Details for: HOXB4

Gene ID: 3214

Symbol: HOXB4

Ensembl ID: ENSG00000182742

Description: homeobox B4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 74.7371
    Cell Significance Index: -11.6300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 35.9560
    Cell Significance Index: -9.1200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.6759
    Cell Significance Index: -11.9300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.8076
    Cell Significance Index: -10.2000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.0790
    Cell Significance Index: -12.1500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.8196
    Cell Significance Index: 42.0400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.5888
    Cell Significance Index: -4.8800
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 1.5042
    Cell Significance Index: 8.5500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.4790
    Cell Significance Index: 20.5200
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.2931
    Cell Significance Index: 8.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2218
    Cell Significance Index: 667.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8877
    Cell Significance Index: 30.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7644
    Cell Significance Index: 16.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7108
    Cell Significance Index: 135.2700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.6890
    Cell Significance Index: 10.6600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5561
    Cell Significance Index: 4.4400
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.5540
    Cell Significance Index: 2.9200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.5424
    Cell Significance Index: 6.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5375
    Cell Significance Index: 27.9200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4687
    Cell Significance Index: 46.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3684
    Cell Significance Index: 332.6600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3113
    Cell Significance Index: 6.6300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.3001
    Cell Significance Index: 4.3000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2903
    Cell Significance Index: 5.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2518
    Cell Significance Index: 40.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2218
    Cell Significance Index: 39.9900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2158
    Cell Significance Index: 23.4800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1546
    Cell Significance Index: 2.1700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1429
    Cell Significance Index: 8.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1414
    Cell Significance Index: 3.7900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0995
    Cell Significance Index: 11.6000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0882
    Cell Significance Index: 6.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0756
    Cell Significance Index: 9.3000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0442
    Cell Significance Index: 0.7400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0396
    Cell Significance Index: 2.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0302
    Cell Significance Index: 1.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0256
    Cell Significance Index: 1.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0079
    Cell Significance Index: 5.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0080
    Cell Significance Index: -0.2300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0108
    Cell Significance Index: -0.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0143
    Cell Significance Index: -0.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0154
    Cell Significance Index: -11.6200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0172
    Cell Significance Index: -12.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0224
    Cell Significance Index: -12.6400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0357
    Cell Significance Index: -0.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0388
    Cell Significance Index: -3.9700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0416
    Cell Significance Index: -1.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0425
    Cell Significance Index: -12.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0550
    Cell Significance Index: -7.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0603
    Cell Significance Index: -12.0900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0640
    Cell Significance Index: -1.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0647
    Cell Significance Index: -13.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0694
    Cell Significance Index: -8.1800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0717
    Cell Significance Index: -0.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0825
    Cell Significance Index: -14.0800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0861
    Cell Significance Index: -2.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0874
    Cell Significance Index: -11.2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1022
    Cell Significance Index: -6.6000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1047
    Cell Significance Index: -6.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1067
    Cell Significance Index: -12.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1151
    Cell Significance Index: -8.5800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1199
    Cell Significance Index: -9.5000
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.1225
    Cell Significance Index: -1.3300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1229
    Cell Significance Index: -3.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1439
    Cell Significance Index: -4.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1517
    Cell Significance Index: -7.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1614
    Cell Significance Index: -12.3900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1648
    Cell Significance Index: -4.4100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1821
    Cell Significance Index: -5.3500
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1965
    Cell Significance Index: -1.2300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2206
    Cell Significance Index: -1.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2311
    Cell Significance Index: -6.2900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2465
    Cell Significance Index: -2.6800
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.2554
    Cell Significance Index: -1.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2619
    Cell Significance Index: -12.2100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2647
    Cell Significance Index: -6.6000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2702
    Cell Significance Index: -2.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2742
    Cell Significance Index: -7.8600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2890
    Cell Significance Index: -10.6100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3095
    Cell Significance Index: -12.6800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3152
    Cell Significance Index: -4.7500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3397
    Cell Significance Index: -5.0900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3845
    Cell Significance Index: -5.5300
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.4000
    Cell Significance Index: -5.6900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4378
    Cell Significance Index: -11.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4385
    Cell Significance Index: -11.5300
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.4503
    Cell Significance Index: -3.8100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4576
    Cell Significance Index: -11.4300
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.4634
    Cell Significance Index: -2.7200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4748
    Cell Significance Index: -11.5000
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.4761
    Cell Significance Index: -5.3900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.4762
    Cell Significance Index: -3.4200
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.4916
    Cell Significance Index: -5.2300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.5120
    Cell Significance Index: -10.2100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.5207
    Cell Significance Index: -5.0200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5275
    Cell Significance Index: -9.7500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5366
    Cell Significance Index: -11.7500
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.5436
    Cell Significance Index: -5.6300
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: -0.5460
    Cell Significance Index: -3.7500
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.5492
    Cell Significance Index: -4.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HOXB4 is a highly conserved gene present in various species, including humans, mice, and birds. It belongs to the homeobox gene family, which encodes transcription factors that regulate the development and patterning of tissues during embryogenesis. HOXB4 is specifically expressed in various cell types, including neural crest cells, enteric smooth muscle cells, and hematopoietic stem cells. The gene's expression is tightly regulated by a complex interplay of transcriptional and post-transcriptional mechanisms, involving RNA polymerase II and chromatin remodeling complexes. **Pathways and Functions:** HOXB4 is involved in several key developmental pathways, including: 1. **Anterior-Posterior Pattern Specification:** HOXB4 regulates the expression of anterior-posterior patterning genes in the hindbrain during early embryogenesis. 2. **Hematopoiesis:** HOXB4 is essential for the differentiation and proliferation of hematopoietic stem cells, which gives rise to all blood cell types. 3. **Bone Marrow Development:** HOXB4 regulates the expression of genes involved in bone marrow development and function. 4. **Kidney Development:** HOXB4 is involved in the formation of the nephric duct and the development of the kidney. 5. **Morphogenesis of Epithelial Sheets:** HOXB4 regulates the expression of genes involved in the morphogenesis of epithelial sheets, such as the neural crest-derived enteric nervous system. **Functions:** HOXB4 acts as a transcription factor that regulates the expression of downstream genes involved in cell differentiation, proliferation, and survival. Its functions include: 1. **Positive Regulation of Stem Cell Differentiation:** HOXB4 promotes the differentiation of stem cells into specific cell types. 2. **Negative Regulation of Transcription by RNA Polymerase II:** HOXB4 can inhibit the expression of genes involved in cell proliferation and survival. 3. **Sequence-Specific DNA Binding:** HOXB4 binds to specific DNA sequences, regulating the expression of target genes. **Clinical Significance:** HOXB4 has been implicated in various diseases and disorders, including: 1. **Leukemia:** HOXB4 is overexpressed in certain types of leukemia, including acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). 2. **Lymphoma:** HOXB4 is also overexpressed in certain types of lymphoma, including diffuse large B-cell lymphoma (DLBCL). 3. **Neurological Disorders:** HOXB4 has been implicated in the development of neurological disorders, including autism spectrum disorder (ASD) and schizophrenia. 4. **Cancer:** HOXB4 is involved in the development and progression of various cancers, including breast cancer, lung cancer, and colon cancer. In conclusion, HOXB4 is a critical regulator of developmental biology and immunology, with implications for our understanding of disease mechanisms and potential therapeutic targets. Further research is needed to fully elucidate the functions and clinical significance of HOXB4.

