Details for: PCSK1N

Gene ID: 27344

Symbol: PCSK1N

Ensembl ID: ENSG00000102109

Description: proprotein convertase subtilisin/kexin type 1 inhibitor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 273.2967
    Cell Significance Index: -42.5100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 169.1351
    Cell Significance Index: -42.9000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.6541
    Cell Significance Index: -35.9500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.1537
    Cell Significance Index: -42.1100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.9906
    Cell Significance Index: -39.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 8.1729
    Cell Significance Index: 429.1100
  • Cell Name: germ cell (CL0000586)
    Fold Change: 5.9876
    Cell Significance Index: 45.2100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 5.4392
    Cell Significance Index: 119.1000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 4.0634
    Cell Significance Index: 31.3200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.8897
    Cell Significance Index: 48.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.9116
    Cell Significance Index: 183.5100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 2.5909
    Cell Significance Index: 44.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.3114
    Cell Significance Index: 142.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6573
    Cell Significance Index: 332.4600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.6161
    Cell Significance Index: 56.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.4216
    Cell Significance Index: 270.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3393
    Cell Significance Index: 480.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3155
    Cell Significance Index: 718.4000
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.1787
    Cell Significance Index: 8.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.1392
    Cell Significance Index: 76.6000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1160
    Cell Significance Index: 1007.7000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.9730
    Cell Significance Index: 14.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9378
    Cell Significance Index: 152.5300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.7997
    Cell Significance Index: 19.1800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5768
    Cell Significance Index: 16.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4422
    Cell Significance Index: 48.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4417
    Cell Significance Index: 87.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.3298
    Cell Significance Index: 241.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2689
    Cell Significance Index: 26.6000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1653
    Cell Significance Index: 11.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1650
    Cell Significance Index: 7.4800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0806
    Cell Significance Index: 9.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0479
    Cell Significance Index: 21.1700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0291
    Cell Significance Index: 20.1400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0221
    Cell Significance Index: 4.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0205
    Cell Significance Index: 38.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0125
    Cell Significance Index: 0.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0072
    Cell Significance Index: 5.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0215
    Cell Significance Index: -13.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0238
    Cell Significance Index: -43.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0285
    Cell Significance Index: -43.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0308
    Cell Significance Index: -17.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0355
    Cell Significance Index: -6.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0361
    Cell Significance Index: -49.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0385
    Cell Significance Index: -24.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0441
    Cell Significance Index: -33.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0579
    Cell Significance Index: -26.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0637
    Cell Significance Index: -8.7500
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0795
    Cell Significance Index: -0.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0878
    Cell Significance Index: -8.9700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1099
    Cell Significance Index: -1.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1142
    Cell Significance Index: -2.4800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1424
    Cell Significance Index: -11.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1505
    Cell Significance Index: -43.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1625
    Cell Significance Index: -29.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1801
    Cell Significance Index: -26.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2023
    Cell Significance Index: -23.5800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2063
    Cell Significance Index: -26.4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2113
    Cell Significance Index: -24.2100
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.2410
    Cell Significance Index: -2.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2573
    Cell Significance Index: -31.6400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2612
    Cell Significance Index: -33.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2677
    Cell Significance Index: -15.0200
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.3001
    Cell Significance Index: -3.3900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3395
    Cell Significance Index: -25.3000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3553
    Cell Significance Index: -7.5400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3626
    Cell Significance Index: -7.2800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3667
    Cell Significance Index: -7.2500
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.3809
    Cell Significance Index: -2.9600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.3974
    Cell Significance Index: -3.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4006
    Cell Significance Index: -41.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4052
    Cell Significance Index: -47.7800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4523
    Cell Significance Index: -5.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4653
    Cell Significance Index: -28.5300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5364
    Cell Significance Index: -11.5900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5592
    Cell Significance Index: -39.5500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.5758
    Cell Significance Index: -6.9800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.6402
    Cell Significance Index: -10.5500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6500
    Cell Significance Index: -21.2800
  • Cell Name: reticular cell (CL0000432)
    Fold Change: -0.6545
    Cell Significance Index: -4.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6591
    Cell Significance Index: -30.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6641
    Cell Significance Index: -21.1500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6683
    Cell Significance Index: -29.5600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6707
    Cell Significance Index: -43.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6732
    Cell Significance Index: -21.5600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.6859
    Cell Significance Index: -11.0100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.6871
    Cell Significance Index: -8.9100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6898
    Cell Significance Index: -35.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7100
    Cell Significance Index: -15.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7172
    Cell Significance Index: -18.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.8070
    Cell Significance Index: -37.9300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.8248
    Cell Significance Index: -10.4100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8313
    Cell Significance Index: -31.4800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.8445
    Cell Significance Index: -23.6000
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.8518
    Cell Significance Index: -8.6600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.8660
    Cell Significance Index: -8.2400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.8869
    Cell Significance Index: -5.7700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9042
    Cell Significance Index: -31.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.9662
    Cell Significance Index: -26.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PCSK1N is a serine protease inhibitor that specifically inhibits the activity of proprotein convertases, including PCSK1. These enzymes are involved in various cellular processes, including protein processing, signaling, and cell migration. PCSK1N is highly expressed in cells that require precise regulation of proprotein convertase activity, such as glycinergic neurons, enteroendocrine cells, and kidney cells. The protein's inhibitory activity is essential for maintaining tissue homeostasis and preventing excessive activation of proprotein convertases. **Pathways and Functions:** PCSK1N regulates proprotein convertase activity through a complex network of pathways, including: 1. **Endopeptidase inhibitor activity:** PCSK1N directly inhibits the activity of proprotein convertases, preventing excessive processing of peptides and proteins. 2. **Neuropeptide signaling pathway:** PCSK1N modulates the activity of neuropeptides, such as gastrin-releasing peptide (GRP) and substance P, which play crucial roles in regulating pain, appetite, and mood. 3. **Peptide hormone processing:** PCSK1N regulates the processing of peptide hormones, such as gastrin and secretin, which are essential for maintaining gut homeostasis. 4. **Response to cold:** PCSK1N is involved in the regulation of thermogenesis, a process that generates heat in response to cold exposure. 5. **Response to dietary excess:** PCSK1N modulates the activity of proprotein convertases involved in nutrient sensing and energy homeostasis. **Clinical Significance:** Dysregulation of PCSK1N has been implicated in various human diseases, including: 1. **Diabetes:** Alterations in PCSK1N expression have been observed in patients with type 2 diabetes, suggesting a link between PCSK1N and glucose metabolism. 2. **Obesity:** PCSK1N has been shown to regulate energy homeostasis, and its dysregulation may contribute to obesity. 3. **Neurological disorders:** PCSK1N is involved in the regulation of pain and mood, and its dysregulation may contribute to conditions such as fibromyalgia and depression. 4. **Cancer:** PCSK1N has been shown to regulate the activity of proprotein convertases involved in tumor growth and metastasis. In conclusion, PCSK1N is a critical regulator of proprotein convertase activity, and its dysregulation has been implicated in various human diseases. Further research is needed to fully elucidate the mechanisms by which PCSK1N regulates proprotein convertase activity and to explore its therapeutic potential in treating human diseases.

