Details for: S1PR3

Gene ID: 1903

Symbol: S1PR3

Ensembl ID: ENSG00000213694

Description: sphingosine-1-phosphate receptor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 79.2695
    Cell Significance Index: -12.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 48.2962
    Cell Significance Index: -12.2500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 10.6992
    Cell Significance Index: -10.2200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.0328
    Cell Significance Index: -12.3700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.6176
    Cell Significance Index: -12.3700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.0942
    Cell Significance Index: -12.2100
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.8141
    Cell Significance Index: 17.4100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.3661
    Cell Significance Index: 34.1500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.2959
    Cell Significance Index: 10.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.2025
    Cell Significance Index: 67.4800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.1991
    Cell Significance Index: 25.1000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.0370
    Cell Significance Index: 63.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8447
    Cell Significance Index: 22.6400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.7147
    Cell Significance Index: 3.3000
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.5994
    Cell Significance Index: 5.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3367
    Cell Significance Index: 64.0900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2561
    Cell Significance Index: 7.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2007
    Cell Significance Index: 5.3600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1980
    Cell Significance Index: 87.5600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1922
    Cell Significance Index: 354.5100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1619
    Cell Significance Index: 11.4500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1403
    Cell Significance Index: 126.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1123
    Cell Significance Index: 11.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1091
    Cell Significance Index: 168.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0842
    Cell Significance Index: 52.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0756
    Cell Significance Index: 12.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0745
    Cell Significance Index: 9.5500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0503
    Cell Significance Index: 0.9300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0480
    Cell Significance Index: 5.2200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0347
    Cell Significance Index: 0.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0317
    Cell Significance Index: 1.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0283
    Cell Significance Index: 12.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0276
    Cell Significance Index: 0.9700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0102
    Cell Significance Index: 0.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0066
    Cell Significance Index: 0.1900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0026
    Cell Significance Index: 0.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0014
    Cell Significance Index: 0.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0007
    Cell Significance Index: 1.0000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0004
    Cell Significance Index: -0.2900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0013
    Cell Significance Index: -0.7100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0030
    Cell Significance Index: -0.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0048
    Cell Significance Index: -0.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0057
    Cell Significance Index: -1.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0058
    Cell Significance Index: -10.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0062
    Cell Significance Index: -4.5600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0062
    Cell Significance Index: -0.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0083
    Cell Significance Index: -4.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0119
    Cell Significance Index: -0.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0136
    Cell Significance Index: -4.8900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0143
    Cell Significance Index: -10.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0144
    Cell Significance Index: -9.1700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0145
    Cell Significance Index: -0.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0156
    Cell Significance Index: -11.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0243
    Cell Significance Index: -1.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0274
    Cell Significance Index: -7.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0280
    Cell Significance Index: -5.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0280
    Cell Significance Index: -2.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0286
    Cell Significance Index: -6.0200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0301
    Cell Significance Index: -0.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0314
    Cell Significance Index: -0.6800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0324
    Cell Significance Index: -1.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0430
    Cell Significance Index: -7.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0462
    Cell Significance Index: -6.7200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0666
    Cell Significance Index: -1.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0691
    Cell Significance Index: -8.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0734
    Cell Significance Index: -2.3500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0752
    Cell Significance Index: -8.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0813
    Cell Significance Index: -9.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0837
    Cell Significance Index: -10.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0917
    Cell Significance Index: -9.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1025
    Cell Significance Index: -11.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1034
    Cell Significance Index: -12.1900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1117
    Cell Significance Index: -7.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1138
    Cell Significance Index: -11.8500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1171
    Cell Significance Index: -1.9300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1210
    Cell Significance Index: -2.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1228
    Cell Significance Index: -2.6200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1390
    Cell Significance Index: -5.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1476
    Cell Significance Index: -9.0700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1539
    Cell Significance Index: -4.3000
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1577
    Cell Significance Index: -1.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1672
    Cell Significance Index: -11.2400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1752
    Cell Significance Index: -11.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1765
    Cell Significance Index: -9.1900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1810
    Cell Significance Index: -6.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1985
    Cell Significance Index: -10.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2131
    Cell Significance Index: -5.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2203
    Cell Significance Index: -10.3600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2212
    Cell Significance Index: -1.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2325
    Cell Significance Index: -12.0800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2342
    Cell Significance Index: -6.0200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2651
    Cell Significance Index: -3.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2693
    Cell Significance Index: -11.9100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2753
    Cell Significance Index: -7.2400
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.2938
    Cell Significance Index: -1.8000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3140
    Cell Significance Index: -11.8900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3194
    Cell Significance Index: -11.1900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3293
    Cell Significance Index: -9.7000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3414
    Cell Significance Index: -4.7900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3520
    Cell Significance Index: -12.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** S1PR3 belongs to the class A/1 rhodopsin-like receptors, characterized by a seven-transmembrane domain structure. 2. **Ligand:** The primary ligand for S1PR3 is sphingosine-1-phosphate, which is involved in various cellular processes, including cell migration, proliferation, and survival. 3. **Expression:** S1PR3 is widely expressed in various cell types, including anterior lens cells, neural progenitor cells, vascular leptomeningeal cells, and fibroblasts from connective tissue. **Pathways and Functions:** 1. **Adenylate Cyclase-Activating Signaling Pathway:** S1PR3 activation leads to the stimulation of adenylate cyclase, resulting in increased cAMP levels and activation of downstream signaling pathways. 2. **Negative Regulation of Endothelial Barrier Establishment:** S1PR3 has been shown to regulate the establishment of the endothelial barrier, suggesting its role in maintaining vascular integrity. 3. **Inflammatory Response:** S1PR3 can modulate the inflammatory response by regulating the production of interleukin-1 beta and other pro-inflammatory cytokines. 4. **Cell Proliferation and Survival:** S1PR3 activation promotes cell proliferation and survival, which is relevant to various physiological and pathological processes, including cancer and cardiovascular diseases. 5. **Neurotransmission:** S1PR3 is expressed in GABAergic interneurons of the cerebral cortex, suggesting its role in neurotransmission and neuronal function. **Clinical Significance:** 1. **Cancer:** S1PR3 has been implicated in cancer progression, including cell proliferation, migration, and invasion. 2. **Cardiovascular Diseases:** S1PR3 may play a role in cardiovascular diseases, such as atherosclerosis and hypertension, by regulating endothelial barrier function and inflammatory responses. 3. **Neurological Disorders:** S1PR3 is expressed in GABAergic interneurons, suggesting its potential involvement in neurological disorders, such as epilepsy and Parkinson's disease. 4. **Inflammatory Diseases:** S1PR3 can modulate inflammatory responses, making it a potential target for the treatment of inflammatory diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, S1PR3 is a multifaceted G protein-coupled receptor involved in various biological processes, including cell proliferation, survival, inflammation, and neurotransmission. Its clinical significance is evident in its potential role in cancer, cardiovascular diseases, neurological disorders, and inflammatory diseases. Further research is necessary to fully elucidate the functions and mechanisms of S1PR3 and its potential therapeutic applications.

