Details for: NME1

Gene ID: 4830

Symbol: NME1

Ensembl ID: ENSG00000239672

Description: NME/NM23 nucleoside diphosphate kinase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 270.3394
    Cell Significance Index: -42.0500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 126.3996
    Cell Significance Index: -52.0700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 123.1651
    Cell Significance Index: -31.2400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 107.7051
    Cell Significance Index: -50.8500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 92.3724
    Cell Significance Index: -47.5200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 75.7054
    Cell Significance Index: -50.8000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 39.7662
    Cell Significance Index: -49.0300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.7227
    Cell Significance Index: -39.4400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.4438
    Cell Significance Index: -53.0500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.3199
    Cell Significance Index: -37.8400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 5.1700
    Cell Significance Index: 56.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 4.0094
    Cell Significance Index: 252.7000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 3.8633
    Cell Significance Index: 103.3400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.6177
    Cell Significance Index: 28.8900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.6128
    Cell Significance Index: 54.6900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.6098
    Cell Significance Index: 90.6900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.0771
    Cell Significance Index: 1875.4600
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 2.0144
    Cell Significance Index: 11.4500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.8219
    Cell Significance Index: 296.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.6585
    Cell Significance Index: 214.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.6398
    Cell Significance Index: 115.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.5618
    Cell Significance Index: 72.8200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.5478
    Cell Significance Index: 13.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.3989
    Cell Significance Index: 104.2600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.3715
    Cell Significance Index: 12.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3373
    Cell Significance Index: 730.3200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.3065
    Cell Significance Index: 10.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.2839
    Cell Significance Index: 567.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2261
    Cell Significance Index: 150.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.2098
    Cell Significance Index: 56.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1381
    Cell Significance Index: 205.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1250
    Cell Significance Index: 58.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0478
    Cell Significance Index: 67.6000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0293
    Cell Significance Index: 71.1800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.9862
    Cell Significance Index: 51.7800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.9155
    Cell Significance Index: 10.4000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7436
    Cell Significance Index: 17.1800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5435
    Cell Significance Index: 103.4400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4240
    Cell Significance Index: 11.1500
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.4109
    Cell Significance Index: 3.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3775
    Cell Significance Index: 51.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.3773
    Cell Significance Index: 108.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2692
    Cell Significance Index: 54.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2662
    Cell Significance Index: 34.1300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2368
    Cell Significance Index: 27.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2351
    Cell Significance Index: 40.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2274
    Cell Significance Index: 172.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1436
    Cell Significance Index: 6.5100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1406
    Cell Significance Index: 4.0300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0931
    Cell Significance Index: 1.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0878
    Cell Significance Index: 1.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0567
    Cell Significance Index: 20.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0476
    Cell Significance Index: 1.2700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0326
    Cell Significance Index: 0.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0018
    Cell Significance Index: -1.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0042
    Cell Significance Index: -3.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0149
    Cell Significance Index: -9.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0277
    Cell Significance Index: -52.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0392
    Cell Significance Index: -72.3600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0397
    Cell Significance Index: -27.4400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0454
    Cell Significance Index: -2.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0469
    Cell Significance Index: -72.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0531
    Cell Significance Index: -72.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0599
    Cell Significance Index: -33.7900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0690
    Cell Significance Index: -43.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0727
    Cell Significance Index: -7.4300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0867
    Cell Significance Index: -3.5500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0971
    Cell Significance Index: -2.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1104
    Cell Significance Index: -23.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1117
    Cell Significance Index: -12.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1126
    Cell Significance Index: -51.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1320
    Cell Significance Index: -15.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1611
    Cell Significance Index: -15.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1867
    Cell Significance Index: -5.9800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1939
    Cell Significance Index: -11.6400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2298
    Cell Significance Index: -3.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2326
    Cell Significance Index: -46.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2368
    Cell Significance Index: -8.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2883
    Cell Significance Index: -17.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3301
    Cell Significance Index: -47.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3542
    Cell Significance Index: -9.6400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3563
    Cell Significance Index: -40.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3937
    Cell Significance Index: -8.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4172
    Cell Significance Index: -33.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4534
    Cell Significance Index: -25.4400
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.4771
    Cell Significance Index: -5.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5167
    Cell Significance Index: -53.8000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5558
    Cell Significance Index: -6.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5982
    Cell Significance Index: -16.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6728
    Cell Significance Index: -51.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7027
    Cell Significance Index: -43.0800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7742
    Cell Significance Index: -8.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7897
    Cell Significance Index: -53.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.8197
    Cell Significance Index: -20.4900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.8490
    Cell Significance Index: -5.2300
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.9201
    Cell Significance Index: -5.7600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.9592
    Cell Significance Index: -28.1700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0172
    Cell Significance Index: -29.9600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.0556
    Cell Significance Index: -46.6900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.0661
    Cell Significance Index: -15.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Multifunctional Protein:** NME1 is a nucleoside diphosphate kinase that catalyzes the interconversion of nucleotide di- and triphosphates, which is essential for various cellular processes, including DNA synthesis, repair, and metabolism. 2. **Cellular Expression:** NME1 is significantly expressed in various cell types, including myoepithelial cells of the mammary gland, retinal rod cells, erythroid progenitor cells, and neural crest cells. 3. **Regulation of Cell Proliferation:** NME1 is involved in the regulation of cell proliferation, particularly in the context of epithelial cell proliferation and negative regulation of cell population proliferation. 4. **Apoptosis Regulation:** NME1 plays a role in regulating apoptotic processes, which is essential for maintaining cellular homeostasis and preventing tumor formation. **Pathways and Functions:** 1. **Nucleotide Metabolism:** NME1 is involved in the interconversion of nucleotide di- and triphosphates, which is essential for DNA synthesis, repair, and metabolism. 2. **Phosphorylation Events:** NME1 catalyzes the phosphorylation of various substrates, including nucleosides, nucleotides, and proteins, which regulates cellular processes, including differentiation and cell proliferation. 3. **Apoptosis Regulation:** NME1 regulates apoptotic processes by interacting with pro-apoptotic and anti-apoptotic proteins, which modulates the balance between cell survival and death. 4. **Cell Differentiation:** NME1 is involved in the regulation of cell differentiation, particularly in the context of epithelial cell differentiation and development. **Clinical Significance:** 1. **Cancer Therapy:** NME1 is a potential target for cancer therapy, as its overexpression has been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Regulation of Cell Proliferation:** NME1's role in regulating cell proliferation makes it a potential target for the treatment of diseases characterized by uncontrolled cell growth, such as cancer and autoimmune disorders. 3. **Neurological Disorders:** NME1's involvement in neuronal development and function makes it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Regulation of Apoptosis:** NME1's role in regulating apoptosis makes it a potential target for the treatment of diseases characterized by uncontrolled cell death, such as cancer and neurodegenerative disorders. In conclusion, NME1 is a multifunctional gene that plays a crucial role in various cellular processes, including metabolism, differentiation, and regulation of cell proliferation. Its clinical significance is evident in its potential as a target for cancer therapy, regulation of cell proliferation, and treatment of neurological disorders. Further research is needed to fully understand the mechanisms of NME1 and its potential applications in human disease.

