Details for: STOML2

Gene ID: 30968

Symbol: STOML2

Ensembl ID: ENSG00000165283

Description: stomatin like 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.73
    Marker Score: 5,757
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.61
    Marker Score: 2,728
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.28
    Marker Score: 4,766
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.23
    Marker Score: 9,139
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.15
    Marker Score: 74,467
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.08
    Marker Score: 27,464
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.08
    Marker Score: 2,221
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.07
    Marker Score: 8,149
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.99
    Marker Score: 1,876
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.99
    Marker Score: 1,330
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.97
    Marker Score: 2,088
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.97
    Marker Score: 4,673
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.96
    Marker Score: 7,264
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.95
    Marker Score: 3,318
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.94
    Marker Score: 1,218
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.93
    Marker Score: 5,250
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.9
    Marker Score: 16,386
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.9
    Marker Score: 1,913
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.89
    Marker Score: 2,003
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.87
    Marker Score: 8,080
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.87
    Marker Score: 8,957
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.85
    Marker Score: 14,459
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.85
    Marker Score: 12,035
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.82
    Marker Score: 4,454
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.81
    Marker Score: 643
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.81
    Marker Score: 2,662
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.78
    Marker Score: 1,206
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.78
    Marker Score: 4,182
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.77
    Marker Score: 19,889
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.75
    Marker Score: 1,885
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.73
    Marker Score: 3,936
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.71
    Marker Score: 6,609
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.69
    Marker Score: 12,600
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.69
    Marker Score: 1,221
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.68
    Marker Score: 1,324
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.67
    Marker Score: 3,784
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.66
    Marker Score: 16,675
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.64
    Marker Score: 526
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.64
    Marker Score: 2,356
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.62
    Marker Score: 2,609
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.62
    Marker Score: 2,864
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.61
    Marker Score: 831
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.61
    Marker Score: 10,315
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 1.61
    Marker Score: 1,217
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.6
    Marker Score: 2,655
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.6
    Marker Score: 4,344
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.59
    Marker Score: 2,612
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.59
    Marker Score: 2,114
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.59
    Marker Score: 597
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.58
    Marker Score: 2,971
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.58
    Marker Score: 901
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.58
    Marker Score: 1,319
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.58
    Marker Score: 2,231
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.57
    Marker Score: 994
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.57
    Marker Score: 1,768
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.57
    Marker Score: 369
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.57
    Marker Score: 13,651
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.57
    Marker Score: 2,739
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.57
    Marker Score: 4,646
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.56
    Marker Score: 4,889
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.55
    Marker Score: 1,034
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.53
    Marker Score: 51,974
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.52
    Marker Score: 2,339
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.52
    Marker Score: 5,385
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.51
    Marker Score: 1,896
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.51
    Marker Score: 1,133
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.51
    Marker Score: 739
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.5
    Marker Score: 1,094
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.49
    Marker Score: 823
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.48
    Marker Score: 519
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.48
    Marker Score: 816
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.45
    Marker Score: 2,313
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.44
    Marker Score: 14,642
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.44
    Marker Score: 9,175
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.43
    Marker Score: 713
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.43
    Marker Score: 3,827
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.42
    Marker Score: 675
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.42
    Marker Score: 1,336
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.41
    Marker Score: 1,259
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.4
    Marker Score: 3,542
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.39
    Marker Score: 401
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.39
    Marker Score: 400
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.37
    Marker Score: 1,388
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.37
    Marker Score: 1,418
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.36
    Marker Score: 6,702
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.36
    Marker Score: 2,097
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.36
    Marker Score: 266
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.35
    Marker Score: 334
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.35
    Marker Score: 717
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.34
    Marker Score: 442
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.34
    Marker Score: 2,547
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.34
    Marker Score: 15,558
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.34
    Marker Score: 661
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.33
    Marker Score: 376
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.32
    Marker Score: 1,705
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.32
    Marker Score: 1,265
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.31
    Marker Score: 455
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.31
    Marker Score: 613
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.31
    Marker Score: 619
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.31
    Marker Score: 333

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** STOML2 is a member of the stomatin family of proteins, which are known for their role in regulating mitochondrial calcium homeostasis. This protein is specifically localized to the inner mitochondrial membrane and is involved in the processing and regulation of mitochondrial proteins. STOML2 has been identified in a wide range of cell types, including immune cells, epithelial cells, and neural crest cells. **Pathways and Functions:** STOML2 is intricately involved in several mitochondrial pathways, including: 1. **Mitochondrial calcium ion homeostasis:** STOML2 helps regulate the influx and efflux of calcium ions across the mitochondrial membrane, which is crucial for maintaining mitochondrial function and preventing calcium overload. 2. **Intracellular calcium ion homeostasis:** By modulating calcium levels within the cell, STOML2 contributes to the regulation of various cellular processes, including muscle contraction, neurotransmitter release, and immune response. 3. **Mitochondrial protein processing:** STOML2 is involved in the processing and regulation of mitochondrial proteins, which is essential for maintaining mitochondrial function and preventing protein aggregation. 4. **T cell receptor signaling pathway:** STOML2 has been shown to interact with the T cell receptor, modulating its signaling activity and influencing T cell activation and proliferation. **Clinical Significance:** The dysregulation of STOML2 has been implicated in various diseases, including: 1. **Autoimmune disorders:** Alterations in STOML2 expression have been linked to autoimmune diseases, such as type 1 diabetes and multiple sclerosis, where mitochondrial dysfunction plays a key role in disease pathogenesis. 2. **Cancer:** STOML2 has been identified as a potential tumor suppressor gene, with altered expression levels observed in various types of cancer, including breast and lung cancer. 3. **Neurodegenerative diseases:** The dysregulation of STOML2 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where mitochondrial dysfunction contributes to disease progression. In conclusion, STOML2 is a critical regulator of mitochondrial function and immune response, with far-reaching implications for our understanding of various diseases. Further research is needed to fully elucidate the mechanisms by which STOML2 regulates mitochondrial function and to explore its potential as a therapeutic target for the treatment of diseases associated with mitochondrial dysfunction.

