UNC5C | ENSG00000182168 | NCBI 8633

Details for: UNC5C

Gene ID: 8633

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: UNC5C

Ensembl ID: ENSG00000182168

Description: unc-5 netrin receptor C

Cell Significance Landscape

Display Count:

Associated with

Developmental biology
(R-HSA-1266738)
Nervous system development
(R-HSA-9675108)
Netrin-1 signaling
(R-HSA-373752)
Netrin mediated repulsion signals
(R-HSA-418886)
Anterior/posterior axon guidance
(GO:0033564)
Apoptotic process
(GO:0006915)
Axon guidance
(GO:0007411)
Brain development
(GO:0007420)
Cell surface
(GO:0009986)
Chemorepulsion of axon
(GO:0061643)
Dendrite
(GO:0030425)
Dorsal root ganglion development
(GO:1990791)
Ectopic germ cell programmed cell death
(GO:0035234)
Filopodium
(GO:0030175)
Growth cone
(GO:0030426)
Lamellipodium
(GO:0030027)
Netrin-activated signaling pathway
(GO:0038007)
Netrin receptor activity
(GO:0005042)
Netrin receptor activity involved in chemorepulsion
(GO:0005043)
Neuronal cell body
(GO:0043025)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of developmental process
(GO:0051094)
Positive regulation of reproductive process
(GO:2000243)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of neuron migration
(GO:2001222)
Synapse
(GO:0045202)
Tubulin binding
(GO:0015631)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

