Details for: DACT1

Gene ID: 51339

Symbol: DACT1

Ensembl ID: ENSG00000165617

Description: dishevelled binding antagonist of beta catenin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 55.7394
    Cell Significance Index: -8.6700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 33.9453
    Cell Significance Index: -8.6100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 18.5597
    Cell Significance Index: -7.5400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 17.3737
    Cell Significance Index: -8.2000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 7.9236
    Cell Significance Index: -7.5700
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.3499
    Cell Significance Index: 19.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.2700
    Cell Significance Index: 139.1800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.1997
    Cell Significance Index: -8.6800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.2533
    Cell Significance Index: 16.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8676
    Cell Significance Index: 165.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7252
    Cell Significance Index: 15.1800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4982
    Cell Significance Index: 29.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4046
    Cell Significance Index: 40.0300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3627
    Cell Significance Index: 39.4500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3360
    Cell Significance Index: 303.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3129
    Cell Significance Index: 19.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2383
    Cell Significance Index: 38.7600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2376
    Cell Significance Index: 3.7700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2254
    Cell Significance Index: 2.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1879
    Cell Significance Index: 25.8000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1868
    Cell Significance Index: 12.9200
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.1755
    Cell Significance Index: 1.0300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.1494
    Cell Significance Index: 1.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1385
    Cell Significance Index: 3.9900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1367
    Cell Significance Index: 60.4300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1019
    Cell Significance Index: 2.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0982
    Cell Significance Index: 19.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0965
    Cell Significance Index: 34.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0923
    Cell Significance Index: 2.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0906
    Cell Significance Index: 18.1700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0760
    Cell Significance Index: 1.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0744
    Cell Significance Index: 46.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0595
    Cell Significance Index: 1.2900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0364
    Cell Significance Index: 0.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0302
    Cell Significance Index: 1.3700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0270
    Cell Significance Index: 0.9500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0152
    Cell Significance Index: 0.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0137
    Cell Significance Index: 0.2300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0133
    Cell Significance Index: 9.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0023
    Cell Significance Index: 0.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0014
    Cell Significance Index: -1.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0027
    Cell Significance Index: -5.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0052
    Cell Significance Index: -9.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0056
    Cell Significance Index: -8.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0058
    Cell Significance Index: -1.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0059
    Cell Significance Index: -7.9900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0063
    Cell Significance Index: -0.1400
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: -0.0070
    Cell Significance Index: -0.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0079
    Cell Significance Index: -4.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0105
    Cell Significance Index: -6.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0110
    Cell Significance Index: -8.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0111
    Cell Significance Index: -8.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0112
    Cell Significance Index: -1.9100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0152
    Cell Significance Index: -0.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0159
    Cell Significance Index: -7.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0166
    Cell Significance Index: -9.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0175
    Cell Significance Index: -5.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0255
    Cell Significance Index: -3.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0290
    Cell Significance Index: -0.9300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0293
    Cell Significance Index: -0.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0335
    Cell Significance Index: -6.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0349
    Cell Significance Index: -4.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0383
    Cell Significance Index: -4.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0386
    Cell Significance Index: -2.4900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0462
    Cell Significance Index: -5.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0475
    Cell Significance Index: -5.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0489
    Cell Significance Index: -5.0000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0569
    Cell Significance Index: -1.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0569
    Cell Significance Index: -4.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0648
    Cell Significance Index: -8.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0722
    Cell Significance Index: -8.5100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0735
    Cell Significance Index: -1.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0806
    Cell Significance Index: -5.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0815
    Cell Significance Index: -8.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0822
    Cell Significance Index: -5.5300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0856
    Cell Significance Index: -0.5800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0866
    Cell Significance Index: -1.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0877
    Cell Significance Index: -4.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1058
    Cell Significance Index: -8.1200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1105
    Cell Significance Index: -3.8400
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1134
    Cell Significance Index: -0.7100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1137
    Cell Significance Index: -2.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1179
    Cell Significance Index: -8.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1215
    Cell Significance Index: -6.3800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1221
    Cell Significance Index: -6.3600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1254
    Cell Significance Index: -1.4300
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.1311
    Cell Significance Index: -0.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1367
    Cell Significance Index: -7.1000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1370
    Cell Significance Index: -3.7300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1381
    Cell Significance Index: -4.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1394
    Cell Significance Index: -7.8200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1431
    Cell Significance Index: -2.8300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1479
    Cell Significance Index: -4.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1577
    Cell Significance Index: -7.4100
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1600
    Cell Significance Index: -0.9800
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1719
    Cell Significance Index: -0.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1788
    Cell Significance Index: -7.9100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1816
    Cell Significance Index: -4.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DACT1 is a protein that belongs to the Dapper family of proteins, which are known for their involvement in Wnt signaling pathways. The gene is significantly expressed in various cell types, including hematopoietic cells, smooth muscle cells, and epithelial cells. DACT1's unique structure allows it to interact with multiple proteins, including beta-catenin, Wnt proteins, and histone deacetylases, thereby modulating its activity. **Pathways and Functions:** DACT1 is a key regulator of the Wnt signaling pathway, which is crucial for embryonic development, tissue homeostasis, and cancer progression. The gene's primary function is to antagonize the activity of beta-catenin, a central component of the Wnt signaling complex. By binding to beta-catenin, DACT1 prevents its association with T-cell factor (TCF) and the subsequent activation of the Wnt/β-catenin transcriptional complex. This antagonistic action of DACT1 has two distinct effects: 1. **Negative regulation of Wnt signaling:** DACT1's interaction with beta-catenin inhibits the canonical Wnt signaling pathway, which is involved in cell proliferation, differentiation, and survival. 2. **Positive regulation of Wnt signaling:** Conversely, DACT1 can also interact with Wnt proteins, facilitating their signaling and promoting the activation of the Wnt/β-catenin transcriptional complex. In addition to its role in Wnt signaling, DACT1 is involved in other cellular processes, including: * **Histone deacetylase binding:** DACT1 interacts with histone deacetylases, modulating chromatin structure and gene expression. * **Protein binding:** DACT1 interacts with various proteins, including beta-catenin, Wnt proteins, and transcription factors, influencing their activity and localization. * **Cell cycle regulation:** DACT1's interaction with the G1/S transition of the cell cycle is also crucial for regulating cell proliferation. **Clinical Significance:** DACT1's role in Wnt signaling pathways has significant implications for various diseases, including: * **Cancer:** Aberrant Wnt signaling is a common feature in many cancers, including colorectal, breast, and lung cancer. DACT1's antagonistic action against beta-catenin may contribute to cancer progression. * **Immune system disorders:** DACT1's interaction with Wnt proteins may also influence immune system function, potentially contributing to autoimmune diseases, such as rheumatoid arthritis. * **Neurological disorders:** DACT1's involvement in Wnt signaling pathways may also play a role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, DACT1 is a multifaceted gene that plays a critical role in regulating Wnt signaling pathways. Its antagonistic action against beta-catenin has significant implications for various cellular processes, including cell proliferation, differentiation, and survival. Further research is necessary to fully elucidate the complexities of DACT1's function and its potential role in various diseases.

