Details for: MAG

Gene ID: 4099

Symbol: MAG

Ensembl ID: ENSG00000105695

Description: myelin associated glycoprotein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 26.0208
    Cell Significance Index: -6.6000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 4.5035
    Cell Significance Index: 57.6800
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 3.0801
    Cell Significance Index: 14.9800
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.5379
    Cell Significance Index: 9.0400
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.2820
    Cell Significance Index: 8.8900
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.1486
    Cell Significance Index: 5.7300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6626
    Cell Significance Index: 17.7600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5688
    Cell Significance Index: 8.2900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.5624
    Cell Significance Index: 6.0300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5250
    Cell Significance Index: 12.1300
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.5186
    Cell Significance Index: 5.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4434
    Cell Significance Index: 11.6600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1502
    Cell Significance Index: 43.2100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1161
    Cell Significance Index: 3.4200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0724
    Cell Significance Index: 39.5300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.0435
    Cell Significance Index: 0.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0086
    Cell Significance Index: 1.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0085
    Cell Significance Index: 3.0600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0006
    Cell Significance Index: 0.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0031
    Cell Significance Index: -5.7800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0033
    Cell Significance Index: -6.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0040
    Cell Significance Index: -6.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0047
    Cell Significance Index: -6.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0070
    Cell Significance Index: -1.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0075
    Cell Significance Index: -5.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0083
    Cell Significance Index: -5.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0089
    Cell Significance Index: -6.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0097
    Cell Significance Index: -7.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0120
    Cell Significance Index: -5.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0125
    Cell Significance Index: -7.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0136
    Cell Significance Index: -1.8700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0181
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0264
    Cell Significance Index: -4.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0294
    Cell Significance Index: -1.8100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0300
    Cell Significance Index: -5.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0314
    Cell Significance Index: -6.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0351
    Cell Significance Index: -5.1000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0377
    Cell Significance Index: -4.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0388
    Cell Significance Index: -2.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0390
    Cell Significance Index: -3.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0401
    Cell Significance Index: -4.9300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0406
    Cell Significance Index: -1.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0409
    Cell Significance Index: -5.2800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0412
    Cell Significance Index: -1.7900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0482
    Cell Significance Index: -6.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0520
    Cell Significance Index: -6.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0589
    Cell Significance Index: -6.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0621
    Cell Significance Index: -4.6300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0645
    Cell Significance Index: -6.7200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0647
    Cell Significance Index: -2.2500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0689
    Cell Significance Index: -5.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0921
    Cell Significance Index: -7.0700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1030
    Cell Significance Index: -0.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1034
    Cell Significance Index: -2.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1035
    Cell Significance Index: -4.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1097
    Cell Significance Index: -5.7000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1106
    Cell Significance Index: -0.9400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1123
    Cell Significance Index: -5.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1141
    Cell Significance Index: -6.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1143
    Cell Significance Index: -3.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1190
    Cell Significance Index: -5.5500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1251
    Cell Significance Index: -3.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1299
