Details for: SMC2

Gene ID: 10592

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: SMC2

Ensembl ID: ENSG00000136824

Description: structural maintenance of chromosomes 2

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • transit amplifying cell of colon CL0009011
    CSI 14.6
    rCSI 17.15%
    PRS 83.64
  • fraction A pre-pro B cell CL0002045
    CSI 11.73
    rCSI 13.43%
    PRS 91.16
  • large pre-B-II cell CL0000957
    CSI 11.41
    rCSI 32.57%
    PRS 86.58
  • peripheral nervous system neuron CL2000032
    CSI 11.07
    rCSI 15.09%
    PRS 74.09
  • double negative thymocyte CL0002489
    CSI 10.03
    rCSI 6.97%
    PRS 92.39
  • pro-B cell CL0000826
    CSI 9.76
    rCSI 8.08%
    PRS 84.22
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 8.78
    rCSI 10.14%
    PRS 74.45
  • precursor B cell CL0000817
    CSI 7.51
    rCSI 6.58%
    PRS 88.6
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 6.8
    rCSI 6.14%
    PRS 80.34
  • ciliated epithelial cell CL0000067
    CSI 6.58
    rCSI 5.78%
    PRS 71.69
  • sst GABAergic cortical interneuron CL4023017
    CSI 5.93
    rCSI 7.64%
    PRS 65.9
  • neural crest cell CL0011012
    CSI 5.73
    rCSI 4.53%
    PRS 71.63
  • transit amplifying cell of small intestine CL0009012
    CSI 5.68
    rCSI 24.94%
    PRS 89.01
  • stem cell CL0000034
    CSI 5.55
    rCSI 5.35%
    PRS 76
  • keratinocyte CL0000312
    CSI 5.47
    rCSI 4.58%
    PRS 84.42
  • common myeloid progenitor CL0000049
    CSI 5.24
    rCSI 4.24%
    PRS 84.19
  • promonocyte CL0000559
    CSI 5.14
    rCSI 8.81%
    PRS 87.36
  • intestine goblet cell CL0019031
    CSI 4.95
    rCSI 4.39%
    PRS 79.91
  • plasmablast CL0000980
    CSI 4.68
    rCSI 3.68%
    PRS 86.64
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 4.56
    rCSI 5.85%
    PRS 78.31
  • megakaryocyte CL0000556
    CSI 4.46
    rCSI 19.36%
    PRS 86.47
  • primitive red blood cell CL0002355
    CSI 4.44
    rCSI 23.96%
    PRS 87.5
  • early lymphoid progenitor CL0000936
    CSI 4.38
    rCSI 3.85%
    PRS 86.92
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 4.2
    rCSI 7.63%
    PRS 73.92
  • vascular associated smooth muscle cell CL0000359
    CSI 4.19
    rCSI 13.6%
    PRS 80.16
  • duct epithelial cell CL0000068
    CSI 4.16
    rCSI 6.09%
    PRS 86.73
  • radial glial cell CL0000681
    CSI 3.99
    rCSI 5.55%
    PRS 80.59
  • common dendritic progenitor CL0001029
    CSI 3.94
    rCSI 4.95%
    PRS 89.61
  • glioblast CL0000030
    CSI 3.86
    rCSI 6.15%
    PRS 73.82
  • epithelial cell CL0000066
    CSI 3.72
    rCSI 5.71%
    PRS 71.24
  • multi-ciliated epithelial cell CL0005012
    CSI 3.54
    rCSI 3.54%
    PRS 76.08
  • hematopoietic precursor cell CL0008001
    CSI 3.42
    rCSI 3.52%
    PRS 91.96
  • interneuron CL0000099
    CSI 3.41
    rCSI 6.84%
    PRS 72.95
  • respiratory basal cell CL0002633
    CSI 3.35
    rCSI 3.47%
    PRS 85.63
  • cerebral cortex GABAergic interneuron CL0010011
    CSI 3.33
    rCSI 9.84%
    PRS 82.92
  • intermediate monocyte CL0002393
    CSI 3.33
    rCSI 5.03%
    PRS 87.1
  • respiratory suprabasal cell CL4033048
    CSI 3.22
    rCSI 4.12%
    PRS 84.97
  • enteric smooth muscle cell CL0002504
    CSI 3.2
    rCSI 4.57%
    PRS 82.84
  • fallopian tube secretory epithelial cell CL4030006
    CSI 3.08
    rCSI 2.96%
    PRS 81.53
  • hematopoietic stem cell CL0000037
    CSI 2.84
    rCSI 1.89%
    PRS 84.59
  • placental villous trophoblast CL2000060
    CSI 2.69
    rCSI 4.16%
    PRS 81.26
  • interstitial cell of Cajal CL0002088
    CSI 2.66
    rCSI 3.39%
    PRS 86.93
  • goblet cell CL0000160
    CSI 2.63
    rCSI 2.48%
    PRS 80.57
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 2.59
    rCSI 2%
    PRS 85.04
  • myeloid leukocyte CL0000766
    CSI 2.58
    rCSI 2.38%
    PRS 83.59
  • group 3 innate lymphoid cell CL0001071
    CSI 2.48
    rCSI 1.87%
    PRS 87.54
  • epithelial cell of lung CL0000082
