HIPK2 | ENSG00000064393 | NCBI 28996

Details for: HIPK2

Gene ID: 28996

Symbol: HIPK2

Ensembl ID: ENSG00000064393

Description: homeodomain interacting protein kinase 2

Associated with

Cardiac conduction
(R-HSA-5576891)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Metabolism of proteins
(R-HSA-392499)
Muscle contraction
(R-HSA-397014)
Physiological factors
(R-HSA-5578768)
Post-translational protein modification
(R-HSA-597592)
Regulation of mecp2 expression and activity
(R-HSA-9022692)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through phosphorylation
(R-HSA-6804756)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 interacts with co-factors whose precise effect on runx1 targets is not known
(R-HSA-8939243)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of transcription cofactors
(R-HSA-3899300)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by tp53
(R-HSA-3700989)
Yap1- and wwtr1 (taz)-stimulated gene expression
(R-HSA-2032785)
Adult walking behavior
(GO:0007628)
Anterior/posterior pattern specification
(GO:0009952)
Atp binding
(GO:0005524)
Cell population proliferation
(GO:0008283)
Cellular response to hypoxia
(GO:0071456)
Cytoplasm
(GO:0005737)
Cytoplasmic stress granule
(GO:0010494)
Dna damage response, signal transduction by p53 class mediator
(GO:0030330)
Embryonic camera-type eye morphogenesis
(GO:0048596)
Embryonic retina morphogenesis in camera-type eye
(GO:0060059)
Epigenetic regulation of gene expression
(GO:0040029)
Erythrocyte differentiation
(GO:0030218)
Eye development
(GO:0001654)
Gene expression
(GO:0010467)
Histone h2as1 kinase activity
(GO:0044024)
Intrinsic apoptotic signaling pathway
(GO:0097193)
Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
(GO:0042771)
Iris morphogenesis
(GO:0061072)
Lens induction in camera-type eye
(GO:0060235)
Lung morphogenesis
(GO:0060425)
Negative regulation of bmp signaling pathway
(GO:0030514)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of ubiquitin-dependent protein catabolic process
(GO:2000059)
Neuron apoptotic process
(GO:0051402)
Neuron differentiation
(GO:0030182)
Nuclear body
(GO:0016604)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Peptidyl-serine phosphorylation
(GO:0018105)
Peptidyl-threonine phosphorylation
(GO:0018107)
Pml body
(GO:0016605)
Pml body organization
(GO:0030578)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of protein binding
(GO:0032092)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transforming growth factor beta receptor signaling pathway
(GO:0030511)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Protein tyrosine kinase activity
(GO:0004713)
Regulation of cell cycle
(GO:0051726)
Regulation of signal transduction by p53 class mediator
(GO:1901796)
Respiratory system process
(GO:0003016)
Retina layer formation
(GO:0010842)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Smad binding
(GO:0046332)
Smad protein signal transduction
(GO:0060395)
Smoothened signaling pathway
(GO:0007224)
Thyroid gland development
(GO:0030878)
Transcription coactivator activity
(GO:0003713)
Transcription corepressor activity
(GO:0003714)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Virion binding
(GO:0046790)
Voluntary musculoskeletal movement
(GO:0050882)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 442.1865
Cell Significance Index: -68.7800
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 268.2309
Cell Significance Index: -68.0400
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 148.6902
Cell Significance Index: -70.2000
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 147.3205
Cell Significance Index: -59.8500
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 129.2222
Cell Significance Index: -66.4700
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 104.9146
Cell Significance Index: -70.4000
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 62.7813
Cell Significance Index: -59.9400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 55.7846
Cell Significance Index: -68.7800
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 25.0704
Cell Significance Index: -67.1600
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 19.2319
Cell Significance Index: -59.0700
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 17.4808
Cell Significance Index: -68.9800
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 16.3530
Cell Significance Index: -35.7900
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 5.0964
Cell Significance Index: 73.3000
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 3.0302
Cell Significance Index: 170.0400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 2.9896
Cell Significance Index: 229.4200
Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.0727
Cell Significance Index: 411.3400
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.9397
Cell Significance Index: 49.8600
Cell Name: kidney cell (CL1000497)
Fold Change: 1.6019
Cell Significance Index: 12.7900
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.5683
Cell Significance Index: 43.8300
Cell Name: type I muscle cell (CL0002211)
Fold Change: 1.4414
Cell Significance Index: 35.1700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.2764
Cell Significance Index: 457.8400
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.2235
Cell Significance Index: 20.6100
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.9860
Cell Significance Index: 7.6000
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.9265
Cell Significance Index: 43.2000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.8547
Cell Significance Index: 171.4600
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.7780
Cell Significance Index: 538.1100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.6859
Cell Significance Index: 84.3400
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.6656
Cell Significance Index: 40.9100
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.6401
Cell Significance Index: 349.5500
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.5886
Cell Significance Index: 8.6900
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.5691
Cell Significance Index: 361.4400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.5416
Cell Significance Index: 97.6300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.4844
Cell Significance Index: 36.1000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4533
Cell Significance Index: 409.3100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.4017
Cell Significance Index: 25.3200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3827
Cell Significance Index: 62.2500
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3453
Cell Significance Index: 152.6600
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.3391
Cell Significance Index: 638.5800
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.2639
Cell Significance Index: 3.6000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.2569
Cell Significance Index: 116.6100
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2365
Cell Significance Index: 6.8200
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.2260
Cell Significance Index: 307.2500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2134
Cell Significance Index: 40.6200
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1922
Cell Significance Index: 295.9500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.1431
Cell Significance Index: 104.9100
