Gene HOXC5 - ENSG00000172789 | NCBI Gene ID: 3222

Details for: HOXC5

Gene ID: 3222

Symbol: HOXC5

Ensembl ID: ENSG00000172789

Description: homeobox C5

Associated with

Anterior/posterior pattern specification
(GO:0009952)
Cell junction
(GO:0030054)
Chromatin
(GO:0000785)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Embryonic skeletal system development
(GO:0048706)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 15.99
Marker Score: 162069
Cell Name: microglial cell (CL0000129)
Fold Change: 2.26
Marker Score: 4116
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 2.19
Marker Score: 1510
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2
Marker Score: 1991
Cell Name: plasma cell (CL0000786)
Fold Change: 1.98
Marker Score: 2212
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1169
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 869
Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7682
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4807
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.1
Marker Score: 2588
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 795
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71817
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48042
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.99
Marker Score: 409
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 508
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 461
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.98
Marker Score: 660.5
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5346
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 373
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.92
Marker Score: 424
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2737
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 325.5
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5293
Cell Name: mast cell (CL0000097)
Fold Change: 0.8
Marker Score: 462
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1267
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 708
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 396
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.76
Marker Score: 500
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.74
Marker Score: 1179
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 179
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.66
Marker Score: 1370
Cell Name: neutrophil (CL0000775)
Fold Change: 0.63
Marker Score: 386
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.62
Marker Score: 395
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 149
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 445
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.56
Marker Score: 176
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.56
Marker Score: 232
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 174
Cell Name: B cell (CL0000236)
Fold Change: 0.55
Marker Score: 519
Cell Name: enteric neuron (CL0007011)
Fold Change: 0.51
Marker Score: 269
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.49
Marker Score: 474
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.48
Marker Score: 997
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.46
Marker Score: 277
Cell Name: motor neuron (CL0000100)
Fold Change: 0.42
Marker Score: 249
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.41
Marker Score: 165
Cell Name: T cell (CL0000084)
Fold Change: 0.4
Marker Score: 683
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 371
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.33
Marker Score: 217
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.32
Marker Score: 251
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.31
Marker Score: 176
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.31
Marker Score: 236
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.3
Marker Score: 215
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.3
Marker Score: 159
Cell Name: stromal cell (CL0000499)
Fold Change: 0.29
Marker Score: 344
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.29
Marker Score: 181
Cell Name: monocyte (CL0000576)
Fold Change: 0.27
Marker Score: 354
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.27
Marker Score: 456
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 0.27
Marker Score: 90
Cell Name: neural crest cell (CL0011012)
Fold Change: 0.26
Marker Score: 277
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.26
Marker Score: 240
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 0.25
Marker Score: 119
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.24
Marker Score: 3217
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 66
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 76
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.22
Marker Score: 118
Cell Name: fibroblast (CL0000057)
Fold Change: 0.21
Marker Score: 205
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.2
Marker Score: 53
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.2
Marker Score: 93
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.2
Marker Score: 223
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 0.19
Marker Score: 510
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.19
Marker Score: 161
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.19
Marker Score: 329
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.18
Marker Score: 44
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.17
Marker Score: 185
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 0.17
Marker Score: 60
Cell Name: neural cell (CL0002319)
Fold Change: 0.17
Marker Score: 83.5
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.16
Marker Score: 51
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.16
Marker Score: 163
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.16
Marker Score: 381
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.16
Marker Score: 31
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.16
Marker Score: 426
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.16
Marker Score: 50
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 0.16
Marker Score: 192
Cell Name: kidney cell (CL1000497)
Fold Change: 0.15
Marker Score: 103
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.15
Marker Score: 56
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.15
Marker Score: 1550
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.15
Marker Score: 192
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 0.15
Marker Score: 33
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.15
Marker Score: 32
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.14
Marker Score: 129
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.14
Marker Score: 66
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.14
Marker Score: 171
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.13
Marker Score: 874
Cell Name: secretory cell (CL0000151)
Fold Change: 0.13
Marker Score: 239
Cell Name: type L enteroendocrine cell (CL0002279)
Fold Change: 0.12
Marker Score: 34
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.12
Marker Score: 198
Cell Name: M cell of gut (CL0000682)
Fold Change: 0.12
Marker Score: 31
Cell Name: muscle cell (CL0000187)
Fold Change: 0.12
Marker Score: 33.5

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**Key characteristics:** - HOXC5 is a homeobox gene, which are a family of transcription factors that play a critical role in specifying the identity of tissues and organs. - It is expressed in a variety of cell types, including neurons, glial cells, and epithelial cells. - HOXC5 is involved in a number of important cellular processes, including anterior/posterior pattern specification, cell junction, chromatin remodeling, and embryonic skeletal system development. **Pathways and functions:** - HOXC5 is a key regulator of anterior/posterior (A/P) patterning during embryonic development. - It is expressed in a wave-like pattern, with high expression in the anterior (A) and low expression in the posterior (P) of the developing embryo. - HOXC5 binds to specific DNA sequences in the regulatory region of the HoxC1 gene, which is responsible for specifying the A/P identity of the developing somites. - This binding leads to the repression of HoxC1 expression in the A and the activation of HoxC1 expression in the P, resulting in the formation of the A and P somites, respectively. **Clinical significance:** - Mutations in the HOXC5 gene have been linked to a number of human diseases, including Angelman syndrome, autism, and schizophrenia. - HOXC5 is a potential therapeutic target for these diseases, as it can be used to correct the abnormal expression of HoxC1 and restore the A/P patterning of the somites.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Homeobox protein Hox-C5

Genular Protein ID: 386421539

Symbol: HXC5_HUMAN

Name: Homeobox protein Hox-C5

UniProtKB Accession Codes:

Q00444

Database IDs:

Citations:

PubMed ID: 1346761

Title: The upstream region of the human homeobox gene HOX3D is a target for regulation by retinoic acid and HOX homeoproteins.

PubMed ID: 1346761

DOI: 10.1002/j.1460-2075.1992.tb05049.x

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

Sequence Information:

Length: 222
Mass: 24976
Checksum: 9ABA38D35E4E61AB
Sequence:

MSSYVANSFY KQSPNIPAYN MQTCGNYGSA SEVQASRYCY GGLDLSITFP PPAPSNSLHG 
VDMAANPRAH PDRPACSAAA APGHAPGRDE AAPLNPGMYS QKAARPALEE RAKSSGEIKE 
EQAQTGQPAG LSQPPAPPQI YPWMTKLHMS HETDGKRSRT SYTRYQTLEL EKEFHFNRYL 
TRRRRIEIAN NLCLNERQIK IWFQNRRMKW KKDSKMKSKE AL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.