Details for: HTR2B

Gene ID: 3357

Symbol: HTR2B

Ensembl ID: ENSG00000135914

Description: 5-hydroxytryptamine receptor 2B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 30.0395
    Cell Significance Index: -4.6700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 18.4314
    Cell Significance Index: -4.6800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 12.8536
    Cell Significance Index: -5.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.3760
    Cell Significance Index: 76.1000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.0866
    Cell Significance Index: 66.6200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.9248
    Cell Significance Index: 7.8600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.7916
    Cell Significance Index: 16.9200
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.7089
    Cell Significance Index: 3.7300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6314
    Cell Significance Index: 21.9400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.5236
    Cell Significance Index: 16.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4429
    Cell Significance Index: 84.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4416
    Cell Significance Index: 30.5400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3391
    Cell Significance Index: 234.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3263
    Cell Significance Index: 9.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2949
    Cell Significance Index: 58.5200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2872
    Cell Significance Index: 17.2400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1866
    Cell Significance Index: 20.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1768
    Cell Significance Index: 3.7700
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.1676
    Cell Significance Index: 2.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1605
    Cell Significance Index: 4.3000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1367
    Cell Significance Index: 13.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1340
    Cell Significance Index: 121.0100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0947
    Cell Significance Index: 15.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0763
    Cell Significance Index: 15.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0737
    Cell Significance Index: 3.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0732
    Cell Significance Index: 5.6200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0615
    Cell Significance Index: 2.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0555
    Cell Significance Index: 2.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0535
    Cell Significance Index: 3.2900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0466
    Cell Significance Index: 1.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0365
    Cell Significance Index: 5.0100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0339
    Cell Significance Index: 1.7100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0310
    Cell Significance Index: 42.1100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0246
    Cell Significance Index: 0.4800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0188
    Cell Significance Index: 0.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0184
    Cell Significance Index: 6.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0152
    Cell Significance Index: 23.4100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0138
    Cell Significance Index: 25.4900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0092
    Cell Significance Index: 0.2200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0076
    Cell Significance Index: 0.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0039
    Cell Significance Index: 7.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0034
    Cell Significance Index: 0.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0009
    Cell Significance Index: -0.0400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0021
    Cell Significance Index: -0.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0030
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0053
    Cell Significance Index: -3.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0056
    Cell Significance Index: -3.5300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0059
    Cell Significance Index: -2.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0073
    Cell Significance Index: -4.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0084
    Cell Significance Index: -4.7600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0093
    Cell Significance Index: -0.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0114
    Cell Significance Index: -1.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0120
    Cell Significance Index: -1.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0128
    Cell Significance Index: -3.6800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0185
    Cell Significance Index: -0.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0231
    Cell Significance Index: -1.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0260
    Cell Significance Index: -5.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0281
    Cell Significance Index: -1.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0317
    Cell Significance Index: -5.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0351
    Cell Significance Index: -4.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0412
    Cell Significance Index: -4.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0415
    Cell Significance Index: -4.7600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0440
    Cell Significance Index: -5.6900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0451