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1349
Cell Significance Index: 248.8500
Cell Name: odontoblast (CL0000060)
Fold Change: 0.1203
Cell Significance Index: 15.4200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0953
Cell Significance Index: 16.2700
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0370
Cell Significance Index: -27.3900
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0453
Cell Significance Index: -28.2900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0541
Cell Significance Index: -30.5300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0705
Cell Significance Index: -1.9200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0768
Cell Significance Index: -3.4800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0829
Cell Significance Index: -62.7700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1028
Cell Significance Index: -10.5000
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.1085
Cell Significance Index: -2.3200
Cell Name: peg cell (CL4033014)
Fold Change: -0.1104
Cell Significance Index: -2.5500
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1293
Cell Significance Index: -16.7100
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1350
Cell Significance Index: -7.0900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1432
Cell Significance Index: -6.7300
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1513
Cell Significance Index: -17.2700
Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.1573
Cell Significance Index: -15.5600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1650
Cell Significance Index: -34.7500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1982
Cell Significance Index: -27.2200
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2020
Cell Significance Index: -23.5400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2034
Cell Significance Index: -29.5600
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.2039
Cell Significance Index: -4.8900
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2057
Cell Significance Index: -59.1700
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2259
Cell Significance Index: -7.8500
Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: -0.3101
Cell Significance Index: -1.3500
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.3114
Cell Significance Index: -33.8700
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.3367
Cell Significance Index: -4.9700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3510
Cell Significance Index: -23.6000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.3657
Cell Significance Index: -12.8500
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.4126
Cell Significance Index: -29.1800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4366
Cell Significance Index: -50.0200
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: -0.4538
Cell Significance Index: -4.7000
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.4558
Cell Significance Index: -23.7400
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5249
Cell Significance Index: -54.6500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.5287
Cell Significance Index: -11.2600
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5420
Cell Significance Index: -42.9300
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.5445
Cell Significance Index: -3.2900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.5496
Cell Significance Index: -64.8100
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.5544
Cell Significance Index: -12.1400
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.6626
Cell Significance Index: -13.7500
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.7363
Cell Significance Index: -47.5100
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.7514
Cell Significance Index: -21.5400
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -0.7523
Cell Significance Index: -4.6300
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.7594
Cell Significance Index: -33.5900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.8437
Cell Significance Index: -43.8300
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.8724
Cell Significance Index: -10.4000
Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -0.8961
Cell Significance Index: -12.5300
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.9595
Cell Significance Index: -9.9300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.9609
Cell Significance Index: -58.9200
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -1.0201
Cell Significance Index: -12.7200
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -1.0361
Cell Significance Index: -39.2400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.1118
Cell Significance Index: -35.6100
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -1.1268
Cell Significance Index: -19.3100
Cell Name: oligodendrocyte (CL0000128)
Fold Change: -1.1705
Cell Significance Index: -12.5500
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -1.1841
Cell Significance Index: -14.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** HIPK2 is a nuclear protein that is highly expressed in various cell types, including neurons, immune cells, and epithelial cells. It is characterized by its ability to phosphorylate and regulate the activity of multiple transcription factors and signaling pathways. HIPK2 is also known for its role in DNA damage response, apoptosis, and cell cycle regulation. **Pathways and Functions:** HIPK2 is involved in multiple signaling pathways, including: 1. **DNA damage response:** HIPK2 phosphorylates and activates p53, a key transcription factor involved in DNA damage response and apoptosis. 2. **Apoptosis:** HIPK2 regulates the expression of pro-apoptotic and anti-apoptotic genes, influencing cell survival and death. 3. **Cell cycle regulation:** HIPK2 phosphorylates and regulates the activity of cyclin-dependent kinases, influencing cell cycle progression. 4. **Transcriptional regulation:** HIPK2 interacts with multiple transcription factors, including p53, Runx1, and MeCP2, to modulate the expression of target genes involved in development, cell growth, and differentiation. 5. **Signal transduction:** HIPK2 phosphorylates and regulates the activity of signaling molecules, including JNK and Smad proteins, influencing cell growth and differentiation. **Clinical Significance:** HIPK2 has been implicated in various diseases, including: 1. **Cancer:** HIPK2 is often downregulated in cancer cells, leading to increased cell proliferation and survival. 2. **Neurodegenerative diseases:** HIPK2 has been implicated in Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders. 3. **Cardiovascular disease:** HIPK2 regulates the expression of genes involved in cardiac development and function, making it a potential target for cardiovascular disease treatment. 4. **Immunological disorders:** HIPK2 has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. In conclusion, HIPK2 is a complex protein that plays a crucial role in regulating gene expression and cellular processes. Its dysregulation has been implicated in various diseases, making it a potential target for therapeutic intervention. Further research is needed to fully understand the mechanisms of HIPK2 and its role in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Homeodomain-interacting protein kinase 2

