Details for: FZD7

Gene ID: 8324

Symbol: FZD7

Ensembl ID: ENSG00000155760

Description: frizzled class receptor 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 69.1117
    Cell Significance Index: -10.7500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 42.4021
    Cell Significance Index: -10.7600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.7192
    Cell Significance Index: -10.7300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.4426
    Cell Significance Index: 274.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.0519
    Cell Significance Index: 465.0700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8745
    Cell Significance Index: 30.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8329
    Cell Significance Index: 82.3900
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.7849
    Cell Significance Index: 4.1300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.7727
    Cell Significance Index: 8.2100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7462
    Cell Significance Index: 44.8000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7152
    Cell Significance Index: 14.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6812
    Cell Significance Index: 48.1800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6440
    Cell Significance Index: 581.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5853
    Cell Significance Index: 16.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5839
    Cell Significance Index: 30.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5401
    Cell Significance Index: 24.4800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.5143
    Cell Significance Index: 8.1600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5104
    Cell Significance Index: 4.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4760
    Cell Significance Index: 22.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4665
    Cell Significance Index: 75.8800
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.3589
    Cell Significance Index: 2.0400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2640
    Cell Significance Index: 5.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2522
    Cell Significance Index: 11.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2417
    Cell Significance Index: 6.5800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2401
    Cell Significance Index: 4.9800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2225
    Cell Significance Index: 2.8500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2177
    Cell Significance Index: 6.2400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2177
    Cell Significance Index: 2.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2165
    Cell Significance Index: 27.7600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1720
    Cell Significance Index: 1.8700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1706
    Cell Significance Index: 22.0400
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.1306
    Cell Significance Index: 0.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1161
    Cell Significance Index: 63.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1036
    Cell Significance Index: 18.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0982
    Cell Significance Index: 3.4500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0881
    Cell Significance Index: 1.5100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0872
    Cell Significance Index: 2.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0754
    Cell Significance Index: 4.2300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0566
    Cell Significance Index: 1.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0559
    Cell Significance Index: 11.1000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0521
    Cell Significance Index: 1.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0503
    Cell Significance Index: 6.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0209
    Cell Significance Index: 0.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0044
    Cell Significance Index: 8.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0034
    Cell Significance Index: 6.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0009
    Cell Significance Index: 1.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0072
    Cell Significance Index: -3.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0077
    Cell Significance Index: -5.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0102
    Cell Significance Index: -13.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0111
    Cell Significance Index: -7.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0172
    Cell Significance Index: -12.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0185
    Cell Significance Index: -5.3300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0190
    Cell Significance Index: -0.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0199
    Cell Significance Index: -11.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0249
    Cell Significance Index: -3.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0249
    Cell Significance Index: -15.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0311
    Cell Significance Index: -11.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0312
    Cell Significance Index: -6.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0321
    Cell Significance Index: -4.6700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0466
    Cell Significance Index: -1.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0467
    Cell Significance Index: -5.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0478
    Cell Significance Index: -4.8800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0517
    Cell Significance Index: -0.3500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0517
    Cell Significance Index: -2.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0597
    Cell Significance Index: -12.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0640
    Cell Significance Index: -7.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0674
    Cell Significance Index: -4.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0700
    Cell Significance Index: -11.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0704
    Cell Significance Index: -5.4000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0716
    Cell Significance Index: -1.8400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0749
    Cell Significance Index: -2.4000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0909
    Cell Significance Index: -3.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0938
    Cell Significance Index: -9.7700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0952
    Cell Significance Index: -2.6600
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1054
    Cell Significance Index: -0.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1065
    Cell Significance Index: -7.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1229
    Cell Significance Index: -9.7300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1256
    Cell Significance Index: -1.3000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1266
    Cell Significance Index: -3.0900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1399
    Cell Significance Index: -0.8300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1399
    Cell Significance Index: -8.6000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1419
    Cell Significance Index: -2.7700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1420
    Cell Significance Index: -2.1400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1579
    Cell Significance Index: -10.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1582
    Cell Significance Index: -10.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1620
    Cell Significance Index: -8.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1847
    Cell Significance Index: -11.6400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1882
    Cell Significance Index: -1.6000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2028
    Cell Significance Index: -4.4400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2239
    Cell Significance Index: -8.2200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2379
    Cell Significance Index: -12.4900
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.2433
    Cell Significance Index: -1.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2460
    Cell Significance Index: -10.8800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2461
    Cell Significance Index: -5.2600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2579
    Cell Significance Index: -2.9300
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.2586
    Cell Significance Index: -2.7000
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.2687
    Cell Significance Index: -2.5900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2769
    Cell Significance Index: -2.5500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2857
    Cell Significance Index: -6.9200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2929
    Cell Significance Index: -11.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FZD7 exhibits several key characteristics that distinguish it from other receptors in the Wnt signaling pathway. These include: 1. **High affinity for Wnt proteins**: FZD7 has a high affinity for Wnt proteins, allowing it to efficiently bind and activate the receptor. 2. **G protein-coupled receptor activity**: FZD7 is a G protein-coupled receptor, which means that it can activate a G protein and initiate a signaling cascade. 3. **Regulation of canonical and non-canonical Wnt signaling**: FZD7 is involved in both canonical and non-canonical Wnt signaling pathways, which are distinct and regulate different cellular processes. 4. **Expression in multiple tissues**: FZD7 is expressed in a wide range of tissues, including the nervous system, epithelial cells, and muscle cells. 5. **Regulation of various cellular processes**: FZD7 regulates a range of cellular processes, including cell proliferation, differentiation, survival, and migration. **Pathways and Functions** FZD7 is involved in several key signaling pathways, including: 1. **Canonical Wnt signaling pathway**: FZD7 is involved in the canonical Wnt signaling pathway, which regulates cell proliferation, differentiation, and survival. 2. **Non-canonical Wnt signaling pathway**: FZD7 is also involved in the non-canonical Wnt signaling pathway, which regulates cell migration, adhesion, and polarity. 3. **Planar cell polarity pathway**: FZD7 is involved in the planar cell polarity pathway, which regulates cell polarity and orientation. 4. **Leishmania infection pathways**: FZD7 has been implicated in the regulation of Leishmania infection pathways, which are involved in the immune response to this parasitic infection. FZD7 regulates various cellular processes, including: 1. **Cell proliferation**: FZD7 regulates cell proliferation in various tissues, including the nervous system and epithelial cells. 2. **Differentiation**: FZD7 regulates cell differentiation, including the differentiation of neural stem cells and muscle cells. 3. **Survival**: FZD7 regulates cell survival, including the regulation of apoptosis and autophagy. 4. **Migration**: FZD7 regulates cell migration, including the regulation of cell adhesion and motility. **Clinical Significance** FZD7 has been implicated in several clinical disorders, including: 1. **Cancer**: FZD7 is overexpressed in several types of cancer, including colorectal, breast, and lung cancer. 2. **Inflammatory disorders**: FZD7 is involved in the regulation of inflammatory responses, and its dysregulation has been implicated in inflammatory disorders, including rheumatoid arthritis and atherosclerosis. 3. **Neurological disorders**: FZD7 is involved in the regulation of neural development and function, and its dysregulation has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Developmental disorders**: FZD7 is involved in the regulation of embryonic development, and its dysregulation has been implicated in developmental disorders, including Down syndrome and congenital heart defects. In conclusion, FZD7 is a critical receptor in the Wnt signaling pathway, and its dysregulation has been implicated in various clinical disorders. Further research is needed to fully understand the role of FZD7 in human disease and to develop therapeutic strategies to target this receptor.

