Details for: FOLH1

Gene ID: 2346

Symbol: FOLH1

Ensembl ID: ENSG00000086205

Description: folate hydrolase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 39.5831
    Cell Significance Index: -10.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.2647
    Cell Significance Index: -10.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.8428
    Cell Significance Index: 128.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.7332
    Cell Significance Index: 87.5400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 2.1215
    Cell Significance Index: 31.9700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3104
    Cell Significance Index: 78.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2184
    Cell Significance Index: 35.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9712
    Cell Significance Index: 45.2800
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.9213
    Cell Significance Index: 5.7000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8276
    Cell Significance Index: 90.0200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8266
    Cell Significance Index: 81.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7482
    Cell Significance Index: 16.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6879
    Cell Significance Index: 621.1400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.6001
    Cell Significance Index: 6.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5371
    Cell Significance Index: 37.1500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.4976
    Cell Significance Index: 8.3700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.4954
    Cell Significance Index: 12.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3721
    Cell Significance Index: 70.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3140
    Cell Significance Index: 7.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3024
    Cell Significance Index: 6.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2260
    Cell Significance Index: 12.6800
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.1913
    Cell Significance Index: 3.9900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1695
    Cell Significance Index: 21.9000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1393
    Cell Significance Index: 1.9000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1273
    Cell Significance Index: 1.9700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1151
    Cell Significance Index: 2.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1084
    Cell Significance Index: 3.8100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0729
    Cell Significance Index: 0.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0311
    Cell Significance Index: 1.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0132
    Cell Significance Index: 2.6200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0035
    Cell Significance Index: 4.7900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0034
    Cell Significance Index: 5.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0003
    Cell Significance Index: 0.0500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0041
    Cell Significance Index: -7.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0053
    Cell Significance Index: -9.7800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0067
    Cell Significance Index: -0.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0086
    Cell Significance Index: -6.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0091
    Cell Significance Index: -3.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0134
    Cell Significance Index: -9.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0134
    Cell Significance Index: -10.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0149
    Cell Significance Index: -9.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0176
    Cell Significance Index: -9.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0182
    Cell Significance Index: -9.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0186
    Cell Significance Index: -2.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0188
    Cell Significance Index: -3.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0219
    Cell Significance Index: -9.9300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0250
    Cell Significance Index: -4.0700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0274
    Cell Significance Index: -1.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0319
    Cell Significance Index: -9.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0493
    Cell Significance Index: -5.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0552
    Cell Significance Index: -9.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0599
    Cell Significance Index: -8.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0652
    Cell Significance Index: -8.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0692
    Cell Significance Index: -8.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0710
    Cell Significance Index: -3.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0810
    Cell Significance Index: -9.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0831
    Cell Significance Index: -1.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0859
    Cell Significance Index: -9.8400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0907
    Cell Significance Index: -4.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0997
    Cell Significance Index: -10.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1071
    Cell Significance Index: -7.2000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1088
    Cell Significance Index: -3.0400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1180
    Cell Significance Index: -7.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1212
    Cell Significance Index: -9.6000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1252
    Cell Significance Index: -5.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1295
    Cell Significance Index: -9.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1549
    Cell Significance Index: -11.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1611
    Cell Significance Index: -9.9000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1738
    Cell Significance Index: -2.6400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1879
    Cell Significance Index: -4.8300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1917
    Cell Significance Index: -9.9900
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: -0.2128
    Cell Significance Index: -2.3900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2143
    Cell Significance Index: -3.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2188
    Cell Significance Index: -11.4900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2400
    Cell Significance Index: -8.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2437
    Cell Significance Index: -10.7800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2470
    Cell Significance Index: -5.1700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2503
    Cell Significance Index: -9.1900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2575
    Cell Significance Index: -9.0200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2589
    Cell Significance Index: -8.1900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2838
    Cell Significance Index: -8.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2886
    Cell Significance Index: -9.4500
  • Cell Name: precursor cell (CL0011115)
    Fold Change: -0.2947
    Cell Significance Index: -2.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2950
    Cell Significance Index: -11.1700
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.2977
    Cell Significance Index: -2.2900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2992
    Cell Significance Index: -7.4600
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.3061
    Cell Significance Index: -2.3400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3084
    Cell Significance Index: -8.8000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3099
    Cell Significance Index: -9.8700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3117
    Cell Significance Index: -4.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3377
    Cell Significance Index: -9.6800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3463
    Cell Significance Index: -9.2800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3481
    Cell Significance Index: -7.2200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3505
    Cell Significance Index: -5.5600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3514
    Cell Significance Index: -9.4000
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.3537
    Cell Significance Index: -3.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3708
    Cell Significance Index: -9.9000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3833
    Cell Significance Index: -10.0800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3861
    Cell Significance Index: -9.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FOLH1 is a metalloprotease enzyme that exhibits a wide range of enzymatic activities, including: 1. **Folate hydrolase activity**: FOLH1 catalyzes the hydrolysis of folate-containing compounds, such as tetrahydrofolyl-poly(glutamate) polymers. 2. **C-terminal protein deglutamylation**: FOLH1 removes glutamylation from the C-terminal of proteins, regulating their stability and function. 3. **Peptidase activity**: FOLH1 exhibits dipeptidase and carboxypeptidase activities, breaking down peptides and proteins. 4. **Cell surface and extracellular protein processing**: FOLH1 is involved in the processing and degradation of cell surface proteins and extracellular proteins. **Pathways and Functions:** FOLH1 is intricately linked to various cellular processes, including: 1. **Folate metabolism**: FOLH1 regulates the availability of folate, a crucial cofactor for one-carbon metabolism. 2. **Cell surface protein processing**: FOLH1 modulates the stability and function of cell surface proteins, influencing cell signaling and immune responses. 3. **Extracellular protein degradation**: FOLH1 contributes to the clearance of extracellular proteins, maintaining tissue homeostasis and preventing protein aggregation. 4. **Immune function**: FOLH1 is expressed in immune cells, such as granulocytes and monocytes, suggesting its role in regulating immune responses. **Clinical Significance:** Dysregulation of FOLH1 has been implicated in various diseases, including: 1. **Cancer**: Altered FOLH1 expression has been linked to cancer progression and metastasis. 2. **Neurological disorders**: FOLH1 has been implicated in the pathogenesis of neurological diseases, such as Alzheimer's and Parkinson's. 3. **Immune-mediated diseases**: FOLH1 expression is altered in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. In conclusion, the FOLH1 gene is a complex and multifunctional enzyme that plays a critical role in regulating folate metabolism, cell surface protein processing, and extracellular protein degradation. Further research is needed to fully elucidate the mechanisms by which FOLH1 influences disease pathogenesis and to explore its potential as a therapeutic target.

