Details for: STOML2

Gene ID: 30968

Symbol: STOML2

Ensembl ID: ENSG00000165283

Description: stomatin like 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 193.9629
    Cell Significance Index: -30.1700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 111.0812
    Cell Significance Index: -28.1800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 101.1602
    Cell Significance Index: -47.7600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 90.7588
    Cell Significance Index: -46.6900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 71.3389
    Cell Significance Index: -47.8700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.1351
    Cell Significance Index: -43.3200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.0082
    Cell Significance Index: -47.3900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.7793
    Cell Significance Index: -31.5600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.6762
    Cell Significance Index: -29.7200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 4.3147
    Cell Significance Index: 34.4500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.8267
    Cell Significance Index: 30.7300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.4869
    Cell Significance Index: 86.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.2115
    Cell Significance Index: 46.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.0328
    Cell Significance Index: 94.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8413
    Cell Significance Index: 50.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.8197
    Cell Significance Index: 47.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.7490
    Cell Significance Index: 955.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5048
    Cell Significance Index: 78.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.4962
    Cell Significance Index: 105.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.4807
    Cell Significance Index: 69.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.4650
    Cell Significance Index: 201.1800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4533
    Cell Significance Index: 87.2500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.2755
    Cell Significance Index: 37.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2620
    Cell Significance Index: 155.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2189
    Cell Significance Index: 219.7400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.2162
    Cell Significance Index: 537.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.2076
    Cell Significance Index: 156.0200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1854
    Cell Significance Index: 88.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.1637
    Cell Significance Index: 137.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0539
    Cell Significance Index: 68.0000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0462
    Cell Significance Index: 72.3500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.9940
    Cell Significance Index: 12.7300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7134
    Cell Significance Index: 116.0400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.7130
    Cell Significance Index: 8.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6956
    Cell Significance Index: 15.0700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6889
    Cell Significance Index: 15.9200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6876
    Cell Significance Index: 620.8800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.6220
    Cell Significance Index: 5.3400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6201
    Cell Significance Index: 5.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6168
    Cell Significance Index: 79.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5349
    Cell Significance Index: 106.1600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.5287
    Cell Significance Index: 8.0300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4920
    Cell Significance Index: 93.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4375
    Cell Significance Index: 12.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3944
    Cell Significance Index: 20.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3760
    Cell Significance Index: 10.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2046
    Cell Significance Index: 20.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1921
    Cell Significance Index: 12.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1613
    Cell Significance Index: 32.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0753
    Cell Significance Index: 56.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0709
    Cell Significance Index: 3.2200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0562
    Cell Significance Index: 0.9400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0532
    Cell Significance Index: 39.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0148
    Cell Significance Index: 5.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0088
    Cell Significance Index: 0.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0008
    Cell Significance Index: -0.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0045
    Cell Significance Index: -3.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0146
    Cell Significance Index: -27.5000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0200
    Cell Significance Index: -0.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0285
    Cell Significance Index: -2.9100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0320
    Cell Significance Index: -59.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0368
    Cell Significance Index: -1.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0369