pvalb GABAergic cortical interneuron CL4023018

CSI 39.56

rCSI 49.21%

PRS 79.33
interneuron CL0000099

CSI 39.54

rCSI 79.38%

PRS 87.33
lamp5 GABAergic cortical interneuron CL4023011

CSI 35.96

rCSI 60.37%

PRS 81.57
sst GABAergic cortical interneuron CL4023017

CSI 35.36

rCSI 45.59%

PRS 82.57
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 28.2

rCSI 49.81%

PRS 80.85
VIP GABAergic cortical interneuron CL4023016

CSI 25.23

rCSI 30.13%

PRS 81.5
cerebral cortex endothelial cell CL1001602

CSI 24.16

rCSI 41.79%

PRS 87.98
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 21.74

rCSI 52.84%

PRS 79.39
neural cell CL0002319

CSI 20.68

rCSI 78.04%

PRS 79.4
L2/3 intratelencephalic projecting glutamatergic neuron CL4030059

CSI 20.38

rCSI 44.21%

PRS 82.47
oligodendrocyte CL0000128

CSI 19.5

rCSI 57.64%

PRS 83.82
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 19.27

rCSI 60.25%

PRS 84.4
retinal rod cell CL0000604

CSI 19.15

rCSI 33.76%

PRS 88.91
retinal ganglion cell CL0000740

CSI 18.21

rCSI 40.23%

PRS 83.5
bronchus fibroblast of lung CL2000093

CSI 17.55

rCSI 14.26%

PRS 91.78
L6b glutamatergic cortical neuron CL4023038

CSI 17.52

rCSI 54.74%

PRS 82.71
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 17.31

rCSI 41.4%

PRS 83.57
differentiation-committed oligodendrocyte precursor CL4023059

CSI 17.11

rCSI 31.1%

PRS 86.94
neuron CL0000540

CSI 16.95

rCSI 45.13%

PRS 81.71
glycinergic amacrine cell CL4030028

CSI 16.86

rCSI 43.92%

PRS 87.22
adipocyte CL0000136

CSI 16.58

rCSI 21.29%

PRS 85.44
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 15.52

rCSI 51.01%

PRS 82.35
cerebellar granule cell CL0001031

CSI 14.82

rCSI 21.79%

PRS 88.24
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 14.54

rCSI 52.33%

PRS 79.67
renal interstitial pericyte CL1001318

CSI 14.23

rCSI 39.21%

PRS 90.54
Bergmann glial cell CL0000644

CSI 14.17

rCSI 19.39%

PRS 86.14
oligodendrocyte precursor cell CL0002453

CSI 13.37

rCSI 29.42%

PRS 76.93
vascular leptomeningeal cell CL4023051

CSI 12.92

rCSI 22.66%

PRS 89.67
amacrine cell CL0000561

CSI 11.8

rCSI 34.2%

PRS 85.13
glioblast CL0000030

CSI 11.64

rCSI 18.57%

PRS 85.84
chondrocyte CL0000138

CSI 11.59

rCSI 18.43%

PRS 88.55
sncg GABAergic cortical interneuron CL4023015

CSI 11.44

rCSI 18.39%

PRS 82.52
inhibitory interneuron CL0000498

CSI 10.56

rCSI 24.37%

PRS 84.71
mural cell CL0008034

CSI 10.43

rCSI 35.34%

PRS 89.51
contractile cell CL0000183

CSI 10.29

rCSI 30.38%

PRS 92.31
neuroblast (sensu Vertebrata) CL0000031

CSI 10.25

rCSI 13.16%

PRS 89.11
parietal epithelial cell CL1000452

CSI 10.2

rCSI 27.27%

PRS 88.27
near-projecting glutamatergic cortical neuron CL4023012

CSI 10.18

rCSI 38.48%

PRS 81.73
tracheobronchial smooth muscle cell CL0019019

CSI 10

rCSI 17.63%

PRS 94.73
hepatic stellate cell CL0000632

CSI 9.36

rCSI 35.05%

PRS 89.04
glutamatergic neuron CL0000679

CSI 9.03

rCSI 18.55%

PRS 82.07
peripheral nervous system neuron CL2000032

CSI 8.96

rCSI 12.21%

PRS 86.76
astrocyte of the cerebral cortex CL0002605

CSI 8.95

rCSI 20.07%

PRS 81.8
Mueller cell CL0000636

CSI 8.92

rCSI 20.36%

PRS 86.91
fibroblast of lung CL0002553

CSI 8.89

rCSI 8.27%

PRS 93.68
Schwann cell CL0002573

CSI 8.59

rCSI 24.42%

PRS 89.4
Kupffer cell CL0000091

CSI 8.43

rCSI 19.28%

PRS 93.41
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 8.37

rCSI 49.3%

PRS 81.92
GABAergic amacrine cell CL4030027

CSI 8.33

rCSI 28.52%

PRS 81.1
cerebral cortex neuron CL0010012

CSI 8.28

rCSI 33.74%

PRS 86.11
mature astrocyte CL0002627

CSI 7.87

rCSI 33.46%

PRS 86.4
dopaminergic neuron CL0000700

CSI 7.73

rCSI 43.71%

PRS 83.05
cardiac muscle cell CL0000746

CSI 7.73

rCSI 11.09%

PRS 85.41
BEST4+ enteroycte CL4030026

CSI 7.66

rCSI 9.53%

PRS 91.93
epicardial adipocyte CL1000309

CSI 7.65

rCSI 24.89%

PRS 90.14
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 7.53

rCSI 8.69%

PRS 85.63
alveolar type 1 fibroblast cell CL4028004

CSI 7.49

rCSI 8.2%

PRS 94
central nervous system neuron CL2000029

CSI 7.38

rCSI 54.25%

PRS 85.49
basket cell CL0000118

CSI 7.32

rCSI 45.87%

PRS 74.28
smooth muscle cell CL0000192

CSI 7.24

rCSI 17.27%

PRS 87.15
neural crest cell CL0011012

CSI 7.12

rCSI 5.62%

PRS 86.6
podocyte CL0000653

CSI 6.76

rCSI 30.04%

PRS 92.79
fibroblast of cardiac tissue CL0002548

CSI 6.76

rCSI 32.37%

PRS 93.41
endocardial cell CL0002350

CSI 6.65

rCSI 31.84%

PRS 89.55
serotonergic neuron CL0000850

