Details for: MKI67

Gene ID: 4288

Symbol: MKI67

Ensembl ID: ENSG00000148773

Description: marker of proliferation Ki-67

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 49.4001
    Cell Significance Index: -12.5300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 28.2334
    Cell Significance Index: -11.4700
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 10.4522
    Cell Significance Index: 4.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.4651
    Cell Significance Index: -11.6700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.4463
    Cell Significance Index: -14.5900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.0646
    Cell Significance Index: -8.9000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.3248
    Cell Significance Index: -13.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 3.0804
    Cell Significance Index: 586.2300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.9171
    Cell Significance Index: 51.2800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.8429
    Cell Significance Index: 217.3300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.7989
    Cell Significance Index: 177.9600
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.7476
    Cell Significance Index: 17.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.7070
    Cell Significance Index: 277.6300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.4486
    Cell Significance Index: 9.6100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.1599
    Cell Significance Index: 12.6100
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 1.1585
    Cell Significance Index: 14.3900
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 1.1418
    Cell Significance Index: 6.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.1222
    Cell Significance Index: 62.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9413
    Cell Significance Index: 109.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9221
    Cell Significance Index: 832.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9012
    Cell Significance Index: 25.9700
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.7844
    Cell Significance Index: 6.7400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7174
    Cell Significance Index: 24.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6364
    Cell Significance Index: 126.3000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5721
    Cell Significance Index: 14.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4691
    Cell Significance Index: 15.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3326
    Cell Significance Index: 181.6200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3250
    Cell Significance Index: 9.5500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3132
    Cell Significance Index: 18.8100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2631
    Cell Significance Index: 7.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2131
    Cell Significance Index: 4.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1951
    Cell Significance Index: 5.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1660
    Cell Significance Index: 3.5400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.1397
    Cell Significance Index: 2.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1321
    Cell Significance Index: 6.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1198
    Cell Significance Index: 5.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1184
    Cell Significance Index: 4.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1006
    Cell Significance Index: 2.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0907
    Cell Significance Index: 40.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0592
    Cell Significance Index: 36.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0573
    Cell Significance Index: 1.5300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0222
    Cell Significance Index: 0.2300
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 0.0121
    Cell Significance Index: 0.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0064
    Cell Significance Index: 0.7900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0063
    Cell Significance Index: 0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0051
    Cell Significance Index: -3.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0065
    Cell Significance Index: -12.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0080
    Cell Significance Index: -4.4900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0082
    Cell Significance Index: -0.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0113
    Cell Significance Index: -2.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0130
    Cell Significance Index: -0.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0156
    Cell Significance Index: -11.8000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0251
    Cell Significance Index: -0.7400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0262
    Cell Significance Index: -1.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0305
    Cell Significance Index: -13.8700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0347
    Cell Significance Index: -4.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0354
    Cell Significance Index: -6.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0357
    Cell Significance Index: -3.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0381
    Cell Significance Index: -13.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0500
    Cell Significance Index: -14.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0534
    Cell Significance Index: -9.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0624
    Cell Significance Index: -3.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0672
    Cell Significance Index: -13.4900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0884
    Cell Significance Index: -10.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0912