    CSI 2.48
    rCSI 2.06%
    PRS 83.06
  • plasmacytoid dendritic cell, human CL0001058
    CSI 2.38
    rCSI 1.66%
    PRS 85.55
  • ionocyte CL0005006
    CSI 2.37
    rCSI 2.54%
    PRS 83.55
  • double-positive, alpha-beta thymocyte CL0000809
    CSI 2.36
    rCSI 2.41%
    PRS 90.71
  • erythrocyte CL0000232
    CSI 2.34
    rCSI 5.3%
    PRS 82.33
  • respiratory hillock cell CL4030023
    CSI 2.31
    rCSI 4.13%
    PRS 89.64
  • colon epithelial cell CL0011108
    CSI 2.31
    rCSI 2.42%
    PRS 79.59
  • intestinal epithelial cell CL0002563
    CSI 2.3
    rCSI 2.4%
    PRS 79.78
  • pancreatic A cell CL0000171
    CSI 2.2
    rCSI 2.31%
    PRS 85.18
  • lung neuroendocrine cell CL1000223
    CSI 2.18
    rCSI 3.22%
    PRS 85.67
  • granulocyte monocyte progenitor cell CL0000557
    CSI 2.12
    rCSI 1.84%
    PRS 85.81
  • rod bipolar cell CL0000751
    CSI 2.08
    rCSI 3.74%
    PRS 75.69
  • OFF-bipolar cell CL0000750
    CSI 2.04
    rCSI 2.79%
    PRS 83.29
  • mesodermal cell CL0000222
    CSI 2.03
    rCSI 2.44%
    PRS 80.21
  • Hofbauer cell CL3000001
    CSI 2.03
    rCSI 3.83%
    PRS 89.19
  • club cell CL0000158
    CSI 1.93
    rCSI 2.83%
    PRS 76.87
  • lung macrophage CL1001603
    CSI 1.91
    rCSI 4.26%
    PRS 88.71
  • retinal bipolar neuron CL0000748
    CSI 1.88
    rCSI 3.53%
    PRS 70.81
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 1.88
    rCSI 2.34%
    PRS 62.6
  • extravillous trophoblast CL0008036
    CSI 1.78
    rCSI 2.21%
    PRS 80.37
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.76
    rCSI 3.11%
    PRS 64.25
  • type B pancreatic cell CL0000169
    CSI 1.67
    rCSI 3.7%
    PRS 81.55
  • retinal cone cell CL0000573
    CSI 1.65
    rCSI 2.66%
    PRS 72.54
  • promyelocyte CL0000836
    CSI 1.62
    rCSI 2.33%
    PRS 87.15
  • Schwann cell CL0002573
    CSI 1.47
    rCSI 4.17%
    PRS 77.75
  • amacrine cell CL0000561
    CSI 1.45
    rCSI 4.19%
    PRS 71.81
  • chondrocyte CL0000138
    CSI 1.44
    rCSI 2.29%
    PRS 75.48
  • mesenchymal cell CL0008019
    CSI 1.42
    rCSI 3.6%
    PRS 75.92
  • neural cell CL0002319
    CSI 1.38
    rCSI 5.2%
    PRS 65.58
  • transit amplifying cell CL0009010
    CSI 1.29
    rCSI 1.97%
    PRS 89.36
  • forebrain radial glial cell CL0013000
    CSI 1.28
    rCSI 4.1%
    PRS 83.54
  • pluripotent stem cell CL0002248
    CSI 1.16
    rCSI 34.82%
    PRS 91.13
  • neural progenitor cell CL0011020
    CSI 1.12
    rCSI 4.91%
    PRS 70.64
  • thymocyte CL0000893
    CSI 1.1
    rCSI 3.89%
    PRS 96.74
  • retinal ganglion cell CL0000740
    CSI 1.03
    rCSI 2.27%
    PRS 68.37
  • mammary gland epithelial cell CL0002327
    CSI 1
    rCSI 3.52%
    PRS 89.11
  • germinal center B cell CL0000844
    CSI 0.98
    rCSI 2.93%
    PRS 90.47
  • erythroblast CL0000765
    CSI 0.9
    rCSI 2.39%
    PRS 86.81
  • erythroid lineage cell CL0000764
    CSI 0.88
    rCSI 5.69%
    PRS 89.57
  • myeloid lineage restricted progenitor cell CL0000839
    CSI 0.87
    rCSI 4.49%
    PRS 94.33
  • lymphoid lineage restricted progenitor cell CL0000838
    CSI 0.85
    rCSI 3.32%
    PRS 94.7
  • type EC enteroendocrine cell CL0000577
    CSI 0.84
    rCSI 2.97%
    PRS 85.73
  • podocyte CL0000653
    CSI 0.78
    rCSI 3.47%
    PRS 82.66
  • epithelial cell of nephron CL1000449
    CSI 0.75
    rCSI 7.14%
    PRS 95.76
  • microcirculation associated smooth muscle cell CL0008035
    CSI 0.69
    rCSI 2.01%
    PRS 81.56
  • eosinophil CL0000771
    CSI 0.68
    rCSI 4.46%
    PRS 95.11
  • pre-conventional dendritic cell CL0002010
    CSI 0.67
    rCSI 8.91%
    PRS 95.14
  • basal cell of epithelium of trachea CL1000348
    CSI 0.55
    rCSI 3.87%
    PRS 86.94
  • megakaryocyte progenitor cell CL0000553
    CSI 0.42
    rCSI 7.63%
    PRS 95.49
  • erythroid progenitor cell CL0000038
    CSI 0.37
    rCSI 2.11%
    PRS 86.72
  • mesenchymal stem cell CL0000134
    CSI 0.13
    rCSI 1.47%
    PRS 86.88

