Details for: TUSC3

Gene ID: 7991

Symbol: TUSC3

Ensembl ID: ENSG00000104723

Description: tumor suppressor candidate 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 239.9432
    Cell Significance Index: -60.8600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 157.5686
    Cell Significance Index: -64.9100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 133.2069
    Cell Significance Index: -62.8900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 130.8039
    Cell Significance Index: -53.1400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 55.5647
    Cell Significance Index: -53.0500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.3850
    Cell Significance Index: -60.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 10.7417
    Cell Significance Index: 286.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 4.0190
    Cell Significance Index: 177.7700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.6699
    Cell Significance Index: 138.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.1011
    Cell Significance Index: 174.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.0782
    Cell Significance Index: 159.9100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.6334
    Cell Significance Index: 24.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.3133
    Cell Significance Index: 464.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.0101
    Cell Significance Index: 1097.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.9404
    Cell Significance Index: 349.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.8398
    Cell Significance Index: 113.0800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.6927
    Cell Significance Index: 197.2600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.6821
    Cell Significance Index: 35.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.6550
    Cell Significance Index: 203.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.6124
    Cell Significance Index: 108.4200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.5443
    Cell Significance Index: 1068.0700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.5161
    Cell Significance Index: 36.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4569
    Cell Significance Index: 522.5600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.3930
    Cell Significance Index: 17.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2282
    Cell Significance Index: 33.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1245
    Cell Significance Index: 182.8900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0947
    Cell Significance Index: 208.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0867
    Cell Significance Index: 149.2400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.0627
    Cell Significance Index: 36.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9051
    Cell Significance Index: 69.4600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.8288
    Cell Significance Index: 10.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7972
    Cell Significance Index: 22.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7361
    Cell Significance Index: 19.7300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6263
    Cell Significance Index: 68.1300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.6023
    Cell Significance Index: 12.8800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.5812
    Cell Significance Index: 9.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5768
    Cell Significance Index: 73.9400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3716
    Cell Significance Index: 335.5000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2979
    Cell Significance Index: 15.6400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2961
    Cell Significance Index: 8.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2941
    Cell Significance Index: 58.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2925
    Cell Significance Index: 129.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2716
    Cell Significance Index: 35.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2668
    Cell Significance Index: 26.3900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2596
    Cell Significance Index: 19.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2145
    Cell Significance Index: 13.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1637
    Cell Significance Index: 11.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1569
    Cell Significance Index: 4.5200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1495
    Cell Significance Index: 10.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1270
    Cell Significance Index: 21.6800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1258
    Cell Significance Index: 0.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1041
    Cell Significance Index: 66.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1032
    Cell Significance Index: 194.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0643
    Cell Significance Index: 98.9900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0536
    Cell Significance Index: 1.4100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0530
    Cell Significance Index: 97.6700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0179
    Cell Significance Index: 0.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0146
    Cell Significance Index: 19.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0069
    Cell Significance Index: -5.1100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0134
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0363
    Cell Significance Index: -22.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0410
    Cell Significance Index: -1.9200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0466
    Cell Significance Index: -34.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0517
    Cell Significance Index: -7.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0545
    Cell Significance Index: -1.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0577
    Cell Significance Index: -12.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0585
    Cell Significance Index: -44.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0660
    Cell Significance Index: -37.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0848
    Cell Significance Index: -38.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1751
    Cell Significance Index: -50.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1911
    Cell Significance Index: -8.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2078
    Cell Significance Index: -9.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2166
    Cell Significance Index: -24.8100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2386
    Cell Significance Index: -12.4300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3084
    Cell Significance Index: -35.2000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3128
    Cell Significance Index: -6.8500
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.3782
    Cell Significance Index: -3.9400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4103
    Cell Significance Index: -9.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4212
    Cell Significance Index: -14.8000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.4716
    Cell Significance Index: -48.1800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5108
    Cell Significance Index: -10.1000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5459
    Cell Significance Index: -8.0600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.5636
    Cell Significance Index: -66.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5646
    Cell Significance Index: -58.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5954
    Cell Significance Index: -12.6800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6316
    Cell Significance Index: -12.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6619
    Cell Significance Index: -21.2000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6842
    Cell Significance Index: -21.7900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6869
    Cell Significance Index: -22.4900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.7500
    Cell Significance Index: -4.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7556
    Cell Significance Index: -59.8400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7605
    Cell Significance Index: -16.1400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.8372
    Cell Significance Index: -11.9900
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.8749
    Cell Significance Index: -8.3100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8810
    Cell Significance Index: -25.9500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.0062
    Cell Significance Index: -12.5500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -1.0122
    Cell Significance Index: -15.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.0131
    Cell Significance Index: -65.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0332
    Cell Significance Index: -63.3500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -1.0646
    Cell Significance Index: -8.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Multiple Expression Patterns:** TUSC3 is expressed in various cell types, including enterocytes, granule cells, syncytiotrophoblast cells, cortical cells of the adrenal gland, stellate neurons, taste receptor cells, and macroglial cells. 2. **Asparagine N-Linked Glycosylation:** TUSC3 is involved in the asparagine N-linked glycosylation pathway, which is essential for protein maturation and function. 3. **Diverse Pathways:** TUSC3 interacts with multiple signaling pathways, including those involved in cognition, disease, endoplasmic reticulum membrane transport, magnesium ion transmembrane transport, and viral infection pathways. 4. **Tumor Suppressor Function:** TUSC3 acts as a tumor suppressor, preventing cancerous transformations by regulating cell growth, differentiation, and apoptosis. **Pathways and Functions:** 1. **Asparagine N-Linked Glycosylation:** TUSC3 participates in the asparagine N-linked glycosylation pathway, which is crucial for protein maturation and function. This process involves the transfer of a carbohydrate molecule to the asparagine residue of a protein, influencing its stability, folding, and activity. 2. **Protein Synthesis and Metabolism:** TUSC3 regulates protein synthesis and metabolism by interacting with the translation machinery and influencing the expression of structural proteins. 3. **Immune Response and Viral Infection:** TUSC3 plays a role in modulating the immune response and preventing viral infections by interacting with pathways involved in viral entry, replication, and immune evasion. 4. **Cell Signaling and Cognition:** TUSC3 participates in cell signaling pathways involved in cognition, including those related to magnesium ion transmembrane transport and oligosaccharyltransferase complex activity. **Clinical Significance:** TUSC3's involvement in various biological processes makes it a valuable gene for understanding human diseases. Its tumor suppressor function suggests that alterations in TUSC3 expression or function may contribute to cancer development. Additionally, TUSC3's role in protein synthesis, metabolism, and immune responses highlights its potential as a therapeutic target for diseases related to these processes. In conclusion, TUSC3 is a complex gene that plays a multifaceted role in various cellular processes. Its tumor suppressor function, involvement in asparagine N-linked glycosylation, and participation in diverse signaling pathways make it an attractive candidate for further research. Further studies are needed to fully elucidate the mechanisms by which TUSC3 regulates cellular homeostasis and to explore its potential as a therapeutic target for human diseases.

