Details for: PLD3
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 72.78rCSI 71.58%PRS 62.53
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CSI 70.95rCSI 74.33%PRS 63.48
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CSI 60.93rCSI 55.94%PRS 68.68
-
CSI 43.45rCSI 82.03%PRS 70.4
-
CSI 40.96rCSI 65.88%PRS 43.91
-
CSI 38.91rCSI 65.32%PRS 41.81
-
CSI 36.5rCSI 33.68%PRS 61.35
-
CSI 35.4rCSI 29.35%PRS 58.83
-
CSI 35.38rCSI 44.48%PRS 71.89
-
CSI 35.29rCSI 43.9%PRS 39.88
-
CSI 34.14rCSI 40.98%PRS 57.93
-
CSI 31.86rCSI 38.06%PRS 41.64
-
CSI 31.74rCSI 43.25%PRS 51.78
-
CSI 31.08rCSI 54.89%PRS 40.85
-
CSI 29.53rCSI 38.07%PRS 43.04
-
CSI 28.13rCSI 62.13%PRS 46.23
-
CSI 28.05rCSI 68.17%PRS 40.45
-
CSI 27.92rCSI 29.18%PRS 57.95
-
CSI 26.37rCSI 18.93%PRS 74.23
-
CSI 26rCSI 42.82%PRS 65.26
-
CSI 25.06rCSI 35.76%PRS 62.28
-
CSI 23.44rCSI 29.84%PRS 66.47
-
CSI 21.89rCSI 33.96%PRS 67.57
-
CSI 20.93rCSI 16.47%PRS 66.5
-
CSI 20.51rCSI 46.54%PRS 64.02
-
CSI 20.37rCSI 63.66%PRS 43.4
-
CSI 18.84rCSI 67.8%PRS 40.22
-
CSI 18.67rCSI 70.56%PRS 42.67
-
CSI 18.49rCSI 57.82%PRS 45.99
-
CSI 17.87rCSI 42.97%PRS 67.74
-
CSI 16.96rCSI 45.18%PRS 49.3
-
CSI 16.2rCSI 16.58%PRS 74.8
-
CSI 16.04rCSI 60.54%PRS 46.57
-
CSI 15.89rCSI 63.25%PRS 72.88
-
CSI 15.82rCSI 40.17%PRS 54.24
-
CSI 15.24rCSI 34.85%PRS 59.69
-
CSI 15.09rCSI 14.26%PRS 59.37
-
CSI 14.98rCSI 10.42%PRS 70.83
-
CSI 14.87rCSI 11.01%PRS 52.49
-
CSI 14.75rCSI 26.83%PRS 78.55
-
CSI 13.95rCSI 22.49%PRS 63.84
-
CSI 13.88rCSI 31%PRS 67.62
-
CSI 13.61rCSI 13.1%PRS 60.1
-
CSI 13.5rCSI 19.76%PRS 64.24
-
CSI 13.44rCSI 16.1%PRS 76.93
-
CSI 12.73rCSI 58.8%PRS 78.77
-
CSI 12.4rCSI 73.02%PRS 43.14
-
CSI 11.75rCSI 54.78%PRS 77.15
-
CSI 11.73rCSI 15.69%PRS 68.77
-
CSI 11.67rCSI 25.31%PRS 47.91
-
CSI 11.59rCSI 25.66%PRS 57.82
-
CSI 11.52rCSI 9.65%PRS 64.38
-
CSI 11.34rCSI 15.7%PRS 61.17
-
CSI 11.1rCSI 24.91%PRS 77.96
-
CSI 10.82rCSI 8.13%PRS 65.28
-
CSI 10.65rCSI 8.65%PRS 60.38
-
CSI 10.63rCSI 21.33%PRS 49.05
-
CSI 10.57rCSI 27.31%PRS 54.83
-
CSI 10.5rCSI 10.96%PRS 60.14
-
CSI 10.41rCSI 19.5%PRS 48.43
-
CSI 10.11rCSI 12.6%PRS 70.71
-
CSI 10.04rCSI 15.52%PRS 57.92
-
CSI 9.9rCSI 8.7%PRS 65.34
