Details for: ISYNA1

Gene ID: 51477

Symbol: ISYNA1

Ensembl ID: ENSG00000105655

Description: inositol-3-phosphate synthase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 141.6951
    Cell Significance Index: -22.0400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 60.1533
    Cell Significance Index: -24.7800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 52.8695
    Cell Significance Index: -13.4100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 50.6330
    Cell Significance Index: -20.5700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 50.1988
    Cell Significance Index: -23.7000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.7493
    Cell Significance Index: -20.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.1677
    Cell Significance Index: -22.4000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 10.8973
    Cell Significance Index: 91.5400
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 9.6606
    Cell Significance Index: 46.9900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.7458
    Cell Significance Index: -20.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 7.1311
    Cell Significance Index: 190.4100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 6.4954
    Cell Significance Index: 83.1900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.7602
    Cell Significance Index: -22.7300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 4.6140
    Cell Significance Index: 106.6000
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.6590
    Cell Significance Index: 16.9000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.3754
    Cell Significance Index: 26.9500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.9700
    Cell Significance Index: 80.8400
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.1523
    Cell Significance Index: 17.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.6320
    Cell Significance Index: 56.7100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.5258
    Cell Significance Index: 38.9800
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.5111
    Cell Significance Index: 9.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4507
    Cell Significance Index: 143.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.3359
    Cell Significance Index: 171.2600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.0141
    Cell Significance Index: 15.6900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.9684
    Cell Significance Index: 20.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9079
    Cell Significance Index: 495.8400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8839
    Cell Significance Index: 12.0600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8589
    Cell Significance Index: 775.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8466
    Cell Significance Index: 22.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7388
    Cell Significance Index: 120.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6836
    Cell Significance Index: 35.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6505
    Cell Significance Index: 79.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6494
    Cell Significance Index: 33.8300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6467
    Cell Significance Index: 7.0300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6291
    Cell Significance Index: 17.5800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.5540
    Cell Significance Index: 9.7900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.5285
    Cell Significance Index: 2.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5013
    Cell Significance Index: 68.8400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4449
    Cell Significance Index: 26.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4152
    Cell Significance Index: 74.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3880
    Cell Significance Index: 25.0300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.3763
    Cell Significance Index: 3.3400
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.3752
    Cell Significance Index: 2.2200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3545
    Cell Significance Index: 67.4700
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.3307
    Cell Significance Index: 1.6500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2818
    Cell Significance Index: 7.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2644
    Cell Significance Index: 18.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2245
    Cell Significance Index: 99.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2175
    Cell Significance Index: 138.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2030
    Cell Significance Index: 40.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1483
    Cell Significance Index: 19.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1304
    Cell Significance Index: 7.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1296
    Cell Significance Index: 9.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0630
    Cell Significance Index: 116.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0614
    Cell Significance Index: 4.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0537
    Cell Significance Index: 82.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0531
    Cell Significance Index: 1.5300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0417
    Cell Significance Index: 28.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0293
    Cell Significance Index: 1.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0259
    Cell Significance Index: 9.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0252
    Cell Significance Index: 47.4500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0238
    Cell Significance Index: 17.4500
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.0187
    Cell Significance Index: 0.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0128
    Cell Significance Index: 0.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0063
    Cell Significance Index: 0.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0131
    Cell Significance Index: -17.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0224
    Cell Significance Index: -1.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0224
    Cell Significance Index: -16.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0243
    Cell Significance Index: -11.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0245
    Cell Significance Index: -18.5800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0339
    Cell Significance Index: -0.9100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0382
    Cell Significance Index: -21.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0421
    Cell Significance Index: -4.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0448
    Cell Significance Index: -28.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0457
    Cell Significance Index: -9.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0532
    Cell Significance Index: -6.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0554
    Cell Significance Index: -6.4600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0589
    Cell Significance Index: -16.9400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0595
    Cell Significance Index: -3.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0632
    Cell Significance Index: -9.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0803
    Cell Significance Index: -13.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0902
    Cell Significance Index: -1.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1073
    Cell Significance Index: -10.9600
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: -0.1179
    Cell Significance Index: -0.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1250
    Cell Significance Index: -26.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1337
    Cell Significance Index: -8.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1675
    Cell Significance Index: -7.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1993
    Cell Significance Index: -20.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2092
    Cell Significance Index: -16.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2173
    Cell Significance Index: -13.3200
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.2179
    Cell Significance Index: -2.0700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2217
    Cell Significance Index: -2.3000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2297
    Cell Significance Index: -2.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2793
    Cell Significance Index: -21.4300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2906
    Cell Significance Index: -8.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2940
    Cell Significance Index: -6.3700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3416
    Cell Significance Index: -7.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3428
    Cell Significance Index: -23.0500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3639
    Cell Significance Index: -22.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3678
    Cell Significance Index: -11.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ISYNA1 is a cytoplasmic enzyme that catalyzes the synthesis of inositol-3-phosphate (IP3) from inositol-1-phosphate (IP1). This enzyme is a key player in the inositol phosphate metabolism pathway, which is essential for various cellular functions, including cell signaling, proliferation, and differentiation. ISYNA1 is also involved in the synthesis of other inositol phosphates, such as inositol 1,4,5-trisphosphate (IP3) and inositol 1,3,4,5-tetrakisphosphate (IP4). **Pathways and Functions** ISYNA1 is involved in several key pathways, including: 1. **Inositol biosynthetic process**: ISYNA1 is the rate-limiting enzyme in this pathway, which is responsible for the production of inositol phosphates. 2. **Inositol phosphate metabolism**: ISYNA1 plays a crucial role in the regulation of IP3 and IP4 levels, which are involved in various cellular processes, including cell signaling and proliferation. 3. **Phospholipid biosynthetic process**: ISYNA1 is involved in the synthesis of phospholipids, which are essential components of cellular membranes. 4. **Protein binding**: ISYNA1 interacts with various proteins, including inositol-1-phosphate synthase, which regulates its activity. **Clinical Significance** ISYNA1 is significantly expressed in various cell types, including hematopoietic cells, smooth muscle cells, and epithelial cells. This suggests that ISYNA1 plays a crucial role in maintaining cellular homeostasis and regulating cellular processes, such as proliferation and differentiation. Alterations in ISYNA1 expression or activity may contribute to various diseases, including: 1. **Hematological disorders**: ISYNA1 is expressed in hematopoietic cells, and alterations in its expression may contribute to hematological disorders, such as leukemia or lymphoma. 2. **Smooth muscle disorders**: ISYNA1 is expressed in smooth muscle cells, and alterations in its expression may contribute to smooth muscle disorders, such as atherosclerosis or hypertension. 3. **Cancer**: ISYNA1 is expressed in epithelial cells, and alterations in its expression may contribute to cancer development and progression. In conclusion, ISYNA1 is a crucial enzyme involved in the biosynthesis of inositol phosphates, which play pivotal roles in various cellular processes. Its significant expression in various cell types highlights its importance in maintaining cellular homeostasis and regulating cellular processes. Further research is needed to fully understand the function and significance of ISYNA1 in various diseases.