Genular Protein ID: 2323591806

Symbol: TUSC3_HUMAN

Name: Tumor suppressor candidate 3

UniProtKB Accession Codes:

Q13454 A8MSM0 D3DSP2 Q14911 Q14912 Q96FW0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 27 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 2 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8661104

Title: Structure and methylation-associated silencing of a gene within a homozygously deleted region of human chromosome band 8p22.

PubMed ID: 8661104

DOI: 10.1006/geno.1996.0322

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12887896

Title: Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties.

PubMed ID: 12887896

DOI: 10.1016/s1097-2765(03)00243-0

PubMed ID: 18455129

Title: Oligosaccharyltransferase-subunit mutations in nonsyndromic mental retardation.

PubMed ID: 18455129

DOI: 10.1016/j.ajhg.2008.03.021

PubMed ID: 18452889

Title: A defect in the TUSC3 gene is associated with autosomal recessive mental retardation.

PubMed ID: 18452889

DOI: 10.1016/j.ajhg.2008.03.018

PubMed ID: 19717468

Title: Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development.

PubMed ID: 19717468

DOI: 10.1073/pnas.0908332106

PubMed ID: 25135935

Title: Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins.

PubMed ID: 25135935

DOI: 10.1083/jcb.201404083

PubMed ID: 24685145

Title: Structural basis of substrate specificity of human oligosaccharyl transferase subunit N33/Tusc3 and its role in regulating protein N-glycosylation.

PubMed ID: 24685145

DOI: 10.1016/j.str.2014.02.013

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

Sequence Information:

  • Length: 348
  • Mass: 39676
  • Checksum: 16D97CB1E00C5190
  • Sequence:
    • MGARGAPSRR RQAGRRLRYL PTGSFPFLLL LLLLCIQLGG GQKKKENLLA EKVEQLMEWS 
SRRSIFRMNG DKFRKFIKAP PRNYSMIVMF TALQPQRQCS VCRQANEEYQ ILANSWRYSS 
AFCNKLFFSM VDYDEGTDVF QQLNMNSAPT FMHFPPKGRP KRADTFDLQR IGFAAEQLAK 
WIADRTDVHI RVFRPPNYSG TIALALLVSL VGGLLYLRRN NLEFIYNKTG WAMVSLCIVF 
AMTSGQMWNH IRGPPYAHKN PHNGQVSYIH GSSQAQFVAE SHIILVLNAA ITMGMVLLNE 
AATSKGDVGK RRIICLVGLG LVVFFFSFLL SIFRSKYHGY PYSDLDFE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.