-
CSI 9.79rCSI 22.34%PRS 51.77
-
CSI 9.75rCSI 25.72%PRS 68.78
-
CSI 9.7rCSI 7.33%PRS 73.79
-
CSI 9.67rCSI 27.2%PRS 56.66
-
CSI 9.64rCSI 25.04%PRS 76.21
-
CSI 9.54rCSI 16.72%PRS 51.93
-
CSI 9.47rCSI 8.17%PRS 65.66
-
CSI 9.44rCSI 32.33%PRS 49.01
-
CSI 9.34rCSI 12.76%PRS 61.71
-
CSI 9.21rCSI 6.14%PRS 80.11
-
CSI 9.06rCSI 38.09%PRS 73.57
-
CSI 9.02rCSI 15.9%PRS 68.2
-
CSI 9rCSI 8.37%PRS 60.34
-
CSI 8.87rCSI 13.55%PRS 69.28
-
CSI 8.54rCSI 10.32%PRS 68.64
-
CSI 8.39rCSI 21.28%PRS 49.33
-
CSI 8.31rCSI 12.77%PRS 56.36
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CSI 8.22rCSI 12.09%PRS 53.76
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CSI 8.18rCSI 23.56%PRS 73.64
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CSI 8.11rCSI 6.28%PRS 61.5
-
CSI 8.09rCSI 10.38%PRS 57.22
-
CSI 8rCSI 12.64%PRS 61.94
-
CSI 7.82rCSI 20.32%PRS 63.47
-
CSI 7.79rCSI 6.16%PRS 46.76
-
CSI 7.76rCSI 60.77%PRS 71.81
-
CSI 7.68rCSI 56.43%PRS 46.8
-
CSI 7.67rCSI 8.22%PRS 59.08
-
CSI 7.55rCSI 15.51%PRS 78.48
-
CSI 7.55rCSI 5.61%PRS 73.12
-
CSI 7.46rCSI 11.37%PRS 56.24
-
CSI 7.4rCSI 26.29%PRS 69.06
-
CSI 7.36rCSI 17.47%PRS 63.73
-
CSI 7.29rCSI 28.18%PRS 74.72
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CSI 7.28rCSI 6.57%PRS 56.72
-
CSI 7.19rCSI 11.77%PRS 49.2
-
CSI 7.18rCSI 6.92%PRS 50.4
-
CSI 7.13rCSI 4.74%PRS 63.1
-
CSI 0.3rCSI 2.6%PRS 79.3%
-
CSI 0.3rCSI 3.2%PRS 81.5%
-
CSI 0.3rCSI 4.9%PRS 83.0%
-
CSI 0.3rCSI 1.7%PRS 69.4%
-
CSI 0.3rCSI 1.3%PRS 72.5%
-
CSI 0.4rCSI 10.1%PRS 79.3%
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CSI 0.6rCSI 5.6%PRS 90.7%
-
CSI 0.6rCSI 2.9%PRS 71.2%
-
CSI 0.7rCSI 7.1%PRS 75.1%
-
CSI 0.7rCSI 4.0%PRS 79.0%
-
CSI 0.7rCSI 2.2%PRS 60.6%
-
CSI 0.8rCSI 8.5%PRS 58.4%
-
CSI 0.8rCSI 3.8%PRS 87.2%
-
CSI 0.8rCSI 0.9%PRS 70.5%
-
CSI 0.9rCSI 8.0%PRS 70.8%
-
CSI 0.9rCSI 27.8%PRS 79.9%
-
CSI 0.9rCSI 3.7%PRS 76.3%
-
CSI 0.9rCSI 4.4%PRS 76.7%
-
CSI 1.0rCSI 6.9%PRS 77.1%
-
CSI 1.0rCSI 4.7%PRS 58.8%
-
CSI 1.0rCSI 2.7%PRS 57.6%
-
CSI 1.1rCSI 4.2%PRS 59.4%
-
CSI 1.1rCSI 2.9%PRS 51.1%
-
CSI 1.1rCSI 14.5%PRS 80.5%
-
CSI 1.1rCSI 2.5%PRS 74.0%
-
CSI 1.2rCSI 2.4%PRS 77.3%
-
CSI 1.2rCSI 1.7%PRS 79.6%
-