Genular Protein ID: 2429145760

Symbol: HIPK2_HUMAN

Name: Homeodomain-interacting protein kinase 2

UniProtKB Accession Codes:

Q9H2X6 Q75MR7 Q8WWI4 Q9H2Y1

Database IDs:

Citations:

PubMed ID: 11267674

Title: Isolation and characterization of cDNAs for the protein kinase HIPK2.

PubMed ID: 11267674

DOI: 10.1016/s0167-4781(00)00308-0

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 11032752

Title: The serine/threonine kinase HIPK2 interacts with TRADD, but not with CD95 or TNF-R1 in 293T cells.

PubMed ID: 11032752

DOI: 10.1006/bbrc.2000.3700

PubMed ID: 11798164

Title: The homeodomain-interacting protein kinase 2 gene is expressed late in embryogenesis and preferentially in retina, muscle, and neural tissues.

PubMed ID: 11798164

DOI: 10.1006/bbrc.2001.6310

PubMed ID: 12220523

Title: HIPK2 associates with RanBPM.

PubMed ID: 12220523

DOI: 10.1016/s0006-291x(02)02020-x

PubMed ID: 11925430

Title: Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo.

PubMed ID: 11925430

DOI: 10.1074/jbc.m200153200

PubMed ID: 11740489

Title: Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2.