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [SMC2](/details-gene/10592) (Structural Maintenance of Chromosomes 2) is a core subunit of the condensin complex, a crucial molecular machine essential for the condensation and stabilization of chromosomes during mitosis and meiosis. Functionally, it is involved in ATP-dependent chromatin binding and restructuring, which is fundamental for proper chromosome segregation and the maintenance of genomic integrity during cell division. Its expression profile is tightly linked to cellular proliferation, with data showing its highest significance in rapidly dividing cell populations. **Overall**, it is a key marker for [transit amplifying cell of colon](/details-cell/CL0009011), as well as various hematopoietic precursors such as [fraction A pre-pro B cell](/details-cell/CL0002045) and [large pre-B-II cell](/details-cell/CL0000957), underscoring its indispensable role in tissue renewal and development. ## Cellular Roles and Expression Landscape The expression pattern of [SMC2](/details-gene/10592) robustly identifies it as a canonical marker of actively proliferating cells across multiple lineages. **Overall**, the gene exhibits its highest significance in progenitor and transit-amplifying populations responsible for tissue homeostasis and development. A primary functional context for [SMC2](/details-gene/10592) is within epithelial and hematopoietic compartments characterized by high turnover rates. It is most significant in [transit amplifying cell of colon](/details-cell/CL0009011) (CSI: 14.60) and [transit amplifying cell of small intestine](/details-cell/CL0009012), which are responsible for the continuous renewal of the intestinal lining. Similarly, its high significance in a spectrum of B-lymphocyte precursors, including [fraction A pre-pro B cell](/details-cell/CL0002045), [large pre-B-II cell](/details-cell/CL0000957), [pro-B cell](/details-cell/CL0000826), and [precursor B cell](/details-cell/CL0000817), highlights its critical role during the rapid clonal expansion phases of lymphopoiesis. Its importance extends to other hematopoietic progenitors, such as the [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050), and developing T-cells like the [double negative thymocyte](/details-cell/CL0002489). Furthermore, [SMC2](/details-gene/10592) is highly significant in developmental contexts, particularly in neural progenitors like [neuroblast (sensu Nematoda and Protostomia)](/details-cell/CL0000338) and [neural crest cell](/details-cell/CL0011012). This suggests that beyond its role in adult tissue maintenance, [SMC2](/details-gene/10592) is a fundamental component of the machinery driving embryonic and postnatal development. The gene's general association with proliferation is further supported by its high significance in unspecified [stem cell](/details-cell/CL0000034) populations and [keratinocyte](/details-cell/CL0000312) populations of the skin. ## Pathways and Molecular Function The molecular functions of [SMC2](/details-gene/10592) are centrally located within the mechanics of cell division, which is consistent with its expression profile. As a core component of the condensin complex ([GO:0000796](https://www.ebi.ac.uk/QuickGO/term/GO:0000796)), [SMC2](/details-gene/10592) forms a heterodimer with SMC4, creating the ATPase-driven motor of the complex [Link](https://doi.org/10.1073/pnas.95.22.12906). This is reflected in its annotated molecular functions, including [Atp binding](/details-go/GO:0005524) and [Atp hydrolysis activity](/details-go/GO:0016887), which power the structural reorganization of [chromatin](/details-go/GO:0000785). Biologically, [SMC2](/details-gene/10592) is integral to the overarching process of the 'Cell cycle' ([R-HSA-1640170](https://reactome.org/content/detail/R-HSA-1640170)) and more specifically, 'M phase' ([R-HSA-68886](https://reactome.org/content/detail/R-HSA-68886)). Its primary role is in 'Mitotic chromosome condensation' ([GO:0007076](https://www.ebi.ac.uk/QuickGO/term/GO:0007076)), a process detailed in Reactome pathways such as 'Condensation of prophase chromosomes' ([R-HSA-2299718](https://reactome.org/content/detail/R-HSA-2299718)) and 'Condensation of prometaphase chromosomes' ([R-HSA-2514853](https://reactome.org/content/detail/R-HSA-2514853)). The proper execution of these steps is essential for orderly 'Meiotic chromosome segregation' ([GO:0045132](https://www.ebi.ac.uk/QuickGO/term/GO:0045132)) and subsequent 'Cell division' ([GO:0051301](https://www.ebi.ac.uk/QuickGO/term/GO:0051301)). This direct involvement in orchestrating chromosome structure for cell division explains its high significance in the rapidly cycling progenitor cells identified in the expression landscape. ## Research Directions The indispensable role of [SMC2](/details-gene/10592) in cell proliferation makes it a critical gene to study in the context of hyperproliferative diseases such as cancer. Its high expression in transit-amplifying cells of the colon and hematopoietic precursors suggests it could be a key vulnerability in malignancies arising from these tissues. Based on the available data, several testable hypotheses can be proposed: 1. **Hypothesis:** Pharmacological or genetic inhibition of [SMC2](/details-gene/10592) will disproportionately induce mitotic catastrophe and apoptosis in rapidly dividing cancer cells, such as those found in colorectal adenocarcinoma or B-cell acute lymphoblastic leukemia, compared to quiescent, healthy differentiated cells. 2. **Hypothesis:** The fidelity of chromosome segregation is dependent on precise [SMC2](/details-gene/10592) dosage. Consequently, subtle variations in its expression or function within hematopoietic stem and progenitor cells could be a predisposing factor for aneuploidy and subsequent leukemogenesis. **Proposed Experiment:** To test the first hypothesis, one could employ a CRISPRi (interference) system to achieve tunable knockdown of [SMC2](/details-gene/10592) in a panel of colorectal cancer cell lines (e.g., HCT116, SW480) and normal human intestinal organoids. Following knockdown, cell proliferation rates would be measured via IncuCyte live-cell imaging. Cell cycle distribution and evidence of mitotic failure (e.g., micronuclei formation, polyploidy) would be quantified using high-content imaging and flow cytometry analysis of DNA content. This would establish a direct link between [SMC2](/details-gene/10592) levels and the maintenance of genomic stability in cancer cells versus healthy tissue models. **Therapeutic Potential:** Given its central role in cell division, [SMC2](/details-gene/10592) represents a compelling therapeutic target for oncology. **Inhibition** of its function is a rational strategy to halt the proliferation of tumor cells. Small-molecule inhibitors targeting the ATPase activity of the SMC2/4 motor could serve as potent anti-mitotic agents. However, as [SMC2](/details-gene/10592) is also essential for healthy proliferating tissues (e.g., gut epithelium, bone marrow), a significant challenge would be managing on-target toxicity. The therapeutic window may be narrow, but such a strategy could be highly effective against aggressive, highly proliferative cancers, potentially in combination with other therapies.