    Cell Significance Index: -5.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0918
    Cell Significance Index: -10.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0951
    Cell Significance Index: -13.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1030
    Cell Significance Index: -13.3100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1127
    Cell Significance Index: -2.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1144
    Cell Significance Index: -7.0300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1181
    Cell Significance Index: -1.7800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1191
    Cell Significance Index: -12.4000
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.1244
    Cell Significance Index: -0.6000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1258
    Cell Significance Index: -2.6100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1403
    Cell Significance Index: -2.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1513
    Cell Significance Index: -19.3900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1686
    Cell Significance Index: -13.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1795
    Cell Significance Index: -13.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1937
    Cell Significance Index: -14.4400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2005
    Cell Significance Index: -1.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2088
    Cell Significance Index: -14.0400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2128
    Cell Significance Index: -13.4100
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.2270
    Cell Significance Index: -1.6500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2327
    Cell Significance Index: -16.4600
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.2338
    Cell Significance Index: -1.7700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2577
    Cell Significance Index: -12.1100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2805
    Cell Significance Index: -6.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2963
    Cell Significance Index: -7.7900
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.3233
    Cell Significance Index: -3.6600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3316
    Cell Significance Index: -4.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3360
    Cell Significance Index: -14.8600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3383
    Cell Significance Index: -4.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3480
    Cell Significance Index: -16.2300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.3490
    Cell Significance Index: -4.4100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3520
    Cell Significance Index: -12.9200
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.3726
    Cell Significance Index: -2.3400
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.3839
    Cell Significance Index: -2.7900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.3883
    Cell Significance Index: -3.3000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3919
    Cell Significance Index: -14.8400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3936
    Cell Significance Index: -13.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell cycle regulation:** MKI67 is expressed throughout the cell cycle, but its levels are highest during the G1 phase, where DNA replication occurs. This suggests that MKI67 is involved in the regulation of DNA replication and cell division. 2. **Proliferation marker:** MKI67 is widely used as a marker of cell proliferation due to its high expression levels in proliferating cells, such as cancer cells. 3. **Tissue-specific expression:** MKI67 is expressed in various tissues, including the brain, immune cells, and epithelial cells, highlighting its broad role in cellular processes. 4. **Cell type-specific expression:** MKI67 is expressed in specific cell types, such as migratory enteric neural crest cells, IgG plasmablasts, and large pre-B-II cells, suggesting its involvement in cell differentiation and development. **Pathways and Functions:** 1. **Cell cycle regulation:** MKI67 is involved in the regulation of the cell cycle, particularly during the G1 phase, where DNA replication occurs. 2. **DNA replication:** MKI67 is required for DNA replication, as it helps to maintain the integrity of the genome during the S phase. 3. **Cell division:** MKI67 is involved in the regulation of cell division, particularly during the G2 and M phases, where it helps to ensure accurate chromosome segregation. 4. **Regulation of chromatin organization:** MKI67 plays a role in regulating chromatin organization, which is essential for gene expression and cellular differentiation. 5. **Regulation of mitotic nuclear division:** MKI67 is involved in the regulation of mitotic nuclear division, ensuring accurate chromosome segregation and proper nuclear morphology. **Clinical Significance:** 1. **Cancer diagnosis:** MKI67 is widely used as a marker of cell proliferation in cancer diagnosis, particularly in breast cancer, where it is often used to assess tumor aggressiveness. 2. **Monitoring treatment response:** MKI67 levels can be used to monitor treatment response in cancer patients, as changes in expression levels can indicate tumor regression or progression. 3. **Immunohistochemistry:** MKI67 is commonly used as a marker in immunohistochemistry, allowing for the identification of proliferating cells in tissue sections. 4. **Cellular differentiation:** MKI67 plays a role in cellular differentiation, particularly in the development of immune cells and neural crest cells. In conclusion, MKI67 is a critical protein involved in various cellular processes, including cell cycle regulation, DNA replication, and cellular differentiation. Its expression is significantly elevated in proliferating cells, making it an essential tool in immunohistochemistry and diagnostic pathology.

