UBE2S | ENSG00000108106 | NCBI 27338

Details for: UBE2S

Gene ID: 27338

Symbol: UBE2S

Ensembl ID: ENSG00000108106

Description: ubiquitin conjugating enzyme E2 S

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic exit in cancer due to rb1 defects
(R-HSA-9687136)
Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176814)
Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Apc-cdc20 mediated degradation of nek2a
(R-HSA-179409)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apc/c:cdc20 mediated degradation of cyclin b
(R-HSA-174048)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176409)
Apc/c:cdc20 mediated degradation of securin
(R-HSA-174154)
Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
(R-HSA-174178)
Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(R-HSA-179419)
Assembly of the pre-replicative complex
(R-HSA-68867)
Autodegradation of cdh1 by cdh1:apc/c
(R-HSA-174084)
Cdc20:phospho-apc/c mediated degradation of cyclin a
(R-HSA-174184)
Cdk-mediated phosphorylation and removal of cdc6
(R-HSA-69017)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Conversion from apc/c:cdc20 to apc/c:cdh1 in late anaphase
(R-HSA-176407)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Inactivation of apc/c via direct inhibition of the apc/c complex
(R-HSA-141430)
Inhibition of the proteolytic activity of apc/c required for the onset of anaphase by mitotic spindle checkpoint components
(R-HSA-141405)
Metabolism of proteins
(R-HSA-392499)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Phosphorylation of the apc/c
(R-HSA-176412)
Post-translational protein modification
(R-HSA-597592)
Protein ubiquitination
(R-HSA-8852135)
Regulation of apc/c activators between g1/s and early anaphase
(R-HSA-176408)
Regulation of mitotic cell cycle
(R-HSA-453276)
Rna polymerase ii transcription
(R-HSA-73857)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Separation of sister chromatids
(R-HSA-2467813)
S phase
(R-HSA-69242)
Switching of origins to a post-replicative state
(R-HSA-69052)
Synthesis of active ubiquitin: roles of e1 and e2 enzymes
(R-HSA-8866652)
Synthesis of dna
(R-HSA-69239)
Transcriptional regulation by ventx
(R-HSA-8853884)
Anaphase-promoting complex
(GO:0005680)
Anaphase-promoting complex-dependent catabolic process
(GO:0031145)
Anaphase-promoting complex binding
(GO:0010997)
Atp binding
(GO:0005524)
Cell division
(GO:0051301)
Cytosol
(GO:0005829)
Exit from mitosis
(GO:0010458)
Free ubiquitin chain polymerization
(GO:0010994)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of ubiquitin protein ligase activity
(GO:1904668)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein binding
(GO:0005515)
Protein k6-linked ubiquitination
(GO:0085020)
Protein k11-linked ubiquitination
(GO:0070979)
Protein k27-linked ubiquitination
(GO:0044314)
Protein k29-linked ubiquitination
(GO:0035519)
Protein k63-linked ubiquitination
(GO:0070534)
Protein modification process
(GO:0036211)
Protein polyubiquitination
(GO:0000209)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin conjugating enzyme activity
(GO:0061631)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 226.3007
Cell Significance Index: -35.2000
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 176.1134
Cell Significance Index: -44.6700
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 93.0814
Cell Significance Index: -37.8200
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 89.9715
Cell Significance Index: -46.2800
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 40.6392
Cell Significance Index: -38.8000
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 36.7978
Cell Significance Index: -45.3700
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 15.5029
Cell Significance Index: -41.5300
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 11.7510
Cell Significance Index: -46.3700
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 8.1232
Cell Significance Index: -24.9500
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 4.1762
Cell Significance Index: -9.1400
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 2.7034
Cell Significance Index: 29.3900
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.2368
Cell Significance Index: 64.1200
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 2.2030
Cell Significance Index: 18.9300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.0768
Cell Significance Index: 56.5300
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.6372
Cell Significance Index: 34.2700
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.6259
Cell Significance Index: 104.9000
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.4915
Cell Significance Index: 242.5700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.3688
Cell Significance Index: 96.8100
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.3319
Cell Significance Index: 144.8700
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.2921
Cell Significance Index: 44.9000
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.2209
Cell Significance Index: 666.7800
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.1608
Cell Significance Index: 60.3000
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.0631
Cell Significance Index: 470.0200
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 1.0483
Cell Significance Index: 8.0800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.9824
Cell Significance Index: 46.1700
Cell Name: odontoblast (CL0000060)
Fold Change: 0.9393
Cell Significance Index: 120.4100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.8662
Cell Significance Index: 39.2600
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.8050
Cell Significance Index: 145.1200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.8002
Cell Significance Index: 98.3900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.7783
Cell Significance Index: 91.7900
Cell Name: germ cell (CL0000586)
Fold Change: 0.7496
Cell Significance Index: 5.6600
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.7099
Cell Significance Index: 15.3800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7082
Cell Significance Index: 20.4100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.6577
Cell Significance Index: 90.3200
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.6528
Cell Significance Index: 39.1900
Cell Name: lactocyte (CL0002325)
Fold Change: 0.6478
Cell Significance Index: 83.6900
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.6380
Cell Significance Index: 5.8800
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.6193
Cell Significance Index: 8.4500
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.5800
Cell Significance Index: 15.2500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.4962
Cell Significance Index: 36.9800
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4877
Cell Significance Index: 92.8100
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4755
Cell Significance Index: 32.8900
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3587
Cell Significance Index: 71.1900
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.3511
Cell Significance Index: 22.1300
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.3411
Cell Significance Index: 17.7700
Cell Name: sensory neuron (CL0000101)
Fold Change: 0.3219
Cell Significance Index: 1.8300
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.3209
Cell Significance Index: 5.6700
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1929
