Details for: GRM3

Gene ID: 2913

Symbol: GRM3

Ensembl ID: ENSG00000198822

Description: glutamate metabotropic receptor 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.6
    Marker Score: 121722
  • Cell Name: interneuron (CL0000099)
    Fold Change: 3.46
    Marker Score: 1580
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 3.35
    Marker Score: 8029
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.88
    Marker Score: 1108
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.38
    Marker Score: 12797
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.24
    Marker Score: 1477
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.19
    Marker Score: 20611
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.19
    Marker Score: 2940
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.15
    Marker Score: 45970
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.95
    Marker Score: 120149
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.91
    Marker Score: 18178
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.85
    Marker Score: 2128
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.74
    Marker Score: 1911
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1176
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.61
    Marker Score: 13788
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.56
    Marker Score: 4450
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.54
    Marker Score: 2384
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168279
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.39
    Marker Score: 4665
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 876
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.35
    Marker Score: 1174
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.33
    Marker Score: 1606
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.31
    Marker Score: 2474
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.29
    Marker Score: 2169
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 861
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.2
    Marker Score: 696
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 491
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4821
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.15
    Marker Score: 2329
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.13
    Marker Score: 634
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.13
    Marker Score: 4602
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 802
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.04
    Marker Score: 6935
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.04
    Marker Score: 622
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48053
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 513
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.99
    Marker Score: 10237
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 466
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.96
    Marker Score: 3699
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.96
    Marker Score: 439
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 377
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5350
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 329
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.91
    Marker Score: 1130.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.83
    Marker Score: 400
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.81
    Marker Score: 255
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.8
    Marker Score: 422
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.79
    Marker Score: 1446
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.78
    Marker Score: 237
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.77
    Marker Score: 11583
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.77
    Marker Score: 12009
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.73
    Marker Score: 7357
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 466
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.69
    Marker Score: 5308
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.67
    Marker Score: 1385
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.66
    Marker Score: 388
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.65
    Marker Score: 2501
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.63
    Marker Score: 23267
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 487
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.59
    Marker Score: 22359
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.58
    Marker Score: 1183
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.55
    Marker Score: 264
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.55
    Marker Score: 231
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.54
    Marker Score: 2510
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.53
    Marker Score: 168
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.52
    Marker Score: 166
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.51
    Marker Score: 2094
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.5
    Marker Score: 2998
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.49
    Marker Score: 2569
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.47
    Marker Score: 193
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.45
    Marker Score: 8985
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.44
    Marker Score: 121
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.4
    Marker Score: 112
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.39
    Marker Score: 102
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.39
    Marker Score: 3986
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.38
    Marker Score: 120
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.38
    Marker Score: 885
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.37
    Marker Score: 165
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 375
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.37
    Marker Score: 218
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.36
    Marker Score: 114
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.36
    Marker Score: 112
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.33
    Marker Score: 5829
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.33
    Marker Score: 136
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.32
    Marker Score: 2426
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.32
    Marker Score: 116
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.31
    Marker Score: 386.5
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.29
    Marker Score: 267
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.29
    Marker Score: 1203

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Other Information

**Key characteristics:** * GRM3 is a transmembrane protein with a molecular weight of approximately 140 kDa. * It is a member of the glutamate receptor superfamily. * It is expressed in a variety of brain regions, including the cerebral cortex, hippocampus, and cerebellum. * It is a ligand for the G protein-coupled glutamate receptor (GPCR) GRM1. **Pathways and functions:** * GRM3 is a key component of the adenylate cyclase-inhibiting g protein-coupled glutamate receptor signaling pathway, which is involved in synaptic plasticity and learning and memory. * It is also involved in the regulation of calcium channel activity, chemical synaptic transmission, and postsynaptic modulation of synaptic transmission. * It is a negative regulator of adenylate cyclase activity, which is involved in the regulation of synaptic plasticity. * It is expressed in Purkinje cells, interneurons, oligodendrocytes, GABAergic interneurons, stellate neurons, and mature astrocytes. **Clinical significance:** * Mutations in the GRM3 gene have been linked to a number of neurodevelopmental disorders, including autism, schizophrenia, and epilepsy. * These disorders are characterized by abnormal synaptic plasticity and learning and memory deficits. * GRM3 is a potential target for therapeutic interventions in these disorders. **Additional notes:** * GRM3 is a highly conserved protein, with a similar sequence in mice and humans. * It is a promising drug target for a variety of neurological disorders.

Genular Protein ID: 3124168382

Symbol: GRM3_HUMAN

Name: Metabotropic glutamate receptor 3

UniProtKB Accession Codes:

Q14832 Q2PNZ6 Q75MV4 Q75N17 Q86YG6 Q8TBH9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 7 EMDB 3 Ensembl 2 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 21 PDBsum 18 PRINTS 3 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8840013

Title: Molecular characterization and localization of human metabotropic glutamate receptor type 3.

PubMed ID: 8840013

DOI: 10.1016/0169-328x(96)00037-x

PubMed ID: 16417579

Title: Alternative splicing of human metabotropic glutamate receptor 3.

PubMed ID: 16417579

DOI: 10.1111/j.1471-4159.2005.03609.x

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 879
  • Mass: 98879
  • Checksum: 7EB84521676E8304
  • Sequence:
    • MKMLTRLQVL TLALFSKGFL LSLGDHNFLR REIKIEGDLV LGGLFPINEK GTGTEECGRI 
NEDRGIQRLE AMLFAIDEIN KDDYLLPGVK LGVHILDTCS RDTYALEQSL EFVRASLTKV 
DEAEYMCPDG SYAIQENIPL LIAGVIGGSY SSVSIQVANL LRLFQIPQIS YASTSAKLSD 
KSRYDYFART VPPDFYQAKA MAEILRFFNW TYVSTVASEG DYGETGIEAF EQEARLRNIC 
IATAEKVGRS NIRKSYDSVI RELLQKPNAR VVVLFMRSDD SRELIAAASR ANASFTWVAS 
DGWGAQESII KGSEHVAYGA ITLELASQPV RQFDRYFQSL NPYNNHRNPW FRDFWEQKFQ 
CSLQNKRNHR RVCDKHLAID SSNYEQESKI MFVVNAVYAM AHALHKMQRT LCPNTTKLCD 
AMKILDGKKL YKDYLLKINF TAPFNPNKDA DSIVKFDTFG DGMGRYNVFN FQNVGGKYSY 
LKVGHWAETL SLDVNSIHWS RNSVPTSQCS DPCAPNEMKN MQPGDVCCWI CIPCEPYEYL 
ADEFTCMDCG SGQWPTADLT GCYDLPEDYI RWEDAWAIGP VTIACLGFMC TCMVVTVFIK 
HNNTPLVKAS GRELCYILLF GVGLSYCMTF FFIAKPSPVI CALRRLGLGS SFAICYSALL 
TKTNCIARIF DGVKNGAQRP KFISPSSQVF ICLGLILVQI VMVSVWLILE APGTRRYTLA 
EKRETVILKC NVKDSSMLIS LTYDVILVIL CTVYAFKTRK CPENFNEAKF IGFTMYTTCI 
IWLAFLPIFY VTSSDYRVQT TTMCISVSLS GFVVLGCLFA PKVHIILFQP QKNVVTHRLH 
LNRFSVSGTG TTYSQSSAST YVPTVCNGRE VLDSTTSSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.