CSI 6.39

rCSI 28.53%

PRS 79.35
myoepithelial cell CL0000185

CSI 6.17

rCSI 15.61%

PRS 94.15
GABAergic neuron CL0000617

CSI 5

rCSI 16.76%

PRS 80.67
glial cell CL0000125

CSI 4.82

rCSI 18.37%

PRS 86.93
kidney connecting tubule epithelial cell CL1000768

CSI 4.77

rCSI 12.09%

PRS 87.7
lung pericyte CL0009089

CSI 4.66

rCSI 12.31%

PRS 95.59
adventitial cell CL0002503

CSI 4.11

rCSI 9.81%

PRS 94.39
medium spiny neuron CL1001474

CSI 3.96

rCSI 34.16%

PRS 85.42
cerebellar neuron CL1001611

CSI 3.31

rCSI 29.09%

PRS 81.17
diffuse bipolar 6 cell CL4033032

CSI 3.22

rCSI 16.93%

PRS 83.3
alveolar adventitial fibroblast CL4028006

CSI 2.88

rCSI 4.56%

PRS 93.35
ON parasol ganglion cell CL4033052

CSI 2.8

rCSI 39.76%

PRS 85.94
macroglial cell CL0000126

CSI 2.79

rCSI 7.17%

PRS 89.12
basal cell CL0000646

CSI 2.77

rCSI 3.7%

PRS 89.97
keratocyte CL0002363

CSI 2.77

rCSI 6.65%

PRS 93.25
OFF midget ganglion cell CL4033047

CSI 2.56

rCSI 52.1%

PRS 85.6
regular atrial cardiac myocyte CL0002129

CSI 2.54

rCSI 8.19%

PRS 89.28
ON midget ganglion cell CL4033046

CSI 2.53

rCSI 51.59%

PRS 84.95
mesenchymal cell CL0008019

CSI 2.46

rCSI 6.24%

PRS 88.09
blood vessel smooth muscle cell CL0019018

CSI 2.39

rCSI 19.41%

PRS 90.68
direct pathway medium spiny neuron CL4023026

CSI 2.27

rCSI 54.28%

PRS 79.29
indirect pathway medium spiny neuron CL4023029

CSI 2.24

rCSI 54.1%

PRS 79.38
Hofbauer cell CL3000001

CSI 2.2

rCSI 4.16%

PRS 96.08
stromal cell CL0000499

CSI 2.19

rCSI 6.17%

PRS 89.09
mesodermal cell CL0000222

CSI 1.84

rCSI 2.2%

PRS 91.47
kidney distal convoluted tubule epithelial cell CL1000849

CSI 1.69

rCSI 17.85%

PRS 89.24
midbrain dopaminergic neuron CL2000097

CSI 1.65

rCSI 10.58%

PRS 86.61
neuroplacodal cell CL0000032

CSI 1.65

rCSI 15.21%

PRS 89.58
smooth muscle cell of the pulmonary artery CL0002591

CSI 1.57

rCSI 12.01%

PRS 93.35

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [UNC5C](/details-gene/8633) (unc-5 netrin receptor C) is a protein-coding gene located on chromosome 4q22.3 that encodes a transmembrane receptor for the netrin family of axon guidance molecules. As a key component of the netrin signaling pathway, [UNC5C](/details-gene/8633) plays a fundamental role in nervous system development, particularly in mediating chemorepulsive signals for axon guidance ([Link](https://doi.org/10.1006/geno.1998.5425)). Beyond its developmental functions, it is also implicated in regulating apoptotic processes and has been identified as a putative tumor suppressor ([Link](https://doi.org/10.1073/pnas.0738063100)). Consistent with its role in neural wiring, expression data shows that [UNC5C](/details-gene/8633) is a highly significant gene in numerous neuronal subtypes, especially cortical interneurons such as the [pvalb GABAergic cortical interneuron](/details-cell/CL4023018) and the [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011). Recent research has also linked rare mutations in [UNC5C](/details-gene/8633) to an increased risk for late-onset Alzheimer's disease, highlighting its importance in neuronal health and survival ([Link](https://doi.org/10.1038/nm.3736)). ## Cellular Roles and Expression Landscape The expression profile of [UNC5C](/details-gene/8633) strongly indicates a specialized role within the central nervous system. **Overall**, the gene demonstrates its highest significance in various subtypes of inhibitory neurons, establishing it as a key marker for cortical interneuron populations. It is most prominent in [pvalb GABAergic cortical interneuron](/details-cell/CL4023018) (CSI: 39.56), [interneuron](/details-cell/CL0000099) (CSI: 39.54), [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011) (CSI: 35.96), and [sst GABAergic cortical interneuron](/details-cell/CL4023017) (CSI: 35.36). Its high significance extends to other neuronal cell types, including [L2/3-6 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4023040) and specialized sensory neurons like [retinal rod cell](/details-cell/CL0000604) and [retinal ganglion cell](/details-cell/CL0000740). This expression pattern is highly consistent with its established function in axon guidance and neuronal development. The gene is also significantly expressed in non-neuronal cells within the brain, such as [oligodendrocyte](/details-cell/CL0000128) and [cerebral cortex endothelial cell](/details-cell/CL1001602), suggesting potential roles in myelination or blood-brain barrier regulation. The notable