    Cell Significance Index: -0.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0472
    Cell Significance Index: -4.8200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0499
    Cell Significance Index: -0.7200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0532
    Cell Significance Index: -3.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0581
    Cell Significance Index: -3.0200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0650
    Cell Significance Index: -0.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0680
    Cell Significance Index: -1.9000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0760
    Cell Significance Index: -2.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0769
    Cell Significance Index: -5.7300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0786
    Cell Significance Index: -1.7200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0801
    Cell Significance Index: -2.3600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0847
    Cell Significance Index: -1.1300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0854
    Cell Significance Index: -1.0700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0860
    Cell Significance Index: -3.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0875
    Cell Significance Index: -4.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0932
    Cell Significance Index: -4.3800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0951
    Cell Significance Index: -1.9900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1004
    Cell Significance Index: -2.4500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1038
    Cell Significance Index: -1.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1070
    Cell Significance Index: -1.7900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1102
    Cell Significance Index: -3.1600
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1118
    Cell Significance Index: -1.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1121
    Cell Significance Index: -3.6700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1171
    Cell Significance Index: -3.7300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1203
    Cell Significance Index: -4.2200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1266
    Cell Significance Index: -2.1700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1268
    Cell Significance Index: -5.2000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1293
    Cell Significance Index: -2.0000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1304
    Cell Significance Index: -1.7600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1337
    Cell Significance Index: -1.9200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1355
    Cell Significance Index: -2.0000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1392
    Cell Significance Index: -5.1100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1479
    Cell Significance Index: -3.1400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1514
    Cell Significance Index: -2.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1558
    Cell Significance Index: -4.2400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1579
    Cell Significance Index: -2.3300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1594
    Cell Significance Index: -3.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Receptor Structure:** HTR2B is a G protein-coupled receptor consisting of seven transmembrane alpha-helices, which forms a binding pocket for serotonin. 2. **Ligand Binding:** HTR2B binds to serotonin, leading to the activation of downstream signaling pathways. 3. **Signaling Pathways:** HTR2B activates various signaling pathways, including phospholipase C activity, calcium-mediated signaling, and G-protein coupled receptor signaling. 4. **Cellular Expression:** HTR2B is expressed in the retina, colon, cardiac muscle, smooth muscle, and immune cells, indicating its widespread role in different physiological processes. 5. **Regulatory Mechanisms:** HTR2B is subject to negative regulation by various mechanisms, including receptor internalization, desensitization, and phosphorylation. **Pathways and Functions:** 1. **Phospholipase C Activity:** Activation of HTR2B by serotonin leads to the activation of phospholipase C, which in turn generates inositol trisphosphate (IP3) and diacylglycerol (DAG), resulting in increased intracellular calcium levels. 2. **Calcium-Mediated Signaling:** Calcium influx triggers various cellular responses, including contraction, proliferation, and differentiation. 3. **G-Protein Coupled Receptor Signaling:** HTR2B activates G-proteins, which in turn modulate downstream signaling pathways, including adenylate cyclase activity and protein kinase C activation. 4. **Cardiac Muscle Hypertrophy:** HTR2B activation has been linked to cardiac hypertrophy, a condition characterized by an increase in cardiac muscle mass. 5. **Behavioral Modulation:** HTR2B plays a role in modulating behavior, including anxiety, aggression, and cognitive functions. **Clinical Significance:** 1. **Neurological Disorders:** HTR2B has been implicated in various neurological disorders, including depression, anxiety, and schizophrenia. 2. **Cardiovascular Diseases:** HTR2B activation has been linked to cardiac hypertrophy, heart failure, and arrhythmias. 3. **Cancer:** HTR2B expression has been observed in various types of cancer, including colorectal, breast, and prostate cancer. 4. **Inflammatory Diseases:** HTR2B plays a role in modulating immune responses, which may contribute to the development of inflammatory diseases, such as arthritis and multiple sclerosis. In conclusion, the HTR2B gene is a complex receptor that plays a multifaceted role in various physiological and pathological processes. Further research is necessary to fully understand the mechanisms underlying HTR2B function and its implications for human health and disease.

