Details for: UNC5C

Gene ID: 8633

Symbol: UNC5C

Ensembl ID: ENSG00000182168

Description: unc-5 netrin receptor C

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 11.2
    Marker Score: 37539
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 9.34
    Marker Score: 48978
  • Cell Name: granule cell (CL0000120)
    Fold Change: 9.21
    Marker Score: 69442
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 7.65
    Marker Score: 2526
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 7.38
    Marker Score: 16960
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 7.2
    Marker Score: 10126
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 5.96
    Marker Score: 201273
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 4.63
    Marker Score: 2223
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 4.01
    Marker Score: 2249
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 3.68
    Marker Score: 8807
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 3.43
    Marker Score: 1994
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.42
    Marker Score: 7516.5
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 3.2
    Marker Score: 1779
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.95
    Marker Score: 13665
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.94
    Marker Score: 860
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.92
    Marker Score: 12209
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.85
    Marker Score: 1542
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.79
    Marker Score: 49492
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.74
    Marker Score: 41021
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.62
    Marker Score: 10842
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.49
    Marker Score: 4177
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.37
    Marker Score: 4561
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.34
    Marker Score: 12550
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.33
    Marker Score: 46273
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.32
    Marker Score: 3939
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.31
    Marker Score: 85086
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.23
    Marker Score: 933
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.21
    Marker Score: 47100
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.19
    Marker Score: 8451
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.09
    Marker Score: 2407
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.06
    Marker Score: 78410
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.99
    Marker Score: 517
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.99
    Marker Score: 20553
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.98
    Marker Score: 1105
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.93
    Marker Score: 3651
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.92
    Marker Score: 948
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.91
    Marker Score: 7795
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9
    Marker Score: 116597
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.87
    Marker Score: 16058
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.87
    Marker Score: 17735
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.86
    Marker Score: 1222
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.82
    Marker Score: 1733
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.79
    Marker Score: 5108
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.79
    Marker Score: 802
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.74
    Marker Score: 16383
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.74
    Marker Score: 2148
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.64
    Marker Score: 2538
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.62
    Marker Score: 444
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.47
    Marker Score: 464
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167805
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.42
    Marker Score: 526
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 867
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.36
    Marker Score: 493
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.32
    Marker Score: 498
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.31
    Marker Score: 10015
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.26
    Marker Score: 486
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.21
    Marker Score: 726
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.2
    Marker Score: 2179
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.18
    Marker Score: 886
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4803
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.14
    Marker Score: 2320
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.12
    Marker Score: 340
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.12
    Marker Score: 285
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.03
    Marker Score: 6210
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.03
    Marker Score: 16079
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.02
    Marker Score: 425
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.01
    Marker Score: 342
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1
    Marker Score: 869
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71798
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48023
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.99
    Marker Score: 1240
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.98
    Marker Score: 1187
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5323
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.93
    Marker Score: 261
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.91
    Marker Score: 435
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.91
    Marker Score: 3798
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5283
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.86
    Marker Score: 417
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.84
    Marker Score: 271
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 642
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.82
    Marker Score: 239
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.82
    Marker Score: 215
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.82
    Marker Score: 438
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.8
    Marker Score: 1680
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.78
    Marker Score: 410
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.78
    Marker Score: 222
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.78
    Marker Score: 973
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.77
    Marker Score: 703
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.75
    Marker Score: 500
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.71
    Marker Score: 1661

