Details for: MAD2L1

Gene ID: 4085

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: MAD2L1

Ensembl ID: ENSG00000164109

Description: mitotic arrest deficient 2 like 1

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 21.06
    rCSI 24.32%
    PRS 87.53
  • early lymphoid progenitor CL0000936
    CSI 16.72
    rCSI 14.69%
    PRS 96.06
  • large pre-B-II cell CL0000957
    CSI 13.79
    rCSI 39.36%
    PRS 93.05
  • regulatory T cell CL0000815
    CSI 13.47
    rCSI 15.61%
    PRS 87.86
  • mesodermal cell CL0000222
    CSI 12.4
    rCSI 14.88%
    PRS 93.03
  • precursor B cell CL0000817
    CSI 12.22
    rCSI 10.71%
    PRS 96.29
  • vascular associated smooth muscle cell CL0000359
    CSI 12.13
    rCSI 39.36%
    PRS 92.41
  • epithelial cell of lung CL0000082
    CSI 11.8
    rCSI 9.79%
    PRS 94.77
  • fraction A pre-pro B cell CL0002045
    CSI 11.42
    rCSI 13.07%
    PRS 96.06
  • radial glial cell CL0000681
    CSI 10.41
    rCSI 14.46%
    PRS 92.4
  • pro-B cell CL0000826
    CSI 9.7
    rCSI 8.03%
    PRS 94.52
  • transit amplifying cell of colon CL0009011
    CSI 9.3
    rCSI 10.92%
    PRS 93.76
  • erythroblast CL0000765
    CSI 9.21
    rCSI 24.43%
    PRS 93.85
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 8.76
    rCSI 7.91%
    PRS 92.88
  • myeloid leukocyte CL0000766
    CSI 8.13
    rCSI 7.5%
    PRS 94.92
  • plasmablast CL0000980
    CSI 7.3
    rCSI 5.74%
    PRS 95.04
  • common myeloid progenitor CL0000049
    CSI 6.07
    rCSI 4.91%
    PRS 94.66
  • hematopoietic stem cell CL0000037
    CSI 5.87
    rCSI 3.9%
    PRS 94.72
  • neural crest cell CL0011012
    CSI 5.79
    rCSI 4.58%
    PRS 88.67
  • chondrocyte CL0000138
    CSI 5.56
    rCSI 8.85%
    PRS 90.37
  • fallopian tube secretory epithelial cell CL4030006
    CSI 5.56
    rCSI 5.35%
    PRS 92.57
  • colon epithelial cell CL0011108
    CSI 5.39
    rCSI 5.64%
    PRS 91.85
  • stromal cell CL0000499
    CSI 5.25
    rCSI 14.78%
    PRS 90.71
  • primitive red blood cell CL0002355
    CSI 5.14
    rCSI 27.74%
    PRS 94.29
  • intestine goblet cell CL0019031
    CSI 5.12
    rCSI 4.54%
    PRS 91.87
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 4.58
    rCSI 5.88%
    PRS 90.57
  • neural progenitor cell CL0011020
    CSI 4.55
    rCSI 20.01%
    PRS 84.71
  • placental villous trophoblast CL2000060
    CSI 4.51
    rCSI 6.97%
    PRS 92.19
  • double-positive, alpha-beta thymocyte CL0000809
    CSI 4.48
    rCSI 4.57%
    PRS 97.01
  • erythrocyte CL0000232
    CSI 4.48
    rCSI 10.16%
    PRS 91.8
  • multi-ciliated epithelial cell CL0005012
