Details for: HTR2B

Gene ID: 3357

Symbol: HTR2B

Ensembl ID: ENSG00000135914

Description: 5-hydroxytryptamine receptor 2B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 4.53
    Marker Score: 4339
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1170
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169532
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.41
    Marker Score: 358
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.37
    Marker Score: 1362
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.34
    Marker Score: 5797
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 855
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.2
    Marker Score: 2450
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 487
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4815
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 502
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.02
    Marker Score: 648
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48052
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.83
    Marker Score: 1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.78
    Marker Score: 457
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 585
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.73
    Marker Score: 11440
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 462
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.7
    Marker Score: 1651
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.69
    Marker Score: 329
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.64
    Marker Score: 435.5
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.6
    Marker Score: 189
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.54
    Marker Score: 655
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.53
    Marker Score: 692
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 475
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.49
    Marker Score: 5529
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.43
    Marker Score: 179
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.43
    Marker Score: 257
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.42
    Marker Score: 868
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.36
    Marker Score: 2171
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.3
    Marker Score: 134
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.3
    Marker Score: 303
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.3
    Marker Score: 510
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.3
    Marker Score: 462
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.28
    Marker Score: 138
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.27
    Marker Score: 3585
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.27
    Marker Score: 323
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.26
    Marker Score: 149
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.25
    Marker Score: 333
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.22
    Marker Score: 464
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.22
    Marker Score: 57
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.21
    Marker Score: 60
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.2
    Marker Score: 174
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2
    Marker Score: 433
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.19
    Marker Score: 136
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.19
    Marker Score: 100
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.19
    Marker Score: 170
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.19
    Marker Score: 76
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.19
    Marker Score: 354
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.18
    Marker Score: 86
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.17
    Marker Score: 65
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.17
    Marker Score: 71
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.17
    Marker Score: 318
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.17
    Marker Score: 110
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.16
    Marker Score: 1361
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.16
    Marker Score: 288
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.16
    Marker Score: 1500
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.16
    Marker Score: 41
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.16
    Marker Score: 165
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.15
    Marker Score: 119
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.15
    Marker Score: 38
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.15
    Marker Score: 9380
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.15
    Marker Score: 47
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.15
    Marker Score: 52
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.15
    Marker Score: 1533
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.15
    Marker Score: 53
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.15
    Marker Score: 60
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.14
    Marker Score: 95
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.14
    Marker Score: 174
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.14
    Marker Score: 135
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.14
    Marker Score: 125
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.14
    Marker Score: 81
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.14
    Marker Score: 75
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.13
    Marker Score: 73
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.13
    Marker Score: 159
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.13
    Marker Score: 37
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.12
    Marker Score: 47
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.12
    Marker Score: 2650
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.12
    Marker Score: 50
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.12
    Marker Score: 70
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.12
    Marker Score: 30

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Other Information

**Key characteristics:** - Gene name: HTR2B - Ensembl ID: ENSG00000135914 - Protein name: 5-hydroxytryptamine receptor 2B - Protein type: G protein-coupled receptor - Subfamily: Class a/1 (rhodopsin-like receptors) - Pathway: G-protein alpha-subunit binding, G alpha (q) signalling events, Gpcr downstream signalling, Gpcr ligand binding, G protein-coupled serotonin receptor activity, Serotonin receptors, Signaling by gpcr **Pathways and functions:** - 5-HT2B is a G protein-coupled receptor that is expressed in a variety of cell types, including retinal horizontal cells, colon goblet cells, mural cells, and enterocytes. - It is involved in cell migration, neurotransmitter release, and immune responses. - In the retina, 5-HT2B is expressed on photoreceptors and is involved in the regulation of circadian rhythms and the response to light. - In the gut, 5-HT2B is expressed on epithelial cells and is involved in the regulation of intestinal motility and immune responses. - In the immune system, 5-HT2B is expressed on dendritic cells and is involved in the regulation of immune responses. **Clinical significance:** - Mutations in the HTR2B gene have been linked to a number of human diseases, including schizophrenia, autism, and depression. - 5-HT2B is a potential therapeutic target for these diseases, as it is involved in the regulation of immune responses and cell migration.