Genular Protein ID: 2353846258

Symbol: FOLH1_HUMAN

Name: Cell growth-inhibiting gene 27 protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8417812

Title: Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen.

PubMed ID: 8417812

PubMed ID: 7882349

Title: Alternatively spliced variants of prostate-specific membrane antigen RNA: ratio of expression as a potential measurement of progression.

PubMed ID: 7882349

PubMed ID: 9838072

Title: Mapping, genomic organization and promoter analysis of the human prostate-specific membrane antigen gene.

PubMed ID: 9838072

DOI: 10.1016/s0167-4781(98)00200-0

PubMed ID: 9694964

Title: Molecular characterization of human brain N-acetylated alpha-linked acidic dipeptidase (NAALADase).

PubMed ID: 9694964

PubMed ID: 10085079

Title: Isolation and expression of novel human glutamate carboxypeptidases with N-acetylated alpha-linked acidic dipeptidase and dipeptidyl peptidase IV activity.

PubMed ID: 10085079

DOI: 10.1074/jbc.274.13.8470

PubMed ID: 11092759

Title: Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia.

PubMed ID: 11092759

DOI: 10.1093/hmg/9.19.2837

PubMed ID: 17929272

Title: High expression of PSM-E correlated with tumor grade in prostate cancer: a new alternatively spliced variant of prostate-specific membrane antigen.

PubMed ID: 17929272

DOI: 10.1002/pros.20664

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9809977

Title: Identification, purification, and subcellular localization of prostate-specific membrane antigen PSM' protein in the LNCaP prostatic carcinoma cell line.

PubMed ID: 9809977

PubMed ID: 9622670

Title: Hydrolysis of the neuropeptide N-acetylaspartylglutamate (NAAG) by cloned human glutamate carboxypeptidase II.