Genular Protein ID: 1451828628

Symbol: KI67_HUMAN

Name: N/A

UniProtKB Accession Codes:

P46013 Q5VWH2

Database IDs:

AGR 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 3 CPTC 1 CTD 1 CarbonylDB 1 ChEBI 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8227122

Title: The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins.

PubMed ID: 8227122

DOI: 10.1083/jcb.123.3.513

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 6339421

Title: Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation.

PubMed ID: 6339421

DOI: 10.1002/ijc.2910310104

PubMed ID: 6206131

Title: Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67.

PubMed ID: 6206131

PubMed ID: 2674163

Title: Ki-67 detects a nuclear matrix-associated proliferation-related antigen. I. Intracellular localization during interphase.

PubMed ID: 2674163

DOI: 10.1242/jcs.92.1.123

PubMed ID: 8799815

Title: Localisation of the Ki-67 antigen within the nucleolus. Evidence for a fibrillarin-deficient region of the dense fibrillar component.

PubMed ID: 8799815

DOI: 10.1242/jcs.109.6.1253

PubMed ID: 9510506

Title: Association of pKi-67 with satellite DNA of the human genome in early G1 cells.

PubMed ID: 9510506

DOI: 10.1023/a:1009210206855

PubMed ID: 10502411

Title: Biochemical characterization of pKi67 with the identification of a mitotic-specific form associated with hyperphosphorylation and altered DNA binding.

PubMed ID: 10502411

DOI: 10.1006/excr.1999.4600

PubMed ID: 10878014

Title: The forkhead-associated domain of Ki-67 antigen interacts with the novel kinesin-like protein Hklp2.

PubMed ID: 10878014

DOI: 10.1074/jbc.m003879200

PubMed ID: 10653604

Title: Posttranslational modifications of the KI-67 protein coincide with two major checkpoints during mitosis.

PubMed ID: 10653604

DOI: 10.1002/(sici)1097-4652(200003)182:3<371::aid-jcp8>3.0.co;2-j

PubMed ID: 10878551

Title: The biochemical characterization of the DNA binding activity of pKi67.

PubMed ID: 10878551

DOI: 10.1002/1096-9896(2000)9999:9999<::aid-path628>3.0.co;2-j

PubMed ID: 11342549

Title: A novel nucleolar protein, NIFK, interacts with the forkhead associated domain of Ki-67 antigen in mitosis.

PubMed ID: 11342549

DOI: 10.1074/jbc.m102227200

PubMed ID: 15896774

Title: In vivo dynamics and kinetics of pKi-67: transition from a mobile to an immobile form at the onset of anaphase.

PubMed ID: 15896774

DOI: 10.1016/j.yexcr.2005.04.010

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19131338

Title: Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation.

PubMed ID: 19131338

DOI: 10.1074/jbc.m805872200

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21960707

Title: Assessment of Ki67 in breast cancer: recommendations from the International Ki67 in Breast Cancer working group.

PubMed ID: 21960707

DOI: 10.1093/jnci/djr393

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23178126

Title: Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation.

PubMed ID: 23178126

DOI: 10.1016/j.cell.2012.10.043

PubMed ID: 22002106

Title: Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization.

PubMed ID: 22002106

DOI: 10.1074/mcp.m111.013680

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24867636

Title: Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery.

PubMed ID: 24867636

DOI: 10.7554/elife.01641

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 26680267

Title: The assessment of Ki-67 as a prognostic marker in neuroendocrine tumours: a systematic review and meta-analysis.

PubMed ID: 26680267

DOI: 10.1136/jclinpath-2015-203340

PubMed ID: 27362226

Title: Ki-67 acts as a biological surfactant to disperse mitotic chromosomes.

PubMed ID: 27362226

DOI: 10.1038/nature18610

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 14659764

Title: Structure of human Ki67 FHA domain and its binding to a phosphoprotein fragment from hNIFK reveal unique recognition sites and new views to the structural basis of FHA domain functions.

PubMed ID: 14659764

DOI: 10.1016/j.jmb.2003.10.032

PubMed ID: 16244663

Title: Sequential phosphorylation and multisite interactions characterize specific target recognition by the FHA domain of Ki67.

