ORC6 | ENSG00000091651 | NCBI 23594

Details for: ORC6

Gene ID: 23594

Symbol: ORC6

Ensembl ID: ENSG00000091651

Description: origin recognition complex subunit 6

Associated with

Activation of atr in response to replication stress
(R-HSA-176187)
Activation of the pre-replicative complex
(R-HSA-68962)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
Cdc6 association with the orc:origin complex
(R-HSA-68689)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
E2f-enabled inhibition of pre-replication complex formation
(R-HSA-113507)
E2f mediated regulation of dna replication
(R-HSA-113510)
G1/s transition
(R-HSA-69206)
G2/m checkpoints
(R-HSA-69481)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Orc1 removal from chromatin
(R-HSA-68949)
S phase
(R-HSA-69242)
Switching of origins to a post-replicative state
(R-HSA-69052)
Synthesis of dna
(R-HSA-69239)
Cytosol
(GO:0005829)
Dna binding
(GO:0003677)
Dna replication initiation
(GO:0006270)
Fibrillar center
(GO:0001650)
Membrane
(GO:0016020)
Nuclear origin of replication recognition complex
(GO:0005664)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Origin recognition complex
(GO:0000808)
Protein binding
(GO:0005515)

Other Information

Proteins

Origin recognition complex subunit 6

Genular Protein ID: 2031690660

Symbol: ORC6_HUMAN

Name: Origin recognition complex subunit 6

UniProtKB Accession Codes:

Q9Y5N6 B3KN89

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17716973

Title: ATP-dependent assembly of the human origin recognition complex.

PubMed ID: 17716973

DOI: 10.1074/jbc.m705905200

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22427655

Title: Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing.

PubMed ID: 22427655

DOI: 10.1074/jbc.m111.337980

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 21502537

Title: Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB.

PubMed ID: 21502537

DOI: 10.1073/pnas.1013676108

PubMed ID: 21358632

Title: Mutations in the pre-replication complex cause Meier-Gorlin syndrome.

PubMed ID: 21358632

DOI: 10.1038/ng.775

Sequence Information:

Length: 252
Mass: 28107
Checksum: 78840387605F45FE
Sequence:

MGSELIGRLA PRLGLAEPDM LRKAEEYLRL SRVKCVGLSA RTTETSSAVM CLDLAASWMK 
CPLDRAYLIK LSGLNKETYQ SCLKSFECLL GLNSNIGIRD LAVQFSCIEA VNMASKILKS 
YESSLPQTQQ VDLDLSRPLF TSAALLSACK ILKLKVDKNK MVATSGVKKA IFDRLCKQLE 
KIGQQVDREP GDVATPPRKR KKIVVEAPAK EMEKVEEMPH KPQKDEDLTQ DYEEWKRKIL 
ENAASAQKAT AE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ORC6

Associated with

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

ATP-dependent assembly of the human origin recognition complex. PubMed ID: 17716973

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing. PubMed ID: 22427655

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB. PubMed ID: 21502537

Mutations in the pre-replication complex cause Meier-Gorlin syndrome. PubMed ID: 21358632