Details for: HMGB3

Gene ID: 3149

Symbol: HMGB3

Ensembl ID: ENSG00000029993

Description: high mobility group box 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 73.8438
    Cell Significance Index: -18.7300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 65.3724
    Cell Significance Index: -26.9300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 55.9812
    Cell Significance Index: -26.4300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 39.2983
    Cell Significance Index: -26.3700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.3932
    Cell Significance Index: -21.4500
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 16.1368
    Cell Significance Index: -2.5100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.0080
    Cell Significance Index: -26.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.2848
    Cell Significance Index: -24.8000
  • Cell Name: germ cell (CL0000586)
    Fold Change: 5.3538
    Cell Significance Index: 40.4300
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 4.8336
    Cell Significance Index: 27.4800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 4.5698
    Cell Significance Index: 49.6800
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 4.1637
    Cell Significance Index: 18.4300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.1850
    Cell Significance Index: 19.7900
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 3.1620
    Cell Significance Index: 1.4400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.0199
    Cell Significance Index: 104.9400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.9369
    Cell Significance Index: 116.2800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.8928
    Cell Significance Index: 39.6200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.8324
    Cell Significance Index: 14.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4899
    Cell Significance Index: 242.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.4702
    Cell Significance Index: 38.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2270
    Cell Significance Index: 670.0900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.1700
    Cell Significance Index: 82.7500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1202
    Cell Significance Index: 58.1900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.0998
    Cell Significance Index: 25.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0213
    Cell Significance Index: 27.2700
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.9927
    Cell Significance Index: 10.2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8934
    Cell Significance Index: 806.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8344
    Cell Significance Index: 98.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7949
    Cell Significance Index: 92.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7638
    Cell Significance Index: 34.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6548
    Cell Significance Index: 18.8700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5956
    Cell Significance Index: 73.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5644
    Cell Significance Index: 249.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5415
    Cell Significance Index: 53.5700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5270
    Cell Significance Index: 7.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5264
    Cell Significance Index: 16.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4762
    Cell Significance Index: 85.8500
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.4601
    Cell Significance Index: 2.8800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3263
    Cell Significance Index: 3.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2584
    Cell Significance Index: 15.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2457
    Cell Significance Index: 18.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2177
    Cell Significance Index: 10.1500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1916
    Cell Significance Index: 4.0800
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 0.1749
    Cell Significance Index: 1.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1599
    Cell Significance Index: 30.4300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1484
    Cell Significance Index: 3.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1352
    Cell Significance Index: 26.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1199
    Cell Significance Index: 15.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1064
    Cell Significance Index: 5.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0967
    Cell Significance Index: 6.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0796
    Cell Significance Index: 10.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0781
    Cell Significance Index: 13.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0771
    Cell Significance Index: 2.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0545
    Cell Significance Index: 19.5600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0511
    Cell Significance Index: 0.5800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0318
    Cell Significance Index: 0.8900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0057
    Cell Significance Index: 4.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0041
    Cell Significance Index: -3.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0075
    Cell Significance Index: -0.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0108
    Cell Significance Index: -6.7200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0120
    Cell Significance Index: -22.5700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0171
    Cell Significance Index: -31.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0180
    Cell Significance Index: -13.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0193
    Cell Significance Index: -29.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0201
    Cell Significance Index: -27.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0234
    Cell Significance Index: -13.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0289
    Cell Significance Index: -3.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0318
    Cell Significance Index: -20.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0334
    Cell Significance Index: -6.7100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0497
    Cell Significance Index: -1.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0519
    Cell Significance Index: -5.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0547
    Cell Significance Index: -11.5300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0549
    Cell Significance Index: -24.9100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1020
    Cell Significance Index: -2.2100
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1032
    Cell Significance Index: -0.9800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1090
    Cell Significance Index: -12.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1168
    Cell Significance Index: -5.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1344
    Cell Significance Index: -19.5400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1350
    Cell Significance Index: -2.2600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.1490
    Cell Significance Index: -1.2800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1516
    Cell Significance Index: -16.4900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1569
    Cell Significance Index: -4.2700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1680
    Cell Significance Index: -1.3700
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.1854
    Cell Significance Index: -1.8700
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1860
    Cell Significance Index: -1.2100
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.2022
    Cell Significance Index: -1.2700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2049
    Cell Significance Index: -1.9500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2162
    Cell Significance Index: -6.3500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2186
    Cell Significance Index: -2.8000
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.2382
    Cell Significance Index: -1.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2382
    Cell Significance Index: -24.8000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2473
    Cell Significance Index: -7.2900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2477
    Cell Significance Index: -19.6200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2612
    Cell Significance Index: -6.2700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2621
    Cell Significance Index: -3.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2751
    Cell Significance Index: -7.3600
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.3146
    Cell Significance Index: -1.5300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3236
    Cell Significance Index: -3.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3414
    Cell Significance Index: -20.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3432
    Cell Significance Index: -23.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HMGB3 is a member of the high mobility group (HMG) protein family, characterized by its ability to bind to DNA and regulate gene expression. The protein is composed of three distinct domains: the HMG box, the zinc finger domain, and the C-terminal domain. These domains enable HMGB3 to interact with DNA, RNA polymerase II, and other proteins, thereby modulating transcriptional activities. **Pathways and Functions:** HMGB3 is involved in various cellular processes, including: 1. **Innate Immune Response:** HMGB3 acts as a damage-associated molecular pattern (DAMP) molecule, released by necrotic cells and recognized by pattern recognition receptors (PRRs) such as RIG-I and TLR4. This recognition triggers an innate immune response, leading to the activation of inflammatory signaling pathways. 2. **Regulation of Transcription:** HMGB3 binds to DNA and RNA polymerase II, modulating the transcription of target genes involved in immune responses, cellular differentiation, and growth. 3. **Cellular Differentiation:** HMGB3 regulates the differentiation of various cell types, including B cells, myeloid cells, and neural crest cells, by modulating transcriptional programs. 4. **Nucleus Organization:** HMGB3 plays a role in maintaining chromatin organization and structure, influencing gene expression and cellular behavior. **Significantly Expressed Cells:** HMGB3 is expressed in a wide range of cell types, including: 1. Skeletal muscle satellite cells 2. Extravillous trophoblasts 3. Migratory enteric neural crest cells 4. Bronchial goblet cells 5. Placental villous trophoblasts 6. Oogonial cells 7. Erythroid progenitor cells 8. Enteric neurons 9. Neural crest cells 10. Tracheobronchial smooth muscle cells **Clinical Significance:** HMGB3 dysregulation has been implicated in various diseases, including: 1. **Autoimmune Disorders:** HMGB3 has been linked to autoimmune diseases such as rheumatoid arthritis, lupus, and multiple sclerosis, where it contributes to the dysregulation of immune responses. 2. **Cancer:** HMGB3 has been shown to promote cancer progression by regulating tumor cell growth, invasion, and metastasis. 3. **Neurological Disorders:** HMGB3 has been implicated in neurological disorders such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis, where it contributes to neuronal damage and degeneration. In conclusion, HMGB3 is a multifaceted gene that plays a critical role in regulating immune responses, cellular differentiation, and transcriptional processes. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its complex functions and pathways. Further research is needed to fully elucidate the mechanisms by which HMGB3 influences cellular behavior and disease progression.