Genular Protein ID: 2594490458

Symbol: S1PR3_HUMAN

Name: Sphingosine 1-phosphate receptor 3

UniProtKB Accession Codes:

Q99500 Q5SQD8 Q7Z5I2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 8 EMDB 3 Ensembl 2 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8878560

Title: Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9.

PubMed ID: 8878560

DOI: 10.1006/bbrc.1996.1553

PubMed ID: 9409733

Title: Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids.

PubMed ID: 9409733

DOI: 10.1016/s0014-5793(97)01301-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10383399

Title: Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5.

PubMed ID: 10383399

DOI: 10.1074/jbc.274.27.18997

PubMed ID: 10617617

Title: Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5.

PubMed ID: 10617617

DOI: 10.1074/jbc.275.1.288

PubMed ID: 10908314

Title: Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytes.

PubMed ID: 10908314

DOI: 10.1124/mol.58.2.449

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 378
  • Mass: 42250
  • Checksum: 79A00300968F439F
  • Sequence:
    • MATALPPRLQ PVRGNETLRE HYQYVGKLAG RLKEASEGST LTTVLFLVIC SFIVLENLMV 
LIAIWKNNKF HNRMYFFIGN LALCDLLAGI AYKVNILMSG KKTFSLSPTV WFLREGSMFV 
ALGASTCSLL AIAIERHLTM IKMRPYDANK RHRVFLLIGM CWLIAFTLGA LPILGWNCLH 
NLPDCSTILP LYSKKYIAFC ISIFTAILVT IVILYARIYF LVKSSSRKVA NHNNSERSMA 
LLRTVVIVVS VFIACWSPLF ILFLIDVACR VQACPILFKA QWFIVLAVLN SAMNPVIYTL 
ASKEMRRAFF RLVCNCLVRG RGARASPIQP ALDPSRSKSS SSNNSSHSPK VKEDLPHTAP 
SSCIMDKNAA LQNGIFCN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.