Details for: UBE2T

Gene ID: 29089

Symbol: UBE2T

Ensembl ID: ENSG00000077152

Description: ubiquitin conjugating enzyme E2 T

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 42.8554
    Cell Significance Index: -10.8700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 33.6329
    Cell Significance Index: -13.8600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 27.5195
    Cell Significance Index: -11.1800
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 20.4213
    Cell Significance Index: 9.3000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.8892
    Cell Significance Index: -10.9600
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 4.2616
    Cell Significance Index: 3.2500
  • Cell Name: germ cell (CL0000586)
    Fold Change: 3.9632
    Cell Significance Index: 29.9300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.8990
    Cell Significance Index: -10.4500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.3223
    Cell Significance Index: -13.1100
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 2.0144
    Cell Significance Index: 11.4500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.9860
    Cell Significance Index: 21.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.4820
    Cell Significance Index: 282.0300
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 1.4561
    Cell Significance Index: 6.4500
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.2911
    Cell Significance Index: 3.7000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.1580
    Cell Significance Index: 40.2400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.0706
    Cell Significance Index: 22.4100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0369
    Cell Significance Index: 112.7800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0069
    Cell Significance Index: 60.4500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0032
    Cell Significance Index: 118.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9604
    Cell Significance Index: 156.2000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.8555
    Cell Significance Index: 27.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8279
    Cell Significance Index: 96.4800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.7082
    Cell Significance Index: -1.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5958
    Cell Significance Index: 30.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5690
    Cell Significance Index: 310.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5091
    Cell Significance Index: 50.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4717
    Cell Significance Index: 12.6000
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 0.3652
    Cell Significance Index: 3.3200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3092
    Cell Significance Index: 279.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3029
    Cell Significance Index: 60.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3008
    Cell Significance Index: 8.0500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2717
    Cell Significance Index: 7.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2552
    Cell Significance Index: 14.3200
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.2484
    Cell Significance Index: 1.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2085
    Cell Significance Index: 92.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1962
    Cell Significance Index: 24.1200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1854
    Cell Significance Index: 5.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1713
    Cell Significance Index: 34.3600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1248
    Cell Significance Index: 3.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1142
    Cell Significance Index: 3.2900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1043
    Cell Significance Index: 2.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0991
    Cell Significance Index: 17.8700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0741
    Cell Significance Index: 5.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0677
    Cell Significance Index: 24.2900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0538
    Cell Significance Index: 1.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0390
    Cell Significance Index: 0.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0202
    Cell Significance Index: 0.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0199
    Cell Significance Index: 0.7000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0191
    Cell Significance Index: 0.3200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0175
    Cell Significance Index: 1.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0010
    Cell Significance Index: -0.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0020
    Cell Significance Index: -1.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0048
    Cell Significance Index: -9.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0080
    Cell Significance Index: -1.0200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0090
    Cell Significance Index: -0.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0093
    Cell Significance Index: -17.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0097
    Cell Significance Index: -0.4400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0111
    Cell Significance Index: -17.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0113
    Cell Significance Index: -7.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0117
    Cell Significance Index: -1.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0130
    Cell Significance Index: -17.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0139
    Cell Significance Index: -0.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0160
    Cell Significance Index: -11.7500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0188
    Cell Significance Index: -11.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0193
    Cell Significance Index: -14.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0221
    Cell Significance Index: -12.4500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0228
    Cell Significance Index: -0.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0260
    Cell Significance Index: -11.7900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0274
    Cell Significance Index: -17.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0277
    Cell Significance Index: -7.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0349
    Cell Significance Index: -3.5600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0364
    Cell Significance Index: -0.9300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0670
    Cell Significance Index: -8.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0700
    Cell Significance Index: -14.7500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0731
    Cell Significance Index: -0.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0824
    Cell Significance Index: -3.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0826
    Cell Significance Index: -14.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0854
    Cell Significance Index: -12.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0892
    Cell Significance Index: -10.2300
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1086
    Cell Significance Index: -0.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1145
    Cell Significance Index: -7.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1257
    Cell Significance Index: -13.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1347
    Cell Significance Index: -6.3300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1385
    Cell Significance Index: -10.6300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1429
    Cell Significance Index: -1.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1503
    Cell Significance Index: -6.6500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.1513
    Cell Significance Index: -1.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1526
    Cell Significance Index: -11.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1564
    Cell Significance Index: -12.3900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1593
    Cell Significance Index: -2.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1661
    Cell Significance Index: -10.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1677
    Cell Significance Index: -10.2800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1886
    Cell Significance Index: -7.1400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2007
    Cell Significance Index: -1.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2027
    Cell Significance Index: -10.5600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2030
    Cell Significance Index: -2.6000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2123
    Cell Significance Index: -1.2600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2241
    Cell Significance Index: -6.6000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2439
    Cell Significance Index: -6.2700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2520
    Cell Significance Index: -8.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** UBE2T is a small, 15-kDa protein belonging to the E2 subfamily of ubiquitin-conjugating enzymes. Its structure consists of a catalytic domain and a C-terminal tail, which interacts with ubiquitin and other proteins. UBE2T exhibits a high degree of specificity, primarily conjugating ubiquitin to lysine residues on target proteins, such as K48, K63, and K11. This specificity is crucial for regulating protein activity, localization, and stability. **Pathways and Functions** UBE2T is integral to several cellular pathways, including: 1. **DNA Damage Response**: UBE2T participates in the repair of DNA double-strand breaks by interacting with proteins involved in homologous recombination and non-homologous end joining. 2. **Protein Degradation**: UBE2T is a key component of the ubiquitin-proteasome system, regulating protein turnover and cellular homeostasis. 3. **Cell Cycle Regulation**: UBE2T modulates cell cycle progression by targeting proteins involved in DNA replication and mitosis. 4. **Metabolism of Proteins**: UBE2T participates in the regulation of protein synthesis, degradation, and transport. **Clinical Significance** Dysregulation of UBE2T has been implicated in various diseases, including: 1. **Cancer**: UBE2T mutations have been associated with breast, ovarian, and prostate cancers, highlighting its potential as a therapeutic target. 2. **Neurodegenerative Disorders**: UBE2T has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's, where it may contribute to protein aggregation and tau phosphorylation. 3. **Hematological Malignancies**: UBE2T mutations have been identified in acute myeloid leukemia and lymphoma, suggesting its role in tumorigenesis and disease progression. 4. **Genetic Disorders**: UBE2T mutations have been associated with Fanconi anemia, a rare genetic disorder characterized by bone marrow failure and congenital abnormalities. In conclusion, UBE2T is a multifunctional protein that plays a critical role in various cellular processes, including protein modification, DNA repair, and cell cycle regulation. Its dysregulation has far-reaching implications for human health, highlighting the need for further research into the molecular mechanisms underlying UBE2T-mediated diseases.

