696
    Cell Significance Index: -9.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.3726
    Cell Significance Index: -71.3000
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -1.4272
    Cell Significance Index: -21.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.5717
    Cell Significance Index: -54.6200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.6114
    Cell Significance Index: -32.3500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.6379
    Cell Significance Index: -51.8100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.6827
    Cell Significance Index: -35.1200
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -1.6950
    Cell Significance Index: -22.2000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -1.7332
    Cell Significance Index: -23.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.7924
    Cell Significance Index: -51.3800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.8024
    Cell Significance Index: -35.6400
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -1.8103
    Cell Significance Index: -25.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Metabotropic Glutamate Receptor**: GRM3 belongs to the class C/3 metabotropic glutamate receptors, which are G-protein coupled receptors that modulate synaptic transmission through the activation of G proteins. 2. **Adenylate Cyclase Inhibition**: GRM3 inhibits adenylate cyclase activity, leading to decreased cAMP levels and reduced excitatory neurotransmission. 3. **Calcium Channel Regulation**: GRM3 modulates calcium channel regulation, influencing neuronal excitability and synaptic plasticity. 4. **Widespread Expression**: GRM3 is expressed in various brain regions, including the cerebral cortex, hippocampus, and cerebellum, with significant presence in Purkinje cells, interneurons, and astrocytes. 5. **Signal Transduction**: GRM3 is involved in signaling pathways that regulate synaptic transmission, including G alpha (i) signaling events and scaffold protein binding. **Pathways and Functions:** 1. **Adenylate Cyclase-Inhibiting G Protein-Coupled Glutamate Receptor Signaling Pathway**: GRM3 inhibits adenylate cyclase activity, leading to decreased cAMP levels and reduced excitatory neurotransmission. 2. **Astrocyte Projection**: GRM3 is involved in regulating astrocyte projection and function, influencing neural homeostasis and synaptic plasticity. 3. **Chemical Synaptic Transmission**: GRM3 modulates chemical synaptic transmission, influencing neuronal excitability and synaptic plasticity. 4. **Class C/3 (Metabotropic Glutamate/Phenomone Receptors)**: GRM3 belongs to the class C/3 metabotropic glutamate receptors, which are involved in regulating synaptic transmission and modulating neuronal excitability. 5. **G Alpha (i) Signaling Events**: GRM3 is involved in G alpha (i) signaling events, influencing neuronal excitability and synaptic plasticity. **Clinical Significance:** Dysregulation of GRM3 has been implicated in various neurological disorders, including: 1. **Epilepsy**: GRM3 mutations have been associated with epilepsy, highlighting its importance in regulating neuronal excitability and synaptic plasticity. 2. **Alzheimer's Disease**: GRM3 expression is reduced in Alzheimer's disease, suggesting its involvement in the pathophysiology of the disease. 3. **Schizophrenia**: GRM3 has been implicated in schizophrenia, with studies suggesting its involvement in regulating synaptic transmission and neuronal excitability. 4. **Migraine**: GRM3 has been implicated in migraine, with studies suggesting its involvement in regulating pain transmission and neuronal excitability. In conclusion, GRM3 is a critical component of glutamatergic synaptic transmission and plays a pivotal role in regulating neuronal excitability, synaptic plasticity, and neural homeostasis. Its dysregulation has been implicated in various neurological disorders, highlighting the importance of further research into its function and clinical significance.

Genular Protein ID: 3124168382

Symbol: GRM3_HUMAN

Name: Metabotropic glutamate receptor 3

UniProtKB Accession Codes:

Q14832 Q2PNZ6 Q75MV4 Q75N17 Q86YG6 Q8TBH9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 7 EMDB 4 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 18 PDBsum 18 PRINTS 3 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8840013

Title: Molecular characterization and localization of human metabotropic glutamate receptor type 3.

PubMed ID: 8840013

DOI: 10.1016/0169-328x(96)00037-x

PubMed ID: 16417579

Title: Alternative splicing of human metabotropic glutamate receptor 3.

PubMed ID: 16417579

DOI: 10.1111/j.1471-4159.2005.03609.x

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 879
  • Mass: 98879
  • Checksum: 7EB84521676E8304
  • Sequence:
    • MKMLTRLQVL TLALFSKGFL LSLGDHNFLR REIKIEGDLV LGGLFPINEK GTGTEECGRI 
NEDRGIQRLE AMLFAIDEIN KDDYLLPGVK LGVHILDTCS RDTYALEQSL EFVRASLTKV 
DEAEYMCPDG SYAIQENIPL LIAGVIGGSY SSVSIQVANL LRLFQIPQIS YASTSAKLSD 
KSRYDYFART VPPDFYQAKA MAEILRFFNW TYVSTVASEG DYGETGIEAF EQEARLRNIC 
IATAEKVGRS NIRKSYDSVI RELLQKPNAR VVVLFMRSDD SRELIAAASR ANASFTWVAS 
DGWGAQESII KGSEHVAYGA ITLELASQPV RQFDRYFQSL NPYNNHRNPW FRDFWEQKFQ 
CSLQNKRNHR RVCDKHLAID SSNYEQESKI MFVVNAVYAM AHALHKMQRT LCPNTTKLCD 
AMKILDGKKL YKDYLLKINF TAPFNPNKDA DSIVKFDTFG DGMGRYNVFN FQNVGGKYSY 
LKVGHWAETL SLDVNSIHWS RNSVPTSQCS DPCAPNEMKN MQPGDVCCWI CIPCEPYEYL 
ADEFTCMDCG SGQWPTADLT GCYDLPEDYI RWEDAWAIGP VTIACLGFMC TCMVVTVFIK 
HNNTPLVKAS GRELCYILLF GVGLSYCMTF FFIAKPSPVI CALRRLGLGS SFAICYSALL 
TKTNCIARIF DGVKNGAQRP KFISPSSQVF ICLGLILVQI VMVSVWLILE APGTRRYTLA 
EKRETVILKC NVKDSSMLIS LTYDVILVIL CTVYAFKTRK CPENFNEAKF IGFTMYTTCI 
IWLAFLPIFY VTSSDYRVQT TTMCISVSLS GFVVLGCLFA PKVHIILFQP QKNVVTHRLH 
LNRFSVSGTG TTYSQSSAST YVPTVCNGRE VLDSTTSSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.