Details for: GDNF

Gene ID: 2668

Symbol: GDNF

Ensembl ID: ENSG00000168621

Description: glial cell derived neurotrophic factor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 2.99
    Marker Score: 4294
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.15
    Marker Score: 2160
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.64
    Marker Score: 2833
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.23
    Marker Score: 466
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7691
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.12
    Marker Score: 2310
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.06
    Marker Score: 1274
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71829
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48054
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.99
    Marker Score: 2322
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.98
    Marker Score: 2478
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5340
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.87
    Marker Score: 591
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.78
    Marker Score: 1472
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.71
    Marker Score: 247
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.7
    Marker Score: 669
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.65
    Marker Score: 10194
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.62
    Marker Score: 362
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.61
    Marker Score: 8040
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 472
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.56
    Marker Score: 1141
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.5
    Marker Score: 1868
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.44
    Marker Score: 195
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.42
    Marker Score: 982
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.4
    Marker Score: 126
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.39
    Marker Score: 100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.37
    Marker Score: 223
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.37
    Marker Score: 916
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.35
    Marker Score: 186
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.32
    Marker Score: 674
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.3
    Marker Score: 78
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.3
    Marker Score: 103
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.29
    Marker Score: 487.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.27
    Marker Score: 2567
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.25
    Marker Score: 118
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.25
    Marker Score: 189
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.24
    Marker Score: 96
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.22
    Marker Score: 256
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.21
    Marker Score: 132
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.21
    Marker Score: 65
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.21
    Marker Score: 86
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.2
    Marker Score: 155
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.2
    Marker Score: 73
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.18
    Marker Score: 186
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.17
    Marker Score: 100
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.16
    Marker Score: 53
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.13
    Marker Score: 145
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.13
    Marker Score: 766
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.13
    Marker Score: 244
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.13
    Marker Score: 38
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.12
    Marker Score: 117
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.11
    Marker Score: 81
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.11
    Marker Score: 135
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.11
    Marker Score: 187.5
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.11
    Marker Score: 21
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.11
    Marker Score: 113
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.1
    Marker Score: 101
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.1
    Marker Score: 87
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.1
    Marker Score: 130
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.1
    Marker Score: 22
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.1
    Marker Score: 21
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.09
    Marker Score: 114
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.09
    Marker Score: 3172
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.09
    Marker Score: 34
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.09
    Marker Score: 41
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.08
    Marker Score: 118
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.08
    Marker Score: 37.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.08
    Marker Score: 96
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.08
    Marker Score: 40
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.07
    Marker Score: 70
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.07
    Marker Score: 118
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.07
    Marker Score: 28
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.06
    Marker Score: 30
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.06
    Marker Score: 102.5
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.06
    Marker Score: 152
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.06
    Marker Score: 78
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.06
    Marker Score: 60
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.06
    Marker Score: 417
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.06
    Marker Score: 48
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.05
    Marker Score: 193

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Other Information

**Key characteristics:** - GDNF is a glycoprotein that is produced by glial cells. - It is a potent neurotrophic factor that is essential for the survival and growth of neurons. - It is involved in the development of the central nervous system, the peripheral nervous system, and the retina. **Pathways and functions:** - GDNF binds to the GDNF receptor, which is expressed on neurons. - This binding triggers a signaling cascade that involves the MAPK family of kinases. - The MAPK signaling cascade is a major regulator of neuronal development and survival. - GDNF also binds to the Ncam1 receptor, which is expressed on endothelial cells. - This binding promotes the migration of endothelial cells to the developing central nervous system. - GDNF is also involved in the development of the kidney. - It is produced by renal epithelial cells and promotes the survival and growth of renal cells. **Clinical significance:** - Mutations in the GDNF gene have been linked to a number of human diseases, including cerebral palsy, autism, and schizophrenia. - GDNF is a potential therapeutic for these diseases. - Clinical trials are currently testing the use of GDNF as a treatment for neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

Genular Protein ID: 3742650941

Symbol: GDNF_HUMAN

Name: Glial cell line-derived neurotrophic factor

UniProtKB Accession Codes:

P39905 B7WPK7 O95448 O95449 O95986 Q6FH33 Q96L44 Q9UD32 Q9UD33 Q9UMV2 Q9UP67 Q9UP97

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 EMBL 17 EMDB 2 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 45 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 4 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 3 RefSeq 7 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8493557

Title: GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons.

PubMed ID: 8493557

DOI: 10.1126/science.8493557

PubMed ID: 7867768

Title: Multiple astrocyte transcripts encode nigral trophic factors in rat and human.

