Details for: TLE4

Gene ID: 7091

Symbol: TLE4

Ensembl ID: ENSG00000106829

Description: TLE family member 4, transcriptional corepressor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.75
    Marker Score: 2941
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.6
    Marker Score: 22798
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.51
    Marker Score: 6016
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.45
    Marker Score: 10247.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.44
    Marker Score: 2563
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.38
    Marker Score: 81121
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.23
    Marker Score: 39547
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.22
    Marker Score: 3120
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 2.18
    Marker Score: 2627
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.17
    Marker Score: 1263
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.15
    Marker Score: 20222
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.13
    Marker Score: 919
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.97
    Marker Score: 20014
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.92
    Marker Score: 1634
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.89
    Marker Score: 17952
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.89
    Marker Score: 585
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.84
    Marker Score: 15808
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.81
    Marker Score: 2238
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.79
    Marker Score: 2643
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.77
    Marker Score: 37805
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.75
    Marker Score: 19736
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.71
    Marker Score: 1965
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.71
    Marker Score: 629
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.7
    Marker Score: 4264
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.7
    Marker Score: 4760
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.7
    Marker Score: 2282
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.7
    Marker Score: 8330
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.69
    Marker Score: 854
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.67
    Marker Score: 697
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.66
    Marker Score: 3191.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.64
    Marker Score: 607
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.62
    Marker Score: 1910
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.61
    Marker Score: 480
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.6
    Marker Score: 1544
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.6
    Marker Score: 3859
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.59
    Marker Score: 97651
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.59
    Marker Score: 456
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.56
    Marker Score: 775
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.54
    Marker Score: 1052
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.53
    Marker Score: 419
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.53
    Marker Score: 1973
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.52
    Marker Score: 759
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.5
    Marker Score: 1302
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.49
    Marker Score: 1397
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.49
    Marker Score: 891
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.49
    Marker Score: 1501
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.49
    Marker Score: 723
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.48
    Marker Score: 2508
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.48
    Marker Score: 4209
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.47
    Marker Score: 3069
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.46
    Marker Score: 15073
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.44
    Marker Score: 165694
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.44
    Marker Score: 1185
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.43
    Marker Score: 518
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.43
    Marker Score: 4179
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.43
    Marker Score: 342
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.43
    Marker Score: 1311.5
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.43
    Marker Score: 1422
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.43
    Marker Score: 355
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.42
    Marker Score: 1120
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.41
    Marker Score: 355
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.41
    Marker Score: 317
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.4
    Marker Score: 348
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.4
    Marker Score: 305
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.4
    Marker Score: 1693
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.4
    Marker Score: 5490
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.39
    Marker Score: 8894
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.39
    Marker Score: 449
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.39
    Marker Score: 440
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.39
    Marker Score: 500
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.39
    Marker Score: 2141
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.38
    Marker Score: 399
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.37
    Marker Score: 307
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.37
    Marker Score: 315
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 1.37
    Marker Score: 340
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.37
    Marker Score: 572
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.35
    Marker Score: 1473
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.35
    Marker Score: 5005
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.35
    Marker Score: 490
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.35
    Marker Score: 1021
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.35
    Marker Score: 1576
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.34
    Marker Score: 1483
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.34
    Marker Score: 1277
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.33
    Marker Score: 1512
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.33
    Marker Score: 13347
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.33
    Marker Score: 2414
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.32
    Marker Score: 326
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 1.32
    Marker Score: 329
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.32
    Marker Score: 738
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.31
    Marker Score: 1106
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.31
    Marker Score: 3090
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.31
    Marker Score: 456
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.31
    Marker Score: 785
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.3
    Marker Score: 1284
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.3
    Marker Score: 72729
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.29
    Marker Score: 1868
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.28
    Marker Score: 2818
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.27
    Marker Score: 440
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.27
    Marker Score: 911
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.27
    Marker Score: 475