Genular Protein ID: 4031384550

Symbol: FZD7_HUMAN

Name: Frizzled-7

UniProtKB Accession Codes:

O75084 O94816 Q53S59 Q96B74

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 2 Ensembl 1 GO 31 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9707618

Title: A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.

PubMed ID: 9707618

DOI: 10.1073/pnas.95.17.10164

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 9813155

Title: Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7.

PubMed ID: 9813155

DOI: 10.1006/bbrc.1998.9607

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19188438

Title: Myocilin is a modulator of Wnt signaling.

PubMed ID: 19188438

DOI: 10.1128/mcb.01274-08

PubMed ID: 17224074

Title: Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas.

PubMed ID: 17224074

DOI: 10.1186/bcr1637

PubMed ID: 24496449

Title: Glypican-3 binds to Frizzled and plays a direct role in the stimulation of canonical Wnt signaling.

PubMed ID: 24496449

DOI: 10.1242/jcs.140871

PubMed ID: 26126266

Title: Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling.

PubMed ID: 26126266

DOI: 10.7554/elife.07091

PubMed ID: 27680706

Title: Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.

PubMed ID: 27680706

DOI: 10.1038/nature19799

PubMed ID: 27386966

Title: Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling.

PubMed ID: 27386966

DOI: 10.1038/ncomms12101

Sequence Information:

  • Length: 574
  • Mass: 63620
  • Checksum: 801934246B426DF5
  • Sequence:
    • MRDPGAAAPL SSLGLCALVL ALLGALSAGA GAQPYHGEKG ISVPDHGFCQ PISIPLCTDI 
AYNQTILPNL LGHTNQEDAG LEVHQFYPLV KVQCSPELRF FLCSMYAPVC TVLDQAIPPC 
RSLCERARQG CEALMNKFGF QWPERLRCEN FPVHGAGEIC VGQNTSDGSG GPGGGPTAYP 
TAPYLPDLPF TALPPGASDG RGRPAFPFSC PRQLKVPPYL GYRFLGERDC GAPCEPGRAN 
GLMYFKEEER RFARLWVGVW SVLCCASTLF TVLTYLVDMR RFSYPERPII FLSGCYFMVA 
VAHVAGFLLE DRAVCVERFS DDGYRTVAQG TKKEGCTILF MVLYFFGMAS SIWWVILSLT 
WFLAAGMKWG HEAIEANSQY FHLAAWAVPA VKTITILAMG QVDGDLLSGV CYVGLSSVDA 
LRGFVLAPLF VYLFIGTSFL LAGFVSLFRI RTIMKHDGTK TEKLEKLMVR IGVFSVLYTV 
PATIVLACYF YEQAFREHWE RTWLLQTCKS YAVPCPPGHF PPMSPDFTVF MIKYLMTMIV 
GITTGFWIWS GKTLQSWRRF YHRLSHSSKG ETAV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.