Genular Protein ID: 2708375702

Symbol: 5HT2B_HUMAN

Name: 5-hydroxytryptamine receptor 2B

UniProtKB Accession Codes:

P41595 B2R9D5 Q53TI1 Q62221 Q6P523

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 45 DrugCentral 1 EMBL 10 EMDB 3 Ensembl 1 GO 50 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 19 PDBsum 11 PIR 2 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8143856

Title: Cloning and functional characterization of the human 5-HT2B serotonin receptor.

PubMed ID: 8143856

DOI: 10.1016/0014-5793(94)80590-3

PubMed ID: 7926008

Title: The human serotonin 5-HT2B receptor: pharmacological link between 5-HT2 and 5-HT1D receptors.

PubMed ID: 7926008

DOI: 10.1016/0014-5793(94)00968-6

PubMed ID: 8078486

Title: Molecular cloning, functional expression, and mRNA tissue distribution of the human 5-hydroxytryptamine2B receptor.

PubMed ID: 8078486

PubMed ID: 10722792

Title: Mutation screening of human 5-HT(2B) receptor gene in early-onset obsessive-compulsive disorder.

PubMed ID: 10722792

DOI: 10.1006/mcpr.1999.0281

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8882600

Title: 5-HT2B receptor-mediated calcium release from ryanodine-sensitive intracellular stores in human pulmonary artery endothelial cells.

PubMed ID: 8882600

DOI: 10.1111/j.1476-5381.1996.tb16700.x

PubMed ID: 11150294

Title: Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1.

PubMed ID: 11150294

DOI: 10.1074/jbc.m008089200

PubMed ID: 12970106

Title: Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy.

PubMed ID: 12970106

DOI: 10.1038/sj.bjp.0705437

PubMed ID: 18476671

Title: Serotonin receptors.

PubMed ID: 18476671

DOI: 10.1021/cr078224o

PubMed ID: 18703043

Title: Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells.

PubMed ID: 18703043

DOI: 10.1016/j.ejphar.2008.07.040

PubMed ID: 21179162

Title: A population-specific HTR2B stop codon predisposes to severe impulsivity.

PubMed ID: 21179162

DOI: 10.1038/nature09629

PubMed ID: 20945968

Title: Serotonin receptors - from molecular biology to clinical applications.

PubMed ID: 20945968

DOI: 10.33549/physiolres.931903

PubMed ID: 23519210

Title: Structural basis for molecular recognition at serotonin receptors.

PubMed ID: 23519210

DOI: 10.1126/science.1232807

PubMed ID: 23519215

Title: Structural features for functional selectivity at serotonin receptors.

PubMed ID: 23519215

DOI: 10.1126/science.1232808

PubMed ID: 24357322

Title: Serial femtosecond crystallography of G protein-coupled receptors.

PubMed ID: 24357322

DOI: 10.1126/science.1244142

PubMed ID: 28129538

Title: Crystal structure of an LSD-bound human serotonin receptor.

PubMed ID: 28129538

DOI: 10.1016/j.cell.2016.12.033

Sequence Information:

  • Length: 481
  • Mass: 54298
  • Checksum: CDA4447ECDBA3B46
  • Sequence:
    • MALSYRVSEL QSTIPEHILQ STFVHVISSN WSGLQTESIP EEMKQIVEEQ GNKLHWAALL 
ILMVIIPTIG GNTLVILAVS LEKKLQYATN YFLMSLAVAD LLVGLFVMPI ALLTIMFEAM 
WPLPLVLCPA WLFLDVLFST ASIMHLCAIS VDRYIAIKKP IQANQYNSRA TAFIKITVVW 
LISIGIAIPV PIKGIETDVD NPNNITCVLT KERFGDFMLF GSLAAFFTPL AIMIVTYFLT 
IHALQKKAYL VKNKPPQRLT WLTVSTVFQR DETPCSSPEK VAMLDGSRKD KALPNSGDET 
LMRRTSTIGK KSVQTISNEQ RASKVLGIVF FLFLLMWCPF FITNITLVLC DSCNQTTLQM 
LLEIFVWIGY VSSGVNPLVY TLFNKTFRDA FGRYITCNYR ATKSVKTLRK RSSKIYFRNP 
MAENSKFFKK HGIRNGINPA MYQSPMRLRS STIQSSSIIL LDTLLLTENE GDKTEEQVSY 
V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.