    CSI 4.46
    rCSI 4.45%
    PRS 89.04
  • extravillous trophoblast CL0008036
    CSI 4.45
    rCSI 5.5%
    PRS 92.45
  • interstitial cell of Cajal CL0002088
    CSI 4.04
    rCSI 5.15%
    PRS 96.14
  • promyelocyte CL0000836
    CSI 3.99
    rCSI 5.76%
    PRS 95.15
  • stem cell CL0000034
    CSI 3.87
    rCSI 3.73%
    PRS 91.05
  • goblet cell CL0000160
    CSI 3.86
    rCSI 3.65%
    PRS 91.8
  • glioblast CL0000030
    CSI 3.82
    rCSI 6.09%
    PRS 87.74
  • megakaryocyte CL0000556
    CSI 3.82
    rCSI 16.56%
    PRS 93.94
  • enteric smooth muscle cell CL0002504
    CSI 3.56
    rCSI 5.07%
    PRS 93.65
  • promonocyte CL0000559
    CSI 3.27
    rCSI 5.61%
    PRS 95.03
  • erythroid progenitor cell CL0000038
    CSI 3.22
    rCSI 18.43%
    PRS 94.74
  • ON-bipolar cell CL0000749
    CSI 3.14
    rCSI 4.66%
    PRS 92.52
  • ciliated epithelial cell CL0000067
    CSI 3.11
    rCSI 2.73%
    PRS 86.76
  • granulocyte monocyte progenitor cell CL0000557
    CSI 3.04
    rCSI 2.63%
    PRS 95.13
  • intestinal epithelial cell CL0002563
    CSI 2.85
    rCSI 2.98%
    PRS 91.85
  • erythroid lineage cell CL0000764
    CSI 2.71
    rCSI 17.43%
    PRS 94.93
  • mesenchymal cell CL0008019
    CSI 2.71
    rCSI 6.87%
    PRS 90.08
  • ciliated cell CL0000064
    CSI 2.6
    rCSI 4.22%
    PRS 88.46
  • common dendritic progenitor CL0001029
    CSI 2.52
    rCSI 3.16%
    PRS 96.83
  • mature alpha-beta T cell CL0000791
    CSI 2.11
    rCSI 7.65%
    PRS 99.02
  • peripheral nervous system neuron CL2000032
    CSI 1.99
    rCSI 2.71%
    PRS 88.63
  • germinal center B cell CL0000844
    CSI 1.95
    rCSI 5.82%
    PRS 95.58
  • respiratory hillock cell CL4030023
    CSI 1.7
    rCSI 3.03%
    PRS 96.09
  • deuterosomal cell CL4033044
    CSI 1.58
    rCSI 5.34%
    PRS 88.68
  • pluripotent stem cell CL0002248
    CSI 1.51
    rCSI 45.44%
    PRS 96.51
  • forebrain radial glial cell CL0013000
    CSI 1.39
    rCSI 4.46%
    PRS 93.38
  • basophil mast progenitor cell CL0002028
    CSI 1.15
    rCSI 6.16%
    PRS 98.31
  • epithelial cell of nephron CL1000449
    CSI 0.99
    rCSI 9.4%
    PRS 98.44
  • myeloid lineage restricted progenitor cell CL0000839
    CSI 0.85
    rCSI 4.39%
    PRS 98.37
  • transit amplifying cell of small intestine CL0009012
    CSI 0.83
    rCSI 3.66%
    PRS 95.7
  • pre-conventional dendritic cell CL0002010
    CSI 0.74
    rCSI 9.84%
    PRS 98.14
  • eosinophil CL0000771
    CSI 0.63
    rCSI 4.13%
    PRS 97.92
  • epithelial cell of esophagus CL0002252
    CSI 0.47
    rCSI 4.61%
    PRS 92.03