Genular Protein ID: 2708375702

Symbol: 5HT2B_HUMAN

Name: N/A

UniProtKB Accession Codes:

P41595 B2R9D5 Q53TI1 Q62221 Q6P523

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 46 DrugCentral 1 EMBL 10 EMDB 3 Ensembl 1 EvolutionaryTrace 1 GO 48 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PIR 2 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8143856

Title: Cloning and functional characterization of the human 5-HT2B serotonin receptor.

PubMed ID: 8143856

DOI: 10.1016/0014-5793(94)80590-3

PubMed ID: 7926008

Title: The human serotonin 5-HT2B receptor: pharmacological link between 5-HT2 and 5-HT1D receptors.

PubMed ID: 7926008

DOI: 10.1016/0014-5793(94)00968-6

PubMed ID: 8078486

Title: Molecular cloning, functional expression, and mRNA tissue distribution of the human 5-hydroxytryptamine2B receptor.

PubMed ID: 8078486

PubMed ID: 10722792

Title: Mutation screening of human 5-HT(2B) receptor gene in early-onset obsessive-compulsive disorder.

PubMed ID: 10722792

DOI: 10.1006/mcpr.1999.0281

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8882600

Title: 5-HT2B receptor-mediated calcium release from ryanodine-sensitive intracellular stores in human pulmonary artery endothelial cells.

PubMed ID: 8882600

DOI: 10.1111/j.1476-5381.1996.tb16700.x

PubMed ID: 11150294

Title: Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1.

PubMed ID: 11150294

DOI: 10.1074/jbc.m008089200

PubMed ID: 12970106

Title: Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy.

PubMed ID: 12970106

DOI: 10.1038/sj.bjp.0705437

PubMed ID: 18476671

Title: Serotonin receptors.

PubMed ID: 18476671

DOI: 10.1021/cr078224o

PubMed ID: 18703043

Title: Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells.

PubMed ID: 18703043

DOI: 10.1016/j.ejphar.2008.07.040

PubMed ID: 21179162

Title: A population-specific HTR2B stop codon predisposes to severe impulsivity.

PubMed ID: 21179162

DOI: 10.1038/nature09629

PubMed ID: 20945968

Title: Serotonin receptors - from molecular biology to clinical applications.

PubMed ID: 20945968

DOI: 10.33549/physiolres.931903

PubMed ID: 23519210

Title: Structural basis for molecular recognition at serotonin receptors.

PubMed ID: 23519210

DOI: 10.1126/science.1232807

PubMed ID: 23519215

Title: Structural features for functional selectivity at serotonin receptors.

PubMed ID: 23519215

DOI: 10.1126/science.1232808

PubMed ID: 24357322

Title: Serial femtosecond crystallography of G protein-coupled receptors.

PubMed ID: 24357322

DOI: 10.1126/science.1244142

PubMed ID: 28129538

Title: Crystal structure of an LSD-bound human serotonin receptor.

PubMed ID: 28129538

DOI: 10.1016/j.cell.2016.12.033

PubMed ID: 30127358

Title: Structural determinants of 5-HT2B receptor activation and biased agonism.

PubMed ID: 30127358

DOI: 10.1038/s41594-018-0116-7

PubMed ID: 36087581

Title: Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD.

PubMed ID: 36087581

DOI: 10.1016/j.neuron.$2022.08.006

Sequence Information:

  • Length: 481
  • Mass: 54298
  • Checksum: CDA4447ECDBA3B46
  • Sequence:
    • MALSYRVSEL QSTIPEHILQ STFVHVISSN WSGLQTESIP EEMKQIVEEQ GNKLHWAALL 
ILMVIIPTIG GNTLVILAVS LEKKLQYATN YFLMSLAVAD LLVGLFVMPI ALLTIMFEAM 
WPLPLVLCPA WLFLDVLFST ASIMHLCAIS VDRYIAIKKP IQANQYNSRA TAFIKITVVW 
LISIGIAIPV PIKGIETDVD NPNNITCVLT KERFGDFMLF GSLAAFFTPL AIMIVTYFLT 
IHALQKKAYL VKNKPPQRLT WLTVSTVFQR DETPCSSPEK VAMLDGSRKD KALPNSGDET 
LMRRTSTIGK KSVQTISNEQ RASKVLGIVF FLFLLMWCPF FITNITLVLC DSCNQTTLQM 
LLEIFVWIGY VSSGVNPLVY TLFNKTFRDA FGRYITCNYR ATKSVKTLRK RSSKIYFRNP 
MAENSKFFKK HGIRNGINPA MYQSPMRLRS STIQSSSIIL LDTLLLTENE GDKTEEQVSY 
V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.