PubMed ID: 7867768

DOI: 10.1006/exnr.1994.1218

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10366742

Title: Characterization of a promoter for the human glial cell line-derived neurotrophic factor gene.

PubMed ID: 10366742

DOI: 10.1016/s0169-328x(99)00106-0

PubMed ID: 9811930

Title: Analysis of the human GDNF gene reveals an inducible promoter, three exons, a triplet repeat within the 3'-UTR and alternative splice products.

PubMed ID: 9811930

DOI: 10.1093/hmg/7.12.1873

PubMed ID: 8988018

Title: Glial cell line-derived neurotrophic factor: selective reduction of the intermolecular disulfide linkage and characterization of its disulfide structure.

PubMed ID: 8988018

DOI: 10.1021/bi9605550

PubMed ID: 9215674

Title: Genetic predisposition to phaeochromocytoma: analysis of candidate genes GDNF, RET and VHL.

PubMed ID: 9215674

DOI: 10.1093/hmg/6.7.1051

PubMed ID: 15364913

Title: Functional organization of the sortilin Vps10p domain.

PubMed ID: 15364913

DOI: 10.1074/jbc.m408873200

PubMed ID: 21994944

Title: Sorting protein-related receptor SorLA controls regulated secretion of glial cell line-derived neurotrophic factor.

PubMed ID: 21994944

DOI: 10.1074/jbc.m111.246413

PubMed ID: 22081608

Title: Identification of novel GDNF isoforms and cis-antisense GDNFOS gene and their regulation in human middle temporal gyrus of Alzheimer disease.

PubMed ID: 22081608

DOI: 10.1074/jbc.m111.310250

PubMed ID: 9359036

Title: Mutations in Hirschsprung disease: when does a mutation contribute to the phenotype.

PubMed ID: 9359036

PubMed ID: 23333276

Title: SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRalpha1 and RET.

PubMed ID: 23333276

DOI: 10.1016/j.celrep.2012.12.011

PubMed ID: 19478429

Title: Comparison of GFL-GFRalpha complexes: further evidence relating GFL bend angle to RET signalling.

PubMed ID: 19478429

DOI: 10.1107/s1744309109017722

PubMed ID: 8968758

Title: De novo mutation of GDNF, ligand for the RET/GDNFR-alpha receptor complex, in Hirschsprung disease.

PubMed ID: 8968758

DOI: 10.1093/hmg/5.12.2023

PubMed ID: 8896568

Title: Germline mutations in glial cell line-derived neurotrophic factor (GDNF) and RET in a Hirschsprung disease patient.

PubMed ID: 8896568

DOI: 10.1038/ng1196-341

PubMed ID: 8896569

Title: Germline mutations of the RET ligand GDNF are not sufficient to cause Hirschsprung disease.

PubMed ID: 8896569

DOI: 10.1038/ng1196-345

PubMed ID: 9497256

Title: Mutations of the RET-GDNF signaling pathway in Ondine's curse.

PubMed ID: 9497256

DOI: 10.1086/301759

PubMed ID: 10917288

Title: Pathogenesis of Hirschsprung's disease.

PubMed ID: 10917288

DOI: 10.1053/jpsu.2000.7763

Sequence Information:

  • Length: 211
  • Mass: 23720
  • Checksum: A0D1EBF77FC82691
  • Sequence:
    • MKLWDVVAVC LVLLHTASAF PLPAGKRPPE APAEDRSLGR RRAPFALSSD SNMPEDYPDQ 
FDDVMDFIQA TIKRLKRSPD KQMAVLPRRE RNRQAAAANP ENSRGKGRRG QRGKNRGCVL 
TAIHLNVTDL GLGYETKEEL IFRYCSGSCD AAETTYDKIL KNLSRNRRLV SDKVGQACCR 
PIAFDDDLSF LDDNLVYHIL RKHSAKRCGC I

Genular Protein ID: 1991348726

Symbol: A0A0S2Z3T2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z3T2

Database IDs:

ARBA 8 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 5 Gene3D 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 Pfam 1 RefSeq 2 RuleBase 1 SAM 2 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 185
  • Mass: 20885
  • Checksum: 1988C50DA5EA1B10
  • Sequence:
    • MKLWDVVAVC LVLLHTASAF PLPAANMPED YPDQFDDVMD FIQATIKRLK RSPDKQMAVL 
PRRERNRQAA AANPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS 
GSCDAAETTY DKILKNLSRN RRLVSDKVGQ ACCRPIAFDD DLSFLDDNLV YHILRKHSAK 
RCGCI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.