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [MAD2L1](/details-gene/4085), or Mitotic Arrest Deficient 2 Like 1, encodes a critical component of the mitotic spindle assembly checkpoint (SAC). This protein, also known as MAD2A, plays an essential role in ensuring the fidelity of chromosome segregation during cell division. It functions by inhibiting the anaphase-promoting complex/cyclosome (APC/C) until all chromosomes are correctly attached to the mitotic spindle, thereby preventing premature anaphase entry. Consistent with its fundamental role in cell proliferation, **Overall** expression data shows that [MAD2L1](/details-gene/4085) is a highly significant gene in actively dividing cell populations, including progenitor cells such as [early lymphoid progenitor](/details-cell/CL0000936) and various B-cell precursors, as well as specialized proliferative cells like [neuroblast (sensu Nematoda and Protostomia)](/details-cell/CL0000338). Its function is central to maintaining genomic stability, and its dysregulation is associated with aneuploidy, a hallmark of many cancers ([OMIM: 601467](https://omim.org/entry/601467)). ## Cellular Roles and Expression Landscape The expression profile of [MAD2L1](/details-gene/4085) underscores its central function in cell cycle progression and proliferation. The gene demonstrates high significance in a wide range of progenitor and transit-amplifying cells across multiple lineages, indicating it is a key workhorse for cellular expansion and differentiation. **Overall**, the highest significance is observed in populations characterized by rapid division: * **Neurogenesis:** [MAD2L1](/details-gene/4085) is most significant in [neuroblast (sensu Nematoda and Protostomia)](/details-cell/CL0000338) and also shows high significance in [radial glial cell](/details-cell/CL0000681), suggesting a critical role during the development of the nervous system. * **Hematopoiesis and Lymphopoiesis:** The gene is a prominent marker across multiple stages of B-cell development, including [early lymphoid progenitor](/details-cell/CL0000936), [large pre-B-II cell](/details-cell/CL0000957), [precursor B cell](/details-cell/CL0000817), [fraction A pre-pro B cell](/details-cell/CL0002045), and [pro-B cell](/details-cell/CL0000826). Its high significance in [erythroblast](/details-cell/CL0000765) and [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050) further highlights its indispensable role in the broader hematopoietic system. * **Immune System:** A high CSI in [regulatory T cell](/details-cell/CL0000815) suggests that [MAD2L1](/details-gene/4085) is important for the clonal expansion of this immunosuppressive lineage upon activation. * **Tissue Homeostasis:** High significance in cells like [epithelial cell of lung](/details-cell/CL0000082) and [transit amplifying cell of colon](/details-cell/CL0009011) is consistent with its function in maintaining tissues that undergo constant turnover. The expression pattern strongly suggests that [MAD2L1](/details-gene/4085) is a universal and essential component of the machinery governing proliferation in precursor and rapidly dividing somatic cells. ## Pathways and Molecular Function The functional annotations for [MAD2L1](/details-gene/4085) confirm its identity as a master regulator of mitotic progression. Its activity is tightly linked to ensuring genomic integrity during cell division. **Biological Processes and Cellular Components:** [MAD2L1](/details-gene/4085) is integral to the process of '[Cell division](/details-ontology/GO:0051301)' and specifically to '[Mitotic sister chromatid segregation](/details-ontology/GO:0000070)'. The protein localizes to the '[Kinetochore](/details-ontology/GO:0000776)', the '[Mitotic spindle](/details-ontology/GO:0072686)', and the '[Spindle pole](/details-ontology/GO:0000922)', where it forms part of the '[Mitotic checkpoint complex](/details-ontology/GO:0033597)'. This complex is responsible for executing the '[Mitotic spindle assembly checkpoint signaling](/details-ontology/GO:0007094)', a critical surveillance mechanism. The identification of [MAD2L1](/details-gene/4085) as a human mitotic checkpoint gene was a key discovery in the field [Link](https://doi.org/10.1126/science.274.5285.246). **Reactome