Genular Protein ID: 3737685944

Symbol: NDKA_HUMAN

Name: Nucleoside diphosphate kinase A

UniProtKB Accession Codes:

P15531 Q6FGK3 Q86XQ2 Q9UDJ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTC 1 CTD 1 ChEBI 15 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 26 EC 3 EMBL 11 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 Rhea 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2509941

Title: Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development.

PubMed ID: 2509941

DOI: 10.1038/342177a0

PubMed ID: 1851158

Title: Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme.

PubMed ID: 1851158

DOI: 10.1016/s0021-9258(18)31515-1

PubMed ID: 7916650

Title: Mutation in the nm23 gene is associated with metastasis in colorectal cancer.

PubMed ID: 7916650

PubMed ID: 8270257

Title: Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1.

PubMed ID: 8270257

DOI: 10.1007/bf00218915

PubMed ID: 12601555

Title: Isolation and characterization of a novel human NM23-H1B gene, a different transcript of NM23-H1.

PubMed ID: 12601555

DOI: 10.1007/s100380300014

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2056128

Title: High levels of p19/nm23 protein in neuroblastoma are associated with advanced stage disease and with N-myc gene amplification.

PubMed ID: 2056128

DOI: 10.1172/jci115299

PubMed ID: 8810265

Title: Site-directed mutagenesis of nm23-H1. Mutation of proline 96 or serine 120 abrogates its motility inhibitory activity upon transfection into human breast carcinoma cells.

PubMed ID: 8810265

DOI: 10.1074/jbc.271.41.25107

PubMed ID: 10512675

Title: Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display.

PubMed ID: 10512675

DOI: 10.1006/geno.1999.5939

PubMed ID: 12628186

Title: Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor.

PubMed ID: 12628186

DOI: 10.1016/s0092-8674(03)00150-8

PubMed ID: 16442775

Title: Read-through transcript from NM23-H1 into the neighboring NM23-H2 gene encodes a novel protein, NM23-LV.

PubMed ID: 16442775

DOI: 10.1016/j.ygeno.2005.11.004

PubMed ID: 16818237

Title: The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death.

PubMed ID: 16818237

DOI: 10.1016/j.molcel.2006.06.005

PubMed ID: 17906697

Title: Phosphorylation of nm23-H1 by CKI induces its complex formation with h-prune and promotes cell motility.

PubMed ID: 17906697

DOI: 10.1038/sj.onc.1210822

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 11835509

Title: Crystal structure of human nucleoside diphosphate kinase A, a metastasis suppressor.

PubMed ID: 11835509

DOI: 10.1002/prot.10038

PubMed ID: 12972261

Title: Nucleotide binding to nucleoside diphosphate kinases: X-ray structure of human NDPK-A in complex with ADP and comparison to protein kinases.

PubMed ID: 12972261

DOI: 10.1016/j.jmb.2003.07.004

PubMed ID: 8047138

Title: Nm23-H1 mutation in neuroblastoma.

PubMed ID: 8047138

DOI: 10.1038/370335a0

Sequence Information:

  • Length: 152
  • Mass: 17149
  • Checksum: AAE9C0DF63CB70A1
  • Sequence:
    • MANCERTFIA IKPDGVQRGL VGEIIKRFEQ KGFRLVGLKF MQASEDLLKE HYVDLKDRPF 
FAGLVKYMHS GPVVAMVWEG LNVVKTGRVM LGETNPADSK PGTIRGDFCI QVGRNIIHGS 
DSVESAEKEI GLWFHPEELV DYTSCAQNWI YE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.