Cell Significance Index: 174.1700
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1747
Cell Significance Index: 6.1400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1631
Cell Significance Index: 16.1300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1566
Cell Significance Index: 31.4100
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.1556
Cell Significance Index: 8.1700
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0498
Cell Significance Index: 1.3300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0487
Cell Significance Index: 17.4500
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.0255
Cell Significance Index: 0.2900
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0094
Cell Significance Index: 0.5200
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0052
Cell Significance Index: -3.8700
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0175
Cell Significance Index: -32.9000
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0256
Cell Significance Index: -47.2400
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0262
Cell Significance Index: -18.0900
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0294
Cell Significance Index: -45.3100
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0320
Cell Significance Index: -43.5100
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0327
Cell Significance Index: -20.4300
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0353
Cell Significance Index: -25.9000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0408
Cell Significance Index: -30.8900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0576
Cell Significance Index: -32.4900
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0584
Cell Significance Index: -37.0900
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0717
Cell Significance Index: -7.3200
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -0.0723
Cell Significance Index: -0.4500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0761
Cell Significance Index: -1.6200
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0866
Cell Significance Index: -39.3000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1012
Cell Significance Index: -17.2900
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1132
Cell Significance Index: -1.9000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1167
Cell Significance Index: -33.5700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1354
Cell Significance Index: -28.5200
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1433
Cell Significance Index: -16.7000
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1841
Cell Significance Index: -21.0900
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1986
Cell Significance Index: -5.5500
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2162
Cell Significance Index: -13.2900
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2342
Cell Significance Index: -7.5000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2828
Cell Significance Index: -41.1100
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3032
Cell Significance Index: -7.7500
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3114
Cell Significance Index: -20.9400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3312
Cell Significance Index: -15.4400
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.3404
Cell Significance Index: -4.3600
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3413
Cell Significance Index: -38.9600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4396
Cell Significance Index: -45.7700
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.4716
Cell Significance Index: -13.8500
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5047
Cell Significance Index: -39.9700
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: -0.5127
Cell Significance Index: -4.2400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5430
Cell Significance Index: -33.2900
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.5833
Cell Significance Index: -4.9000
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.6368
Cell Significance Index: -48.8700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.6910
Cell Significance Index: -18.4900
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.7174
Cell Significance Index: -5.8500
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.7711
Cell Significance Index: -11.6200
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.8269
Cell Significance Index: -33.8800
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.8628
Cell Significance Index: -43.6000
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.8902
Cell Significance Index: -26.2200
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.8971
Cell Significance Index: -18.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** UBE2S is a member of the ubiquitin-conjugating enzyme family, specifically E2 enzymes, which play a central role in the ubiquitination pathway. The UBE2S protein is characterized by its ability to conjugate ubiquitin to target proteins, marking them for degradation by the proteasome. This process is essential for the regulation of protein turnover, cell cycle progression, and immune response. Key features of UBE2S include: * Ubiquitin-conjugating enzyme activity * Ability to interact with various ubiquitin ligases and E1 enzymes * Involvement in the regulation of cell cycle checkpoints and mitotic progression * Role in the degradation of mitotic proteins and the regulation of the anaphase-promoting complex (APC) * Expression in various cell types, including immune cells, epithelial cells, and fibroblasts **Pathways and Functions** UBE2S is involved in multiple cellular pathways, including: * Cell cycle regulation: UBE2S plays a crucial role in the progression from mitosis to the G1 phase by regulating the APC and the degradation of mitotic proteins. * Immune response: UBE2S is essential for the regulation of antigen processing and presentation, as well as the degradation of proteins involved in the adaptive immune response. * Protein degradation: UBE2S is involved in the ubiquitination and degradation of proteins, which is essential for maintaining cellular homeostasis. * Mitotic regulation: UBE2S regulates the APC and the degradation of mitotic proteins, ensuring proper mitotic progression and preventing aneuploidy. * DNA replication: UBE2S is involved in the regulation of DNA replication and the assembly of the pre-replicative complex. **Clinical Significance** UBE2S has been implicated in various diseases, including: * Cancer: UBE2S overexpression has been observed in several types of cancer, including breast, lung, and colon cancer, suggesting its potential role as an oncogene. * Immune-related disorders: UBE2S has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where dysregulation of the ubiquitination pathway contributes to disease pathogenesis. * Neurodegenerative disorders: UBE2S has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's, where aberrant ubiquitination and protein degradation contribute to disease progression. In conclusion, UBE2S is a critical gene involved in various cellular processes, including cell cycle regulation, immune response, and protein degradation. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its role in maintaining cellular homeostasis and preventing disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Ubiquitin-conjugating enzyme E2 S