    Cell Significance Index: -1.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0392
    Cell Significance Index: -60.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0462
    Cell Significance Index: -62.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0517
    Cell Significance Index: -38.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0525
    Cell Significance Index: -33.3600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0752
    Cell Significance Index: -42.4100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0796
    Cell Significance Index: -0.4900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0888
    Cell Significance Index: -2.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0903
    Cell Significance Index: -56.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0981
    Cell Significance Index: -44.5200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1257
    Cell Significance Index: -3.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1398
    Cell Significance Index: -40.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2544
    Cell Significance Index: -29.1400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2562
    Cell Significance Index: -20.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2610
    Cell Significance Index: -54.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2650
    Cell Significance Index: -30.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2872
    Cell Significance Index: -41.7500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3746
    Cell Significance Index: -6.6200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3788
    Cell Significance Index: -9.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3943
    Cell Significance Index: -5.3800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4525
    Cell Significance Index: -3.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4540
    Cell Significance Index: -47.2700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4593
    Cell Significance Index: -4.7600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4794
    Cell Significance Index: -14.1200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4916
    Cell Significance Index: -13.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5106
    Cell Significance Index: -28.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5633
    Cell Significance Index: -37.8800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5753
    Cell Significance Index: -44.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6069
    Cell Significance Index: -37.3000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6488
    Cell Significance Index: -3.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6629
    Cell Significance Index: -40.6400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.9096
    Cell Significance Index: -12.7500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.9524
    Cell Significance Index: -8.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0010
    Cell Significance Index: -25.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.0045
    Cell Significance Index: -44.4300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.0729
    Cell Significance Index: -19.8300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0766
    Cell Significance Index: -39.5200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -1.1241
    Cell Significance Index: -16.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** STOML2 is a member of the stomatin family of proteins, which are known for their role in regulating mitochondrial calcium homeostasis. This protein is specifically localized to the inner mitochondrial membrane and is involved in the processing and regulation of mitochondrial proteins. STOML2 has been identified in a wide range of cell types, including immune cells, epithelial cells, and neural crest cells. **Pathways and Functions:** STOML2 is intricately involved in several mitochondrial pathways, including: 1. **Mitochondrial calcium ion homeostasis:** STOML2 helps regulate the influx and efflux of calcium ions across the mitochondrial membrane, which is crucial for maintaining mitochondrial function and preventing calcium overload. 2. **Intracellular calcium ion homeostasis:** By modulating calcium levels within the cell, STOML2 contributes to the regulation of various cellular processes, including muscle contraction, neurotransmitter release, and immune response. 3. **Mitochondrial protein processing:** STOML2 is involved in the processing and regulation of mitochondrial proteins, which is essential for maintaining mitochondrial function and preventing protein aggregation. 4. **T cell receptor signaling pathway:** STOML2 has been shown to interact with the T cell receptor, modulating its signaling activity and influencing T cell activation and proliferation. **Clinical Significance:** The dysregulation of STOML2 has been implicated in various diseases, including: 1. **Autoimmune disorders:** Alterations in STOML2 expression have been linked to autoimmune diseases, such as type 1 diabetes and multiple sclerosis, where mitochondrial dysfunction plays a key role in disease pathogenesis. 2. **Cancer:** STOML2 has been identified as a potential tumor suppressor gene, with altered expression levels observed in various types of cancer, including breast and lung cancer. 3. **Neurodegenerative diseases:** The dysregulation of STOML2 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where mitochondrial dysfunction contributes to disease progression. In conclusion, STOML2 is a critical regulator of mitochondrial function and immune response, with far-reaching implications for our understanding of various diseases. Further research is needed to fully elucidate the mechanisms by which STOML2 regulates mitochondrial function and to explore its potential as a therapeutic target for the treatment of diseases associated with mitochondrial dysfunction.