Genular Protein ID: 3885049468

Symbol: SMC2_HUMAN

Name: Structural maintenance of chromosomes protein 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9789013

Title: Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics.

PubMed ID: 9789013

DOI: 10.1073/pnas.95.22.12906

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14660695

Title: The evolution of SMC proteins: phylogenetic analysis and structural implications.

PubMed ID: 14660695

DOI: 10.1093/molbev/msh023

PubMed ID: 10958694

Title: A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation.

PubMed ID: 10958694

DOI: 10.1128/mcb.20.18.6996-7006.2000

PubMed ID: 11136719

Title: Chromosome condensation by a human condensin complex in Xenopus egg extracts.

PubMed ID: 11136719

DOI: 10.1074/jbc.c000873200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23728299

Title: The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.

PubMed ID: 23728299

DOI: 10.1038/nature12147

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 1197
  • Mass: 135656
  • Checksum: 15EBB56B31FC1364
  • Sequence:
  • MHIKSIILEG FKSYAQRTEV NGFDPLFNAI TGLNGSGKSN ILDSICFLLG ISNLSQVRAS 
    NLQDLVYKNG QAGITKASVS ITFDNSDKKQ SPLGFEVHDE ITVTRQVVIG GRNKYLINGV 
    NANNTRVQDL FCSVGLNVNN PHFLIMQGRI TKVLNMKPPE ILSMIEEAAG TRMYEYKKIA 
    AQKTIEKKEA KLKEIKTILE EEITPTIQKL KEERSSYLEY QKVMREIEHL SRLYIAYQFL 
    LAEDTKVRSA EELKEMQDKV IKLQEELSEN DKKIKALNHE IEELEKRKDK ETGGILRSLE 
    DALAEAQRVN TKSQSAFDLK KKNLACEESK RKELEKNMVE DSKTLAAKEK EVKKITDGLH 
    ALQEASNKDA EALAAAQQHF NAVSAGLSSN EDGAEATLAG QMMACKNDIS KAQTEAKQAQ 
    MKLKHAQQEL KNKQAEVKKM DSGYRKDQEA LEAVKRLKEK LEAEMKKLNY EENKEESLLE 
    KRRQLSRDIG RLKETYEALL ARFPNLRFAY KDPEKNWNRN CVKGLVASLI SVKDTSATTA 
    LELVAGERLY NVVVDTEVTG KKLLERGELK RRYTIIPLNK ISARCIAPET LRVAQNLVGP 
    DNVHVALSLV EYKPELQKAM EFVFGTTFVC DNMDNAKKVA FDKRIMTRTV TLGGDVFDPH 
    GTLSGGARSQ AASILTKFQE LKDVQDELRI KENELRALEE ELAGLKNTAE KYRQLKQQWE 
    MKTEEADLLQ TKLQQSSYHK QQEELDALKK TIEESEETLK NTKEIQRKAE EKYEVLENKM 
    KNAEAERERE LKDAQKKLDC AKTKADASSK KMKEKQQEVE AITLELEELK REHTSYKQQL 
    EAVNEAIKSY ESQIEVMAAE VAKNKESVNK AQEEVTKQKE VITAQDTVIK AKYAEVAKHK 
    EQNNDSQLKI KELDHNISKH KREAEDGAAK VSKMLKDYDW INAERHLFGQ PNSAYDFKTN 
    NPKEAGQRLQ KLQEMKEKLG RNVNMRAMNV LTEAEERYND LMKKKRIVEN DKSKILTTIE 
    DLDQKKNQAL NIAWQKVNKD FGSIFSTLLP GANAMLAPPE GQTVLDGLEF KVALGNTWKE 
    NLTELSGGQR SLVALSLILS MLLFKPAPIY ILDEVDAALD LSHTQNIGQM LRTHFTHSQF 
    IVVSLKEGMF NNANVLFKTK FVDGVSTVAR FTQCQNGKIS KEAKSKAKPP KGAHVEV