Genular Protein ID: 3775447676

Symbol: UBE2S_HUMAN

Name: Ubiquitin-conjugating enzyme E2 S

UniProtKB Accession Codes:

Q16763 Q9BTC1

Database IDs:

Citations:

PubMed ID: 1379239

Title: cDNA cloning of a novel human ubiquitin carrier protein. An antigenic domain specifically recognized by endemic pemphigus foliaceus autoantibodies is encoded in a secondary reading frame of this human epidermal transcript.

PubMed ID: 1379239

DOI: 10.1016/s0021-9258(19)49610-5

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16819549

Title: E2-EPF UCP targets pVHL for degradation and associates with tumor growth and metastasis.

PubMed ID: 16819549

DOI: 10.1038/nm1440

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19820702

Title: UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit.

PubMed ID: 19820702

DOI: 10.1038/ncb1983

PubMed ID: 19822757

Title: Identification of a physiological E2 module for the human anaphase-promoting complex.

PubMed ID: 19822757

DOI: 10.1073/pnas.0907887106

PubMed ID: 20061386

Title: The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.

PubMed ID: 20061386

DOI: 10.1074/jbc.m109.089003

PubMed ID: 20622874

Title: Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne.

PubMed ID: 20622874

DOI: 10.1038/nsmb.1873

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 27910872

Title: SAG/RBX2 E3 ligase complexes with UBCH10 and UBE2S E2s to ubiquitylate beta-TrCP1 via K11-linkage for degradation.

PubMed ID: 27910872

DOI: 10.1038/srep37441

PubMed ID: 22496338

Title: A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.

PubMed ID: 22496338

DOI: 10.1074/mcp.o111.013706

PubMed ID: 27259151

Title: Dual RING E3 architectures regulate multiubiquitination and ubiquitin chain elongation by APC/C.

PubMed ID: 27259151

DOI: 10.1016/j.cell.2016.05.037

PubMed ID: 26828794

Title: Crystal structure of a Ube2S-ubiquitin conjugate.

PubMed ID: 26828794

DOI: 10.1371/journal.pone.0147550

Sequence Information:

Length: 222
Mass: 23845
Checksum: 2842DC3DCD2AFCB5
Sequence:

MNSNVENLPP HIIRLVYKEV TTLTADPPDG IKVFPNEEDL TDLQVTIEGP EGTPYAGGLF 
RMKLLLGKDF PASPPKGYFL TKIFHPNVGA NGEICVNVLK RDWTAELGIR HVLLTIKCLL 
IHPNPESALN EEAGRLLLEN YEEYAARARL LTEIHGGAGG PSGRAEAGRA LASGTEASST 
DPGAPGGPGG AEGPMAKKHA GERDKKLAAK KKTDKKRALR RL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: UBE2S

Associated with

Cells (max top 100)

Other Information

cDNA cloning of a novel human ubiquitin carrier protein. An antigenic domain specifically recognized by endemic pemphigus foliaceus autoantibodies is encoded in a secondary reading frame of this human epidermal transcript. PubMed ID: 1379239

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

E2-EPF UCP targets pVHL for degradation and associates with tumor growth and metastasis. PubMed ID: 16819549

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit. PubMed ID: 19820702

Identification of a physiological E2 module for the human anaphase-promoting complex. PubMed ID: 19822757

The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. PubMed ID: 20061386

Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne. PubMed ID: 20622874

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

SAG/RBX2 E3 ligase complexes with UBCH10 and UBE2S E2s to ubiquitylate beta-TrCP1 via K11-linkage for degradation. PubMed ID: 27910872

A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen. PubMed ID: 22496338

Dual RING E3 architectures regulate multiubiquitination and ubiquitin chain elongation by APC/C. PubMed ID: 27259151

Crystal structure of a Ube2S-ubiquitin conjugate. PubMed ID: 26828794