PTTG1 | ENSG00000164611 | NCBI 9232

Details for: PTTG1

Gene ID: 9232

Symbol: PTTG1

Ensembl ID: ENSG00000164611

Description: PTTG1 regulator of sister chromatid separation, securin

Associated with

Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176814)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176409)
Apc/c:cdc20 mediated degradation of securin
(R-HSA-174154)
Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
(R-HSA-174178)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Regulation of mitotic cell cycle
(R-HSA-453276)
Separation of sister chromatids
(R-HSA-2467813)
Cell division
(GO:0051301)
Chromosome organization
(GO:0051276)
Cysteine-type endopeptidase inhibitor activity
(GO:0004869)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna repair
(GO:0006281)
Homologous chromosome segregation
(GO:0045143)
Molecular function activator activity
(GO:0140677)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Sh3 domain binding
(GO:0017124)
Spermatogenesis
(GO:0007283)

Other Information

Proteins

Securin

Genular Protein ID: 3035931495

Symbol: PTTG1_HUMAN

Name: Securin

UniProtKB Accession Codes:

O95997

Database IDs:

Citations:

PubMed ID: 9811450

Title: hPTTG, a human homologue of rat PTTG, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG.

PubMed ID: 9811450

DOI: 10.1038/sj.onc.1202140

PubMed ID: 10393434

Title: Molecular cloning and characterization of the tumor transforming gene (TUTR1): a novel gene in human tumorigenesis.

PubMed ID: 10393434

DOI: 10.1159/000015261

PubMed ID: 10580151

Title: Molecular cloning, genomic organization, and identification of the promoter for the human pituitary tumor transforming gene (PTTG).

PubMed ID: 10580151

DOI: 10.1016/s0378-1119(99)00446-1

PubMed ID: 9892021

Title: Structure, expression, and function of human pituitary tumor-transforming gene (PTTG).

PubMed ID: 9892021

DOI: 10.1210/mend.13.1.0225

PubMed ID: 10022450

Title: Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas.

PubMed ID: 10022450

DOI: 10.1210/jcem.84.2.5432

PubMed ID: 10411507

Title: Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis.

PubMed ID: 10411507

DOI: 10.1126/science.285.5426.418

PubMed ID: 10781616

Title: A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product.

PubMed ID: 10781616

DOI: 10.1074/jbc.m910105199

PubMed ID: 11238996

Title: Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase.

PubMed ID: 11238996

DOI: 10.1093/nar/29.6.1300

PubMed ID: 11371342

Title: Securin is required for chromosomal stability in human cells.

PubMed ID: 11371342

DOI: 10.1016/s0092-8674(01)00340-3

PubMed ID: 11158059

Title: Human pituitary tumor-transforming gene induces angiogenesis.

PubMed ID: 11158059

DOI: 10.1210/jcem.86.2.7184

PubMed ID: 12355087

Title: Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis.

PubMed ID: 12355087

DOI: 10.1038/ng997

PubMed ID: 10656688

Title: Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product.

PubMed ID: 10656688

DOI: 10.1038/sj.onc.1203320

PubMed ID: 18485873

Title: Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex.

PubMed ID: 18485873

DOI: 10.1016/j.cell.2008.04.012

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

Length: 202
Mass: 22024
Checksum: 5F4740619AB8856F
Sequence:

MATLIYVDKE NGEPGTRVVA KDGLKLGSGP SIKALDGRSQ VSTPRFGKTF DAPPALPKAT 
RKALGTVNRA TEKSVKTKGP LKQKQPSFSA KKMTEKTVKA KSSVPASDDA YPEIEKFFPF 
NPLDFESFDL PEEHQIAHLP LSGVPLMILD EERELEKLFQ LGPPSPVKMP SPPWESNLLQ 
SPSSILSTLD VELPPVCCDI DI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PTTG1

Associated with

Other Information

hPTTG, a human homologue of rat PTTG, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG. PubMed ID: 9811450

Molecular cloning and characterization of the tumor transforming gene (TUTR1): a novel gene in human tumorigenesis. PubMed ID: 10393434

Molecular cloning, genomic organization, and identification of the promoter for the human pituitary tumor transforming gene (PTTG). PubMed ID: 10580151

Structure, expression, and function of human pituitary tumor-transforming gene (PTTG). PubMed ID: 9892021

Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas. PubMed ID: 10022450

Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. PubMed ID: 10411507

A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product. PubMed ID: 10781616

Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase. PubMed ID: 11238996

Securin is required for chromosomal stability in human cells. PubMed ID: 11371342

Human pituitary tumor-transforming gene induces angiogenesis. PubMed ID: 11158059

Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis. PubMed ID: 12355087

Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product. PubMed ID: 10656688

Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. PubMed ID: 18485873

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378