Details for: FOLH1

Gene ID: 2346

Symbol: FOLH1

Ensembl ID: ENSG00000086205

Description: folate hydrolase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 7.02
    Marker Score: 10818
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.54
    Marker Score: 6084
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1162
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.6
    Marker Score: 929
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.47
    Marker Score: 1178
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.37
    Marker Score: 340
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 863
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.25
    Marker Score: 2849
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.24
    Marker Score: 493
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.2
    Marker Score: 621
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.11
    Marker Score: 2100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251796
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 791
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71814
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48039
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.96
    Marker Score: 232
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.95
    Marker Score: 1537
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5321
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5283
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.82
    Marker Score: 1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8
    Marker Score: 793
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 318
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.76
    Marker Score: 1549
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 497
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 684
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.74
    Marker Score: 471
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.72
    Marker Score: 417
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.69
    Marker Score: 1259
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.69
    Marker Score: 322
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.67
    Marker Score: 4323
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2795.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.61
    Marker Score: 1426
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6
    Marker Score: 9455
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.6
    Marker Score: 276
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.6
    Marker Score: 359
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.57
    Marker Score: 2468
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.56
    Marker Score: 234
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 231
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.49
    Marker Score: 2628
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.46
    Marker Score: 2205
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.44
    Marker Score: 5765
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.43
    Marker Score: 1544.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.38
    Marker Score: 442
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.38
    Marker Score: 214
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.37
    Marker Score: 178
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.37
    Marker Score: 346
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 368
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.37
    Marker Score: 391
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.36
    Marker Score: 84
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.34
    Marker Score: 565
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.33
    Marker Score: 121
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.33
    Marker Score: 191
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.32
    Marker Score: 635
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.31
    Marker Score: 215
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.31
    Marker Score: 380
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.31
    Marker Score: 89
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.31
    Marker Score: 325
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.3
    Marker Score: 79
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.3
    Marker Score: 256
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.27
    Marker Score: 135
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.27
    Marker Score: 893
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.27
    Marker Score: 86
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.27
    Marker Score: 131
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.26
    Marker Score: 234
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.26
    Marker Score: 741
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.25
    Marker Score: 79
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.25
    Marker Score: 177
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.24
    Marker Score: 146
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.23
    Marker Score: 73
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.22
    Marker Score: 71
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.22
    Marker Score: 216
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.22
    Marker Score: 408
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.22
    Marker Score: 97
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.22
    Marker Score: 299
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.21
    Marker Score: 670
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.21
    Marker Score: 227
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.21
    Marker Score: 78
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.2
    Marker Score: 58
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.2
    Marker Score: 253
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.2
    Marker Score: 44
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.2
    Marker Score: 57
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.2
    Marker Score: 177
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.19
    Marker Score: 231
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.19
    Marker Score: 1144
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.19
    Marker Score: 56
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.19
    Marker Score: 60
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.19
    Marker Score: 166
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.18
    Marker Score: 484
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.18
    Marker Score: 69

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Other Information

## Summary The gene encoding FolH1 is a protein that is highly expressed in epithelial cells of the colon, oligodendrocytes, goblet cells of the colon, luminal cells of the prostate, pulmonary interstitial fibroblasts, and serous secreting cells. It is involved in a variety of cellular processes, including cell surface recognition, protein degradation, and the metabolism of folate and its derivatives. ## Key characteristics * FolH1 is a transmembrane protein with a molecular weight of approximately 500 kDa. * It is a member of the FolH family of folate hydrolases. * FolH1 is expressed in a variety of cell types, including epithelial cells, immune cells, and stromal cells. * It is a key regulator of cell growth, differentiation, and migration. ## Pathways and functions * FolH1 is involved in the degradation of aspartate and asparagine, two amino acids that are involved in the synthesis of collagen. * It is also involved in the regulation of cell surface recognition and adhesion. * FolH1 is a key regulator of the integrity of the epithelial cell layer of the colon. * It is involved in the metabolism of folate and its derivatives, including the synthesis of DNA, RNA, and proteins. * FolH1 is also involved in the regulation of inflammation. ## Clinical significance Mutations in the FOLH1 gene have been linked to a number of human diseases, including colorectal cancer, breast cancer, and liver cancer. These mutations can lead to the loss of FolH1 function, which can result in the accumulation of folate and its derivatives in the body. This can lead to a number of cellular problems, including cell proliferation, migration, and differentiation abnormalities. FolH1 is a promising target for the treatment of cancer. Several drugs that target FolH1 have been shown to be effective in inhibiting cancer growth and metastasis. These drugs are currently being evaluated in clinical trials for the treatment of a variety of human cancers.

Genular Protein ID: 2353846258

Symbol: FOLH1_HUMAN

Name: Cell growth-inhibiting gene 27 protein

UniProtKB Accession Codes:

Q04609 A4UU12 A9CB79 B7Z312 B7Z343 D3DQS5 E9PDX8 O43748 Q16305 Q541A4 Q8TAY3 Q9NP15 Q9NYE2 Q9P1P8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 2 CPTAC 1 CTD 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 EC 2 EMBL 20 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 81 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 RNAct 1 Reactome 1 RefSeq 16 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8417812

Title: Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen.

PubMed ID: 8417812

PubMed ID: 7882349

Title: Alternatively spliced variants of prostate-specific membrane antigen RNA: ratio of expression as a potential measurement of progression.

PubMed ID: 7882349

PubMed ID: 9838072

Title: Mapping, genomic organization and promoter analysis of the human prostate-specific membrane antigen gene.