Genular Protein ID: 4188496840

Symbol: STML2_HUMAN

Name: Stomatin-like protein 2, mitochondrial

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10713127

Title: Identification and characterization of human SLP-2, a novel homologue of stomatin (band 7.2b) present in erythrocytes and other tissues.

PubMed ID: 10713127

DOI: 10.1074/jbc.275.11.8062

PubMed ID: 11435687

Title: A novel member of the stomatin/EPB72/mec-2 family, stomatin-like 2 (STOML2), is ubiquitously expressed and localizes to HSA chromosome 9p13.1.

PubMed ID: 11435687

DOI: 10.1159/000056902

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 16671055

Title: Mass spectrometrical verification of stomatin-like protein 2 (SLP-2) primary structure.

PubMed ID: 16671055

DOI: 10.1002/prot.20987

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17121834

Title: Identification of a novel mitochondrial complex containing mitofusin 2 and stomatin-like protein 2.

PubMed ID: 17121834

DOI: 10.1074/jbc.m608168200

PubMed ID: 18339324

Title: SLP-2 interacts with prohibitins in the mitochondrial inner membrane and contributes to their stability.

PubMed ID: 18339324

DOI: 10.1016/j.bbamcr.2008.02.006

PubMed ID: 18641330

Title: Modulation of T cell activation by stomatin-like protein 2.

PubMed ID: 18641330

DOI: 10.4049/jimmunol.181.3.1927

PubMed ID: 19597348

Title: Downregulation of a mitochondria associated protein SLP-2 inhibits tumor cell motility, proliferation and enhances cell sensitivity to chemotherapeutic reagents.

PubMed ID: 19597348

DOI: 10.4161/cbt.8.17.9283

PubMed ID: 19405124

Title: A frequent target of paraproteins in the sera of patients with multiple myeloma and MGUS.

PubMed ID: 19405124

DOI: 10.1002/ijc.24427

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 19944461

Title: SLP-2 negatively modulates mitochondrial sodium-calcium exchange.

PubMed ID: 19944461

DOI: 10.1016/j.ceca.2009.10.005

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21791414

Title: Hyperphosphorylation of autoantigenic targets of paraproteins is due to inactivation of PP2A.

PubMed ID: 21791414

DOI: 10.1182/blood-2011-04-351668

PubMed ID: 21746876

Title: Stomatin-like protein 2 binds cardiolipin and regulates mitochondrial biogenesis and function.

PubMed ID: 21746876

DOI: 10.1128/mcb.05393-11

PubMed ID: 22623988

Title: Mitochondrial and plasma membrane pools of stomatin-like protein 2 coalesce at the immunological synapse during T cell activation.

PubMed ID: 22623988

DOI: 10.1371/journal.pone.0037144

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 356
  • Mass: 38534
  • Checksum: 672331B57C82654E
  • Sequence:
  • MLARAARGTG ALLLRGSLLA SGRAPRRASS GLPRNTVVLF VPQQEAWVVE RMGRFHRILE 
    PGLNILIPVL DRIRYVQSLK EIVINVPEQS AVTLDNVTLQ IDGVLYLRIM DPYKASYGVE 
    DPEYAVTQLA QTTMRSELGK LSLDKVFRER ESLNASIVDA INQAADCWGI RCLRYEIKDI 
    HVPPRVKESM QMQVEAERRK RATVLESEGT RESAINVAEG KKQAQILASE AEKAEQINQA 
    AGEASAVLAK AKAKAEAIRI LAAALTQHNG DAAASLTVAE QYVSAFSKLA KDSNTILLPS 
    NPGDVTSMVA QAMGVYGALT KAPVPGTPDS LSSGSSRDVQ GTDASLDEEL DRVKMS

Genular Protein ID: 543221498

Symbol: A0A087WYB4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 310
  • Mass: 33409
  • Checksum: 88E2157CF853F298
  • Sequence:
  • MLARAARGTG ALLLRGLNIL IPVLDRIRYV QSLKEIVINV PEQSAVTLDN VTLQIDGVLY 
    LRIMDPYKAS YGVEDPEYAV TQLAQTTMRS ELGKLSLDKV FRERESLNAS IVDAINQAAD 
    CWGIRCLRYE IKDIHVPPRV KESMQMQVEA ERRKRATVLE SEGTRESAIN VAEGKKQAQI 
    LASEAEKAEQ INQAAGEASA VLAKAKAKAE AIRILAAALT QHNGDAAASL TVAEQYVSAF 
    SKLAKDSNTI LLPSNPGDVT SMVAQAMGVY GALTKAPVPG TPDSLSSGSS RDVQGTDASL 
    DEELDRVKMS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.