Pathway Analysis:** The gene is a central node in numerous interconnected pathways governing M-phase. It is a key player in the '[Mitotic Spindle Checkpoint](/details-pathway/R-HSA-69618)', where it participates in the '[Amplification of signal from unattached kinetochores via a mad2 inhibitory signal](/details-pathway/R-HSA-141444)'. This signal cascade leads to the '[Inhibition of the proteolytic activity of apc/c required for the onset of anaphase by mitotic spindle checkpoint components](/details-pathway/R-HSA-141405)'. The interaction of MAD2 with CDC20 to inhibit the APC/C is a well-established mechanism that prevents the '[Separation of sister chromatids](/details-pathway/R-HSA-2467813)' until all chromosomes are properly aligned [Link](https://doi.org/10.1101/gad.12.12.1871). This regulatory network ensures that events of the '[Mitotic metaphase and anaphase](/details-pathway/R-HSA-2555396)' proceed in the correct order, which is essential for the '[Regulation of mitotic cell cycle](/details-pathway/R-HSA-453276)'. ## Research Directions The established role of [MAD2L1](/details-gene/4085) in cell cycle control and its expression pattern in proliferative cells provide a solid foundation for further investigation into its roles in development, tissue homeostasis, and disease. **Proposed Hypotheses:** 1. Given its consistently high significance across multiple hematopoietic progenitor cell types ([early lymphoid progenitor](/details-cell/CL0000936), [pro-B cell](/details-cell/CL0000826), [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050)), it is hypothesized that the precise dosage of [MAD2L1](/details-gene/4085) is a critical determinant of lineage fidelity during hematopoiesis. Subtle variations in its expression levels may bias progenitor cell fate decisions or, if significantly dysregulated, contribute to developmental arrest and leukemogenesis. 2. The high significance of [MAD2L1](/details-gene/4085) in [regulatory T cell](/details-cell/CL0000815) suggests a specialized role beyond simple proliferation. It is hypothesized that [MAD2L1](/details-gene/4085) is maintained at a poised level in resting Tregs, enabling their rapid and robust clonal expansion upon antigen recognition, which is essential for their function in maintaining immune tolerance. Dysregulation of this process could impair Treg-mediated suppression and contribute to autoimmune diseases. **Key Experimental Approach:** To test the hypothesis that [MAD2L1](/details-gene/4085) dosage influences hematopoietic lineage fidelity (Hypothesis 1), a dose-dependent knockdown could be performed in primary human CD34+ hematopoietic stem and progenitor cells (HSPCs) using a CRISPR interference (CRISPRi) system with a panel of single-guide RNAs of varying efficiency. These modified HSPCs would then be cultured in vitro under conditions promoting myeloid, erythroid, and lymphoid differentiation. The resulting cell populations would be analyzed by single-cell RNA sequencing (scRNA-seq) to simultaneously assess proliferation status (via cell cycle scoring), differentiation trajectories, and lineage-specific marker gene expression. This would reveal whether reduced [MAD2L1](/details-gene/4085) levels cause mitotic errors, cell cycle arrest, or aberrant lineage priming, thereby directly linking its expression level to hematopoietic outcomes. **Therapeutic Potential:** As an essential component of the cell division machinery, [MAD2L1](/details-gene/4085) and the spindle assembly checkpoint pathway are prominent targets for cancer therapy. Many cancer cells exhibit chromosomal instability and are highly reliant on the SAC to survive mitotic stress, creating a therapeutic window. Inhibition of [MAD2L1](/details-gene/4085) function would force cells with unattached chromosomes into a catastrophic anaphase, leading to apoptosis. Therefore, small molecule inhibitors designed to disrupt the [MAD2L1](/details-gene/4085)-CDC20 interaction represent a promising therapeutic strategy. Such drugs would be most effective against highly proliferative tumors that display underlying genomic instability, making [MAD2L1](/details-gene/4085) a candidate for targeted inhibition rather than activation.