PubMed ID: 11740489

DOI: 10.1038/ncb715

PubMed ID: 12907596

Title: PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains.

PubMed ID: 12907596

PubMed ID: 14678985

Title: HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells.

PubMed ID: 14678985

PubMed ID: 12851404

Title: TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity.

PubMed ID: 12851404

DOI: 10.1074/jbc.m301979200

PubMed ID: 12874272

Title: Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation.

PubMed ID: 12874272

DOI: 10.1074/jbc.m307112200

PubMed ID: 14609633

Title: Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules.

PubMed ID: 14609633

DOI: 10.1016/j.virusres.2003.09.001

PubMed ID: 14647468

Title: Sp100 is important for the stimulatory effect of homeodomain-interacting protein kinase-2 on p53-dependent gene expression.

PubMed ID: 14647468

DOI: 10.1038/sj.onc.1207079

PubMed ID: 16253240

Title: Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1.

PubMed ID: 16253240

DOI: 10.1016/j.febslet.2005.10.010

PubMed ID: 16601678

Title: Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2.

PubMed ID: 16601678

DOI: 10.1038/sj.emboj.7601077

PubMed ID: 17018294

Title: Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2.

PubMed ID: 17018294

DOI: 10.1016/j.molcel.2006.08.004

PubMed ID: 17960875

Title: Homeodomain-interacting protein kinase-2 (HIPK2) phosphorylates HMGA1a at Ser-35, Thr-52, and Thr-77 and modulates its DNA binding affinity.

PubMed ID: 17960875

DOI: 10.1021/pr700571d

PubMed ID: 18695000

Title: PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis.

PubMed ID: 18695000

DOI: 10.1182/blood-2008-01-134122

PubMed ID: 18093972

Title: Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1.

PubMed ID: 18093972

DOI: 10.1074/jbc.m708873200

PubMed ID: 18809579

Title: PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation.

PubMed ID: 18809579

DOI: 10.1128/mcb.00897-08

PubMed ID: 18536714

Title: Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR.

PubMed ID: 18536714

DOI: 10.1038/ncb1743

PubMed ID: 19046997

Title: Transcriptional regulation of hypoxia-inducible factor 1alpha by HIPK2 suggests a novel mechanism to restrain tumor growth.

PubMed ID: 19046997

DOI: 10.1016/j.bbamcr.2008.10.013

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19015637

Title: PML tumor suppressor is regulated by HIPK2-mediated phosphorylation in response to DNA damage.

PubMed ID: 19015637

DOI: 10.1038/onc.2008.420

PubMed ID: 19448668

Title: The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4.

PubMed ID: 19448668

DOI: 10.1038/onc.2009.109

PubMed ID: 19714248

Title: Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha.

PubMed ID: 19714248

DOI: 10.1371/journal.pone.0006819

PubMed ID: 20637728

Title: Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization.

PubMed ID: 20637728

DOI: 10.1016/j.bbrc.2010.07.035

PubMed ID: 20307497

Title: Homeodomain-interacting protein kinase 2 (HIPK2) targets beta-catenin for phosphorylation and proteasomal degradation.

PubMed ID: 20307497

DOI: 10.1016/j.bbrc.2010.03.099

PubMed ID: 20980392

Title: Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress.

PubMed ID: 20980392

DOI: 10.1242/jcs.073627

PubMed ID: 20573984

Title: Regulation of genotoxic stress response by homeodomain-interacting protein kinase 2 through phosphorylation of cyclic AMP response element-binding protein at serine 271.

PubMed ID: 20573984

DOI: 10.1091/mbc.e10-01-0015

PubMed ID: 21145359

Title: Control of nuclear HIPK2 localization and function by a SUMO interaction motif.

PubMed ID: 21145359

DOI: 10.1016/j.bbamcr.2010.11.022

PubMed ID: 21192925

Title: Role of the SUMO-interacting motif in HIPK2 targeting to the PML nuclear bodies and regulation of p53.