Genular Protein ID: 2377458356

Symbol: INO1_HUMAN

Name: Inositol-3-phosphate synthase 1

UniProtKB Accession Codes:

Q9NPH2 B3KRT1 G5E9U0 Q6NXT5 Q7Z525 Q9BT65 Q9H2Y2 Q9NSU0 Q9NVW7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CPTAC 2 CTD 1 ChEBI 28 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 1 EMBL 23 Ensembl 3 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12941308

Title: cDNA cloning and gene expression analysis of human myo-inositol 1-phosphate synthase.

PubMed ID: 12941308

DOI: 10.1016/s0003-9861(03)00388-6

PubMed ID: 17121280

Title: Mammalian inositol 3-phosphate synthase: its role in the biosynthesis of brain inositol and its clinical use as a psychoactive agent.

PubMed ID: 17121280

DOI: 10.1007/0-387-27600-9_12

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15464731

Title: E2F1 regulation of the human myo-inositol 1-phosphate synthase (ISYNA1) gene promoter.

PubMed ID: 15464731

DOI: 10.1016/j.abb.2004.08.002

PubMed ID: 15024000

Title: Human 1-D-myo-inositol-3-phosphate synthase is functional in yeast.

PubMed ID: 15024000

DOI: 10.1074/jbc.m312078200

PubMed ID: 17988368

Title: Human MIP synthase splice variants in bipolar disorder.

PubMed ID: 17988368

DOI: 10.1111/j.1399-5618.2007.00440.x

PubMed ID: 17901568

Title: Effects of valproate derivatives on human brain myo-inositol-1-phosphate (MIP) synthase activity and amphetamine-induced rearing.

PubMed ID: 17901568

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23902760

Title: Phosphorylation regulates myo-inositol-3-phosphate synthase: a novel regulatory mechanism of inositol biosynthesis.

PubMed ID: 23902760

DOI: 10.1074/jbc.m113.479121

Sequence Information:

  • Length: 558
  • Mass: 61068
  • Checksum: 3A1009D941A5F87D
  • Sequence:
    • MEAAAQFFVE SPDVVYGPEA IEAQYEYRTT RVSREGGVLK VHPTSTRFTF RTARQVPRLG 
VMLVGWGGNN GSTLTAAVLA NRLRLSWPTR SGRKEANYYG SLTQAGTVSL GLDAEGQEVF 
VPFSAVLPMV APNDLVFDGW DISSLNLAEA MRRAKVLDWG LQEQLWPHME ALRPRPSVYI 
PEFIAANQSA RADNLIPGSR AQQLEQIRRD IRDFRSSAGL DKVIVLWTAN TERFCEVIPG 
LNDTAENLLR TIELGLEVSP STLFAVASIL EGCAFLNGSP QNTLVPGALE LAWQHRVFVG 
GDDFKSGQTK VKSVLVDFLI GSGLKTMSIV SYNHLGNNDG ENLSAPLQFR SKEVSKSNVV 
DDMVQSNPVL YTPGEEPDHC VVIKYVPYVG DSKRALDEYT SELMLGGTNT LVLHNTCEDS 
LLAAPIMLDL ALLTELCQRV SFCTDMDPEP QTFHPVLSLL SFLFKAPLVP PGSPVVNALF 
RQRSCIENIL RACVGLPPQN HMLLEHKMER PGPSLKRVGP VAATYPMLNK KGPVPAATNG 
CTGDANGHLQ EEPPMPTT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.