PubMed ID: 9838072

DOI: 10.1016/s0167-4781(98)00200-0

PubMed ID: 9694964

Title: Molecular characterization of human brain N-acetylated alpha-linked acidic dipeptidase (NAALADase).

PubMed ID: 9694964

PubMed ID: 10085079

Title: Isolation and expression of novel human glutamate carboxypeptidases with N-acetylated alpha-linked acidic dipeptidase and dipeptidyl peptidase IV activity.

PubMed ID: 10085079

DOI: 10.1074/jbc.274.13.8470

PubMed ID: 11092759

Title: Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia.

PubMed ID: 11092759

DOI: 10.1093/hmg/9.19.2837

PubMed ID: 17929272

Title: High expression of PSM-E correlated with tumor grade in prostate cancer: a new alternatively spliced variant of prostate-specific membrane antigen.

PubMed ID: 17929272

DOI: 10.1002/pros.20664

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9809977

Title: Identification, purification, and subcellular localization of prostate-specific membrane antigen PSM' protein in the LNCaP prostatic carcinoma cell line.

PubMed ID: 9809977

PubMed ID: 9622670

Title: Hydrolysis of the neuropeptide N-acetylaspartylglutamate (NAAG) by cloned human glutamate carboxypeptidase II.

PubMed ID: 9622670

DOI: 10.1016/s0006-8993(98)00244-3

PubMed ID: 9187245

Title: Structure of membrane glutamate carboxypeptidase.

PubMed ID: 9187245

DOI: 10.1016/s0167-4838(97)00008-3

PubMed ID: 9882712

Title: Site-directed mutagenesis of predicted active site residues in glutamate carboxypeptidase II.

PubMed ID: 9882712

DOI: 10.1124/mol.55.1.179

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 15152093

Title: Identification of the N-glycosylation sites on glutamate carboxypeptidase II necessary for proteolytic activity.

PubMed ID: 15152093

DOI: 10.1110/ps.04622104

PubMed ID: 14716746

Title: Comparative analysis of prostate-specific membrane antigen (PSMA) versus a prostate-specific membrane antigen-like gene.

PubMed ID: 14716746

DOI: 10.1002/pros.10319

PubMed ID: 16555021

Title: Expression of prostate-specific membrane antigen in normal and malignant human tissues.

PubMed ID: 16555021

DOI: 10.1007/s00268-005-0544-5

PubMed ID: 17150306

Title: Expression of glutamate carboxypeptidase II in human brain.

PubMed ID: 17150306

DOI: 10.1016/j.neuroscience.2006.10.022

PubMed ID: 16467855

Title: Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer.

PubMed ID: 16467855

DOI: 10.1038/sj.emboj.7600969

PubMed ID: 17372356

Title: Human glutamate carboxypeptidase II inhibition: structures of GCPII in complex with two potent inhibitors, quisqualate and 2-PMPA.

PubMed ID: 17372356

DOI: 10.1107/s090744490700902x

PubMed ID: 17567119

Title: Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II.

PubMed ID: 17567119

DOI: 10.1021/jm070133w

PubMed ID: 19053759

Title: Interactions between human glutamate carboxypeptidase II and urea-based inhibitors: structural characterization.

PubMed ID: 19053759

DOI: 10.1021/jm800765e

PubMed ID: 18234225

Title: Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs.

PubMed ID: 18234225

DOI: 10.1016/j.jmb.2007.12.066

PubMed ID: 19301871

Title: Reaction mechanism of glutamate carboxypeptidase II revealed by mutagenesis, X-ray crystallography, and computational methods.

PubMed ID: 19301871

DOI: 10.1021/bi900220s

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 750
  • Mass: 84331
  • Checksum: AD8C0A7DBF47901A
  • Sequence:
    • MWNLLHETDS AVATARRPRW LCAGALVLAG GFFLLGFLFG WFIKSSNEAT NITPKHNMKA 
FLDELKAENI KKFLYNFTQI PHLAGTEQNF QLAKQIQSQW KEFGLDSVEL AHYDVLLSYP 
NKTHPNYISI INEDGNEIFN TSLFEPPPPG YENVSDIVPP FSAFSPQGMP EGDLVYVNYA 
RTEDFFKLER DMKINCSGKI VIARYGKVFR GNKVKNAQLA GAKGVILYSD PADYFAPGVK 
SYPDGWNLPG GGVQRGNILN LNGAGDPLTP GYPANEYAYR RGIAEAVGLP SIPVHPIGYY 
DAQKLLEKMG GSAPPDSSWR GSLKVPYNVG PGFTGNFSTQ KVKMHIHSTN EVTRIYNVIG 
TLRGAVEPDR YVILGGHRDS WVFGGIDPQS GAAVVHEIVR SFGTLKKEGW RPRRTILFAS 
WDAEEFGLLG STEWAEENSR LLQERGVAYI NADSSIEGNY TLRVDCTPLM YSLVHNLTKE 
LKSPDEGFEG KSLYESWTKK SPSPEFSGMP RISKLGSGND FEVFFQRLGI ASGRARYTKN 
WETNKFSGYP LYHSVYETYE LVEKFYDPMF KYHLTVAQVR GGMVFELANS IVLPFDCRDY 
AVVLRKYADK IYSISMKHPQ EMKTYSVSFD SLFSAVKNFT EIASKFSERL QDFDKSNPIV 
LRMMNDQLMF LERAFIDPLG LPDRPFYRHV IYAPSSHNKY AGESFPGIYD ALFDIESKVD 
PSKAWGEVKR QIYVAAFTVQ AAAETLSEVA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.