presence of [bronchus fibroblast of lung](/details-cell/CL2000093) in the top expressed cells suggests that [UNC5C](/details-gene/8633) may have functions outside the nervous system, possibly related to developmental processes or tissue homeostasis in other organs. ## Pathways and Molecular Function Functionally, [UNC5C](/details-gene/8633) is annotated as a [netrin receptor activity](/details-cell/GO0005042) on the [cell surface](/details-cell/GO0009986), primarily localized to structures critical for neuronal wiring, such as the [growth cone](/details-cell/GO0030426) and [synapse](/details-cell/GO0045202). Its involvement is central to the [Netrin-1 signaling](/details-pathway/R-HSA-373752) and [Axon guidance](/details-pathway/R-HSA-422475) pathways, where it typically mediates chemorepulsion ([GO:0061643](https://www.ebi.ac.uk/QuickGO/term/GO:0061643)). This function is achieved through its interaction with other proteins, including Down syndrome cell adhesion molecule (DSCAM) ([Link](https://doi.org/10.1074/jbc.m112.340174)) and its ability to uncouple from polymerized tubulin ([Link](https://doi.org/10.1523/jneurosci.2617-16.2017)). In addition to its role in development, [UNC5C](/details-gene/8633) is a key regulator of the [apoptotic process](/details-cell/GO0006915). In the absence of its ligand, netrin-1, [UNC5C](/details-gene/8633) can induce programmed cell death, a mechanism that has implicated it as a tumor suppressor in certain contexts ([Link](https://doi.org/10.1073/pnas.0738063100)). This pro-apoptotic activity is also relevant in neurodegenerative contexts, where certain mutations appear to potentiate its cell death-inducing signals ([Link](https://doi.org/10.1074/jbc.m115.698092)). ## Research Directions The dual roles of [UNC5C](/details-gene/8633) in axon guidance and apoptosis, combined with its link to Alzheimer's disease, present several compelling avenues for future research. The strong, subtype-specific expression in cortical interneurons suggests a critical role in maintaining the brain's inhibitory circuitry, which is known to be vulnerable in neurodegenerative conditions. **Testable Hypotheses:** 1. The rare Alzheimer's disease-associated mutation in [UNC5C](/details-gene/8633) acts as a gain-of-function variant that enhances its pro-apoptotic signaling cascade, particularly in the highly-expressing [pvalb GABAergic cortical interneuron](/details-cell/CL4023018) and [sst GABAergic cortical interneuron](/details-cell/CL4023017). This leads to a selective loss of these inhibitory neurons, contributing to the network hyperexcitability and cognitive decline characteristic of the disease. 2. Beyond axon guidance during development, [UNC5C](/details-gene/8633) signaling is required for the long-term structural maintenance and synaptic integrity of cortical interneurons in the adult brain. Age-related decline in netrin-1 levels may reduce this protective signaling, leaving these crucial neurons susceptible to degeneration. **Experimental Approach:** To test the first hypothesis, one could employ CRISPR-Cas9 to introduce the specific Alzheimer's-linked mutation into human induced pluripotent stem cells (iPSCs). These edited iPSCs could then be differentiated into cortical interneuron subtypes that show high [UNC5C](/details-gene/8633) expression. By comparing mutant and isogenic control neurons, researchers could use RNA-sequencing to assess transcriptional changes in apoptotic pathways and perform functional assays, such as measuring caspase-3 activation or monitoring cell survival over time in response to trophic factor withdrawal or amyloid-beta oligomer exposure. **Therapeutic Potential:** As a cell surface receptor, [UNC5C](/details-gene/8633) is a potentially druggable target. Given that the Alzheimer's-linked mutation appears to potentiate a toxic function, a therapeutic strategy would likely involve **inhibition** rather than activation. The development of monoclonal antibodies or small molecule inhibitors that specifically block the intracellular death domain of [UNC5C](/details-gene/8633) or disrupt its interaction with downstream apoptotic effectors could represent a targeted neuroprotective strategy for individuals carrying this specific genetic risk factor. However, any such intervention would need to be carefully designed to avoid disrupting the receptor's homeostatic roles in neuronal maintenance.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Netrin receptor UNC5C
A8K385_HUMAN