Genular Protein ID: 817399375

Symbol: Q05BV1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 781
  • Mass: 88673
  • Checksum: 76C95626487B2ED1
  • Sequence:
  • MHIKSIILEG FKSYAQRTEV NGFDPLFNAI TGLNGSGKSN ILDSICFLLG ISNLSQVRAS 
    NLQDLVYKNG QAGITKASVS ITFDNSDKKQ SPLGFEVHDE ITVTRQVVIG GRNKYLINGV 
    NANNTRVQDL FCSVGLNVNN PHFLIMQGRI TKVLNMKPPE ILSMIEEAAG TRMYEYKKIA 
    AQKTIEKKEA KLKEIKTILE EEITPTIQKL KEERSSYLEY QKVMREIEHL SRLYIAYQFL 
    LAEDTKVRSA EELKEMQDKV IKLQEELSEN DKKIKALNHE IEELEKRKDK ETGGILRSLE 
    DALAEAQRVN TKSQSAFDLK KKNLACEESK RKELEKNMVE DSKTLAAKEK EVKKITDGLH 
    ALQEASNKDA EALAAAQQHF NAVSAGLSSN EDGAEATLAG QMMACKNDIS KAQTEAKQAQ 
    MKLKHAQQEL KNKQAEVKKM DSGYRKDQEA LEAVKRLKEK LEAEMKKLNY EENKEESLLE 
    KRRQLSRDIG RLKETYEALL ARFPNLRFAY KDPEKNWNRN CVKGLVASLI SVKDTSATTA 
    LELVAGERLY NVVVDTEVTG KKLLERGELK RRYTIIPLNK ISARCIAPET LRVAQNLVGP 
    DNVHVALSLV EYKPELQKAM EFVFGTTFVC DNMDNAKKVA FDKRIMTRTV TLGGDVFDPH 
    GTLSGGARSQ AASILTKFQE LKDVQDELRI KENELRALEE ELAGLKNTAE KYRQLKQQWE 
    MKTEEADLLQ TKLQQSSYHK QQEELDALKK TIEESEETLK NTKEIQRKAE EKYEVLEKKK 
    K

Genular Protein ID: 349152469

Symbol: B7ZLZ7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1197
  • Mass: 135700
  • Checksum: 785BE17A31FD5321
  • Sequence:
  • MHIKSIILEG FKSYAQRTEV NGFDPLFNAI TGLNGSGKSN ILDSICFLLG ISNLSQVRAS 
    NLQDLVYKNG QAGITKASVS ITFDNSDKKQ SPLGFEVHDE ITVTRQVVIG GRNKYLINGV 
    NANNTRVQDL FFSVGLNVNN PHFLIMQGRI TKVLNMKPPE ILSMIEEAAG TRMYEYKKIA 
    AQKTIEKKEA KLKEIKTILE EEITPTIQKL KEERSSYLEY QKVMREIEHL SRLYIAYQFL 
    LAEDTKVRSA EELKEMQDKV IKLQEELSEN DKKIKALNHE IEELEKRKDK ETGGILRSLE 
    DALAEAQRVN TKSQSAFDLK KKNLACEESK RKELEKNMVE DSKTLAAKEK EVKKITDGLH 
    ALQEASNKDA EALAAAQQHF NAVSAGLSSN EDGAEATLAG QMMACKNDIS KAQTEAKQAQ 
    MKLKHAQQEL KNKQAEVKKM DSGYRKDQEA LEAVKRLKEK LEAEMKKLNY EENKEESLLE 
    KRRQLSRDIG RLKETYEALL ARFPNLRFAY KDPEKNWNRN CVKGLVASLI SVKDTSATTA 
    LELVAGERLY NVVVDTEVTG KKLLERGELK RRYTIIPLNK ISARCIAPET LRVAQNLVGP 
    DNVHVALSLV EYKPELQKAM EFVFGTTFVC DNMDNAKKVA FDKRIMTRTV TLGGDVFDPH 
    GTLSGGARSQ AASILTKFQE LKDVQDELRI KENELRALEE ELAGLKNTAE KYRQLKQQWE 
    MKTEEADLLQ TKLQQSSYHK QQEELDALKK TIEESEETLK NTKEIQRKAE EKYEVLENKM 
    KNAEAERERE LKDAQKKLDC AKTKADASSK KMKEKQQEVE AITLELEELK REHTSYKQQL 
    EAVNEAIKSY ESQIEVMAAE VAKNKESVNK AQEEVTKQKE VITAQDTVIK AKYAEVAKHK 
    EQNNDSQLKI KELDHNISKH KREAEDGAAK VSKMLKDYDW INAERHLFGQ PNSAYDFKTN 
    NPKEAGQRLQ KLQEMKEKLG RNVNMRAMNV LTEAEERYND LMKKKRIVEN DKSKILTTIE 
    DLDQKKNQAL NIAWQKVNKD FGSIFSTLLP GANAMLAPPE GQTVLDGLEF KVALGNTWKE 
    NLTELSGGQR SLVALSLILS MLLFKPAPIY ILDEVDAALD LSHTQNIGQM LRTHFTHSQF 
    IVVSLKEGMF NNANVLFKTK FVDGVSTVAR FTQCQNGKIS KEAKSKAKPP KGAHVEV