PubMed ID: 16244663

DOI: 10.1038/nsmb1008

Sequence Information:

  • Length: 3256
  • Mass: 358694
  • Checksum: 1332BC6C799AD64D
  • Sequence:
    • MWPTRRLVTI KRSGVDGPHF PLSLSTCLFG RGIECDIRIQ LPVVSKQHCK IEIHEQEAIL 
HNFSSTNPTQ VNGSVIDEPV RLKHGDVITI IDRSFRYENE SLQNGRKSTE FPRKIREQEP 
ARRVSRSSFS SDPDEKAQDS KAYSKITEGK VSGNPQVHIK NVKEDSTADD SKDSVAQGTT 
NVHSSEHAGR NGRNAADPIS GDFKEISSVK LVSRYGELKS VPTTQCLDNS KKNESPFWKL 
YESVKKELDV KSQKENVLQY CRKSGLQTDY ATEKESADGL QGETQLLVSR KSRPKSGGSG 
HAVAEPASPE QELDQNKGKG RDVESVQTPS KAVGASFPLY EPAKMKTPVQ YSQQQNSPQK 
HKNKDLYTTG RRESVNLGKS EGFKAGDKTL TPRKLSTRNR TPAKVEDAAD SATKPENLSS 
KTRGSIPTDV EVLPTETEIH NEPFLTLWLT QVERKIQKDS LSKPEKLGTT AGQMCSGLPG 
LSSVDINNFG DSINESEGIP LKRRRVSFGG HLRPELFDEN LPPNTPLKRG EAPTKRKSLV 
MHTPPVLKKI IKEQPQPSGK QESGSEIHVE VKAQSLVISP PAPSPRKTPV ASDQRRRSCK 
TAPASSSKSQ TEVPKRGGRK SGNLPSKRVS ISRSQHDILQ MICSKRRSGA SEANLIVAKS 
WADVVKLGAK QTQTKVIKHG PQRSMNKRQR RPATPKKPVG EVHSQFSTGH ANSPCTIIIG 
KAHTEKVHVP ARPYRVLNNF ISNQKMDFKE DLSGIAEMFK TPVKEQPQLT STCHIAISNS 
ENLLGKQFQG TDSGEEPLLP TSESFGGNVF FSAQNAAKQP SDKCSASPPL RRQCIRENGN 
VAKTPRNTYK MTSLETKTSD TETEPSKTVS TANRSGRSTE FRNIQKLPVE SKSEETNTEI 
VECILKRGQK ATLLQQRREG EMKEIERPFE TYKENIELKE NDEKMKAMKR SRTWGQKCAP 
MSDLTDLKSL PDTELMKDTA RGQNLLQTQD HAKAPKSEKG KITKMPCQSL QPEPINTPTH 
TKQQLKASLG KVGVKEELLA VGKFTRTSGE TTHTHREPAG DGKSIRTFKE SPKQILDPAA 
RVTGMKKWPR TPKEEAQSLE DLAGFKELFQ TPGPSEESMT DEKTTKIACK SPPPESVDTP 
TSTKQWPKRS LRKADVEEEF LALRKLTPSA GKAMLTPKPA GGDEKDIKAF MGTPVQKLDL 
AGTLPGSKRQ LQTPKEKAQA LEDLAGFKEL FQTPGHTEEL VAAGKTTKIP CDSPQSDPVD 
TPTSTKQRPK RSIRKADVEG ELLACRNLMP SAGKAMHTPK PSVGEEKDII IFVGTPVQKL 
DLTENLTGSK RRPQTPKEEA QALEDLTGFK ELFQTPGHTE EAVAAGKTTK MPCESSPPES 
ADTPTSTRRQ PKTPLEKRDV QKELSALKKL TQTSGETTHT DKVPGGEDKS INAFRETAKQ 
KLDPAASVTG SKRHPKTKEK AQPLEDLAGL KELFQTPVCT DKPTTHEKTT KIACRSQPDP 
VDTPTSSKPQ SKRSLRKVDV EEEFFALRKR TPSAGKAMHT PKPAVSGEKN IYAFMGTPVQ 