Genular Protein ID: 2072934684

Symbol: UNC5C_HUMAN

Name: Netrin receptor UNC5C

UniProtKB Accession Codes:

O95185 Q8IUT0

Database IDs:

Citations:

PubMed ID: 9782087

Title: Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23.

PubMed ID: 9782087

DOI: 10.1006/geno.1998.5425

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12655055

Title: The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment.

PubMed ID: 12655055

DOI: 10.1073/pnas.0738063100

PubMed ID: 22685302

Title: Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse.

PubMed ID: 22685302

DOI: 10.1074/jbc.m112.340174

PubMed ID: 25419706

Title: A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.

PubMed ID: 25419706

DOI: 10.1038/nm.3736

PubMed ID: 27068745

Title: An Alzheimer Disease-linked Rare Mutation Potentiates Netrin Receptor Uncoordinated-5C-induced Signaling That Merges with Amyloid beta Precursor Protein Signaling.

PubMed ID: 27068745

DOI: 10.1074/jbc.m115.698092

PubMed ID: 28483977

Title: Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion.

PubMed ID: 28483977

DOI: 10.1523/jneurosci.2617-16.2017

Sequence Information:

Length: 931
Mass: 103146
Checksum: 98A95995129532A7
Sequence:

MRKGLRATAA RCGLGLGYLL QMLVLPALAL LSASGTGSAA QDDDFFHELP ETFPSDPPEP 
LPHFLIEPEE AYIVKNKPVN LYCKASPATQ IYFKCNSEWV HQKDHIVDER VDETSGLIVR 
EVSIEISRQQ VEELFGPEDY WCQCVAWSSA GTTKSRKAYV RIAYLRKTFE QEPLGKEVSL 
EQEVLLQCRP PEGIPVAEVE WLKNEDIIDP VEDRNFYITI DHNLIIKQAR LSDTANYTCV 
AKNIVAKRKS TTATVIVYVN GGWSTWTEWS VCNSRCGRGY QKRTRTCTNP APLNGGAFCE 
GQSVQKIACT TLCPVDGRWT PWSKWSTCGT ECTHWRRREC TAPAPKNGGK DCDGLVLQSK 
NCTDGLCMQT APDSDDVALY VGIVIAVIVC LAISVVVALF VYRKNHRDFE SDIIDSSALN 
GGFQPVNIKA ARQDLLAVPP DLTSAAAMYR GPVYALHDVS DKIPMTNSPI LDPLPNLKIK 
VYNTSGAVTP QDDLSEFTSK LSPQMTQSLL ENEALSLKNQ SLARQTDPSC TAFGSFNSLG 
GHLIVPNSGV SLLIPAGAIP QGRVYEMYVT VHRKETMRPP MDDSQTLLTP VVSCGPPGAL 
LTRPVVLTMH HCADPNTEDW KILLKNQAAQ GQWEDVVVVG EENFTTPCYI QLDAEACHIL 
TENLSTYALV GHSTTKAAAK RLKLAIFGPL CCSSLEYSIR VYCLDDTQDA LKEILHLERQ 
MGGQLLEEPK ALHFKGSTHN LRLSIHDIAH SLWKSKLLAK YQEIPFYHVW SGSQRNLHCT 
FTLERFSLNT VELVCKLCVR QVEGEGQIFQ LNCTVSEEPT GIDLPLLDPA NTITTVTGPS 
AFSIPLPIRQ KLCSSLDAPQ TRGHDWRMLA HKLNLDRYLN YFATKSSPTG VILDLWEAQN 
FPDGNLSMLA AVLEEMGRHE TVVSLAAEGQ Y