Genular Protein ID: 4119328771

Symbol: HXB4_HUMAN

Name: Homeobox protein Hox-B4

UniProtKB Accession Codes:

P17483 Q9NTA0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 5 Ensembl 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1981366

Title: Expression of HOX homeogenes in human neuroblastoma cell culture lines.

PubMed ID: 1981366

DOI: 10.1111/j.1432-0436.1990.tb00458.x

PubMed ID: 11085749

Title: Hematopoietic expression of HOXB4 is regulated in normal and leukemic stem cells through transcriptional activation of the HOXB4 promoter by upstream stimulating factor (USF)-1 and USF-2.

PubMed ID: 11085749

DOI: 10.1084/jem.192.10.1479

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 2570724

Title: Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system.

PubMed ID: 2570724

DOI: 10.1111/j.1432-0436.1989.tb00598.x

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 251
  • Mass: 27604
  • Checksum: 23EE1D0DDCCE2DB4
  • Sequence:
    • MAMSSFLINS NYVDPKFPPC EEYSQSDYLP SDHSPGYYAG GQRRESSFQP EAGFGRRAAC 
TVQRYAACRD PGPPPPPPPP PPPPPPPGLS PRAPAPPPAG ALLPEPGQRC EAVSSSPPPP 
PCAQNPLHPS PSHSACKEPV VYPWMRKVHV STVNPNYAGG EPKRSRTAYT RQQVLELEKE 
FHYNRYLTRR RRVEIAHALC LSERQIKIWF QNRRMKWKKD HKLPNTKIRS GGAAGSAGGP 
PGRPNGGPRA L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.