CSI 1.3rCSI 10.9%PRS 53.2%
-
CSI 1.3rCSI 2.4%PRS 75.3%
-
CSI 1.4rCSI 9.6%PRS 74.8%
-
CSI 1.4rCSI 1.9%PRS 80.9%
-
CSI 1.4rCSI 3.1%PRS 78.1%
-
CSI 1.5rCSI 2.4%PRS 71.0%
-
CSI 1.6rCSI 5.5%PRS 72.5%
-
CSI 1.6rCSI 3.0%PRS 75.5%
-
CSI 1.6rCSI 5.5%PRS 64.3%
-
CSI 1.6rCSI 2.0%PRS 70.3%
-
CSI 1.6rCSI 2.5%PRS 64.1%
-
CSI 1.6rCSI 14.4%PRS 46.6%
-
CSI 1.6rCSI 4.3%PRS 64.2%
-
CSI 1.7rCSI 4.8%PRS 49.7%
-
CSI 1.7rCSI 8.4%PRS 72.3%
-
CSI 1.7rCSI 3.2%PRS 79.9%
-
CSI 1.7rCSI 3.6%PRS 71.5%
-
CSI 1.7rCSI 38.9%PRS 81.8%
-
CSI 1.7rCSI 2.6%PRS 75.6%
-
CSI 1.8rCSI 7.7%PRS 50.5%
-
CSI 1.8rCSI 7.5%PRS 59.9%
-
CSI 1.8rCSI 9.2%PRS 84.5%
-
CSI 1.9rCSI 2.9%PRS 68.8%
-
CSI 1.9rCSI 3.5%PRS 82.1%
-
CSI 1.9rCSI 13.2%PRS 73.2%
-
CSI 1.9rCSI 10.8%PRS 70.6%
-
CSI 2.0rCSI 12.5%PRS 41.8%
-
CSI 2.1rCSI 5.9%PRS 61.4%
-
CSI 2.1rCSI 54.2%PRS 81.9%
-
CSI 2.1rCSI 3.1%PRS 76.0%
-
CSI 2.1rCSI 13.4%PRS 77.9%
-
CSI 2.1rCSI 1.8%PRS 70.5%
-
CSI 2.1rCSI 3.1%PRS 70.8%
-
CSI 2.2rCSI 9.3%PRS 53.8%
-
CSI 2.2rCSI 5.7%PRS 59.7%
-
CSI 2.2rCSI 3.0%PRS 53.7%
-
CSI 2.2rCSI 5.5%PRS 58.3%
-
CSI 2.3rCSI 1.8%PRS 77.9%
-
CSI 2.3rCSI 6.0%PRS 78.6%
-
CSI 2.3rCSI 2.7%PRS 49.9%
-
CSI 2.4rCSI 2.4%PRS 73.0%
-
CSI 2.4rCSI 37.4%PRS 64.8%
-
CSI 2.4rCSI 2.1%PRS 64.7%
-
CSI 2.4rCSI 5.8%PRS 70.9%
-
CSI 2.4rCSI 4.8%PRS 57.7%
-
CSI 2.4rCSI 2.8%PRS 67.6%
-
CSI 2.5rCSI 4.0%PRS 49.6%
-
CSI 2.6rCSI 15.9%PRS 75.2%
-
CSI 2.6rCSI 65.4%PRS 88.3%
-
CSI 2.7rCSI 16.7%PRS 51.9%
-
CSI 2.7rCSI 3.9%PRS 71.4%
-
CSI 2.7rCSI 15.2%PRS 45.1%
-
CSI 2.7rCSI 6.1%PRS 56.4%
-
CSI 2.7rCSI 14.9%PRS 76.1%
-
CSI 2.7rCSI 2.9%PRS 56.3%
-
CSI 2.8rCSI 4.2%PRS 60.5%
-
CSI 2.8rCSI 12.4%PRS 43.9%
-
CSI 2.8rCSI 3.4%PRS 67.4%
-
CSI 2.8rCSI 8.1%PRS 72.7%
-
CSI 2.9rCSI 13.4%PRS 78.1%
-
CSI 3.0rCSI 3.7%PRS 56.2%
-
CSI 3.1rCSI 4.9%PRS 52.2%
-
CSI 3.1rCSI 33.3%PRS 81.9%
-
CSI 3.1rCSI 4.4%PRS 64.1%
-
CSI 3.1rCSI 4.6%PRS 61.7%
-
CSI 3.2rCSI 65.2%PRS 52.3%
-
CSI 3.2rCSI 25.7%PRS 79.5%
-
CSI 3.2rCSI 17.3%PRS 72.3%
-
CSI 3.2rCSI 47.8%PRS 75.3%
-
CSI 3.3rCSI 5.6%PRS 68.7%
-
CSI 3.3rCSI 5.7%PRS 57.0%
-
CSI 3.3rCSI 78.8%PRS 41.9%
-
CSI 3.3rCSI 79.2%PRS 41.0%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Comma-separated if multiple.