Genular Protein ID: 2666106697

Symbol: A8K385_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K385

Database IDs:

Sequence Information:

Length: 931
Mass: 103117
Checksum: F1AC6692F6AB0A7E
Sequence:

MRKGLRATAA RCGLGLGYLL QMLVLPALAL LSASGTGSAA QDDDFFHELP ETFPSDPPEP 
LPHFLIEPEE AYIVKNKPVN LYCKASPATQ IYFKCNSEWV HQKDHIVDER VDETSGLIVR 
EVSIEISRQQ VEELFGPEDY WCQCVAWSSA GTTKSRKAYV RIAYLRKTFE QEPLGKEVSL 
EQEVLLQCRP PEGIPVAEVE WLKNEDIIDP VEDRNFYITI DHNLIIKQAR LSDTANYTCV 
AKNIVAKRKS TTATVIVYVN GGWSTWTEWS VCNSRCGRGY QKRTRTCTNP APLNGGAFCE 
GQSVQKIACT TLCPVDGRWT PWSKWSTCGT ECTHWRRREC TAPAPKNGGK DCDGLVLQSK 
NCTDGLCMQT APDSDDVALY VGIVIAVIVC LAISVVVALF VYRKNHRDFE SDIIDSSALN 
GGFQPVNIKA ARQDLLAVPP DLTSAAAMYR GPVYALHDVS DKIPMTNSPI LDPLPNLKIK 
VYNTSGAVTP QDDLSEFTSK LSPQMTQSLL ENEALSLKNQ SLARQTDPSC TAFGSFNSLG 
GHLIVPNSGV SLLIPAGAIP QGRVYEMYVT VHRKETMRPP MDDSQTLLTP VVSCGPPGAL 
LTRPVVLTMH HCADPNTEDW RILLKNQAAQ GQWEDVVVVG EENFTTPCYI QLDAEACHIL 
TENLSTYALV GHSTTKAAAK RLKLAIFGPL CCSSLEYSIR VYCLDDTQDA LKEILHLERQ 
TGGQLLEEPK ALHFKGSTHN LRLSIHDIAH SLWKSKLLAK YQEIPFYHVW SGSQRNLHCT 
FTLERFSLNT VELVCKLCVR QVEGEGQIFQ LNCTVSEEPT GIDLPLLDPA STITTVTGPS 
AFSIPLPIRQ KLCSSLDAPQ TRGHDWRMLA HKLNLDRYLN YFATKSSPTG VILDLWEAQN 
FPDGNLSMLA AVLEEMGRHE TVVSLAAEGQ Y

Details for: UNC5C

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23. PubMed ID: 9782087

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. PubMed ID: 12655055

Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse. PubMed ID: 22685302

A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death. PubMed ID: 25419706

An Alzheimer Disease-linked Rare Mutation Potentiates Netrin Receptor Uncoordinated-5C-induced Signaling That Merges with Amyloid beta Precursor Protein Signaling. PubMed ID: 27068745

Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion. PubMed ID: 28483977