Genular Protein ID: 4012487839

Symbol: HMGB3_HUMAN

Name: High mobility group protein B3

UniProtKB Accession Codes:

O15347 O95556 Q6NS40

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9370291

Title: Isolation of human and mouse HMG2a cDNAs: evidence for an HMG2a-specific 3' untranslated region.

PubMed ID: 9370291

DOI: 10.1016/s0378-1119(97)00324-7

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 20598277

Title: Terminal osseous dysplasia is caused by a single recurrent mutation in the FLNA gene.

PubMed ID: 20598277

DOI: 10.1016/j.ajhg.2010.06.008

PubMed ID: 24993872

Title: Identification of an HMGB3 frameshift mutation in a family with an X-linked colobomatous microphthalmia syndrome using whole-genome and X-exome sequencing.

PubMed ID: 24993872

DOI: 10.1001/jamaophthalmol.2014.1731

PubMed ID: 24531895

Title: A systematic nomenclature for the redox states of high mobility group box (HMGB) proteins.

PubMed ID: 24531895

DOI: 10.2119/molmed.2014.00022

Sequence Information:

  • Length: 200
  • Mass: 22980
  • Checksum: 31C090FAA4D581E6
  • Sequence:
    • MAKGDPKKPK GKMSAYAFFV QTCREEHKKK NPEVPVNFAE FSKKCSERWK TMSGKEKSKF 
DEMAKADKVR YDREMKDYGP AKGGKKKKDP NAPKRPPSGF FLFCSEFRPK IKSTNPGISI 
GDVAKKLGEM WNNLNDSEKQ PYITKAAKLK EKYEKDVADY KSKGKFDGAK GPAKVARKKV 
EEEDEEEEEE EEEEEEEEDE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.