    Cell Significance Index: -3.3400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1349
    Cell Significance Index: -4.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1350
    Cell Significance Index: -3.6100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1354
    Cell Significance Index: -2.3200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1397
    Cell Significance Index: -1.6300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1431
    Cell Significance Index: -2.4000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1459
    Cell Significance Index: -2.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1481
    Cell Significance Index: -6.5500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1504
    Cell Significance Index: -5.5200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1585
    Cell Significance Index: -5.1900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1598
    Cell Significance Index: -5.0900
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.1608
    Cell Significance Index: -1.0000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1693
    Cell Significance Index: -4.8300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1698
    Cell Significance Index: -4.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1740
    Cell Significance Index: -6.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1767
    Cell Significance Index: -6.2100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1814
    Cell Significance Index: -5.2000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1834
    Cell Significance Index: -3.5900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1836
    Cell Significance Index: -2.0000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2008
    Cell Significance Index: -6.3500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2044
    Cell Significance Index: -4.3400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2065
    Cell Significance Index: -5.1500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2092
    Cell Significance Index: -4.2000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2162
    Cell Significance Index: -4.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2183
    Cell Significance Index: -5.8300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2184
    Cell Significance Index: -5.5800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2229
    Cell Significance Index: -4.8800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2256
    Cell Significance Index: -4.4600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2257
    Cell Significance Index: -3.5800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2296
    Cell Significance Index: -3.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2332
    Cell Significance Index: -11.7800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2348
    Cell Significance Index: -4.9000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.2353
    Cell Significance Index: -3.2900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2394
    Cell Significance Index: -6.1000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2403
    Cell Significance Index: -4.8900
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.2413
    Cell Significance Index: -3.1600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2440
    Cell Significance Index: -5.9100
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.2470
    Cell Significance Index: -2.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MAG is a transmembrane glycoprotein composed of two extracellular domains and a single transmembrane domain. It exhibits a conserved structure among different species, with high sequence homology to other glycoproteins involved in cell-cell adhesion and axonal guidance. MAG's extracellular domain contains two N-glycosylated sites, which are critical for its binding to other molecules, including gangliosides and sialic acid. The protein's transmembrane domain is involved in its localization to the plasma membrane and its interaction with other membrane proteins. **Pathways and Functions** MAG is involved in several cellular pathways, including: 1. **Axonal growth inhibition**: MAG interacts with gangliosides and sialic acid to inhibit axonal growth and promote the formation of compact myelin. 2. **Axon regeneration**: MAG's expression is reduced during axonal regeneration, suggesting that it may play a role in limiting axonal growth and promoting the formation of a new myelin sheath. 3. **Cell-cell adhesion**: MAG interacts with other glycoproteins to mediate cell-cell adhesion and promote the formation of the paranode region of axons. 4. **Myelin sheath formation**: MAG is involved in the formation of compact myelin and the regulation of oligodendrocyte differentiation. 5. **Neurological signaling**: MAG interacts with signaling receptors, including the P75NTR receptor, to regulate axonal development and function. **Clinical Significance** Dysregulation of MAG expression has been implicated in various neurological disorders, including: 1. **Multiple sclerosis**: MAG's expression is altered in patients with multiple sclerosis, suggesting that it may play a role in disease pathogenesis. 2. **Amyotrophic lateral sclerosis (ALS)**: MAG's expression is reduced in ALS patients, suggesting that it may contribute to axonal degeneration. 3. **Neurodevelopmental disorders**: MAG's expression is altered in patients with neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 4. **Cancer**: MAG's expression is altered in certain types of cancer, including glioblastoma and ovarian cancer. In conclusion, MAG is a critical protein involved in the development, maintenance, and function of the CNS. Its dysregulation has been implicated in various neurological disorders, highlighting the importance of further research into its role in human disease.

