Details for: HOXB4

Gene ID: 3214

Symbol: HOXB4

Ensembl ID: ENSG00000182742

Description: homeobox B4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 3.02
    Marker Score: 2415
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.17
    Marker Score: 1361.5
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.07
    Marker Score: 2208
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.05
    Marker Score: 2298
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.94
    Marker Score: 4563
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.93
    Marker Score: 1812
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.66
    Marker Score: 57355
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.64
    Marker Score: 975.5
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.61
    Marker Score: 542
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.45
    Marker Score: 683.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.28
    Marker Score: 16888
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4786
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.01
    Marker Score: 351
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71796
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48021.5
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.99
    Marker Score: 232
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.96
    Marker Score: 1385
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 491
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.95
    Marker Score: 895
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 445
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.94
    Marker Score: 2310
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5269
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2729
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.91
    Marker Score: 1582
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 361
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.79
    Marker Score: 5280
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1239
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 383
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.73
    Marker Score: 233
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 659
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 551
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.72
    Marker Score: 623
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.68
    Marker Score: 2666
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.68
    Marker Score: 688
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.63
    Marker Score: 1067
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.62
    Marker Score: 181
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.6
    Marker Score: 398
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.58
    Marker Score: 392
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.56
    Marker Score: 1069
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.55
    Marker Score: 755
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.54
    Marker Score: 260
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.53
    Marker Score: 1393
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.53
    Marker Score: 336.5
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.52
    Marker Score: 756
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.51
    Marker Score: 192
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.51
    Marker Score: 1058
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.51
    Marker Score: 99
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.49
    Marker Score: 155
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.49
    Marker Score: 203
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.49
    Marker Score: 141
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.49
    Marker Score: 974
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.48
    Marker Score: 256.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.47
    Marker Score: 475
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.46
    Marker Score: 936
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.46
    Marker Score: 671
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.45
    Marker Score: 207
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.45
    Marker Score: 267
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.44
    Marker Score: 170
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.43
    Marker Score: 285
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.42
    Marker Score: 603
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.42
    Marker Score: 245
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.41
    Marker Score: 213
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.38
    Marker Score: 102
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.38
    Marker Score: 81
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.38
    Marker Score: 1095
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.37
    Marker Score: 87
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.37
    Marker Score: 269
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.37
    Marker Score: 332
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.36
    Marker Score: 127
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.36
    Marker Score: 95
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.36
    Marker Score: 150
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.36
    Marker Score: 200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.35
    Marker Score: 233.5
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.35
    Marker Score: 546
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.35
    Marker Score: 950
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.34
    Marker Score: 839
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.33
    Marker Score: 240
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.33
    Marker Score: 223
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.33
    Marker Score: 296
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.32
    Marker Score: 113
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.32
    Marker Score: 80
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.32
    Marker Score: 811
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.32
    Marker Score: 91
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.32
    Marker Score: 530
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.32
    Marker Score: 132
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.32
    Marker Score: 269
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.31
    Marker Score: 73
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.31
    Marker Score: 77
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.31
    Marker Score: 98
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.31
    Marker Score: 142
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.31
    Marker Score: 298
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.31
    Marker Score: 178
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.3
    Marker Score: 80
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.3
    Marker Score: 95

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Other Information

**Key characteristics:** * HOXB4 is a homeobox gene, which are a family of transcription factors that are responsible for regulating the expression of other genes. * It is expressed in a variety of cell types during early embryogenesis, including neural crest cells, smooth muscle cells, and motor neurons. * HOXB4 is a key regulator of neural tube formation and patterning. * Its expression is often used as a marker for neural tube defects. **Pathways and functions:** * HOXB4 is involved in the activation of anterior hox genes in hindbrain development. * It is also involved in the activation of hox genes during differentiation. * It is involved in anterior/posterior pattern specification. * It is involved in bone marrow development. * It is involved in definitive hemopoiesis. * It is involved in embryonic skeletal system morphogenesis. * It is involved in the formation of the nephric duct. * It is involved in hematopoietic stem cell differentiation. * It is involved in hematopoietic stem cell proliferation. * It is involved in kidney development. * It is involved in morphogenesis of an epithelial sheet. * It is involved in the negative regulation of transcription by rna polymerase ii. * It is involved in the positive regulation of transcription by rna polymerase ii. * It is involved in Rna polymerase ii cis-regulatory region sequence-specific DNA binding. * It is involved in sequence-specific double-stranded DNA binding. **Clinical significance:** HOXB4 is a gene that is frequently mutated in human cancers. Mutations in HOXB4 have been linked to a number of human cancers, including glioblastoma, medulloblastoma, and osteosarcoma. HOXB4 is a promising target for cancer therapy.

Genular Protein ID: 4119328771

Symbol: HXB4_HUMAN

Name: Homeobox protein Hox-B4

UniProtKB Accession Codes:

P17483 Q9NTA0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 5 EPD 1 Ensembl 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1981366

Title: Expression of HOX homeogenes in human neuroblastoma cell culture lines.

PubMed ID: 1981366

DOI: 10.1111/j.1432-0436.1990.tb00458.x

PubMed ID: 11085749

Title: Hematopoietic expression of HOXB4 is regulated in normal and leukemic stem cells through transcriptional activation of the HOXB4 promoter by upstream stimulating factor (USF)-1 and USF-2.

PubMed ID: 11085749

DOI: 10.1084/jem.192.10.1479

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 2570724

Title: Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system.

PubMed ID: 2570724

DOI: 10.1111/j.1432-0436.1989.tb00598.x

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 251
  • Mass: 27604
  • Checksum: 23EE1D0DDCCE2DB4
  • Sequence:
    • MAMSSFLINS NYVDPKFPPC EEYSQSDYLP SDHSPGYYAG GQRRESSFQP EAGFGRRAAC 
TVQRYAACRD PGPPPPPPPP PPPPPPPGLS PRAPAPPPAG ALLPEPGQRC EAVSSSPPPP 
PCAQNPLHPS PSHSACKEPV VYPWMRKVHV STVNPNYAGG EPKRSRTAYT RQQVLELEKE 
FHYNRYLTRR RRVEIAHALC LSERQIKIWF QNRRMKWKKD HKLPNTKIRS GGAAGSAGGP 
PGRPNGGPRA L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.