Details for: HOXC5

Gene ID: 3222

Symbol: HOXC5

Ensembl ID: ENSG00000172789

Description: homeobox C5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 7.5192
    Cell Significance Index: -3.5500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.7631
    Cell Significance Index: 169.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.1073
    Cell Significance Index: 67.5000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1553
    Cell Significance Index: 27.9900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.0628
    Cell Significance Index: 12.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9128
    Cell Significance Index: 41.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6846
    Cell Significance Index: 130.2800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4860
    Cell Significance Index: 16.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4709
    Cell Significance Index: 46.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4305
    Cell Significance Index: 388.6900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2838
    Cell Significance Index: 5.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2294
    Cell Significance Index: 37.3100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2248
    Cell Significance Index: 24.4600
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.1777
    Cell Significance Index: 1.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1587
    Cell Significance Index: 3.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1222
    Cell Significance Index: 8.4500
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.1069
    Cell Significance Index: 1.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0950
    Cell Significance Index: 19.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0681
    Cell Significance Index: 4.0900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0637
    Cell Significance Index: 0.6300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0543
    Cell Significance Index: 2.7400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0488
    Cell Significance Index: 0.6300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0389
    Cell Significance Index: 0.5700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0285
    Cell Significance Index: 0.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0157
    Cell Significance Index: 0.3400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0155
    Cell Significance Index: 0.1500
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.0129
    Cell Significance Index: 0.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0115
    Cell Significance Index: 0.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0054
    Cell Significance Index: 0.1900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0030
    Cell Significance Index: 0.0600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.0025
    Cell Significance Index: 0.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0024
    Cell Significance Index: -1.7700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0034
    Cell Significance Index: -0.0700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0048
    Cell Significance Index: -0.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0050
    Cell Significance Index: -3.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0058
    Cell Significance Index: -0.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0060
    Cell Significance Index: -0.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0062
    Cell Significance Index: -3.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0065
    Cell Significance Index: -3.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0115
    Cell Significance Index: -1.5800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0122
    Cell Significance Index: -0.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0139
    Cell Significance Index: -1.4200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0179
    Cell Significance Index: -0.1500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0222
    Cell Significance Index: -0.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0278
    Cell Significance Index: -0.7300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0279
    Cell Significance Index: -0.5600
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0292
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0293
    Cell Significance Index: -3.3600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0315
    Cell Significance Index: -0.3600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0324
    Cell Significance Index: -4.1800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0325
    Cell Significance Index: -0.6900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0418
    Cell Significance Index: -3.3100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0443
    Cell Significance Index: -1.4500
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0457
    Cell Significance Index: -0.2800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0502
    Cell Significance Index: -1.6000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0541
    Cell Significance Index: -0.4600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0542
    Cell Significance Index: -0.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0551
    Cell Significance Index: -4.1100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0565
    Cell Significance Index: -0.5900
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.0589
    Cell Significance Index: -0.3100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0625
    Cell Significance Index: -1.3500
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: -0.0649
    Cell Significance Index: -0.4700
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: -0.0650
    Cell Significance Index: -0.1500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0654
    Cell Significance Index: -1.5100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0667
    Cell Significance Index: -0.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0689
    Cell Significance Index: -3.8700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0710
    Cell Significance Index: -2.0900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0779
    Cell Significance Index: -2.7300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0781
    Cell Significance Index: -0.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0802