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Other Information

**Key Characteristics:** 1. **Transcriptional Corepressor Activity:** TLE4 acts as a transcriptional corepressor, inhibiting the transcription of target genes by interacting with transcriptional activators and co-repressors. 2. **Wnt Signaling Pathway Regulation:** TLE4 is a negative regulator of the Wnt signaling pathway, which is involved in cell proliferation, differentiation, and survival. 3. **Cellular Expression:** TLE4 is expressed in various cell types, including skeletal muscle satellite stem cells, lung endothelial cells, and oligodendrocytes. 4. **Chromatin Binding:** TLE4 binds to chromatin, facilitating the recruitment of co-repressors and transcriptional inhibitors. **Pathways and Functions:** 1. **Beta-catenin-Tcf Complex:** TLE4 interacts with the beta-catenin-Tcf complex, a key regulator of Wnt signaling pathway. 2. **Deactivation of Beta-catenin Transactivating Complex:** TLE4 deactivates the beta-catenin transactivating complex, inhibiting Wnt signaling pathway activation. 3. **Degradation of Beta-catenin by the Destruction Complex:** TLE4 is involved in the degradation of beta-catenin by the destruction complex, further inhibiting Wnt signaling pathway activation. 4. **Negative Regulation of Canonical Wnt Signaling Pathway:** TLE4 negatively regulates the canonical Wnt signaling pathway, which is involved in cell proliferation, differentiation, and survival. 5. **Repression of Wnt Target Genes:** TLE4 represses the expression of Wnt target genes, which are involved in various cellular processes, including cell proliferation and differentiation. **Clinical Significance:** 1. **Cancer:** TLE4 has been implicated in various types of cancer, including breast, lung, and colon cancer, where it is involved in the regulation of Wnt signaling pathway. 2. **Neurological Disorders:** TLE4 has been associated with neurological disorders, including Alzheimer's disease and Parkinson's disease, where it is involved in the regulation of Wnt signaling pathway. 3. **Wnt Signaling Pathway Dysregulation:** TLE4's role in regulating Wnt signaling pathway dysregulation has been implicated in various diseases, including cancer and neurological disorders. 4. **Therapeutic Targeting:** TLE4's involvement in the Wnt signaling pathway makes it a potential therapeutic target for the treatment of various diseases, including cancer and neurological disorders. In conclusion, TLE4 is a transcriptional corepressor that plays a crucial role in regulating the Wnt signaling pathway. Its involvement in various cellular processes, including cell proliferation, differentiation, and survival, makes it an important gene in understanding the regulation of cellular processes. Further research on TLE4's role in various diseases will provide insights into the development of novel therapeutic strategies.

Genular Protein ID: 2702481656

Symbol: TLE4_HUMAN

Name: Transducin-like enhancer protein 4

UniProtKB Accession Codes:

Q04727 F8W6T6 Q3ZCS1 Q5T1Y2 Q6PCB3 Q9BZ07 Q9BZ08 Q9BZ09 Q9NSL3 Q9ULF9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 4 RefSeq 4 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10574462

Title: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10574462

DOI: 10.1093/dnares/6.5.337

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 1303260

Title: Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins.

PubMed ID: 1303260

DOI: 10.1038/ng1092-119

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18254933

Title: The Groucho/TLE/Grg family of transcriptional co-repressors.

PubMed ID: 18254933

DOI: 10.1186/gb-2008-9-1-205

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21429299

Title: EphrinB1 interacts with the transcriptional co-repressor Groucho/xTLE4.

PubMed ID: 21429299

DOI: 10.5483/bmbrep.2011.44.3.199

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22304967

Title: XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling.

PubMed ID: 22304967

DOI: 10.1016/j.molcel.2011.12.032

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24676634

Title: Mutations in PAX2 associate with adult-onset FSGS.

PubMed ID: 24676634

DOI: 10.1681/asn.2013070686

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 773
  • Mass: 83755
  • Checksum: DA138F1DA29E81B6
  • Sequence:
    • MIRDLSKMYP QTRHPAPHQP AQPFKFTISE SCDRIKEEFQ FLQAQYHSLK LECEKLASEK 
TEMQRHYVMY YEMSYGLNIE MHKQAEIVKR LNAICAQVIP FLSQEHQQQV VQAVERAKQV 
TMAELNAIIG QQLQAQHLSH GHGLPVPLTP HPSGLQPPAI PPIGSSAGLL ALSSALGGQS 
HLPIKDEKKH HDNDHQRDRD SIKSSSVSPS ASFRGAEKHR NSADYSSESK KQKTEEKEIA 
ARYDSDGEKS DDNLVVDVSN EDPSSPRGSP AHSPRENGLD KTRLLKKDAP ISPASIASSS 
STPSSKSKEL SLNEKSTTPV SKSNTPTPRT DAPTPGSNST PGLRPVPGKP PGVDPLASSL 
RTPMAVPCPY PTPFGIVPHA GMNGELTSPG AAYAGLHNIS PQMSAAAAAA AAAAAYGRSP 
VVGFDPHHHM RVPAIPPNLT GIPGGKPAYS FHVSADGQMQ PVPFPPDALI GPGIPRHARQ 
INTLNHGEVV CAVTISNPTR HVYTGGKGCV KVWDISHPGN KSPVSQLDCL NRDNYIRSCR 
LLPDGRTLIV GGEASTLSIW DLAAPTPRIK AELTSSAPAC YALAISPDSK VCFSCCSDGN 
IAVWDLHNQT LVRQFQGHTD GASCIDISND GTKLWTGGLD NTVRSWDLRE GRQLQQHDFT 
SQIFSLGYCP TGEWLAVGME NSNVEVLHVT KPDKYQLHLH ESCVLSLKFA HCGKWFVSTG 
KDNLLNAWRT PYGASIFQSK ESSSVLSCDI SVDDKYIVTG SGDKKATVYE VIY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.