Details for: MAD2L1

Gene ID: 4085

Symbol: MAD2L1

Ensembl ID: ENSG00000164109

Description: mitotic arrest deficient 2 like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 30.5379
    Cell Significance Index: -12.5800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 27.8887
    Cell Significance Index: -11.3300
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 26.6575
    Cell Significance Index: 12.1400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 23.0639
    Cell Significance Index: -5.8500
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 10.7702
    Cell Significance Index: 8.2200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.3296
    Cell Significance Index: -10.2700
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 4.1783
    Cell Significance Index: 23.7500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.3559
    Cell Significance Index: -8.9900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.1246
    Cell Significance Index: -12.3300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.7430
    Cell Significance Index: 29.8200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.8579
    Cell Significance Index: 64.5600
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.8243
    Cell Significance Index: 13.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.6308
    Cell Significance Index: 310.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.6242
    Cell Significance Index: 189.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6012
    Cell Significance Index: 158.3900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2741
    Cell Significance Index: 138.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2028
    Cell Significance Index: 72.2100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1098
    Cell Significance Index: 180.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0637
    Cell Significance Index: 125.4400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.9543
    Cell Significance Index: 19.9800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.7837
    Cell Significance Index: 25.1000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.7413
    Cell Significance Index: 6.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6558
    Cell Significance Index: 358.1400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.4872
    Cell Significance Index: 3.8900
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 0.3872
    Cell Significance Index: 3.5200
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.3495
    Cell Significance Index: 2.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3432
    Cell Significance Index: 10.0800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3034
    Cell Significance Index: 15.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2925
    Cell Significance Index: 20.2300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.2828
    Cell Significance Index: 2.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2649
    Cell Significance Index: 52.5800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2546
    Cell Significance Index: 6.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1952
    Cell Significance Index: 86.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1684
    Cell Significance Index: 8.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1525
    Cell Significance Index: 9.8400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1349
    Cell Significance Index: 121.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1173
    Cell Significance Index: 6.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1062
    Cell Significance Index: 2.3000
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.0946
    Cell Significance Index: 0.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0895
    Cell Significance Index: 11.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0843
    Cell Significance Index: 11.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0720
    Cell Significance Index: 1.9300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0592
    Cell Significance Index: 1.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0468
    Cell Significance Index: 1.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0444
    Cell Significance Index: 2.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0279
    Cell Significance Index: 9.9900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0273
    Cell Significance Index: 7.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0260
    Cell Significance Index: 5.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0253
    Cell Significance Index: 3.2500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0242
    Cell Significance Index: 0.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0236
    Cell Significance Index: 1.0700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0155
    Cell Significance Index: 0.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0150
    Cell Significance Index: 0.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0148
    Cell Significance Index: 0.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0137
    Cell Significance Index: 0.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0062
    Cell Significance Index: 0.1800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0036
    Cell Significance Index: 0.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0013
    Cell Significance Index: 0.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0036
    Cell Significance Index: -6.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0067
    Cell Significance Index: -12.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0083
    Cell Significance Index: -12.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0097
    Cell Significance Index: -13.2100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0106
    Cell Significance Index: -7.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0123
    Cell Significance Index: -9.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0156
