Details for: SCD

Gene ID: 6319

Symbol: SCD

Ensembl ID: ENSG00000099194

Description: stearoyl-CoA desaturase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 203.6064
    Cell Significance Index: -31.6700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 122.0611
    Cell Significance Index: -30.9600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.7268
    Cell Significance Index: -31.7200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.8035
    Cell Significance Index: -31.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.0435
    Cell Significance Index: -31.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.1470
    Cell Significance Index: 624.5400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.1047
    Cell Significance Index: 28.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.0246
    Cell Significance Index: 54.2500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.7201
    Cell Significance Index: 45.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0925
    Cell Significance Index: 596.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.9209
    Cell Significance Index: 1252.2000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8858
    Cell Significance Index: 53.1800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.8015
    Cell Significance Index: 13.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7402
    Cell Significance Index: 133.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.7189
    Cell Significance Index: 17.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6701
    Cell Significance Index: 605.0700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6386
    Cell Significance Index: 69.4600
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.6156
    Cell Significance Index: 2.6800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.5862
    Cell Significance Index: 9.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5649
    Cell Significance Index: 29.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.5355
    Cell Significance Index: 405.3300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5236
    Cell Significance Index: 85.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3545
    Cell Significance Index: 19.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3512
    Cell Significance Index: 43.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3490
    Cell Significance Index: 16.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3185
    Cell Significance Index: 31.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2077
    Cell Significance Index: 39.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1325
    Cell Significance Index: 26.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1224
    Cell Significance Index: 230.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1180
    Cell Significance Index: 3.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1174
    Cell Significance Index: 42.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0864
    Cell Significance Index: 132.9500
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.0664
    Cell Significance Index: 1.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0658
    Cell Significance Index: 29.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0545
    Cell Significance Index: 7.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0328
    Cell Significance Index: 60.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0315
    Cell Significance Index: 2.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0310
    Cell Significance Index: 2.3100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0183
    Cell Significance Index: 0.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0005
    Cell Significance Index: 0.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0057
    Cell Significance Index: -3.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0070
    Cell Significance Index: -4.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0107
    Cell Significance Index: -1.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0212
    Cell Significance Index: -2.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0249
    Cell Significance Index: -14.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0270
    Cell Significance Index: -0.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0310
    Cell Significance Index: -1.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0366
    Cell Significance Index: -26.8400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0386
    Cell Significance Index: -0.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0410
    Cell Significance Index: -2.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0473
    Cell Significance Index: -9.9600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0532
    Cell Significance Index: -24.1500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0568
    Cell Significance Index: -1.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0688
    Cell Significance Index: -3.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0780
    Cell Significance Index: -22.4300
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0845
    Cell Significance Index: -0.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1195
    Cell Significance Index: -2.5900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1361
    Cell Significance Index: -1.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1480
    Cell Significance Index: -21.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1549
    Cell Significance Index: -18.0500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1630
    Cell Significance Index: -18.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1830
    Cell Significance Index: -20.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1979
    Cell Significance Index: -6.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2036
    Cell Significance Index: -10.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2063
    Cell Significance Index: -26.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2358
    Cell Significance Index: -27.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2442
    Cell Significance Index: -31.3000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2458
    Cell Significance Index: -6.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2539
    Cell Significance Index: -17.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2719
    Cell Significance Index: -28.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2886
    Cell Significance Index: -10.0300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2924
    Cell Significance Index: -4.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3389
    Cell Significance Index: -15.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3439
    Cell Significance Index: -21.0900
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.3468
    Cell Significance Index: -4.8500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3578
    Cell Significance Index: -28.3400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3922
    Cell Significance Index: -4.8900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.4076
    Cell Significance Index: -4.3700
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.4077
    Cell Significance Index: -2.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4389
    Cell Significance Index: -33.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4464
    Cell Significance Index: -31.5700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4485
    Cell Significance Index: -13.2100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4794
    Cell Significance Index: -6.0500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4869
    Cell Significance Index: -14.3000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4901
    Cell Significance Index: -31.6200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5158
    Cell Significance Index: -14.7200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5241
    Cell Significance Index: -7.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5452
    Cell Significance Index: -34.3700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.5802
    Cell Significance Index: -18.3500
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.6433
    Cell Significance Index: -5.3100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6633
    Cell Significance Index: -24.3500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.6795
    Cell Significance Index: -10.2400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.6929
    Cell Significance Index: -10.7200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7200
    Cell Significance Index: -4.3500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7347
    Cell Significance Index: -12.3000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7707
    Cell Significance Index: -27.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7716
    Cell Significance Index: -34.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8360
    Cell Significance Index: -27.3700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.8465
    Cell Significance Index: -12.0500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.8478
    Cell Significance Index: -7.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression in various tissues:** The SCD gene is significantly expressed in multiple cell types, including hepatoblasts, oligodendrocytes, type II pneumocytes, pneumocytes, secondary lens fibers, corneal endothelial cells, keratinocytes, stratified epithelial cells, type A enteroendocrine cells, and alveolar macrophages. 2. **Enzymatic activity:** SCD is a palmitoyl-CoA 9-desaturase, which catalyzes the conversion of saturated fatty acids to monounsaturated fatty acids. 3. **Regulation by nuclear receptors:** The SCD gene is regulated by nuclear receptors, including SREBP (sterol regulatory element-binding protein) and NR1H2/NR1H3, which are key transcription factors involved in lipid metabolism. 4. **Involvement in fatty acid biosynthesis:** SCD plays a crucial role in the biosynthesis of monounsaturated fatty acids, which are essential for various cellular processes. **Pathways and Functions:** 1. **Fatty acid metabolism:** SCD is involved in the conversion of saturated fatty acids to monounsaturated fatty acids, which are then used for energy production, membrane fluidity, and signaling pathways. 2. **Cholesterol biosynthesis:** SCD regulates cholesterol biosynthesis by influencing the expression of genes involved in the mevalonate pathway. 3. **Thermogenesis:** SCD is involved in the regulation of cold-induced thermogenesis, a process that involves the production of heat in response to cold exposure. 4. **Signaling pathways:** SCD is involved in various signaling pathways, including the peroxisome proliferator-activated receptor gamma (PPARγ) and the nuclear factor kappa B (NF-κB) pathways. 5. **Oxidoreductase activity:** SCD exhibits oxidoreductase activity, which involves the reduction of oxidized fatty acids to their corresponding alcohols. **Clinical Significance:** 1. **Metabolic disorders:** Alterations in SCD expression have been linked to various metabolic disorders, including obesity, type 2 diabetes, and dyslipidemia. 2. **Cancer:** SCD has been implicated in the development and progression of various cancers, including breast, prostate, and colon cancer. 3. **Neurological disorders:** SCD has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Thermogenic regulation:** SCD plays a crucial role in the regulation of thermogenesis, which is essential for energy homeostasis and glucose metabolism. In conclusion, the stearoyl-CoA desaturase gene is a crucial regulator of fatty acid metabolism and has implications for various cellular processes, including lipid metabolism, cholesterol biosynthesis, thermogenesis, and signaling pathways. Further studies are needed to fully elucidate the functions and clinical significance of the SCD gene.