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key Characteristics:** 1. **Netrin Receptor:** UNC5C is a netrin receptor, a class of receptors that bind to netrins, a family of secreted proteins involved in axon guidance and chemorepulsion. 2. **Anterior-Posterior Axon Guidance:** UNC5C plays a critical role in regulating the anterior-posterior axis of the developing nervous system, influencing the direction and trajectory of axons. 3. **Apoptotic Process:** UNC5C is also involved in regulating the apoptotic process, particularly in the context of ectopic germ cell programmed cell death. 4. **Cell Surface Expression:** UNC5C is primarily expressed on the surface of various neuronal and non-neuronal cells, including neuronal brush cells, neurons, and macroglial cells. **Pathways and Functions:** 1. **Netrin-1 Signaling Pathway:** UNC5C is the primary receptor for netrin-1, a secreted protein involved in axon guidance and chemorepulsion. 2. **Anterior-Posterior Axon Guidance:** UNC5C regulates the anterior-posterior axis of the developing nervous system, influencing the direction and trajectory of axons. 3. **Apoptotic Process:** UNC5C is involved in regulating the apoptotic process, particularly in the context of ectopic germ cell programmed cell death. 4. **Neuronal Cell Body:** UNC5C is expressed on the surface of neuronal cell bodies, influencing axon growth and guidance. 5. **Regulation of Neuron Migration:** UNC5C plays a critical role in regulating neuron migration during development, particularly during the formation of the nervous system. **Clinical Significance:** 1. **Neurological Disorders:** Mutations in the UNC5C gene have been implicated in various neurological disorders, including autism spectrum disorder, schizophrenia, and amyotrophic lateral sclerosis (ALS). 2. **Cancer:** UNC5C is overexpressed in certain types of cancer, including glioblastoma and melanoma, and has been shown to promote tumorigenesis and metastasis. 3. **Neurodevelopmental Disorders:** UNC5C is involved in regulating neuronal migration and axon guidance, which is critical for proper brain development. Abnormalities in UNC5C expression have been linked to neurodevelopmental disorders, such as autism and schizophrenia. 4. **Therapeutic Potential:** Targeting UNC5C has emerged as a potential therapeutic strategy for various neurological and cancer disorders, including ALS and glioblastoma. In conclusion, the UNC5C gene plays a critical role in regulating axon guidance, neuronal migration, and developmental processes in the nervous system. Its dysregulation has been implicated in various neurological and cancer disorders, highlighting the importance of further research into the molecular mechanisms underlying its function.

Genular Protein ID: 2072934684

Symbol: UNC5C_HUMAN

Name: Netrin receptor UNC5C

UniProtKB Accession Codes:

O95185 Q8IUT0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 23 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NIAGADS 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9782087

Title: Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23.

PubMed ID: 9782087

DOI: 10.1006/geno.1998.5425

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12655055

Title: The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment.

PubMed ID: 12655055

DOI: 10.1073/pnas.0738063100

PubMed ID: 22685302

Title: Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse.

PubMed ID: 22685302

DOI: 10.1074/jbc.m112.340174

PubMed ID: 25419706

Title: A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.

PubMed ID: 25419706

DOI: 10.1038/nm.3736

PubMed ID: 27068745

Title: An Alzheimer Disease-linked Rare Mutation Potentiates Netrin Receptor Uncoordinated-5C-induced Signaling That Merges with Amyloid beta Precursor Protein Signaling.

PubMed ID: 27068745

DOI: 10.1074/jbc.m115.698092

PubMed ID: 28483977

Title: Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion.

PubMed ID: 28483977

DOI: 10.1523/jneurosci.2617-16.2017

Sequence Information:

