Details for: PTTG1
Gene ID: 9232
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PTTG1
Ensembl ID: ENSG00000164611
Description: PTTG1 regulator of sister chromatid separation, securin
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 37.33rCSI 43.84%PRS 79.92
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CSI 30.52rCSI 35.24%PRS 70.64
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CSI 24.82rCSI 42.53%PRS 84.7
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CSI 24.1rCSI 33.48%PRS 76.98
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CSI 20.85rCSI 14.56%PRS 81.61
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CSI 20.36rCSI 66.04%PRS 76.28
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CSI 19.94rCSI 20.89%PRS 75.7
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CSI 19.65rCSI 56.11%PRS 84.3
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CSI 18.73rCSI 14.73%PRS 83.63
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CSI 15.69rCSI 12.4%PRS 66.75
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CSI 14.48rCSI 12.72%PRS 83.32
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CSI 13.7rCSI 11.35%PRS 80.82
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CSI 13.58rCSI 16.22%PRS 92.56
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CSI 12.71rCSI 15.26%PRS 75.9
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CSI 12.6rCSI 12.15%PRS 71.32
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CSI 12.49rCSI 8.68%PRS 89.22
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CSI 12.24rCSI 8.14%PRS 81.17
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CSI 12.14rCSI 11.69%PRS 77.58
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CSI 11.95rCSI 10.35%PRS 82.4
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CSI 11.3rCSI 17.36%PRS 68.32
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CSI 11.28rCSI 12.91%PRS 89.05
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CSI 10.48rCSI 9.18%PRS 85.65
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CSI 9.54rCSI 21.01%PRS 81.95
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CSI 9.45rCSI 50.99%PRS 85.01
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CSI 9.2rCSI 8.31%PRS 76.48
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CSI 9.05rCSI 20.54%PRS 79.13
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CSI 8.69rCSI 7.92%PRS 90.05
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CSI 8.52rCSI 11.61%PRS 45.35
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CSI 8.5rCSI 7.54%PRS 75.98
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CSI 8.07rCSI 5.8%PRS 90.52
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CSI 7.97rCSI 7.53%PRS 77.03
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CSI 7.91rCSI 11.41%PRS 84.39
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CSI 7.78rCSI 12.82%PRS 82.37
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CSI 7.6rCSI 22.67%PRS 88.38
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CSI 7.59rCSI 5.77%PRS 90.24
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CSI 7.37rCSI 8.83%PRS 88.56
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CSI 7.35rCSI 11.25%PRS 86.95
-
CSI 7.35rCSI 21.09%PRS 93.83
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CSI 7.25rCSI 6.07%PRS 81.39
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CSI 7.06rCSI 9.06%PRS 81.66
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CSI 7.02rCSI 18.63%PRS 84.5
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CSI 6.89rCSI 30.25%PRS 86.91
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CSI 6.75rCSI 8.59%PRS 83.17
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CSI 6.71rCSI 9.3%PRS 75.66
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CSI 6.67rCSI 10.3%PRS 77.33
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CSI 6.65rCSI 5.51%PRS 78.82
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CSI 6.6rCSI 5.13%PRS 91.79
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CSI 6.53rCSI 22.08%PRS 76.67
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CSI 6.5rCSI 5.26%PRS 80.57
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CSI 6.31rCSI 13.43%PRS 84.83
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CSI 6.24rCSI 7.71%PRS 76.17
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CSI 6.19rCSI 9.07%PRS 72.83
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CSI 5.98rCSI 7.99%PRS 77.22
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CSI 5.54rCSI 5.44%PRS 91
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CSI 5.3rCSI 6.41%PRS 85.97
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CSI 5.25rCSI 57.53%PRS 83.92
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CSI 5.1rCSI 14.51%PRS 74.55
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CSI 4.86rCSI 4.5%PRS 92.34
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CSI 4.85rCSI 31.23%PRS 87.95
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CSI 4.57rCSI 4.56%PRS 72.09
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CSI 4.53rCSI 4.18%PRS 79.71
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CSI 4.48rCSI 6.4%PRS 79.2
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CSI 4.26rCSI 7.59%PRS 87
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CSI 4.25rCSI 5.46%PRS 74.44
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CSI 4.02rCSI 23.07%PRS 83.96
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CSI 3.9rCSI 6.22%PRS 70.02
