Details for: UNC5C
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 148.2666
Cell Significance Index: -70.0000 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 19.5925
Cell Significance Index: -42.8800 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 6.5019
Cell Significance Index: 138.9800 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 4.5043
Cell Significance Index: 128.5400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 3.5976
Cell Significance Index: 159.1300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 3.3900
Cell Significance Index: 1215.9400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 3.0197
Cell Significance Index: 114.3500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.8355
Cell Significance Index: 568.8000 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 2.7976
Cell Significance Index: 46.1000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 2.6586
Cell Significance Index: 163.0000 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 2.4292
Cell Significance Index: 53.1900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.9661
Cell Significance Index: 110.3300 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.8129
Cell Significance Index: 1253.8600 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.7489
Cell Significance Index: 26.2100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.2732
Cell Significance Index: 808.6000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.2256
Cell Significance Index: 556.2600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.8654
Cell Significance Index: 164.6900 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.7879
Cell Significance Index: 52.9800 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: 0.7229
Cell Significance Index: 7.5300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.6048
Cell Significance Index: 1138.7000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4357
Cell Significance Index: 393.4000 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.4136
Cell Significance Index: 5.9400 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 0.3838
Cell Significance Index: 5.1200 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.2953
Cell Significance Index: 5.0600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2452
Cell Significance Index: 24.2600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1011
Cell Significance Index: 16.4500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0927
Cell Significance Index: 5.8400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0004
Cell Significance Index: 0.0600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0302
Cell Significance Index: -1.0600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0362
Cell Significance Index: -66.7400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0447
Cell Significance Index: -68.8300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0510
Cell Significance Index: -69.3300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0608
Cell Significance Index: -2.7600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0827
Cell Significance Index: -61.2900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0962
Cell Significance Index: -70.5100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.1055
Cell Significance Index: -3.0400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.1129
Cell Significance Index: -85.4200 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.1334
Cell Significance Index: -72.8700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1341
Cell Significance Index: -83.7700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1351
Cell Significance Index: -76.1800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.1451
Cell Significance Index: -28.7900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1889
Cell Significance Index: -11.6100 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: -0.1966
Cell Significance Index: -2.5500 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.1978
Cell Significance Index: -21.5200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.2036
Cell Significance Index: -5.0900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2232
Cell Significance Index: -64.2200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.2989
Cell Significance Index: -53.8800 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.3549
Cell Significance Index: -4.4300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3856
Cell Significance Index: -40.1500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3953
Cell Significance Index: -83.2600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.4237
Cell Significance Index: -72.3500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.4354
Cell Significance Index: -20.3000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.4365
Cell Significance Index: -59.9500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.5068
Cell Significance Index: -62.3100 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.5150
Cell Significance Index: -66.0200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.5329
Cell Significance Index: -36.8500 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.5454
Cell Significance Index: -13.0800 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.5515
Cell Significance Index: -71.2500 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: -0.5964
Cell Significance Index: -6.4000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.6109
Cell Significance Index: -71.1900 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.6342
Cell Significance Index: -13.4600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.7217
Cell Significance Index: -82.6900 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.7265
Cell Significance Index: -14.1800 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.7310
Cell Significance Index: -74.6700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.7453
Cell Significance Index: -57.2000 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.8109
Cell Significance Index: -17.5200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.8110
Cell Significance Index: -17.5700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.8932
Cell Significance Index: -70.7400 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.9159
Cell Significance Index: -11.5600 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.9215
Cell Significance Index: -18.2200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.9591
Cell Significance Index: -71.4800 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.9888
Cell Significance Index: -14.1600 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.0156
Cell Significance Index: -33.2500 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -1.0365
Cell Significance Index: -45.0700 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -1.0881
Cell Significance Index: -11.8600 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.1033
Cell Significance Index: -35.1400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -1.2356
Cell Significance Index: -64.3600 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.2930
Cell Significance Index: -44.9300 - Cell Name: neural cell (CL0002319)
Fold Change: -1.2935
Cell Significance Index: -15.0900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.3138
Cell Significance Index: -68.9800 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.3586
Cell Significance Index: -36.4100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -1.3652
Cell Significance Index: -70.9200 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -1.3702
Cell Significance Index: -48.0000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -1.4224
Cell Significance Index: -66.8500 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -1.4470
Cell Significance Index: -30.2000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.5018
Cell Significance Index: -48.1000 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -1.5441
Cell Significance Index: -31.0000 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -1.7134
Cell Significance Index: -29.6300 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -1.7707
Cell Significance Index: -44.1700 - Cell Name: neuron (CL0000540)
Fold Change: -1.8082
Cell Significance Index: -17.1400 - Cell Name: granule cell (CL0000120)
Fold Change: -1.8274
Cell Significance Index: -20.8100 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -1.9015
Cell Significance Index: -22.7400 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.9417
Cell Significance Index: -57.1900 - Cell Name: chandelier cell (CL4023083)
Fold Change: -1.9556
Cell Significance Index: -15.7900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -1.9602
Cell Significance Index: -54.7800 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.9975
Cell Significance Index: -42.5400 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -2.0365
Cell Significance Index: -102.9200 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -2.0374
Cell Significance Index: -74.7900 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -2.1024
Cell Significance Index: -35.1900 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -2.1118
Cell Significance Index: -29.5300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2072934684
Symbol: UNC5C_HUMAN
Name: Netrin receptor UNC5C
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9782087
Title: Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23.