Genular Protein ID: 1887230791

Symbol: DACT1_HUMAN

Name: Dapper homolog 1

UniProtKB Accession Codes:

Q9NYF0 A8MYJ2 Q86TY0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 3 ExpressionAtlas 1 GO 28 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 11970895

Title: Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation.

PubMed ID: 11970895

DOI: 10.1016/s1534-5807(02)00140-5

PubMed ID: 15580286

Title: HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: involvement of methylation-mediated gene silencing.

PubMed ID: 15580286

DOI: 10.1038/sj.onc.1208340

PubMed ID: 16446366

Title: Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation.

PubMed ID: 16446366

DOI: 10.1074/jbc.m600274200

PubMed ID: 17197390

Title: The evolutionally conserved activity of Dapper2 in antagonizing TGF-beta signaling.

PubMed ID: 17197390

DOI: 10.1096/fj.06-6246com

PubMed ID: 18936100

Title: Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus.

PubMed ID: 18936100

DOI: 10.1074/jbc.m804088200

PubMed ID: 21718540

Title: All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases.

PubMed ID: 21718540

DOI: 10.1186/1471-2091-12-33

PubMed ID: 21262972

Title: Protein kinase A-mediated 14-3-3 association impedes human Dapper1 to promote dishevelled degradation.

PubMed ID: 21262972

DOI: 10.1074/jbc.m110.211607

PubMed ID: 22470507

Title: Oncogenic function of DACT1 in colon cancer through the regulation of beta-catenin.

PubMed ID: 22470507

DOI: 10.1371/journal.pone.0034004

PubMed ID: 22610794

Title: Identification of novel rare mutations of DACT1 in human neural tube defects.

PubMed ID: 22610794

DOI: 10.1002/humu.22121

PubMed ID: 28054444

Title: Heterozygous pathogenic variant in DACT1 causes an autosomal-dominant syndrome with features overlapping Townes-Brocks syndrome.

PubMed ID: 28054444

DOI: 10.1002/humu.23171

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 836
  • Mass: 90174
  • Checksum: 10B77DC5B7C73485
  • Sequence:
    • MKPSPAGTAK ELEPPAPARG EQRTAEPEGR WREKGEADTE RQRTRERQEA TLAGLAELEY 
LRQRQELLVR GALRGAGGAG AAAPRAGELL GEAAQRSRLE EKFLEENILL LRKQLNCLRR 
RDAGLLNQLQ ELDKQISDLR LDVEKTSEEH LETDSRPSSG FYELSDGASG SLSNSSNSVF 
SECLSSCHSS TCFCSPLEAT LSLSDGCPKS ADLIGLLEYK EGHCEDQASG AVCRSLSTPQ 
FNSLDVIADV NPKYQCDLVS KNGNDVYRYP SPLHAVAVQS PMFLLCLTGN PLREEDRLGN 
HASDICGGSE LDAVKTDSSL PSPSSLWSAS HPSSSKKMDG YILSLVQKKT HPVRTNKPRT 
SVNADPTKGL LRNGSVCVRA PGGVSQGNSV NLKNSKQACL PSGGIPSLNN GTFSPPKQWS 
KESKAEQAES KRVPLPEGCP SGAASDLQSK HLPKTAKPAS QEHARCSAIG TGESPKESAQ 
LSGASPKESP SRGPAPPQEN KVVQPLKKMS QKNSLQGVPP ATPPLLSTAF PVEERPALDF 
KSEGSSQSLE EAHLVKAQFI PGQQPSVRLH RGHRNMGVVK NSSLKHRGPA LQGLENGLPT 
VREKTRAGSK KCRFPDDLDT NKKLKKASSK GRKSGGGPEA GVPGRPAGGG HRAGSRAHGH 
GREAVVAKPK HKRTDYRRWK SSAEISYEEA LRRARRGRRE NVGLYPAPVP LPYASPYAYV 
ASDSEYSAEC ESLFHSTVVD TSEDEQSNYT TNCFGDSESS VSEGEFVGES TTTSDSEESG 
GLIWSQFVQT LPIQTVTAPD LHNHPAKTFV KIKASHNLKK KILRFRSGSL KLMTTV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.