    Cell Significance Index: -3.7700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0817
    Cell Significance Index: -1.1700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0835
    Cell Significance Index: -1.6300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0852
    Cell Significance Index: -1.6700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0859
    Cell Significance Index: -1.0100
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.0869
    Cell Significance Index: -0.5100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0888
    Cell Significance Index: -1.7700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0894
    Cell Significance Index: -2.2300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0957
    Cell Significance Index: -2.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0984
    Cell Significance Index: -2.8200
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.1056
    Cell Significance Index: -0.7600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1102
    Cell Significance Index: -0.8800
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1104
    Cell Significance Index: -1.1800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1146
    Cell Significance Index: -1.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1150
    Cell Significance Index: -3.1300
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.1151
    Cell Significance Index: -1.4500
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1166
    Cell Significance Index: -0.7300
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.1182
    Cell Significance Index: -1.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1206
    Cell Significance Index: -3.2200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1209
    Cell Significance Index: -1.5700
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.1225
    Cell Significance Index: -1.5500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1258
    Cell Significance Index: -3.3700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1274
    Cell Significance Index: -1.9200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1275
    Cell Significance Index: -2.6600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1296
    Cell Significance Index: -2.5500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1349
    Cell Significance Index: -3.3700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1366
    Cell Significance Index: -2.7800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1373
    Cell Significance Index: -3.3500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1384
    Cell Significance Index: -2.0700
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1390
    Cell Significance Index: -1.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HOXC5 is a transcription factor that belongs to the homeobox gene family, which is involved in the regulation of embryonic development and tissue patterning. The HOXC5 gene is specifically expressed in various cell types, including glutamatergic neurons, microglial cells, conventional dendritic cells, and enterocytes. Its expression is tightly regulated, and alterations in its expression have been linked to various developmental and disease-related processes. **Pathways and Functions:** HOXC5 is involved in several critical pathways, including: 1. **Anterior/posterior pattern specification**: HOXC5 plays a crucial role in the development of the embryonic axis, regulating the expression of other homeobox genes and patterning the anterior-posterior axis. 2. **Cell junction**: HOXC5 is involved in the formation and maintenance of cell-cell junctions, which are essential for tissue integrity and function. 3. **Chromatin regulation**: HOXC5 interacts with chromatin-modifying enzymes, influencing gene expression and epigenetic regulation. 4. **DNA-binding transcription factor activity**: HOXC5 acts as a transcription factor, binding to specific DNA sequences and regulating the expression of target genes. 5. **Regulation of transcription by RNA polymerase II**: HOXC5 influences the activity of RNA polymerase II, a key enzyme in gene expression. **Clinical Significance:** Dysregulation of HOXC5 has been implicated in various diseases, including: 1. **Neurological disorders**: Alterations in HOXC5 expression have been linked to neurodevelopmental disorders, such as autism and schizophrenia. 2. **Immune system dysregulation**: HOXC5 is involved in the regulation of immune cell function, and its dysregulation may contribute to autoimmune and inflammatory diseases. 3. **Cancer**: HOXC5 is overexpressed in certain types of cancer, including colorectal and lung cancer, suggesting its potential role as a tumor suppressor or oncogene. In conclusion, HOXC5 is a multifunctional gene that plays a critical role in embryonic development, immune cell function, and disease regulation. Further research is needed to fully elucidate the mechanisms by which HOXC5 contributes to these processes, and to explore its potential as a therapeutic target for various diseases. **Recommendations for Future Research:** 1. Investigate the mechanisms by which HOXC5 regulates gene expression and chromatin structure. 2. Examine the role of HOXC5 in immune cell function and its potential implications in autoimmune diseases. 3. Explore the relationship between HOXC5 expression and cancer development and progression. 4. Develop novel therapeutic strategies targeting HOXC5 for the treatment of diseases associated with its dysregulation. By advancing our understanding of HOXC5, we may uncover new avenues for the treatment and prevention of various diseases, ultimately improving human health and well-being.

Genular Protein ID: 386421539

Symbol: HXC5_HUMAN

Name: Homeobox protein Hox-C5

UniProtKB Accession Codes:

Q00444

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1346761

Title: The upstream region of the human homeobox gene HOX3D is a target for regulation by retinoic acid and HOX homeoproteins.

PubMed ID: 1346761

DOI: 10.1002/j.1460-2075.1992.tb05049.x

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

Sequence Information:

  • Length: 222
  • Mass: 24976
  • Checksum: 9ABA38D35E4E61AB
  • Sequence:
    • MSSYVANSFY KQSPNIPAYN MQTCGNYGSA SEVQASRYCY GGLDLSITFP PPAPSNSLHG 
VDMAANPRAH PDRPACSAAA APGHAPGRDE AAPLNPGMYS QKAARPALEE RAKSSGEIKE 
EQAQTGQPAG LSQPPAPPQI YPWMTKLHMS HETDGKRSRT SYTRYQTLEL EKEFHFNRYL 
TRRRRIEIAN NLCLNERQIK IWFQNRRMKW KKDSKMKSKE AL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.