Genular Protein ID: 3118464859

Symbol: SCD_HUMAN

Name: Acyl-CoA desaturase

UniProtKB Accession Codes:

O00767 B2R5U0 D3DR68 Q16150 Q53GR9 Q5W037 Q5W038 Q6GSS4 Q96KF6 Q9BS07 Q9Y695

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 24 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 12 Ensembl 1 EvolutionaryTrace 1 GO 12 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 6 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10229681

Title: Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites.

PubMed ID: 10229681

DOI: 10.1042/bj3400255

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11415448

Title: Isolation and characterization of the human stearoyl-CoA desaturase gene promoter: requirement of a conserved CCAAT cis-element.

PubMed ID: 11415448

DOI: 10.1042/0264-6021:3570183

PubMed ID: 19892738

Title: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.

PubMed ID: 19892738

DOI: 10.1073/pnas.0908958106

PubMed ID: 7909540

Title: Partial characterization of a cDNA for human stearoyl-CoA desaturase and changes in its mRNA expression in some normal and malignant tissues.

PubMed ID: 7909540

DOI: 10.1002/ijc.2910570310

PubMed ID: 15907797

Title: Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates.

PubMed ID: 15907797

DOI: 10.1016/j.bbrc.2005.05.013

PubMed ID: 15610069

Title: Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells.

PubMed ID: 15610069

DOI: 10.1042/bj20041554

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18765284

Title: Wheat germ cell-free translation, purification, and assembly of a functional human stearoyl-CoA desaturase complex.

PubMed ID: 18765284

DOI: 10.1016/j.pep.2008.08.002

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26098317

Title: Crystal structure of human stearoyl-coenzyme A desaturase in complex with substrate.

PubMed ID: 26098317

DOI: 10.1038/nsmb.3049

Sequence Information:

  • Length: 359
  • Mass: 41523
  • Checksum: ED56A63DBD850F05
  • Sequence:
    • MPAHLLQDDI SSSYTTTTTI TAPPSRVLQN GGDKLETMPL YLEDDIRPDI KDDIYDPTYK 
DKEGPSPKVE YVWRNIILMS LLHLGALYGI TLIPTCKFYT WLWGVFYYFV SALGITAGAH 
RLWSHRSYKA RLPLRLFLII ANTMAFQNDV YEWARDHRAH HKFSETHADP HNSRRGFFFS 
HVGWLLVRKH PAVKEKGSTL DLSDLEAEKL VMFQRRYYKP GLLMMCFILP TLVPWYFWGE 
TFQNSVFVAT FLRYAVVLNA TWLVNSAAHL FGYRPYDKNI SPRENILVSL GAVGEGFHNY 
HHSFPYDYSA SEYRWHINFT TFFIDCMAAL GLAYDRKKVS KAAILARIKR TGDGNYKSG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.