Genular Protein ID: 1833077386

Symbol: A8K984_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 1197
  • Mass: 135596
  • Checksum: 15EEB46B31F56364
  • Sequence:
  • MHIKSIILEG FKSYAQRTEV NGFDPLFNAI TGLNGSGKSN ILDSICFLLG ISNLSQVRAS 
    NLQDLVYKNG QAGITKASVS ITFDNSDKKQ SPLGFEVHDE ITVTRQVVIG GRNKYLINGV 
    NANNTRVQDL FCSVGLNVNN PHFLIMQGRI TKVLNMKPPE ILSMIEEAAG TRMYEYKKIA 
    AQKTIEKKEA KLKEIKTILE EEITPTIQKL KEERSSYLEY QKVMREIEHL SRLYIAYQFL 
    LAEDTKVRSA EELKEMQDKV IKLQEELSEN DKKIKALNHE IEELEKRKDK ETGGILRSLE 
    DALAEAQRVN TKSQSAFDLK KKNLACEESK RKELEKNMVE DSKTLAAKEK EVKKITDGLH 
    ALQEASNKDA EALAAAQQHF NAVSAGLSSN EDGAEATLAG QMMACKNDIS KAQTEAKQAQ 
    MKLKHAQQEL KNKQAEVKKM DSGYRKDQEA LEAVKRLKEK LEAEMKKLNY EENKEESLLE 
    KRRQLSRDIG RLKETYEALL ARFPNLRFAY KDPEKNWNRN CVKGLVASLI SVKDTSATTA 
    LELVAGERLY NVVVDTEVTG KKLLERGELK RRYTIIPLNK ISARCIAPET LRVAQNLVGP 
    DNVHVALSLV EYKPELQKAM EFVFGTTFVC DNMDNAKKVA FDKRIMTRTV TLGGDVFDPH 
    GTLSGGARSQ AASILTKFQE LKDVQDELRI KENELRALEE ELAGLKNTAE KYRQLKQQWE 
    MKTEEADLLQ TKLQQSSYHK QQEELDALKK TIEESEETLK NTKEIQRKAE EKYEVLENKM 
    KNAEAERERE LKDAQKKLDC AKTKADASSK KMKEKQQEVE AITLELEELK REHTSYKQQL 
    EAVNEAIKSY ESQIEVMAAE VAKNKESVNK AQEEVTKQKE VITAQDTVIK AKYAEVAKHK 
    EQNNDSQLKI KELDHNISKH KREAEDGAAK VSKMLKDYDW INAERHLSGQ PNSAYDFKTN 
    NPKEAGQRLQ KLQEMKEKLG RNVNMRAMNV LTEAEERYND LMKKKRIVEN DKSKILTTIE 
    DLDQKKNQAL NIAWQKVNKD FGSIFSTLLP GANAMLAPPE GQTVLDGLEF KVALGNTWKE 
    NLTELSGGQR SLVALSLILS MLLFKPAPIY ILDEVDAALD LSHTQNIGQM LRTHFTHSQF 
    IVVSLKEGMF NNANVLFKTK FVDGVSTVAR FTQCQNGKIS KEAKSKAKPP KGAHVEV

Genular Protein ID: 4156622508

Symbol: Q6IPS5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 356
  • Mass: 40528
  • Checksum: 6EC391E8C6A3E308
  • Sequence:
  • MHIKSIILEG FKSYAQRTEV NGFDPLFNAI TGLNGSGKSN ILDSICFLLG ISNLSQVRAS 
    NLQDLVYKNG QAGITKASVS ITFDNSDKKQ SPLGFEVHDE ITVTRQVVIG GRNKYLINGV 
    NANNTRVQDL FCSVGLNVNN PHFLIMQGRI TKVLNMKPPE ILSMIEEAAG TRMYEYKKIA 
    AQKTIEKKEA KLKEIKTILE EEITPTIQKL KEERSSYLEY QKVMREIEHL SRLYIAYQFL 
    LAEDTKVRSA EELKEMQDKV IKLQEELSEN DKKIKALNHE IEELEKRKDK ETGGILRSLE 
    DALAEAQRVN TKSQSAFDLK KKNLACEESK RKELEKNMVE DSKTLAAKKK KKKKKK

