PLD3 | ENSG00000105223 | NCBI 23646

Details for: PLD3

Gene ID: 23646

Symbol: PLD3

Ensembl ID: ENSG00000105223

Description: phospholipase D family member 3

Associated with

Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Glycerophospholipid biosynthesis
(R-HSA-1483206)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Phospholipid metabolism
(R-HSA-1483257)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Synthesis of pg
(R-HSA-1483148)
Dna metabolic process
(GO:0006259)
Early endosome membrane
(GO:0031901)
Endoplasmic reticulum membrane
(GO:0005789)
Extracellular exosome
(GO:0070062)
Golgi membrane
(GO:0000139)
Immune system process
(GO:0002376)
Inflammatory response
(GO:0006954)
Late endosome membrane
(GO:0031902)
Lysosomal lumen
(GO:0043202)
Lysosomal membrane
(GO:0005765)
Myotube differentiation
(GO:0014902)
Phospholipase d activity
(GO:0004630)
Protein binding
(GO:0005515)
Regulation of cytokine production involved in inflammatory response
(GO:1900015)
Single-stranded dna 5'-3' dna exonuclease activity
(GO:0045145)

Other Information

Proteins

Choline phosphatase 3

Genular Protein ID: 3367634095

Symbol: PLD3_HUMAN

Name: Choline phosphatase 3

UniProtKB Accession Codes:

Q8IV08 Q92853 Q9BW87

Database IDs:

Citations:

PubMed ID: 9140189

Title: A human homolog of the vaccinia virus HindIII K4L gene is a member of the phospholipase D superfamily.

PubMed ID: 9140189

DOI: 10.1016/s0168-1702(96)01422-0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15794758

Title: Hu-K4 is a ubiquitously expressed type 2 transmembrane protein associated with the endoplasmic reticulum.

PubMed ID: 15794758

DOI: 10.1111/j.1742-4658.2005.04601.x

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22428023

Title: A role for phospholipase D3 in myotube formation.

PubMed ID: 22428023

DOI: 10.1371/journal.pone.0033341

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24336208

Title: Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease.

PubMed ID: 24336208

DOI: 10.1038/nature12825

PubMed ID: 26411346

Title: Rare variants in PLD3 do not affect risk for early-onset Alzheimer disease in a European consortium cohort.

PubMed ID: 26411346

DOI: 10.1002/humu.22908

PubMed ID: 25832408

Title: PLD3 and sporadic Alzheimer's disease risk.

PubMed ID: 25832408

DOI: 10.1038/nature14036

PubMed ID: 25832410

Title: PLD3 variants in population studies.

PubMed ID: 25832410

DOI: 10.1038/nature14038

PubMed ID: 25832411

Title: PLD3 in non-familial Alzheimer's disease.

PubMed ID: 25832411

DOI: 10.1038/nature14039

PubMed ID: 25832413

Title: PLD3 gene variants and Alzheimer's disease.

PubMed ID: 25832413

DOI: 10.1038/nature14040

PubMed ID: 25832409

Title: Cruchaga & Goate reply.

PubMed ID: 25832409

DOI: 10.1038/nature14041

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29053796

Title: Exome sequencing and network analysis identifies shared mechanisms underlying spinocerebellar ataxia.

PubMed ID: 29053796

DOI: 10.1093/brain/awx251

PubMed ID: 28128235

Title: PLD3 gene and processing of APP.

PubMed ID: 28128235

DOI: 10.1038/nature21030

PubMed ID: 30312375

Title: PLD3 and spinocerebellar ataxia.

PubMed ID: 30312375

DOI: 10.1093/brain/awy258

PubMed ID: 29368044

Title: Analysis of novel endosome-to-Golgi retrieval genes reveals a role for PLD3 in regulating endosomal protein sorting and amyloid precursor protein processing.

PubMed ID: 29368044

DOI: 10.1007/s00018-018-2752-9

PubMed ID: 29386126

Title: Unconventional Trafficking of Mammalian Phospholipase D3 to Lysosomes.

PubMed ID: 29386126

DOI: 10.1016/j.celrep.2017.12.100

Sequence Information:

Length: 490
Mass: 54705
Checksum: 444EC4D02F5610F1
Sequence:

MKPKLMYQEL KVPAEEPANE LPMNEIEAWK AAEKKARWVL LVLILAVVGF GALMTQLFLW 
EYGDLHLFGP NQRPAPCYDP CEAVLVESIP EGLDFPNAST GNPSTSQAWL GLLAGAHSSL 
DIASFYWTLT NNDTHTQEPS AQQGEEVLRQ LQTLAPKGVN VRIAVSKPSG PQPQADLQAL 
LQSGAQVRMV DMQKLTHGVL HTKFWVVDQT HFYLGSANMD WRSLTQVKEL GVVMYNCSCL 
ARDLTKIFEA YWFLGQAGSS IPSTWPRFYD TRYNQETPME ICLNGTPALA YLASAPPPLC 
PSGRTPDLKA LLNVVDNARS FIYVAVMNYL PTLEFSHPHR FWPAIDDGLR RATYERGVKV 
RLLISCWGHS EPSMRAFLLS LAALRDNHTH SDIQVKLFVV PADEAQARIP YARVNHNKYM 
VTERATYIGT SNWSGNYFTE TAGTSLLVTQ NGRGGLRSQL EAIFLRDWDS PYSHDLDTSA 
DSVGNACRLL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PLD3

Associated with

Other Information

A human homolog of the vaccinia virus HindIII K4L gene is a member of the phospholipase D superfamily. PubMed ID: 9140189

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Hu-K4 is a ubiquitously expressed type 2 transmembrane protein associated with the endoplasmic reticulum. PubMed ID: 15794758

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Initial characterization of the human central proteome. PubMed ID: 21269460

A role for phospholipase D3 in myotube formation. PubMed ID: 22428023

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease. PubMed ID: 24336208

Rare variants in PLD3 do not affect risk for early-onset Alzheimer disease in a European consortium cohort. PubMed ID: 26411346

PLD3 and sporadic Alzheimer's disease risk. PubMed ID: 25832408

PLD3 variants in population studies. PubMed ID: 25832410

PLD3 in non-familial Alzheimer's disease. PubMed ID: 25832411

PLD3 gene variants and Alzheimer's disease. PubMed ID: 25832413

Cruchaga &amp; Goate reply. PubMed ID: 25832409

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Exome sequencing and network analysis identifies shared mechanisms underlying spinocerebellar ataxia. PubMed ID: 29053796

PLD3 gene and processing of APP. PubMed ID: 28128235

PLD3 and spinocerebellar ataxia. PubMed ID: 30312375

Analysis of novel endosome-to-Golgi retrieval genes reveals a role for PLD3 in regulating endosomal protein sorting and amyloid precursor protein processing. PubMed ID: 29368044

Unconventional Trafficking of Mammalian Phospholipase D3 to Lysosomes. PubMed ID: 29386126