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CSI 3.48rCSI 6.58%PRS 95.9
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CSI 3.42rCSI 5.23%PRS 85.67
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CSI 3.37rCSI 8.55%PRS 71.61
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CSI 3.33rCSI 3.54%PRS 83.55
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CSI 3.14rCSI 3.94%PRS 87.03
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CSI 3.11rCSI 6.24%PRS 68.31
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CSI 2.98rCSI 10.47%PRS 86.55
-
CSI 2.97rCSI 2.22%PRS 90.41
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CSI 2.91rCSI 12.79%PRS 66.92
-
CSI 2.88rCSI 12.98%PRS 94.09
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CSI 2.87rCSI 3%PRS 75.89
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CSI 2.85rCSI 2.91%PRS 86.46
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CSI 2.8rCSI 4.78%PRS 90.83
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CSI 2.66rCSI 6.33%PRS 84
-
CSI 2.64rCSI 4.04%PRS 89.26
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CSI 2.64rCSI 2.3%PRS 87.66
-
CSI 2.64rCSI 7.84%PRS 87.13
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CSI 2.62rCSI 13.09%PRS 92.16
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CSI 2.62rCSI 3.7%PRS 77.94
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CSI 2.61rCSI 2.29%PRS 67.3
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CSI 2.46rCSI 2.51%PRS 88.08
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CSI 2.44rCSI 32.22%PRS 94.12
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CSI 2.34rCSI 3.38%PRS 85.32
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CSI 2.29rCSI 1.82%PRS 94.02
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CSI 2.27rCSI 6.56%PRS 85.13
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CSI 2.23rCSI 3.4%PRS 78.65
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CSI 2.2rCSI 7.96%PRS 92.81
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CSI 2.01rCSI 7.57%PRS 61.18
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CSI 2rCSI 2.07%PRS 82.53
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CSI 1.91rCSI 6.14%PRS 80.45
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CSI 1.89rCSI 3.64%PRS 94.63
-
CSI 1.89rCSI 2.52%PRS 92.42
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CSI 1.72rCSI 51.66%PRS 89.34
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CSI 1.59rCSI 10.43%PRS 93.67
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CSI 0.4rCSI 2.0%PRS 82.5%
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CSI 0.4rCSI 4.4%PRS 84.6%
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CSI 0.5rCSI 3.8%PRS 84.2%
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CSI 0.6rCSI 3.5%PRS 75.3%
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CSI 0.6rCSI 2.8%PRS 94.1%
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CSI 0.7rCSI 4.3%PRS 92.4%
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CSI 0.7rCSI 3.7%PRS 92.7%
-
CSI 0.7rCSI 12.3%PRS 89.1%
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CSI 0.8rCSI 20.1%PRS 87.0%
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CSI 1.0rCSI 9.5%PRS 94.6%
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CSI 1.0rCSI 1.6%PRS 71.2%
-
CSI 1.0rCSI 2.6%PRS 92.1%
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CSI 1.1rCSI 5.6%PRS 89.5%
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CSI 1.1rCSI 5.0%PRS 95.9%
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CSI 1.3rCSI 4.7%PRS 95.6%
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CSI 1.4rCSI 3.7%PRS 83.5%
-
CSI 1.4rCSI 3.9%PRS 94.5%
-
CSI 1.5rCSI 2.9%PRS 90.0%
-
CSI 1.5rCSI 6.7%PRS 84.3%
-
CSI 1.6rCSI 2.5%PRS 45.3%
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CSI 1.6rCSI 10.4%PRS 93.7%
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CSI 1.7rCSI 51.7%PRS 89.3%
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CSI 1.9rCSI 2.5%PRS 92.4%
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CSI 1.9rCSI 3.6%PRS 94.6%
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CSI 1.9rCSI 6.1%PRS 80.5%
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CSI 2.0rCSI 2.1%PRS 82.5%
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CSI 2.0rCSI 7.6%PRS 61.2%
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CSI 2.2rCSI 8.0%PRS 92.8%
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CSI 2.2rCSI 3.4%PRS 78.7%
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CSI 2.3rCSI 6.6%PRS 85.1%
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CSI 2.3rCSI 1.8%PRS 94.0%
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CSI 2.3rCSI 3.4%PRS 85.3%
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CSI 2.4rCSI 32.2%PRS 94.1%
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CSI 2.5rCSI 2.5%PRS 88.1%
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CSI 2.6rCSI 2.3%PRS 67.3%
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CSI 2.6rCSI 3.7%PRS 77.9%
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CSI 2.6rCSI 13.1%PRS 92.2%
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CSI 2.6rCSI 7.8%PRS 87.1%
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CSI 2.6rCSI 2.3%PRS 87.7%
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CSI 2.6rCSI 4.0%PRS 89.3%
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CSI 2.7rCSI 6.3%PRS 84.0%
