Details for: IL17B

Gene ID: 27190

Symbol: IL17B

Ensembl ID: ENSG00000127743

Description: interleukin 17B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 8.6904
    Cell Significance Index: -3.5800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 6.9156
    Cell Significance Index: -3.2700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.4800
    Cell Significance Index: 35.8500
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.2495
    Cell Significance Index: 6.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.0272
    Cell Significance Index: 27.5300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.3017
    Cell Significance Index: 4.3200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3012
    Cell Significance Index: 7.9200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.2774
    Cell Significance Index: 2.3300
  • Cell Name: obsolete somatic cell (CL0002371)
    Fold Change: 0.1914
    Cell Significance Index: 1.4500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0647
    Cell Significance Index: 0.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0072
    Cell Significance Index: 0.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0047
    Cell Significance Index: 0.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0013
    Cell Significance Index: -2.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0036
    Cell Significance Index: -6.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0036
    Cell Significance Index: -0.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0037
    Cell Significance Index: -2.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0041
    Cell Significance Index: -6.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0045
    Cell Significance Index: -2.8400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0047
    Cell Significance Index: -6.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0051
    Cell Significance Index: -1.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0051
    Cell Significance Index: -1.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0053
    Cell Significance Index: -3.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0058
    Cell Significance Index: -1.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0060
    Cell Significance Index: -1.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0061
    Cell Significance Index: -2.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0078
    Cell Significance Index: -4.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0084
    Cell Significance Index: -3.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0118
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0134
    Cell Significance Index: -2.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0152
    Cell Significance Index: -2.2200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0167
    Cell Significance Index: -0.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0198
    Cell Significance Index: -2.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0207
    Cell Significance Index: -1.3100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0207
    Cell Significance Index: -0.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0219
    Cell Significance Index: -2.8300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0239
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0257
    Cell Significance Index: -2.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0288
    Cell Significance Index: -2.9400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0289
    Cell Significance Index: -0.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0304
    Cell Significance Index: -4.1700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0325
    Cell Significance Index: -1.6400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0339
    Cell Significance Index: -3.5300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0343
    Cell Significance Index: -1.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0354
    Cell Significance Index: -2.6400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0372
    Cell Significance Index: -0.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0412
    Cell Significance Index: -1.0600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0424
    Cell Significance Index: -0.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0444
    Cell Significance Index: -2.0900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0447
    Cell Significance Index: -2.3300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0457
    Cell Significance Index: -3.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0526
    Cell Significance Index: -3.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0555
    Cell Significance Index: -1.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0563
    Cell Significance Index: -3.4600
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0588
    Cell Significance Index: -0.8000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0601
    Cell Significance Index: -0.7700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0612
    Cell Significance Index: -0.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0634
    Cell Significance Index: -3.3300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0702
    Cell Significance Index: -1.3700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0714
    Cell Significance Index: -1.2200
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0735
    Cell Significance Index: -0.4500
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0745
    Cell Significance Index: -1.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0755
    Cell Significance Index: -2.6500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0772
    Cell Significance Index: -1.3300
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0783
    Cell Significance Index: -0.7600
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0799
    Cell Significance Index: -0.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0809
    Cell Significance Index: -4.5400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0817
    Cell Significance Index: -0.6300
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0842
    Cell Significance Index: -0.9000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0869