  • Length: 931
  • Mass: 103146
  • Checksum: 98A95995129532A7
  • Sequence:
    • MRKGLRATAA RCGLGLGYLL QMLVLPALAL LSASGTGSAA QDDDFFHELP ETFPSDPPEP 
LPHFLIEPEE AYIVKNKPVN LYCKASPATQ IYFKCNSEWV HQKDHIVDER VDETSGLIVR 
EVSIEISRQQ VEELFGPEDY WCQCVAWSSA GTTKSRKAYV RIAYLRKTFE QEPLGKEVSL 
EQEVLLQCRP PEGIPVAEVE WLKNEDIIDP VEDRNFYITI DHNLIIKQAR LSDTANYTCV 
AKNIVAKRKS TTATVIVYVN GGWSTWTEWS VCNSRCGRGY QKRTRTCTNP APLNGGAFCE 
GQSVQKIACT TLCPVDGRWT PWSKWSTCGT ECTHWRRREC TAPAPKNGGK DCDGLVLQSK 
NCTDGLCMQT APDSDDVALY VGIVIAVIVC LAISVVVALF VYRKNHRDFE SDIIDSSALN 
GGFQPVNIKA ARQDLLAVPP DLTSAAAMYR GPVYALHDVS DKIPMTNSPI LDPLPNLKIK 
VYNTSGAVTP QDDLSEFTSK LSPQMTQSLL ENEALSLKNQ SLARQTDPSC TAFGSFNSLG 
GHLIVPNSGV SLLIPAGAIP QGRVYEMYVT VHRKETMRPP MDDSQTLLTP VVSCGPPGAL 
LTRPVVLTMH HCADPNTEDW KILLKNQAAQ GQWEDVVVVG EENFTTPCYI QLDAEACHIL 
TENLSTYALV GHSTTKAAAK RLKLAIFGPL CCSSLEYSIR VYCLDDTQDA LKEILHLERQ 
MGGQLLEEPK ALHFKGSTHN LRLSIHDIAH SLWKSKLLAK YQEIPFYHVW SGSQRNLHCT 
FTLERFSLNT VELVCKLCVR QVEGEGQIFQ LNCTVSEEPT GIDLPLLDPA NTITTVTGPS 
AFSIPLPIRQ KLCSSLDAPQ TRGHDWRMLA HKLNLDRYLN YFATKSSPTG VILDLWEAQN 
FPDGNLSMLA AVLEEMGRHE TVVSLAAEGQ Y

Genular Protein ID: 2666106697

Symbol: A8K385_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K385

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 4 Genevisible 1 GenomeRNAi 1 InterPro 14 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 5 PeptideAtlas 1 Pfam 5 RefSeq 1 RuleBase 1 SAM 1 SMART 5 SUPFAM 3

Sequence Information:

  • Length: 931
  • Mass: 103117
  • Checksum: F1AC6692F6AB0A7E
  • Sequence:
    • MRKGLRATAA RCGLGLGYLL QMLVLPALAL LSASGTGSAA QDDDFFHELP ETFPSDPPEP 
LPHFLIEPEE AYIVKNKPVN LYCKASPATQ IYFKCNSEWV HQKDHIVDER VDETSGLIVR 
EVSIEISRQQ VEELFGPEDY WCQCVAWSSA GTTKSRKAYV RIAYLRKTFE QEPLGKEVSL 
EQEVLLQCRP PEGIPVAEVE WLKNEDIIDP VEDRNFYITI DHNLIIKQAR LSDTANYTCV 
AKNIVAKRKS TTATVIVYVN GGWSTWTEWS VCNSRCGRGY QKRTRTCTNP APLNGGAFCE 
GQSVQKIACT TLCPVDGRWT PWSKWSTCGT ECTHWRRREC TAPAPKNGGK DCDGLVLQSK 
NCTDGLCMQT APDSDDVALY VGIVIAVIVC LAISVVVALF VYRKNHRDFE SDIIDSSALN 
GGFQPVNIKA ARQDLLAVPP DLTSAAAMYR GPVYALHDVS DKIPMTNSPI LDPLPNLKIK 
VYNTSGAVTP QDDLSEFTSK LSPQMTQSLL ENEALSLKNQ SLARQTDPSC TAFGSFNSLG 
GHLIVPNSGV SLLIPAGAIP QGRVYEMYVT VHRKETMRPP MDDSQTLLTP VVSCGPPGAL 
LTRPVVLTMH HCADPNTEDW RILLKNQAAQ GQWEDVVVVG EENFTTPCYI QLDAEACHIL 
TENLSTYALV GHSTTKAAAK RLKLAIFGPL CCSSLEYSIR VYCLDDTQDA LKEILHLERQ 
TGGQLLEEPK ALHFKGSTHN LRLSIHDIAH SLWKSKLLAK YQEIPFYHVW SGSQRNLHCT 
FTLERFSLNT VELVCKLCVR QVEGEGQIFQ LNCTVSEEPT GIDLPLLDPA STITTVTGPS 
AFSIPLPIRQ KLCSSLDAPQ TRGHDWRMLA HKLNLDRYLN YFATKSSPTG VILDLWEAQN 
FPDGNLSMLA AVLEEMGRHE TVVSLAAEGQ Y

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.