PubMed ID: 21192925

DOI: 10.1016/j.yexcr.2010.12.016

PubMed ID: 18974774

Title: How cells switch HIPK2 on and off.

PubMed ID: 18974774

DOI: 10.1038/cdd.2008.154

PubMed ID: 19788416

Title: Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling - roles of p53, p73 and HIPK2.

PubMed ID: 19788416

DOI: 10.1111/j.1742-4658.2009.07331.x

PubMed ID: 20234185

Title: HIPK2-a therapeutical target to be (re)activated for tumor suppression: role in p53 activation and HIF-1? inhibition.

PubMed ID: 20234185

DOI: 10.4161/cc.9.7.11125

PubMed ID: 20514025

Title: Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells.

PubMed ID: 20514025

DOI: 10.1038/onc.2010.183

PubMed ID: 22825850

Title: DNA damage-induced heterogeneous nuclear ribonucleoprotein K SUMOylation regulates p53 transcriptional activation.

PubMed ID: 22825850

DOI: 10.1074/jbc.m112.390120

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27211601

Title: SUMO5, a novel poly-sumo isoform, regulates pml nuclear bodies.

PubMed ID: 27211601

DOI: 10.1038/srep26509

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 33591310

Title: DAZAP2 acts as specifier of the p53 response to DNA damage.

PubMed ID: 33591310

DOI: 10.1093/nar/gkab084

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 1198
Mass: 130966
Checksum: 6022D5710E8D2D93
Sequence:

MAPVYEGMAS HVQVFSPHTL QSSAFCSVKK LKIEPSSNWD MTGYGSHSKV YSQSKNIPLS 
QPATTTVSTS LPVPNPSLPY EQTIVFPGST GHIVVTSASS TSVTGQVLGG PHNLMRRSTV 
SLLDTYQKCG LKRKSEEIEN TSSVQIIEEH PPMIQNNASG ATVATATTST ATSKNSGSNS 
EGDYQLVQHE VLCSMTNTYE VLEFLGRGTF GQVVKCWKRG TNEIVAIKIL KNHPSYARQG 
QIEVSILARL STESADDYNF VRAYECFQHK NHTCLVFEML EQNLYDFLKQ NKFSPLPLKY 
IRPVLQQVAT ALMKLKSLGL IHADLKPENI MLVDPSRQPY RVKVIDFGSA SHVSKAVCST 
YLQSRYYRAP EIILGLPFCE AIDMWSLGCV IAELFLGWPL YPGASEYDQI RYISQTQGLP 
AEYLLSAGTK TTRFFNRDTD SPYPLWRLKT PDDHEAETGI KSKEARKYIF NCLDDMAQVN 
MTTDLEGSDM LVEKADRREF IDLLKKMLTI DADKRITPIE TLNHPFVTMT HLLDFPHSTH 
VKSCFQNMEI CKRRVNMYDT VNQSKTPFIT HVAPSTSTNL TMTFNNQLTT VHNQAPSSTS 
ATISLANPEV SILNYPSTLY QPSAASMAAV AQRSMPLQTG TAQICARPDP FQQALIVCPP 
GFQGLQASPS KHAGYSVRME NAVPIVTQAP GAQPLQIQPG LLAQQAWPSG TQQILLPPAW 
QQLTGVATHT SVQHATVIPE TMAGTQQLAD WRNTHAHGSH YNPIMQQPAL LTGHVTLPAA 
QPLNVGVAHV MRQQPTSTTS SRKSKQHQSS VRNVSTCEVS SSQAISSPQR SKRVKENTPP 
RCAMVHSSPA CSTSVTCGWG DVASSTTRER QRQTIVIPDT PSPTVSVITI SSDTDEEEEQ 
KHAPTSTVSK QRKNVISCVT VHDSPYSDSS SNTSPYSVQQ RAGHNNANAF DTKGSLENHC 
TGNPRTIIVP PLKTQASEVL VECDSLVPVN TSHHSSSYKS KSSSNVTSTS GHSSGSSSGA 
ITYRQQRPGP HFQQQQPLNL SQAQQHITTD RTGSHRRQQA YITPTMAQAP YSFPHNSPSH 
GTVHPHLAAA AAAAHLPTQP HLYTYTAPAA LGSTGTVAHL VASQGSARHT VQHTAYPASI 
VHQVPVSMGP RVLPSPTIHP SQYPAQFAHQ TYISASPAST VYTGYPLSPA KVNQYPYI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: HIPK2