Genular Protein ID: 259919136

Symbol: PCS1N_HUMAN

Name: ProSAAS

UniProtKB Accession Codes:

Q9UHG2 Q4VC04

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 GO 10 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10632593

Title: Identification and characterization of proSAAS, a granin-like neuroendocrine peptide precursor that inhibits prohormone processing.

PubMed ID: 10632593

DOI: 10.1523/jneurosci.20-02-00639.2000

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11435430

Title: Inhibitory specificity and potency of proSAAS-derived peptides toward proprotein convertase 1.

PubMed ID: 11435430

DOI: 10.1074/jbc.m104064200

PubMed ID: 12914799

Title: An N-terminal fragment of ProSAAS (a granin-like neuroendocrine peptide precursor) is associated with tau inclusions in Pick's disease.

PubMed ID: 12914799

DOI: 10.1016/s0006-291x(03)01391-3

PubMed ID: 14746899

Title: A human granin-like neuroendocrine peptide precursor (proSAAS) immunoreactivity in tau inclusions of Alzheimer's disease and parkinsonism-dementia complex on Guam.

PubMed ID: 14746899

DOI: 10.1016/j.neulet.2003.11.028

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

Sequence Information:

  • Length: 260
  • Mass: 27372
  • Checksum: FF8E2722784B7A5C
  • Sequence:
    • MAGSPLLWGP RAGGVGLLVL LLLGLFRPPP ALCARPVKEP RGLSAASPPL AETGAPRRFR 
RSVPRGEAAG AVQELARALA HLLEAERQER ARAEAQEAED QQARVLAQLL RVWGAPRNSD 
PALGLDDDPD APAAQLARAL LRARLDPAAL AAQLVPAPVP AAALRPRPPV YDDGPAGPDA 
EEAGDETPDV DPELLRYLLG RILAGSADSE GVAAPRRLRR AADHDVGSEL PPEGVLGALL 
RVKRLETPAP QVPARRLLPP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.