PubMed ID: 9622670

DOI: 10.1016/s0006-8993(98)00244-3

PubMed ID: 9187245

Title: Structure of membrane glutamate carboxypeptidase.

PubMed ID: 9187245

DOI: 10.1016/s0167-4838(97)00008-3

PubMed ID: 9882712

Title: Site-directed mutagenesis of predicted active site residues in glutamate carboxypeptidase II.

PubMed ID: 9882712

DOI: 10.1124/mol.55.1.179

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 15152093

Title: Identification of the N-glycosylation sites on glutamate carboxypeptidase II necessary for proteolytic activity.

PubMed ID: 15152093

DOI: 10.1110/ps.04622104

PubMed ID: 14716746

Title: Comparative analysis of prostate-specific membrane antigen (PSMA) versus a prostate-specific membrane antigen-like gene.

PubMed ID: 14716746

DOI: 10.1002/pros.10319

PubMed ID: 16555021

Title: Expression of prostate-specific membrane antigen in normal and malignant human tissues.

PubMed ID: 16555021

DOI: 10.1007/s00268-005-0544-5

PubMed ID: 17150306

Title: Expression of glutamate carboxypeptidase II in human brain.

PubMed ID: 17150306

DOI: 10.1016/j.neuroscience.2006.10.022

PubMed ID: 16467855

Title: Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer.

PubMed ID: 16467855

DOI: 10.1038/sj.emboj.7600969

PubMed ID: 17372356

Title: Human glutamate carboxypeptidase II inhibition: structures of GCPII in complex with two potent inhibitors, quisqualate and 2-PMPA.

PubMed ID: 17372356

DOI: 10.1107/s090744490700902x

PubMed ID: 17567119

Title: Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II.

PubMed ID: 17567119

DOI: 10.1021/jm070133w

PubMed ID: 19053759

Title: Interactions between human glutamate carboxypeptidase II and urea-based inhibitors: structural characterization.

PubMed ID: 19053759

DOI: 10.1021/jm800765e

PubMed ID: 18234225

Title: Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs.

PubMed ID: 18234225

DOI: 10.1016/j.jmb.2007.12.066

PubMed ID: 19301871

Title: Reaction mechanism of glutamate carboxypeptidase II revealed by mutagenesis, X-ray crystallography, and computational methods.

PubMed ID: 19301871

DOI: 10.1021/bi900220s

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 750
  • Mass: 84331
  • Checksum: AD8C0A7DBF47901A
  • Sequence:
  • MWNLLHETDS AVATARRPRW LCAGALVLAG GFFLLGFLFG WFIKSSNEAT NITPKHNMKA 
    FLDELKAENI KKFLYNFTQI PHLAGTEQNF QLAKQIQSQW KEFGLDSVEL AHYDVLLSYP 
    NKTHPNYISI INEDGNEIFN TSLFEPPPPG YENVSDIVPP FSAFSPQGMP EGDLVYVNYA 
    RTEDFFKLER DMKINCSGKI VIARYGKVFR GNKVKNAQLA GAKGVILYSD PADYFAPGVK 
    SYPDGWNLPG GGVQRGNILN LNGAGDPLTP GYPANEYAYR RGIAEAVGLP SIPVHPIGYY 
    DAQKLLEKMG GSAPPDSSWR GSLKVPYNVG PGFTGNFSTQ KVKMHIHSTN EVTRIYNVIG 
    TLRGAVEPDR YVILGGHRDS WVFGGIDPQS GAAVVHEIVR SFGTLKKEGW RPRRTILFAS 
    WDAEEFGLLG STEWAEENSR LLQERGVAYI NADSSIEGNY TLRVDCTPLM YSLVHNLTKE 
    LKSPDEGFEG KSLYESWTKK SPSPEFSGMP RISKLGSGND FEVFFQRLGI ASGRARYTKN 
    WETNKFSGYP LYHSVYETYE LVEKFYDPMF KYHLTVAQVR GGMVFELANS IVLPFDCRDY 
    AVVLRKYADK IYSISMKHPQ EMKTYSVSFD SLFSAVKNFT EIASKFSERL QDFDKSNPIV 
    LRMMNDQLMF LERAFIDPLG LPDRPFYRHV IYAPSSHNKY AGESFPGIYD ALFDIESKVD 
    PSKAWGEVKR QIYVAAFTVQ AAAETLSEVA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.