Genular Protein ID: 2230644161

Symbol: B3KMB1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 1197
  • Mass: 135601
  • Checksum: D994BAF111275399
  • Sequence:
  • MHIKSIILEG FKSYAQRTEV NGFDPLFNAI TGLNGSGKSN ILDSICFLLG ISNLSQVRAS 
    NLQDLVYKNG QAGITKASVS ITFDNSDKKQ SPLGFEVHDE ITVTRQVVIG GRNKYLINGV 
    NANNTRVQDL FCSVGLNVNN PHFLIMQGRI TKVLNMKPPE ILSMIEEAAG TRMYEYKKIA 
    AQKTIEKKEA KLKEIKTILE EEITPTIQKL KEERSSYLEY QKVMREIEHL SRLYIAYQFL 
    LAEDTKVRSA EELKEMQDKV IKLQEELSES DKKIKALNHE IEELEKRKDK ETGGILRSLE 
    DALAEAQRVN TKSQSAFDLK KKNLACEESK RKELEKNMVE DSKTLAAKEK EVKKITDGLH 
    ALQEASNKDA EALAAAQQHF NAVSAGLSSN EDGAEATLAG QMMACKNDIS KAQTEAKQAQ 
    MKLKHAQQEL KNKQAEVKKM DSGYRKDQEA LEAVKRLKEK LEAEMKKLNY EENKEESLLE 
    KRRQLSRDIG RLKETYEALL ARFPNLRFAY KDPEKNWNRN CVKGLVASLI SVKDTSATTA 
    LELVAGERLY NVVVDTEVTG KKLLERGELK RRYTIIPLNK ISARCIAPET LRVAQNLVGP 
    DNVHVALSLV EYKPELQKAM EFVFGTTFVC DNMDNAKKVA FDKRIMTRTV TLGGDVFDPH 
    GTLSGGARSQ AASILTKFQE LKDVQDELRI KENELRALEE ELAGLKNTAE KYRQLKQQWE 
    MKTEEADLLQ TKLQQSSYHK QQEELDALKK TIEESEETLK NTKEIQRKAE EKYEVLENKM 
    KNAEAERERE LKDAQKKLDC AKTKADASSK KMKEKQQEVE AITLELEELK REHTSYKQQL 
    EAVNEAIKSY ESQIEVMAAE VAKNKESVNK AQEEVTKQKE VITAQDTVIK AKYAEVAKHK 
    EQNNDSQLKI KELDHNISKH KREAEDGAAK VSKMLKDYDW INAERHLFGQ PNSAYDFKTN 
    NPKEAGQRLQ KLQEMKEKLG RNVNMKAMNV LTEAEERYND LMKKKRIVEN DKSKILTTIE 
    DLDQKKNQAL NIAWQKVNKD FGSIFSTLLP GANAMLAPPE GQTVLDGLEF KVALGNTWKE 
    NLTELSGGQR SLVALSLILS MLLFKPAPIY ILDEVDAALD LSHTQNIGQM LRTHFTHSQF 
    IVVSLKEGMF NNANVLFKTK FVDGVSTVAR FTQCQNGKIS KEAKSKAKPP KGAHVEV

Genular Protein ID: 684023246

Symbol: Q7Z2X1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 209
  • Mass: 24518
  • Checksum: 017375E17C311E66
  • Sequence:
  • MQGRITKVLN MKPPEILSMI EEAAGTRMYE YKRIAAQKTI EKKEAKLKEI KTILEEEITP 
    TIQKLKEERS SYLEYQKVMR EIEHLSRLYI AYQFLLAEDT KVRSAEELKE MQDKVIKLQE 
    ELSENDKKIK ALNHEIEELE KRKDKETGGI LRSLEDALAE AQRVNTKSQS AFDLKKKNLA 
    CEESKRKELE KNMVEDSKTL ATKKKKKKK

Genular Protein ID: 1270373056

Symbol: Q05D74_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 289
  • Mass: 32953
  • Checksum: E74C3928BC5FA893
  • Sequence:
  • MHIKSIILEG FKSYAQRTEV NGFDPLFNAI TGLNGSGKSN ILDSICFLLG ISNLSQVRAS 
    NLQDLVYKNG QAGITKASVS ITFDNSDEKQ SPLGFEVHDE ITVTRQVVIG GRNKYLINGV 
    NANNTRVQDL FCSVGLNVNN PHFLIMQGRI TKVLNMKPPE ILSMIEEAAG TRMYEYKKIA 
    AQKTIEKKEA KLKEIKTILE EEITPTIQKL KEERSSYLEY QKVMREIEHL SRLYIAYQFL 
    LAEDTKVRSA EELKEMQDKV IKLQEELSEN DKKIKALNHE KKKKKKKKK