    Cell Significance Index: -11.4300
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0160
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0167
    Cell Significance Index: -12.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0178
    Cell Significance Index: -11.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0196
    Cell Significance Index: -11.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0208
    Cell Significance Index: -13.0000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0223
    Cell Significance Index: -0.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0246
    Cell Significance Index: -2.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0252
    Cell Significance Index: -11.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0303
    Cell Significance Index: -3.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0385
    Cell Significance Index: -1.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0582
    Cell Significance Index: -9.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0617
    Cell Significance Index: -13.0000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0675
    Cell Significance Index: -1.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0736
    Cell Significance Index: -10.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0839
    Cell Significance Index: -9.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0894
    Cell Significance Index: -5.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0988
    Cell Significance Index: -7.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1011
    Cell Significance Index: -4.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1168
    Cell Significance Index: -12.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1210
    Cell Significance Index: -7.4400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1233
    Cell Significance Index: -1.7300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1287
    Cell Significance Index: -1.9400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1323
    Cell Significance Index: -3.3000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1323
    Cell Significance Index: -1.3700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1376
    Cell Significance Index: -9.2500
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1420
    Cell Significance Index: -0.8700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1499
    Cell Significance Index: -1.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1524
    Cell Significance Index: -12.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1607
    Cell Significance Index: -12.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1612
    Cell Significance Index: -7.5200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1734
    Cell Significance Index: -1.9700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1737
    Cell Significance Index: -2.3700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1828
    Cell Significance Index: -2.6200
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.2016
    Cell Significance Index: -1.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2073
    Cell Significance Index: -10.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MAD2L1 is a 12.5-kilobase gene located on chromosome 1p36.3. It encodes a protein, MAD2A, which is a member of the MAD2 family of proteins. These proteins are known to play a role in regulating the mitotic spindle checkpoint. MAD2L1 is highly expressed in cells undergoing mitosis, and its expression is downregulated during the G0/G1 phase of the cell cycle. The gene is also involved in the regulation of apoptosis, as it can inhibit the proteolytic activity of the APC/C complex. **Pathways and Functions** MAD2L1 is involved in several key pathways and functions, including: 1. **Activation of APC/C and APC/C:cdc20 mediated degradation of mitotic proteins**: MAD2L1 regulates the APC/C complex, which is responsible for degrading mitotic proteins. This process is essential for the proper progression of the mitotic cell cycle. 2. **Amplification of signal from the kinetochores**: MAD2L1 is involved in the amplification of signals from the kinetochores, which are critical structures that attach the sister chromatids to the mitotic spindle. 3. **Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal**: MAD2L1 can inhibit the activity of the MAD2 protein, which is involved in the amplification of signals from unattached kinetochores. 4. **Apc/c-mediated degradation of cell cycle proteins**: MAD2L1 regulates the APC/C complex, which is responsible for degrading cell cycle proteins. 5. **Negative regulation of apoptotic process**: MAD2L1 can inhibit the proteolytic activity of the APC/C complex, which is involved in apoptosis. **Clinical Significance** Dysregulation of MAD2L1 has been implicated in various diseases, including: 1. **Cancer**: MAD2L1 is overexpressed in several types of cancer, including breast, lung, and colon cancer. This overexpression can lead to the deregulation of the mitotic spindle checkpoint, resulting in chromosomal instability and an increased risk of cancer. 2. **Aneuploidy**: MAD2L1 is involved in the regulation of the mitotic spindle checkpoint, and its dysregulation can lead to aneuploidy, a condition characterized by an abnormal number of chromosomes. 3. **Aneuploidies in reproductive cells**: MAD2L1 is highly expressed in oogonial cells, which are involved in the formation of gametes. Dysregulation of MAD2L1 in these cells can lead to aneuploidy, which can result in reproductive disorders. In conclusion, MAD2L1 is a critical gene that plays a key role in regulating the mitotic cell cycle and preventing aneuploidy. Its dysregulation has been implicated in various diseases, including cancer and aneuploidy. Further research is needed to fully understand the mechanisms by which MAD2L1 regulates the mitotic cell cycle and to explore its potential as a therapeutic target.