    Cell Significance Index: -2.7500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0878
    Cell Significance Index: -2.1900
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0884
    Cell Significance Index: -0.8900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0887
    Cell Significance Index: -2.9100
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.0888
    Cell Significance Index: -0.4100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0898
    Cell Significance Index: -3.1200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0962
    Cell Significance Index: -1.6200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0967
    Cell Significance Index: -1.1000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0970
    Cell Significance Index: -2.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0976
    Cell Significance Index: -3.1100
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0979
    Cell Significance Index: -1.3400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0995
    Cell Significance Index: -1.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0997
    Cell Significance Index: -5.1800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1003
    Cell Significance Index: -1.4800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1019
    Cell Significance Index: -1.4800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1029
    Cell Significance Index: -3.0300
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1068
    Cell Significance Index: -1.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1084
    Cell Significance Index: -4.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1085
    Cell Significance Index: -3.1100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1123
    Cell Significance Index: -0.7600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1139
    Cell Significance Index: -1.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1146
    Cell Significance Index: -3.0600
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.1192
    Cell Significance Index: -0.7000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1219
    Cell Significance Index: -2.4800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1227
    Cell Significance Index: -3.1300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1230
    Cell Significance Index: -3.5100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1239
    Cell Significance Index: -2.1900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1259
    Cell Significance Index: -3.1400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1265
    Cell Significance Index: -4.7900
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.1272
    Cell Significance Index: -1.1500
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.1277
    Cell Significance Index: -1.4100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1283
    Cell Significance Index: -2.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IL17B is a 156-amino acid protein, which is structurally similar to its homolog, IL-17A. The protein is secreted by various cell types, including conventional dendritic cells, mesenchymal cells, and certain neuronal cells in the retina. IL17B is characterized by its ability to bind to the IL-17 receptor A (IL-17RA) and IL-17 receptor C (IL-17RC), which are expressed on the surface of various immune cells. The interaction between IL17B and its receptors triggers a signaling cascade that leads to the activation of NF-κB and the production of pro-inflammatory cytokines. **Pathways and Functions:** IL17B's functions can be attributed to its involvement in several key signaling pathways: 1. **Cell-cell signaling:** IL17B promotes the recruitment of immune cells to sites of inflammation by inducing the expression of adhesion molecules and chemokines. 2. **Cytokine activity:** IL17B stimulates the production of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6, which contribute to the inflammatory response. 3. **Extracellular space:** IL17B is secreted into the extracellular space, where it interacts with its receptors and triggers a signaling cascade. 4. **Immune response:** IL17B plays a critical role in the regulation of immune responses, particularly in the context of Th17 cell differentiation and the production of pro-inflammatory cytokines. 5. **Inflammatory response:** IL17B is involved in the regulation of inflammatory responses, including the recruitment of immune cells to sites of inflammation and the production of pro-inflammatory cytokines. **Clinical Significance:** IL17B has been implicated in various disease states, including: 1. **Inflammatory bowel disease (IBD):** IL17B has been shown to play a role in the pathogenesis of IBD, particularly in the context of Crohn's disease and ulcerative colitis. 2. **Rheumatoid arthritis (RA):** IL17B has been implicated in the pathogenesis of RA, where it contributes to joint inflammation and cartilage destruction. 3. **Multiple sclerosis (MS):** IL17B has been shown to play a role in the pathogenesis of MS, where it contributes to demyelination and axonal damage. In conclusion, IL17B is a key effector cytokine that plays a critical role in the regulation of immune responses, particularly in the context of inflammation and autoimmunity. Its involvement in various disease states highlights the importance of IL17B in disease pathogenesis and underscores the potential for therapeutic targeting of IL17B in the treatment of inflammatory and autoimmune diseases.

Genular Protein ID: 2412326529

Symbol: IL17B_HUMAN

Name: Interleukin-17B

UniProtKB Accession Codes:

Q9UHF5 Q14CE5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10749887

Title: A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity.

PubMed ID: 10749887

DOI: 10.1074/jbc.m910228199

PubMed ID: 10639155

Title: Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family.

PubMed ID: 10639155

DOI: 10.1073/pnas.97.2.773

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 180
  • Mass: 20437
  • Checksum: F1B0BC1446D0B14A
  • Sequence:
    • MDWPHNLLFL LTISIFLGLG QPRSPKSKRK GQGRPGPLAP GPHQVPLDLV SRMKPYARME 
EYERNIEEMV AQLRNSSELA QRKCEVNLQL WMSNKRSLSP WGYSINHDPS RIPVDLPEAR 
CLCLGCVNPF TMQEDRSMVS VPVFSQVPVR RRLCPPPPRT GPCRQRAVME TIAVGCTCIF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.