PubMed ID: 9782087
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12655055
Title: The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment.
PubMed ID: 12655055
PubMed ID: 22685302
Title: Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse.
PubMed ID: 22685302
PubMed ID: 25419706
Title: A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.
PubMed ID: 25419706
DOI: 10.1038/nm.3736
PubMed ID: 27068745
Title: An Alzheimer Disease-linked Rare Mutation Potentiates Netrin Receptor Uncoordinated-5C-induced Signaling That Merges with Amyloid beta Precursor Protein Signaling.
PubMed ID: 27068745
PubMed ID: 28483977
Title: Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion.
PubMed ID: 28483977
Sequence Information:
- Length: 931
- Mass: 103146
- Checksum: 98A95995129532A7
- Sequence:
MRKGLRATAA RCGLGLGYLL QMLVLPALAL LSASGTGSAA QDDDFFHELP ETFPSDPPEP LPHFLIEPEE AYIVKNKPVN LYCKASPATQ IYFKCNSEWV HQKDHIVDER VDETSGLIVR EVSIEISRQQ VEELFGPEDY WCQCVAWSSA GTTKSRKAYV RIAYLRKTFE QEPLGKEVSL EQEVLLQCRP PEGIPVAEVE WLKNEDIIDP VEDRNFYITI DHNLIIKQAR LSDTANYTCV AKNIVAKRKS TTATVIVYVN GGWSTWTEWS VCNSRCGRGY QKRTRTCTNP APLNGGAFCE GQSVQKIACT TLCPVDGRWT PWSKWSTCGT ECTHWRRREC TAPAPKNGGK DCDGLVLQSK NCTDGLCMQT APDSDDVALY VGIVIAVIVC LAISVVVALF VYRKNHRDFE SDIIDSSALN GGFQPVNIKA ARQDLLAVPP DLTSAAAMYR GPVYALHDVS DKIPMTNSPI LDPLPNLKIK VYNTSGAVTP QDDLSEFTSK LSPQMTQSLL ENEALSLKNQ SLARQTDPSC TAFGSFNSLG GHLIVPNSGV SLLIPAGAIP QGRVYEMYVT VHRKETMRPP MDDSQTLLTP VVSCGPPGAL LTRPVVLTMH HCADPNTEDW KILLKNQAAQ GQWEDVVVVG EENFTTPCYI QLDAEACHIL TENLSTYALV GHSTTKAAAK RLKLAIFGPL CCSSLEYSIR VYCLDDTQDA LKEILHLERQ MGGQLLEEPK ALHFKGSTHN LRLSIHDIAH SLWKSKLLAK YQEIPFYHVW SGSQRNLHCT FTLERFSLNT VELVCKLCVR QVEGEGQIFQ LNCTVSEEPT GIDLPLLDPA NTITTVTGPS AFSIPLPIRQ KLCSSLDAPQ TRGHDWRMLA HKLNLDRYLN YFATKSSPTG VILDLWEAQN FPDGNLSMLA AVLEEMGRHE TVVSLAAEGQ Y
Genular Protein ID: 2666106697
Symbol: A8K385_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 931
- Mass: 103117
- Checksum: F1AC6692F6AB0A7E
- Sequence:
MRKGLRATAA RCGLGLGYLL QMLVLPALAL LSASGTGSAA QDDDFFHELP ETFPSDPPEP LPHFLIEPEE AYIVKNKPVN LYCKASPATQ IYFKCNSEWV HQKDHIVDER VDETSGLIVR EVSIEISRQQ VEELFGPEDY WCQCVAWSSA GTTKSRKAYV RIAYLRKTFE QEPLGKEVSL EQEVLLQCRP PEGIPVAEVE WLKNEDIIDP VEDRNFYITI DHNLIIKQAR LSDTANYTCV AKNIVAKRKS TTATVIVYVN GGWSTWTEWS VCNSRCGRGY QKRTRTCTNP APLNGGAFCE GQSVQKIACT TLCPVDGRWT PWSKWSTCGT ECTHWRRREC TAPAPKNGGK DCDGLVLQSK NCTDGLCMQT APDSDDVALY VGIVIAVIVC LAISVVVALF VYRKNHRDFE SDIIDSSALN GGFQPVNIKA ARQDLLAVPP DLTSAAAMYR GPVYALHDVS DKIPMTNSPI LDPLPNLKIK VYNTSGAVTP QDDLSEFTSK LSPQMTQSLL ENEALSLKNQ SLARQTDPSC TAFGSFNSLG GHLIVPNSGV SLLIPAGAIP QGRVYEMYVT VHRKETMRPP MDDSQTLLTP VVSCGPPGAL LTRPVVLTMH HCADPNTEDW RILLKNQAAQ GQWEDVVVVG EENFTTPCYI QLDAEACHIL TENLSTYALV GHSTTKAAAK RLKLAIFGPL CCSSLEYSIR VYCLDDTQDA LKEILHLERQ TGGQLLEEPK ALHFKGSTHN LRLSIHDIAH SLWKSKLLAK YQEIPFYHVW SGSQRNLHCT FTLERFSLNT VELVCKLCVR QVEGEGQIFQ LNCTVSEEPT GIDLPLLDPA STITTVTGPS AFSIPLPIRQ KLCSSLDAPQ TRGHDWRMLA HKLNLDRYLN YFATKSSPTG VILDLWEAQN FPDGNLSMLA AVLEEMGRHE TVVSLAAEGQ Y
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.