Genular Protein ID: 429401546

Symbol: MD2L1_HUMAN

Name: Mitotic spindle assembly checkpoint protein MAD2A

UniProtKB Accession Codes:

Q13257 Q53F56 Q548X9 Q6IRW7 Q8IZX3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 19 EMDB 3 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 11 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8824189

Title: Identification of a human mitotic checkpoint gene: hsMAD2.

PubMed ID: 8824189

DOI: 10.1126/science.274.5285.246

PubMed ID: 11390010

Title: Genomic structure of the human MAD2 gene and mutation analysis in human lung and breast cancers.

PubMed ID: 11390010

DOI: 10.1016/s0169-5002(00)00223-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9637688

Title: The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation.

PubMed ID: 9637688

DOI: 10.1101/gad.12.12.1871

PubMed ID: 10527948

Title: Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2-beta.

PubMed ID: 10527948

DOI: 10.1042/bj3430673

PubMed ID: 12456649

Title: Identification of a MAD2-binding protein, CMT2, and its role in mitosis.

PubMed ID: 12456649

DOI: 10.1093/emboj/cdf659

PubMed ID: 12574116

Title: Mad2 phosphorylation regulates its association with Mad1 and the APC/C.

PubMed ID: 12574116

DOI: 10.1093/emboj/cdg071

PubMed ID: 14978040

Title: NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling.

PubMed ID: 14978040

DOI: 10.1074/jbc.m314205200

PubMed ID: 15020684

Title: Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression.

PubMed ID: 15020684

DOI: 10.1242/jcs.01006

PubMed ID: 16495226

Title: FAT10 plays a role in the regulation of chromosomal stability.

PubMed ID: 16495226

DOI: 10.1074/jbc.m507218200

PubMed ID: 18794143

Title: HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression.

PubMed ID: 18794143

DOI: 10.1158/0008-5472.can-08-0129

PubMed ID: 19010891

Title: Role of a novel splice variant of mitotic arrest deficient 1 (MAD1), MAD1beta, in mitotic checkpoint control in liver cancer.

PubMed ID: 19010891

DOI: 10.1158/0008-5472.can-08-2600

PubMed ID: 18981471

Title: Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint.

PubMed ID: 18981471

DOI: 10.1101/gad.1677208

PubMed ID: 18712773

Title: Perturbation of the chromosomal binding of RCC1, Mad2 and survivin causes spindle assembly defects and mitotic catastrophe.

PubMed ID: 18712773

DOI: 10.1002/jcb.21879

PubMed ID: 19029339

Title: The Mad2 partial unfolding model: regulating mitosis through Mad2 conformational switching.

PubMed ID: 19029339

DOI: 10.1083/jcb.200808122

PubMed ID: 20034488

Title: Nek2 targets the mitotic checkpoint proteins Mad2 and Cdc20: a mechanism for aneuploidy in cancer.

PubMed ID: 20034488

DOI: 10.1016/j.yexmp.2009.12.004

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25422469

Title: Disruption of FAT10-MAD2 binding inhibits tumor progression.

PubMed ID: 25422469

DOI: 10.1073/pnas.1403383111

PubMed ID: 29162720

Title: Direct interactions of mitotic arrest deficient 1 (MAD1) domains with each other and MAD2 conformers are required for mitotic checkpoint signaling.

PubMed ID: 29162720

DOI: 10.1074/jbc.ra117.000555

PubMed ID: 10700282

Title: Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20.

PubMed ID: 10700282

DOI: 10.1038/73338

PubMed ID: 12006501

Title: Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint.

PubMed ID: 12006501

DOI: 10.1093/emboj/21.10.2496

PubMed ID: 11804586

Title: The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20.

PubMed ID: 11804586

DOI: 10.1016/s1097-2765(01)00435-x

PubMed ID: 15024386

Title: The Mad2 spindle checkpoint protein has two distinct natively folded states.

PubMed ID: 15024386

DOI: 10.1038/nsmb748

PubMed ID: 18022367

Title: The Mad2 conformational dimer: structure and implications for the spindle assembly checkpoint.

PubMed ID: 18022367

DOI: 10.1016/j.cell.2007.08.049

PubMed ID: 18022368

Title: p31comet blocks Mad2 activation through structural mimicry.

PubMed ID: 18022368

DOI: 10.1016/j.cell.2007.08.048

PubMed ID: 18318601

Title: Insights into Mad2 regulation in the spindle checkpoint revealed by the crystal structure of the symmetric Mad2 dimer.

PubMed ID: 18318601

DOI: 10.1371/journal.pbio.0060050

Sequence Information:

  • Length: 205
  • Mass: 23510
  • Checksum: B8DCBF0043836764
  • Sequence:
    • MALQLSREQG ITLRGSAEIV AEFFSFGINS ILYQRGIYPS ETFTRVQKYG LTLLVTTDLE 
LIKYLNNVVE QLKDWLYKCS VQKLVVVISN IESGEVLERW QFDIECDKTA KDDSAPREKS 
QKAIQDEIRS VIRQITATVT FLPLLEVSCS FDLLIYTDKD LVVPEKWEES GPQFITNSEE 
VRLRSFTTTI HKVNSMVAYK IPVND

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.