Genular Protein ID: 4188496840

Symbol: STML2_HUMAN

Name: Stomatin-like protein 2, mitochondrial

UniProtKB Accession Codes:

Q9UJZ1 B4E1K7 D3DRN3 O60376 Q53G29 Q96FY2 Q9P042

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 2 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10713127

Title: Identification and characterization of human SLP-2, a novel homologue of stomatin (band 7.2b) present in erythrocytes and other tissues.

PubMed ID: 10713127

DOI: 10.1074/jbc.275.11.8062

PubMed ID: 11435687

Title: A novel member of the stomatin/EPB72/mec-2 family, stomatin-like 2 (STOML2), is ubiquitously expressed and localizes to HSA chromosome 9p13.1.

PubMed ID: 11435687

DOI: 10.1159/000056902

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 16671055

Title: Mass spectrometrical verification of stomatin-like protein 2 (SLP-2) primary structure.

PubMed ID: 16671055

DOI: 10.1002/prot.20987

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17121834

Title: Identification of a novel mitochondrial complex containing mitofusin 2 and stomatin-like protein 2.

PubMed ID: 17121834

DOI: 10.1074/jbc.m608168200

PubMed ID: 18339324

Title: SLP-2 interacts with prohibitins in the mitochondrial inner membrane and contributes to their stability.

PubMed ID: 18339324

DOI: 10.1016/j.bbamcr.2008.02.006

PubMed ID: 18641330

Title: Modulation of T cell activation by stomatin-like protein 2.

PubMed ID: 18641330

DOI: 10.4049/jimmunol.181.3.1927

PubMed ID: 19597348

Title: Downregulation of a mitochondria associated protein SLP-2 inhibits tumor cell motility, proliferation and enhances cell sensitivity to chemotherapeutic reagents.

PubMed ID: 19597348

DOI: 10.4161/cbt.8.17.9283

PubMed ID: 19405124

Title: A frequent target of paraproteins in the sera of patients with multiple myeloma and MGUS.

PubMed ID: 19405124

DOI: 10.1002/ijc.24427

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 19944461

Title: SLP-2 negatively modulates mitochondrial sodium-calcium exchange.

PubMed ID: 19944461

DOI: 10.1016/j.ceca.2009.10.005

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21791414

Title: Hyperphosphorylation of autoantigenic targets of paraproteins is due to inactivation of PP2A.

PubMed ID: 21791414

DOI: 10.1182/blood-2011-04-351668

PubMed ID: 21746876

Title: Stomatin-like protein 2 binds cardiolipin and regulates mitochondrial biogenesis and function.

PubMed ID: 21746876

DOI: 10.1128/mcb.05393-11

PubMed ID: 22623988

Title: Mitochondrial and plasma membrane pools of stomatin-like protein 2 coalesce at the immunological synapse during T cell activation.

PubMed ID: 22623988

DOI: 10.1371/journal.pone.0037144

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 356
  • Mass: 38534
  • Checksum: 672331B57C82654E
  • Sequence:
    • MLARAARGTG ALLLRGSLLA SGRAPRRASS GLPRNTVVLF VPQQEAWVVE RMGRFHRILE 
PGLNILIPVL DRIRYVQSLK EIVINVPEQS AVTLDNVTLQ IDGVLYLRIM DPYKASYGVE 
DPEYAVTQLA QTTMRSELGK LSLDKVFRER ESLNASIVDA INQAADCWGI RCLRYEIKDI 
HVPPRVKESM QMQVEAERRK RATVLESEGT RESAINVAEG KKQAQILASE AEKAEQINQA 
AGEASAVLAK AKAKAEAIRI LAAALTQHNG DAAASLTVAE QYVSAFSKLA KDSNTILLPS 
NPGDVTSMVA QAMGVYGALT KAPVPGTPDS LSSGSSRDVQ GTDASLDEEL DRVKMS

Genular Protein ID: 543221498

Symbol: A0A087WYB4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WYB4

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 310
  • Mass: 33409
  • Checksum: 88E2157CF853F298
  • Sequence:
    • MLARAARGTG ALLLRGLNIL IPVLDRIRYV QSLKEIVINV PEQSAVTLDN VTLQIDGVLY 
LRIMDPYKAS YGVEDPEYAV TQLAQTTMRS ELGKLSLDKV FRERESLNAS IVDAINQAAD 
CWGIRCLRYE IKDIHVPPRV KESMQMQVEA ERRKRATVLE SEGTRESAIN VAEGKKQAQI 
LASEAEKAEQ INQAAGEASA VLAKAKAKAE AIRILAAALT QHNGDAAASL TVAEQYVSAF 
SKLAKDSNTI LLPSNPGDVT SMVAQAMGVY GALTKAPVPG TPDSLSSGSS RDVQGTDASL 
DEELDRVKMS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.