Genular Protein ID: 1650392257

Symbol: MAG_HUMAN

Name: Myelin-associated glycoprotein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2476987

Title: cDNA cloning and amino acid sequence for human myelin-associated glycoprotein.

PubMed ID: 2476987

DOI: 10.1016/0006-291x(89)91145-5

PubMed ID: 2479762

Title: Molecular cloning of human myelin-associated glycoprotein.

PubMed ID: 2479762

DOI: 10.1002/jnr.490240203

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9495552

Title: Reciprocal expression of myelin-associated glycoprotein splice variants in the adult human peripheral and central nervous systems.

PubMed ID: 9495552

DOI: 10.1016/s0169-328x(97)00254-4

PubMed ID: 6200494

Title: Myelin-associated glycoprotein (MAG) distribution in human central nervous tissue studied immunocytochemically with monoclonal antibody.

PubMed ID: 6200494

DOI: 10.1016/0165-5728(84)90039-0

PubMed ID: 7505568

Title: Identification of the glycosylated sequons of human myelin-associated glycoprotein.

PubMed ID: 7505568

DOI: 10.1006/bbrc.1993.2501

PubMed ID: 19052207

Title: Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth.

PubMed ID: 19052207

DOI: 10.1523/jneurosci.3828-08.2008

PubMed ID: 24482476

Title: Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders.

PubMed ID: 24482476

DOI: 10.1126/science.1247363

PubMed ID: 26179919

Title: Myelin-associated glycoprotein gene mutation causes Pelizaeus-Merzbacher disease-like disorder.

PubMed ID: 26179919

DOI: 10.1093/brain/awv204

PubMed ID: 27606346

Title: Neurologic syndrome associated with homozygous mutation at MAG sialic acid binding site.

PubMed ID: 27606346

DOI: 10.1002/acn3.329

Sequence Information:

  • Length: 626
  • Mass: 69069
  • Checksum: ED2D36B24F21CAAA
  • Sequence:
  • MIFLTALPLF WIMISASRGG HWGAWMPSSI SAFEGTCVSI PCRFDFPDEL RPAVVHGVWY 
    FNSPYPKNYP PVVFKSRTQV VHESFQGRSR LLGDLGLRNC TLLLSNVSPE LGGKYYFRGD 
    LGGYNQYTFS EHSVLDIVNT PNIVVPPEVV AGTEVEVSCM VPDNCPELRP ELSWLGHEGL 
    GEPAVLGRLR EDEGTWVQVS LLHFVPTREA NGHRLGCQAS FPNTTLQFEG YASMDVKYPP 
    VIVEMNSSVE AIEGSHVSLL CGADSNPPPL LTWMRDGTVL REAVAESLLL ELEEVTPAED 
    GVYACLAENA YGQDNRTVGL SVMYAPWKPT VNGTMVAVEG ETVSILCSTQ SNPDPILTIF 
    KEKQILSTVI YESELQLELP AVSPEDDGEY WCVAENQYGQ RATAFNLSVE FAPVLLLESH 
    CAAARDTVQC LCVVKSNPEP SVAFELPSRN VTVNESEREF VYSERSGLVL TSILTLRGQA 
    QAPPRVICTA RNLYGAKSLE LPFQGAHRLM WAKIGPVGAV VAFAILIAIV CYITQTRRKK 
    NVTESPSFSA GDNPPVLFSS DFRISGAPEK YESERRLGSE RRLLGLRGEP PELDLSYSHS 
    DLGKRPTKDS YTLTEELAEY AEIRVK

Genular Protein ID: 1529254244

Symbol: Q53ES7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 626
  • Mass: 69040
  • Checksum: ED2D36B24F23A73A
  • Sequence:
  • MIFLTALPLF WIMISASRGG HWGAWMPSSI SAFEGTCVSI PCRFDFPDEL RPAVVHGVWY 
    FNSPYPKNYP PVVFKSRTQV VHESFQGRSR LLGDLGLRNC TLLLSNVSPE LGGKYYFRGD 
    LGGYNQYTFS EHSVLDIVNT PNIVVPPEVV AGTEVEVSCM VPDNCPELRP ELSWLGHEGL 
    GEPAVLGRLR EDEGTWVQVS LLHFVPTREA NGHRLGCQAS FPNTTLQFEG YASMDVKYPP 
    VIVEMNSSVE AIEGSHVSLL CGADSNPPPL LTWMRDGTVL REAVAESLLL ELEEVTPAED 
    GVYACLAENA YGQDNRTVGL SVMYAPWKPT VNGTMVAVEG ETVSILCSTQ SNPDPILTIF 
    KEKQILSTVI YESELQLELP AVSPEDDGEY WCVAENQYGQ RATAFNLSVE FAPVLLLESH 
    CAAARDTVQC LCVVKSNPEP SVAFELPSRN VTVNESEREF VYSERSGLVL TSILTLRGQA 
    QAPPRVICTA RNLYGAKSLE LPFQGAHRLM WAKIGPVGAV VAFAILIAIV CYITQTRRKK 
    NVTESPSFSA GDNPPVLFSS DFRISGAPEK YESERRLGSE RRLLGLRGEP PELDLSYSHS 
    DLGKQPTKDS YTLTEELAEY AEIRVK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.