Associated with

Cells (max top 100)

Other Information

Isolation and characterization of cDNAs for the protein kinase HIPK2. PubMed ID: 11267674

The DNA sequence of human chromosome 7. PubMed ID: 12853948

The serine/threonine kinase HIPK2 interacts with TRADD, but not with CD95 or TNF-R1 in 293T cells. PubMed ID: 11032752

The homeodomain-interacting protein kinase 2 gene is expressed late in embryogenesis and preferentially in retina, muscle, and neural tissues. PubMed ID: 11798164

HIPK2 associates with RanBPM. PubMed ID: 12220523

Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo. PubMed ID: 11925430

Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. PubMed ID: 11740489

PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains. PubMed ID: 12907596

HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells. PubMed ID: 14678985

TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity. PubMed ID: 12851404

Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation. PubMed ID: 12874272

Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules. PubMed ID: 14609633

Sp100 is important for the stimulatory effect of homeodomain-interacting protein kinase-2 on p53-dependent gene expression. PubMed ID: 14647468

Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1. PubMed ID: 16253240

Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2. PubMed ID: 16601678

Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2. PubMed ID: 17018294

Homeodomain-interacting protein kinase-2 (HIPK2) phosphorylates HMGA1a at Ser-35, Thr-52, and Thr-77 and modulates its DNA binding affinity. PubMed ID: 17960875

PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis. PubMed ID: 18695000

Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1. PubMed ID: 18093972

PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation. PubMed ID: 18809579

Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR. PubMed ID: 18536714

Transcriptional regulation of hypoxia-inducible factor 1alpha by HIPK2 suggests a novel mechanism to restrain tumor growth. PubMed ID: 19046997

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

PML tumor suppressor is regulated by HIPK2-mediated phosphorylation in response to DNA damage. PubMed ID: 19015637

The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4. PubMed ID: 19448668

Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha. PubMed ID: 19714248

Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization. PubMed ID: 20637728

Homeodomain-interacting protein kinase 2 (HIPK2) targets beta-catenin for phosphorylation and proteasomal degradation. PubMed ID: 20307497

Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress. PubMed ID: 20980392

Regulation of genotoxic stress response by homeodomain-interacting protein kinase 2 through phosphorylation of cyclic AMP response element-binding protein at serine 271. PubMed ID: 20573984

Control of nuclear HIPK2 localization and function by a SUMO interaction motif. PubMed ID: 21145359

Role of the SUMO-interacting motif in HIPK2 targeting to the PML nuclear bodies and regulation of p53. PubMed ID: 21192925

How cells switch HIPK2 on and off. PubMed ID: 18974774

Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling - roles of p53, p73 and HIPK2. PubMed ID: 19788416

HIPK2-a therapeutical target to be (re)activated for tumor suppression: role in p53 activation and HIF-1? inhibition. PubMed ID: 20234185

Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells. PubMed ID: 20514025

DNA damage-induced heterogeneous nuclear ribonucleoprotein K SUMOylation regulates p53 transcriptional activation. PubMed ID: 22825850

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

SUMO5, a novel poly-sumo isoform, regulates pml nuclear bodies. PubMed ID: 27211601

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

DAZAP2 acts as specifier of the p53 response to DNA damage. PubMed ID: 33591310

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846