Comma-separated if multiple.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.
Genular Protein ID: 3367634095
Symbol: PLD3_HUMAN
Name: Choline phosphatase 3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9140189
Title: A human homolog of the vaccinia virus HindIII K4L gene is a member of the phospholipase D superfamily.
PubMed ID: 9140189
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15794758
Title: Hu-K4 is a ubiquitously expressed type 2 transmembrane protein associated with the endoplasmic reticulum.
PubMed ID: 15794758
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22428023
Title: A role for phospholipase D3 in myotube formation.
PubMed ID: 22428023
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24336208
Title: Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease.
PubMed ID: 24336208
DOI: 10.1038/nature12825
PubMed ID: 26411346
Title: Rare variants in PLD3 do not affect risk for early-onset Alzheimer disease in a European consortium cohort.
PubMed ID: 26411346
DOI: 10.1002/humu.22908
PubMed ID: 25832408
PubMed ID: 25832410
PubMed ID: 25832411
PubMed ID: 25832413
PubMed ID: 25832409
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 29053796
Title: Exome sequencing and network analysis identifies shared mechanisms underlying spinocerebellar ataxia.
PubMed ID: 29053796
DOI: 10.1093/brain/awx251
PubMed ID: 28128235
PubMed ID: 30312375
PubMed ID: 29368044
Title: Analysis of novel endosome-to-Golgi retrieval genes reveals a role for PLD3 in regulating endosomal protein sorting and amyloid precursor protein processing.
PubMed ID: 29368044
PubMed ID: 29386126
Title: Unconventional Trafficking of Mammalian Phospholipase D3 to Lysosomes.
PubMed ID: 29386126
Sequence Information:
- Length: 490
- Mass: 54705
- Checksum: 444EC4D02F5610F1
- Sequence:
MKPKLMYQEL KVPAEEPANE LPMNEIEAWK AAEKKARWVL LVLILAVVGF GALMTQLFLW EYGDLHLFGP NQRPAPCYDP CEAVLVESIP EGLDFPNAST GNPSTSQAWL GLLAGAHSSL DIASFYWTLT NNDTHTQEPS AQQGEEVLRQ LQTLAPKGVN VRIAVSKPSG PQPQADLQAL LQSGAQVRMV DMQKLTHGVL HTKFWVVDQT HFYLGSANMD WRSLTQVKEL GVVMYNCSCL ARDLTKIFEA YWFLGQAGSS IPSTWPRFYD TRYNQETPME ICLNGTPALA YLASAPPPLC PSGRTPDLKA LLNVVDNARS FIYVAVMNYL PTLEFSHPHR FWPAIDDGLR RATYERGVKV RLLISCWGHS EPSMRAFLLS LAALRDNHTH SDIQVKLFVV PADEAQARIP YARVNHNKYM VTERATYIGT SNWSGNYFTE TAGTSLLVTQ NGRGGLRSQL EAIFLRDWDS PYSHDLDTSA DSVGNACRLL