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CSI 2.8rCSI 4.8%PRS 90.8%
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CSI 2.9rCSI 2.9%PRS 86.5%
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CSI 2.9rCSI 3.0%PRS 75.9%
-
CSI 2.9rCSI 13.0%PRS 94.1%
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CSI 2.9rCSI 12.8%PRS 66.9%
-
CSI 3.0rCSI 2.2%PRS 90.4%
-
CSI 3.0rCSI 10.5%PRS 86.6%
-
CSI 3.1rCSI 6.2%PRS 68.3%
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CSI 3.1rCSI 3.9%PRS 87.0%
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CSI 3.3rCSI 3.5%PRS 83.6%
-
CSI 3.4rCSI 8.6%PRS 71.6%
-
CSI 3.4rCSI 5.2%PRS 85.7%
-
CSI 3.5rCSI 6.6%PRS 95.9%
-
CSI 3.9rCSI 6.2%PRS 70.0%
-
CSI 4.0rCSI 23.1%PRS 84.0%
-
CSI 4.3rCSI 5.5%PRS 74.4%
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CSI 4.3rCSI 7.6%PRS 87.0%
-
CSI 4.5rCSI 6.4%PRS 79.2%
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CSI 4.5rCSI 4.2%PRS 79.7%
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CSI 4.6rCSI 4.6%PRS 72.1%
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CSI 4.9rCSI 31.2%PRS 88.0%
-
CSI 4.9rCSI 4.5%PRS 92.3%
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CSI 5.1rCSI 14.5%PRS 74.6%
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CSI 5.3rCSI 57.5%PRS 83.9%
-
CSI 5.3rCSI 6.4%PRS 86.0%
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CSI 5.5rCSI 5.4%PRS 91.0%
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CSI 6.0rCSI 8.0%PRS 77.2%
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CSI 6.2rCSI 9.1%PRS 72.8%
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CSI 6.2rCSI 7.7%PRS 76.2%
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CSI 6.3rCSI 13.4%PRS 84.8%
-
CSI 6.5rCSI 5.3%PRS 80.6%
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CSI 6.5rCSI 22.1%PRS 76.7%
-
CSI 6.6rCSI 5.1%PRS 91.8%
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CSI 6.7rCSI 5.5%PRS 78.8%
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CSI 6.7rCSI 10.3%PRS 77.3%
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CSI 6.7rCSI 9.3%PRS 75.7%
-
CSI 6.8rCSI 8.6%PRS 83.2%
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CSI 6.9rCSI 30.3%PRS 86.9%
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CSI 7.0rCSI 18.6%PRS 84.5%
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CSI 7.1rCSI 9.1%PRS 81.7%
-
CSI 7.3rCSI 6.1%PRS 81.4%
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CSI 7.4rCSI 21.1%PRS 93.8%
-
CSI 7.4rCSI 11.3%PRS 87.0%
-
CSI 7.4rCSI 8.8%PRS 88.6%
-
CSI 7.6rCSI 5.8%PRS 90.2%
-
CSI 7.6rCSI 22.7%PRS 88.4%
-
CSI 7.8rCSI 12.8%PRS 82.4%
-
CSI 7.9rCSI 11.4%PRS 84.4%
-
CSI 8.0rCSI 7.5%PRS 77.0%
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CSI 8.1rCSI 5.8%PRS 90.5%
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CSI 8.5rCSI 7.5%PRS 76.0%
-
CSI 8.5rCSI 11.6%PRS 45.4%
-
CSI 8.7rCSI 7.9%PRS 90.1%
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CSI 9.1rCSI 20.5%PRS 79.1%
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CSI 9.2rCSI 8.3%PRS 76.5%
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CSI 9.5rCSI 51.0%PRS 85.0%
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CSI 9.5rCSI 21.0%PRS 82.0%
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CSI 10.5rCSI 9.2%PRS 85.7%
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CSI 11.3rCSI 12.9%PRS 89.1%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3035931495
Symbol: PTTG1_HUMAN
Name: Securin
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9811450
Title: hPTTG, a human homologue of rat PTTG, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG.
PubMed ID: 9811450
PubMed ID: 10393434
Title: Molecular cloning and characterization of the tumor transforming gene (TUTR1): a novel gene in human tumorigenesis.
PubMed ID: 10393434
DOI: 10.1159/000015261
PubMed ID: 10580151
Title: Molecular cloning, genomic organization, and identification of the promoter for the human pituitary tumor transforming gene (PTTG).
PubMed ID: 10580151
PubMed ID: 9892021
Title: Structure, expression, and function of human pituitary tumor-transforming gene (PTTG).
PubMed ID: 9892021
PubMed ID: 10022450
Title: Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas.
PubMed ID: 10022450
PubMed ID: 10411507
Title: Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis.
PubMed ID: 10411507
PubMed ID: 10781616
Title: A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product.
PubMed ID: 10781616
PubMed ID: 11238996
Title: Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase.
PubMed ID: 11238996
PubMed ID: 11371342
Title: Securin is required for chromosomal stability in human cells.
PubMed ID: 11371342
PubMed ID: 11158059
Title: Human pituitary tumor-transforming gene induces angiogenesis.
PubMed ID: 11158059
PubMed ID: 12355087
Title: Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis.
PubMed ID: 12355087
DOI: 10.1038/ng997
PubMed ID: 10656688
Title: Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product.
PubMed ID: 10656688
PubMed ID: 18485873
Title: Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex.
PubMed ID: 18485873
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
Sequence Information:
- Length: 202
- Mass: 22024
- Checksum: 5F4740619AB8856F
- Sequence:
MATLIYVDKE NGEPGTRVVA KDGLKLGSGP SIKALDGRSQ VSTPRFGKTF DAPPALPKAT RKALGTVNRA TEKSVKTKGP LKQKQPSFSA KKMTEKTVKA KSSVPASDDA YPEIEKFFPF NPLDFESFDL PEEHQIAHLP LSGVPLMILD EERELEKLFQ LGPPSPVKMP SPPWESNLLQ SPSSILSTLD VELPPVCCDI DI