Details for: S1PR3

Gene ID: 1903

Symbol: S1PR3

Ensembl ID: ENSG00000213694

Description: sphingosine-1-phosphate receptor 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.14
    Marker Score: 2882
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.8
    Marker Score: 6982
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.67
    Marker Score: 1924
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1161
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.45
    Marker Score: 1236
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.42
    Marker Score: 403
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.3
    Marker Score: 1569
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.14
    Marker Score: 476
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251796
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71813
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48038
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.99
    Marker Score: 228
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.94
    Marker Score: 895
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.93
    Marker Score: 1005
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.92
    Marker Score: 10395
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.92
    Marker Score: 1414.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 368
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.91
    Marker Score: 377.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5178
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.88
    Marker Score: 1268
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5280
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.83
    Marker Score: 10975
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.8
    Marker Score: 1546.5
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.77
    Marker Score: 268
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.77
    Marker Score: 355
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1252
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.76
    Marker Score: 539
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 679
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.71
    Marker Score: 1566
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.7
    Marker Score: 3011
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.69
    Marker Score: 436.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.68
    Marker Score: 520.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2841
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.66
    Marker Score: 917
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.65
    Marker Score: 430
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.65
    Marker Score: 428
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.61
    Marker Score: 153
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.61
    Marker Score: 153
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.6
    Marker Score: 1401
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.57
    Marker Score: 363
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.54
    Marker Score: 2125
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.54
    Marker Score: 224
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.53
    Marker Score: 1249
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.51
    Marker Score: 494
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.5
    Marker Score: 931
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.5
    Marker Score: 126
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.49
    Marker Score: 16745
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.49
    Marker Score: 118
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.48
    Marker Score: 596
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.48
    Marker Score: 135
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.46
    Marker Score: 114
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.46
    Marker Score: 122
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.46
    Marker Score: 249
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.45
    Marker Score: 219
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.45
    Marker Score: 263
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.45
    Marker Score: 614
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.44
    Marker Score: 99
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.43
    Marker Score: 230
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.42
    Marker Score: 460
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.41
    Marker Score: 434
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.41
    Marker Score: 22718
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.37
    Marker Score: 97
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.35
    Marker Score: 456
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.35
    Marker Score: 910
  • Cell Name: fibrocyte (CL0000135)
    Fold Change: 0.34
    Marker Score: 106
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.34
    Marker Score: 380
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.33
    Marker Score: 152
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.32
    Marker Score: 185
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.32
    Marker Score: 5720
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.3
    Marker Score: 320
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.28
    Marker Score: 63
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.28
    Marker Score: 1823
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.28
    Marker Score: 95
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.27
    Marker Score: 87
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.27
    Marker Score: 71
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.27
    Marker Score: 183
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.27
    Marker Score: 83
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.26
    Marker Score: 10037
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.26
    Marker Score: 110
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.26
    Marker Score: 153
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.26
    Marker Score: 501
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 88
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.26
    Marker Score: 111
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.25
    Marker Score: 230
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.25
    Marker Score: 345
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.25
    Marker Score: 162
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.24
    Marker Score: 2249
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.24
    Marker Score: 363
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.23
    Marker Score: 67
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.23
    Marker Score: 521

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Other Information

**Key characteristics:** * S1PR3 is a type of G protein-coupled receptor (GPCR). * It is a ligand-gated channel that is expressed in the plasma membrane. * It is a member of the S1P receptor family. * It is a highly conserved protein with a wide distribution in the human body. **Pathways and functions:** * S1PR3 is a key regulator of inflammation. * It is expressed in cells that are activated by inflammation, such as macrophages and dendritic cells. * When S1PR3 is activated, it opens G protein-coupled receptors on the surface of inflammatory cells. * This opens the G protein, which activates downstream signaling pathways that promote inflammation. * S1PR3 is also involved in cell migration and adhesion. **Clinical significance:** * Mutations in S1PR3 have been linked to a number of human diseases, including rheumatoid arthritis, asthma, and inflammatory bowel disease. * S1PR3 inhibitors are being investigated as potential treatments for these diseases. **Additional information:** * S1PR3 is a relatively new receptor, and there is still much that is unknown about its function. * It is a promising target for the treatment of inflammatory diseases.

Genular Protein ID: 2594490458

Symbol: S1PR3_HUMAN

Name: Sphingosine 1-phosphate receptor 3

UniProtKB Accession Codes:

Q99500 Q5SQD8 Q7Z5I2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 8 EMDB 3 Ensembl 2 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 4 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8878560

Title: Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9.

PubMed ID: 8878560

DOI: 10.1006/bbrc.1996.1553

PubMed ID: 9409733

Title: Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids.

PubMed ID: 9409733

DOI: 10.1016/s0014-5793(97)01301-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10383399

Title: Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5.

PubMed ID: 10383399

DOI: 10.1074/jbc.274.27.18997

PubMed ID: 10617617

Title: Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5.

PubMed ID: 10617617

DOI: 10.1074/jbc.275.1.288

PubMed ID: 10908314

Title: Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytes.

PubMed ID: 10908314

DOI: 10.1124/mol.58.2.449

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 378
  • Mass: 42250
  • Checksum: 79A00300968F439F
  • Sequence:
    • MATALPPRLQ PVRGNETLRE HYQYVGKLAG RLKEASEGST LTTVLFLVIC SFIVLENLMV 
LIAIWKNNKF HNRMYFFIGN LALCDLLAGI AYKVNILMSG KKTFSLSPTV WFLREGSMFV 
ALGASTCSLL AIAIERHLTM IKMRPYDANK RHRVFLLIGM CWLIAFTLGA LPILGWNCLH 
NLPDCSTILP LYSKKYIAFC ISIFTAILVT IVILYARIYF LVKSSSRKVA NHNNSERSMA 
LLRTVVIVVS VFIACWSPLF ILFLIDVACR VQACPILFKA QWFIVLAVLN SAMNPVIYTL 
ASKEMRRAFF RLVCNCLVRG RGARASPIQP ALDPSRSKSS SSNNSSHSPK VKEDLPHTAP 
SSCIMDKNAA LQNGIFCN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.