Details for: FOLH1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 39.5831
Cell Significance Index: -10.0400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 8.2647
Cell Significance Index: -10.1900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2.8428
Cell Significance Index: 128.8600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 2.7332
Cell Significance Index: 87.5400 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 2.1215
Cell Significance Index: 31.9700 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.3104
Cell Significance Index: 78.6700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.2184
Cell Significance Index: 35.1100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.9712
Cell Significance Index: 45.2800 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.9213
Cell Significance Index: 5.7000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.8276
Cell Significance Index: 90.0200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.8266
Cell Significance Index: 81.7700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.7482
Cell Significance Index: 16.2100 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6879
Cell Significance Index: 621.1400 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.6001
Cell Significance Index: 6.2100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.5371
Cell Significance Index: 37.1500 - Cell Name: hepatoblast (CL0005026)
Fold Change: 0.4976
Cell Significance Index: 8.3700 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.4954
Cell Significance Index: 12.0000 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3721
Cell Significance Index: 70.8200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.3140
Cell Significance Index: 7.8500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.3024
Cell Significance Index: 6.4400 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.2260
Cell Significance Index: 12.6800 - Cell Name: seromucus secreting cell (CL0000159)
Fold Change: 0.1913
Cell Significance Index: 3.9900 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.1695
Cell Significance Index: 21.9000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.1393
Cell Significance Index: 1.9000 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.1273
Cell Significance Index: 1.9700 - Cell Name: peg cell (CL4033014)
Fold Change: 0.1151
Cell Significance Index: 2.6600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1084
Cell Significance Index: 3.8100 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0729
Cell Significance Index: 0.7600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0311
Cell Significance Index: 1.4600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0132
Cell Significance Index: 2.6200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0035
Cell Significance Index: 4.7900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0034
Cell Significance Index: 5.1700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0003
Cell Significance Index: 0.0500 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.0000
Cell Significance Index: 0.0000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0041
Cell Significance Index: -7.7300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0053
Cell Significance Index: -9.7800 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0067
Cell Significance Index: -0.2900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0086
Cell Significance Index: -6.3000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0091
Cell Significance Index: -3.2500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0134
Cell Significance Index: -9.9500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0134
Cell Significance Index: -10.1800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0149
Cell Significance Index: -9.4700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0176
Cell Significance Index: -9.9400 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0182
Cell Significance Index: -9.9400 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0186
Cell Significance Index: -2.3900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0188
Cell Significance Index: -3.7800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0219
Cell Significance Index: -9.9300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.0250
Cell Significance Index: -4.0700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0274
Cell Significance Index: -1.6800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0319
Cell Significance Index: -9.1800 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0493
Cell Significance Index: -5.0400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0552
Cell Significance Index: -9.4300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0599
Cell Significance Index: -8.7100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0652
Cell Significance Index: -8.9600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0692
Cell Significance Index: -8.5100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0710
Cell Significance Index: -3.6900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0810
Cell Significance Index: -9.4400 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0831
Cell Significance Index: -1.3900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0859
Cell Significance Index: -9.8400 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0907
Cell Significance Index: -4.5900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0997
Cell Significance Index: -10.3800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1071
Cell Significance Index: -7.2000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1088
Cell Significance Index: -3.0400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1180
Cell Significance Index: -7.4400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1212
Cell Significance Index: -9.6000 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1252
Cell Significance Index: -5.1300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1295
Cell Significance Index: -9.6500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1549
Cell Significance Index: -11.8900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1611
Cell Significance Index: -9.9000 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.1738
Cell Significance Index: -2.6400 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1879
Cell Significance Index: -4.8300 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1917
Cell Significance Index: -9.9900 - Cell Name: endothelial stalk cell (CL0002671)
Fold Change: -0.2128
Cell Significance Index: -2.3900 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.2143
Cell Significance Index: -3.6100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2188
Cell Significance Index: -11.4900 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2400
Cell Significance Index: -8.3400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2437
Cell Significance Index: -10.7800 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2470
Cell Significance Index: -5.1700 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2503
Cell Significance Index: -9.1900 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2575
Cell Significance Index: -9.0200 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.2589
Cell Significance Index: -8.1900 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.2838
Cell Significance Index: -8.3600 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2886
Cell Significance Index: -9.4500 - Cell Name: precursor cell (CL0011115)
Fold Change: -0.2947
Cell Significance Index: -2.2400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2950
Cell Significance Index: -11.1700 - Cell Name: Mueller cell (CL0000636)
Fold Change: -0.2977
Cell Significance Index: -2.2900 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.2992
Cell Significance Index: -7.4600 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: -0.3061
Cell Significance Index: -2.3400 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.3084
Cell Significance Index: -8.8000 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3099
Cell Significance Index: -9.8700 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.3117
Cell Significance Index: -4.6000 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3377
Cell Significance Index: -9.6800 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.3463
Cell Significance Index: -9.2800 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.3481
Cell Significance Index: -7.2200 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.3505
Cell Significance Index: -5.5600 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3514
Cell Significance Index: -9.4000 - Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
Fold Change: -0.3537
Cell Significance Index: -3.5400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.3708
Cell Significance Index: -9.9000 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3833
Cell Significance Index: -10.0800 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.3861
Cell Significance Index: -9.6300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2353846258
Symbol: FOLH1_HUMAN
Name: Cell growth-inhibiting gene 27 protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8417812
Title: Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen.