Genular Protein ID: 429401546

Symbol: MD2L1_HUMAN

Name: Mitotic spindle assembly checkpoint protein MAD2A

UniProtKB Accession Codes:

Q13257 Q53F56 Q548X9 Q6IRW7 Q8IZX3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 19 EMDB 3 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 11 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8824189

Title: Identification of a human mitotic checkpoint gene: hsMAD2.

PubMed ID: 8824189

DOI: 10.1126/science.274.5285.246

PubMed ID: 11390010

Title: Genomic structure of the human MAD2 gene and mutation analysis in human lung and breast cancers.

PubMed ID: 11390010

DOI: 10.1016/s0169-5002(00)00223-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9637688

Title: The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation.

PubMed ID: 9637688

DOI: 10.1101/gad.12.12.1871

PubMed ID: 10527948

Title: Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2-beta.

PubMed ID: 10527948

DOI: 10.1042/bj3430673

PubMed ID: 12456649

Title: Identification of a MAD2-binding protein, CMT2, and its role in mitosis.

PubMed ID: 12456649

DOI: 10.1093/emboj/cdf659

PubMed ID: 12574116

Title: Mad2 phosphorylation regulates its association with Mad1 and the APC/C.

PubMed ID: 12574116

DOI: 10.1093/emboj/cdg071

PubMed ID: 14978040

Title: NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling.

PubMed ID: 14978040

DOI: 10.1074/jbc.m314205200

PubMed ID: 15020684

Title: Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression.

PubMed ID: 15020684

DOI: 10.1242/jcs.01006

PubMed ID: 16495226

Title: FAT10 plays a role in the regulation of chromosomal stability.

PubMed ID: 16495226

DOI: 10.1074/jbc.m507218200

PubMed ID: 18794143

Title: HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression.

PubMed ID: 18794143

DOI: 10.1158/0008-5472.can-08-0129

PubMed ID: 19010891

Title: Role of a novel splice variant of mitotic arrest deficient 1 (MAD1), MAD1beta, in mitotic checkpoint control in liver cancer.

PubMed ID: 19010891

DOI: 10.1158/0008-5472.can-08-2600

PubMed ID: 18981471

Title: Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint.

PubMed ID: 18981471

DOI: 10.1101/gad.1677208

PubMed ID: 18712773

Title: Perturbation of the chromosomal binding of RCC1, Mad2 and survivin causes spindle assembly defects and mitotic catastrophe.

PubMed ID: 18712773

DOI: 10.1002/jcb.21879

PubMed ID: 19029339

Title: The Mad2 partial unfolding model: regulating mitosis through Mad2 conformational switching.

PubMed ID: 19029339

DOI: 10.1083/jcb.200808122

PubMed ID: 20034488

Title: Nek2 targets the mitotic checkpoint proteins Mad2 and Cdc20: a mechanism for aneuploidy in cancer.

PubMed ID: 20034488

DOI: 10.1016/j.yexmp.2009.12.004

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25422469

Title: Disruption of FAT10-MAD2 binding inhibits tumor progression.

PubMed ID: 25422469

DOI: 10.1073/pnas.1403383111

PubMed ID: 29162720

Title: Direct interactions of mitotic arrest deficient 1 (MAD1) domains with each other and MAD2 conformers are required for mitotic checkpoint signaling.

PubMed ID: 29162720

DOI: 10.1074/jbc.ra117.000555

PubMed ID: 10700282

Title: Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20.

PubMed ID: 10700282

DOI: 10.1038/73338

PubMed ID: 12006501

Title: Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint.

PubMed ID: 12006501

DOI: 10.1093/emboj/21.10.2496

PubMed ID: 11804586

Title: The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20.

PubMed ID: 11804586

DOI: 10.1016/s1097-2765(01)00435-x

PubMed ID: 15024386

Title: The Mad2 spindle checkpoint protein has two distinct natively folded states.

PubMed ID: 15024386

DOI: 10.1038/nsmb748

PubMed ID: 18022367

Title: The Mad2 conformational dimer: structure and implications for the spindle assembly checkpoint.

PubMed ID: 18022367

DOI: 10.1016/j.cell.2007.08.049

PubMed ID: 18022368

Title: p31comet blocks Mad2 activation through structural mimicry.

PubMed ID: 18022368

DOI: 10.1016/j.cell.2007.08.048

PubMed ID: 18318601

Title: Insights into Mad2 regulation in the spindle checkpoint revealed by the crystal structure of the symmetric Mad2 dimer.

PubMed ID: 18318601

DOI: 10.1371/journal.pbio.0060050

Sequence Information:

  • Length: 205
  • Mass: 23510
  • Checksum: B8DCBF0043836764
  • Sequence:
    • MALQLSREQG ITLRGSAEIV AEFFSFGINS ILYQRGIYPS ETFTRVQKYG LTLLVTTDLE 
LIKYLNNVVE QLKDWLYKCS VQKLVVVISN IESGEVLERW QFDIECDKTA KDDSAPREKS 
QKAIQDEIRS VIRQITATVT FLPLLEVSCS FDLLIYTDKD LVVPEKWEES GPQFITNSEE 
VRLRSFTTTI HKVNSMVAYK IPVND