Details for: HMGB3

Gene ID: 3149

Symbol: HMGB3

Ensembl ID: ENSG00000029993

Description: high mobility group box 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 3.95
    Marker Score: 2642.5
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.9
    Marker Score: 3484
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.39
    Marker Score: 2245
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.26
    Marker Score: 1114
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.25
    Marker Score: 8856
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.24
    Marker Score: 3225.5
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.16
    Marker Score: 2253
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 2.06
    Marker Score: 1094
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.05
    Marker Score: 2191
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.93
    Marker Score: 566
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.92
    Marker Score: 4016
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.88
    Marker Score: 466
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.76
    Marker Score: 4796
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.76
    Marker Score: 1107
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.68
    Marker Score: 554.5
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.67
    Marker Score: 1767
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.65
    Marker Score: 8682
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.6
    Marker Score: 595
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.59
    Marker Score: 458
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.59
    Marker Score: 20907
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.58
    Marker Score: 1073
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.58
    Marker Score: 54558
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.57
    Marker Score: 1259
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.51
    Marker Score: 831
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.5
    Marker Score: 3530
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.49
    Marker Score: 1872
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.49
    Marker Score: 430
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.45
    Marker Score: 1190
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.43
    Marker Score: 1515
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.34
    Marker Score: 3174
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.31
    Marker Score: 3576
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.3
    Marker Score: 977
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.29
    Marker Score: 9579
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.28
    Marker Score: 857
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.28
    Marker Score: 637
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.27
    Marker Score: 2025
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.26
    Marker Score: 1190
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.22
    Marker Score: 4974
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 1.18
    Marker Score: 490
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.17
    Marker Score: 394
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.14
    Marker Score: 536
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.14
    Marker Score: 1143
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.13
    Marker Score: 1657
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.12
    Marker Score: 3334
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.12
    Marker Score: 615
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.08
    Marker Score: 9383
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.07
    Marker Score: 252
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.04
    Marker Score: 384
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251733
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.01
    Marker Score: 10207
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71753
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47977
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 0.98
    Marker Score: 314
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30401
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.97
    Marker Score: 1014
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 492
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 447
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.94
    Marker Score: 1248
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.93
    Marker Score: 479
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.93
    Marker Score: 202
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5286
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.92
    Marker Score: 564
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2721
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.9
    Marker Score: 361
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.88
    Marker Score: 466
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.88
    Marker Score: 522
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.88
    Marker Score: 281
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.87
    Marker Score: 1020
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.87
    Marker Score: 301
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5257
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.85
    Marker Score: 214
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.85
    Marker Score: 418
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.84
    Marker Score: 392
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.83
    Marker Score: 252
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.81
    Marker Score: 1308
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.8
    Marker Score: 385.5
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.8
    Marker Score: 156
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.78
    Marker Score: 1289
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 306
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.75
    Marker Score: 11766
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.75
    Marker Score: 511
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 571
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.75
    Marker Score: 4857
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.74
    Marker Score: 470
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.74
    Marker Score: 1408
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 383
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.72
    Marker Score: 3475
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.72
    Marker Score: 2263
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.72
    Marker Score: 717
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.72
    Marker Score: 1014
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.72
    Marker Score: 6172
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.71
    Marker Score: 541.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 648
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2955
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.7
    Marker Score: 265
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.7
    Marker Score: 199
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.69
    Marker Score: 618
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.69
    Marker Score: 241

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Other Information

**Key characteristics:** * It is a member of the high mobility group of DNA-binding proteins. * It is a highly conserved protein with a predicted molecular weight of approximately 350 kDa. * It has a unique structure consisting of two globular domains and two transmembrane domains. * It is a transcription factor that regulates the expression of various genes. **Pathways and functions:** * **Cell cycle regulation:** HMGB3 binds to DNA and promotes the progression of cells through the G1/S transition. * **DNA repair:** It is involved in DNA repair mechanisms by forming a complex with other proteins, including DNA repair specialists. * **Inflammation:** HMGB3 is a key regulator of inflammation. It is expressed in immune cells, where it binds to DNA and modulates the inflammatory response. * **Transcription regulation:** HMGB3 is a key regulator of gene expression. It binds to DNA and recruits RNA polymerase II to regulate the expression of various genes involved in cell cycle regulation, DNA repair, and inflammation. **Clinical significance:** * Mutations in HMGB3 have been linked to various human diseases, including cancer, neurodegenerative disorders, and inflammatory diseases. * HMGB3 inhibitors are being investigated as potential therapeutic agents for cancer and other diseases that are characterized by abnormal cell growth. **Additional information:** * It is a ubiquitin-dependent protein, meaning it is targeted for degradation by the proteasome when it is no longer needed. * It is a highly effective transcription factor, with its activity being regulated by various factors, including phosphorylation, ubiquitination, and acetylation.

Genular Protein ID: 4012487839

Symbol: HMGB3_HUMAN

Name: High mobility group protein B3

UniProtKB Accession Codes:

O15347 O95556 Q6NS40

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 4 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 6 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9370291

Title: Isolation of human and mouse HMG2a cDNAs: evidence for an HMG2a-specific 3' untranslated region.

PubMed ID: 9370291

DOI: 10.1016/s0378-1119(97)00324-7

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 20598277

Title: Terminal osseous dysplasia is caused by a single recurrent mutation in the FLNA gene.

PubMed ID: 20598277

DOI: 10.1016/j.ajhg.2010.06.008

PubMed ID: 24993872

Title: Identification of an HMGB3 frameshift mutation in a family with an X-linked colobomatous microphthalmia syndrome using whole-genome and X-exome sequencing.

PubMed ID: 24993872

DOI: 10.1001/jamaophthalmol.2014.1731

PubMed ID: 24531895

Title: A systematic nomenclature for the redox states of high mobility group box (HMGB) proteins.

PubMed ID: 24531895

DOI: 10.2119/molmed.2014.00022

Sequence Information:

  • Length: 200
  • Mass: 22980
  • Checksum: 31C090FAA4D581E6
  • Sequence:
    • MAKGDPKKPK GKMSAYAFFV QTCREEHKKK NPEVPVNFAE FSKKCSERWK TMSGKEKSKF 
DEMAKADKVR YDREMKDYGP AKGGKKKKDP NAPKRPPSGF FLFCSEFRPK IKSTNPGISI 
GDVAKKLGEM WNNLNDSEKQ PYITKAAKLK EKYEKDVADY KSKGKFDGAK GPAKVARKKV 
EEEDEEEEEE EEEEEEEEDE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.