PubMed ID: 8417812
PubMed ID: 7882349
Title: Alternatively spliced variants of prostate-specific membrane antigen RNA: ratio of expression as a potential measurement of progression.
PubMed ID: 7882349
PubMed ID: 9838072
Title: Mapping, genomic organization and promoter analysis of the human prostate-specific membrane antigen gene.
PubMed ID: 9838072
PubMed ID: 9694964
Title: Molecular characterization of human brain N-acetylated alpha-linked acidic dipeptidase (NAALADase).
PubMed ID: 9694964
PubMed ID: 10085079
Title: Isolation and expression of novel human glutamate carboxypeptidases with N-acetylated alpha-linked acidic dipeptidase and dipeptidyl peptidase IV activity.
PubMed ID: 10085079
PubMed ID: 11092759
Title: Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia.
PubMed ID: 11092759
PubMed ID: 17929272
Title: High expression of PSM-E correlated with tumor grade in prostate cancer: a new alternatively spliced variant of prostate-specific membrane antigen.
PubMed ID: 17929272
DOI: 10.1002/pros.20664
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9809977
Title: Identification, purification, and subcellular localization of prostate-specific membrane antigen PSM' protein in the LNCaP prostatic carcinoma cell line.
PubMed ID: 9809977
PubMed ID: 9622670
Title: Hydrolysis of the neuropeptide N-acetylaspartylglutamate (NAAG) by cloned human glutamate carboxypeptidase II.
PubMed ID: 9622670
PubMed ID: 9187245
Title: Structure of membrane glutamate carboxypeptidase.
PubMed ID: 9187245
PubMed ID: 9882712
Title: Site-directed mutagenesis of predicted active site residues in glutamate carboxypeptidase II.
PubMed ID: 9882712
DOI: 10.1124/mol.55.1.179
PubMed ID: 12754519
Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.
PubMed ID: 12754519
DOI: 10.1038/nbt827
PubMed ID: 15152093
Title: Identification of the N-glycosylation sites on glutamate carboxypeptidase II necessary for proteolytic activity.
PubMed ID: 15152093
DOI: 10.1110/ps.04622104
PubMed ID: 14716746
Title: Comparative analysis of prostate-specific membrane antigen (PSMA) versus a prostate-specific membrane antigen-like gene.
PubMed ID: 14716746
DOI: 10.1002/pros.10319
PubMed ID: 16555021
Title: Expression of prostate-specific membrane antigen in normal and malignant human tissues.
PubMed ID: 16555021
PubMed ID: 17150306
Title: Expression of glutamate carboxypeptidase II in human brain.
PubMed ID: 17150306
PubMed ID: 16467855
Title: Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer.
PubMed ID: 16467855
PubMed ID: 17372356
Title: Human glutamate carboxypeptidase II inhibition: structures of GCPII in complex with two potent inhibitors, quisqualate and 2-PMPA.
PubMed ID: 17372356
PubMed ID: 17567119
Title: Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II.
PubMed ID: 17567119
DOI: 10.1021/jm070133w
PubMed ID: 19053759
Title: Interactions between human glutamate carboxypeptidase II and urea-based inhibitors: structural characterization.
PubMed ID: 19053759
DOI: 10.1021/jm800765e
PubMed ID: 18234225
Title: Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs.
PubMed ID: 18234225
PubMed ID: 19301871
Title: Reaction mechanism of glutamate carboxypeptidase II revealed by mutagenesis, X-ray crystallography, and computational methods.
PubMed ID: 19301871
DOI: 10.1021/bi900220s
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
Sequence Information:
- Length: 750
- Mass: 84331
- Checksum: AD8C0A7DBF47901A
- Sequence:
MWNLLHETDS AVATARRPRW LCAGALVLAG GFFLLGFLFG WFIKSSNEAT NITPKHNMKA FLDELKAENI KKFLYNFTQI PHLAGTEQNF QLAKQIQSQW KEFGLDSVEL AHYDVLLSYP NKTHPNYISI INEDGNEIFN TSLFEPPPPG YENVSDIVPP FSAFSPQGMP EGDLVYVNYA RTEDFFKLER DMKINCSGKI VIARYGKVFR GNKVKNAQLA GAKGVILYSD PADYFAPGVK SYPDGWNLPG GGVQRGNILN LNGAGDPLTP GYPANEYAYR RGIAEAVGLP SIPVHPIGYY DAQKLLEKMG GSAPPDSSWR GSLKVPYNVG PGFTGNFSTQ KVKMHIHSTN EVTRIYNVIG TLRGAVEPDR YVILGGHRDS WVFGGIDPQS GAAVVHEIVR SFGTLKKEGW RPRRTILFAS WDAEEFGLLG STEWAEENSR LLQERGVAYI NADSSIEGNY TLRVDCTPLM YSLVHNLTKE LKSPDEGFEG KSLYESWTKK SPSPEFSGMP RISKLGSGND FEVFFQRLGI ASGRARYTKN WETNKFSGYP LYHSVYETYE LVEKFYDPMF KYHLTVAQVR GGMVFELANS IVLPFDCRDY AVVLRKYADK IYSISMKHPQ EMKTYSVSFD SLFSAVKNFT EIASKFSERL QDFDKSNPIV LRMMNDQLMF LERAFIDPLG LPDRPFYRHV IYAPSSHNKY AGESFPGIYD ALFDIESKVD PSKAWGEVKR QIYVAAFTVQ AAAETLSEVA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.