KLDLTENLTG SKRRLQTPKE KAQALEDLAG FKELFQTRGH TEESMTNDKT AKVACKSSQP 
DPDKNPASSK RRLKTSLGKV GVKEELLAVG KLTQTSGETT HTHTEPTGDG KSMKAFMESP 
KQILDSAASL TGSKRQLRTP KGKSEVPEDL AGFIELFQTP SHTKESMTNE KTTKVSYRAS 
QPDLVDTPTS SKPQPKRSLR KADTEEEFLA FRKQTPSAGK AMHTPKPAVG EEKDINTFLG 
TPVQKLDQPG NLPGSNRRLQ TRKEKAQALE ELTGFRELFQ TPCTDNPTTD EKTTKKILCK 
SPQSDPADTP TNTKQRPKRS LKKADVEEEF LAFRKLTPSA GKAMHTPKAA VGEEKDINTF 
VGTPVEKLDL LGNLPGSKRR PQTPKEKAKA LEDLAGFKEL FQTPGHTEES MTDDKITEVS 
CKSPQPDPVK TPTSSKQRLK ISLGKVGVKE EVLPVGKLTQ TSGKTTQTHR ETAGDGKSIK 
AFKESAKQML DPANYGTGME RWPRTPKEEA QSLEDLAGFK ELFQTPDHTE ESTTDDKTTK 
IACKSPPPES MDTPTSTRRR PKTPLGKRDI VEELSALKQL TQTTHTDKVP GDEDKGINVF 
RETAKQKLDP AASVTGSKRQ PRTPKGKAQP LEDLAGLKEL FQTPICTDKP TTHEKTTKIA 
CRSPQPDPVG TPTIFKPQSK RSLRKADVEE ESLALRKRTP SVGKAMDTPK PAGGDEKDMK 
AFMGTPVQKL DLPGNLPGSK RWPQTPKEKA QALEDLAGFK ELFQTPGTDK PTTDEKTTKI 
ACKSPQPDPV DTPASTKQRP KRNLRKADVE EEFLALRKRT PSAGKAMDTP KPAVSDEKNI 
NTFVETPVQK LDLLGNLPGS KRQPQTPKEK AEALEDLVGF KELFQTPGHT EESMTDDKIT 
EVSCKSPQPE SFKTSRSSKQ RLKIPLVKVD MKEEPLAVSK LTRTSGETTQ THTEPTGDSK 
SIKAFKESPK QILDPAASVT GSRRQLRTRK EKARALEDLV DFKELFSAPG HTEESMTIDK 
NTKIPCKSPP PELTDTATST KRCPKTRPRK EVKEELSAVE RLTQTSGQST HTHKEPASGD 
EGIKVLKQRA KKKPNPVEEE PSRRRPRAPK EKAQPLEDLA GFTELSETSG HTQESLTAGK 
ATKIPCESPP LEVVDTTAST KRHLRTRVQK VQVKEEPSAV KFTQTSGETT DADKEPAGED 
KGIKALKESA KQTPAPAASV TGSRRRPRAP RESAQAIEDL AGFKDPAAGH TEESMTDDKT 
TKIPCKSSPE LEDTATSSKR RPRTRAQKVE VKEELLAVGK LTQTSGETTH TDKEPVGEGK 
GTKAFKQPAK RKLDAEDVIG SRRQPRAPKE KAQPLEDLAS FQELSQTPGH TEELANGAAD 
SFTSAPKQTP DSGKPLKISR RVLRAPKVEP VGDVVSTRDP VKSQSKSNTS LPPLPFKRGG 
GKDGSVTGTK RLRCMPAPEE IVEELPASKK QRVAPRARGK SSEPVVIMKR SLRTSAKRIE 
PAEELNSNDM KTNKEEHKLQ DSVPENKGIS LRSRRQNKTE AEQQITEVFV LAERIEINRN 
EKKPMKTSPE MDIQNPDDGA RKPIPRDKVT ENKRCLRSAR QNESSQPKVA EESGGQKSAK 
VLMQNQKGKG EAGNSDSMCL RSRKTKSQPA ASTLESKSVQ RVTRSVKRCA ENPKKAEDNV 
CVKKIRTRSH RDSEDI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.