Genular Protein ID: 1547986445

Symbol: UBE2T_HUMAN

Name: Ubiquitin-conjugating enzyme E2 T

UniProtKB Accession Codes:

Q9NPD8 Q2TU36

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 1 EMBL 9 EMDB 4 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16916645

Title: UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation.

PubMed ID: 16916645

DOI: 10.1016/j.molcel.2006.06.024

PubMed ID: 17938197

Title: UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination.

PubMed ID: 17938197

DOI: 10.1128/mcb.00504-07

PubMed ID: 19111657

Title: Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI.

PubMed ID: 19111657

DOI: 10.1016/j.molcel.2008.12.003

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19887602

Title: Ubiquitination and downregulation of BRCA1 by ubiquitin-conjugating enzyme E2T overexpression in human breast cancer cells.

PubMed ID: 19887602

DOI: 10.1158/0008-5472.can-09-1809

PubMed ID: 19589784

Title: FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL.

PubMed ID: 19589784

DOI: 10.1074/jbc.c109.038075

PubMed ID: 20061386

Title: The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.

PubMed ID: 20061386

DOI: 10.1074/jbc.m109.089003

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21775430

Title: Structural analysis of human FANCL, the E3 ligase in the Fanconi anemia pathway.

PubMed ID: 21775430

DOI: 10.1074/jbc.m111.244632

PubMed ID: 21722982

Title: Hypoxia disrupts the Fanconi anemia pathway and sensitizes cells to chemotherapy through regulation of UBE2T.

PubMed ID: 21722982

DOI: 10.1016/j.radonc.2011.05.059

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26046368

Title: Mutations in the gene encoding the E2 conjugating enzyme UBE2T cause Fanconi anemia.

PubMed ID: 26046368

DOI: 10.1016/j.ajhg.2015.04.022

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 22496338

Title: A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.

PubMed ID: 22496338

DOI: 10.1074/mcp.o111.013706

PubMed ID: 24389026

Title: Structure of the human FANCL RING-Ube2T complex reveals determinants of cognate E3-E2 selection.

PubMed ID: 24389026

DOI: 10.1016/j.str.2013.12.004

PubMed ID: 28437106

Title: Allosteric targeting of the Fanconi anemia ubiquitin-conjugating enzyme Ube2T by fragment screening.

PubMed ID: 28437106

DOI: 10.1021/acs.jmedchem.7b00147

Sequence Information:

  • Length: 197
  • Mass: 22521
  • Checksum: 6C02D774A7FA928A
  • Sequence:
    • MQRASRLKRE LHMLATEPPP GITCWQDKDQ MDDLRAQILG GANTPYEKGV FKLEVIIPER 
YPFEPPQIRF LTPIYHPNID SAGRICLDVL KLPPKGAWRP SLNIATVLTS IQLLMSEPNP 
DDPLMADISS EFKYNKPAFL KNARQWTEKH ARQKQKADEE EMLDNLPEAG DSRVHNSTQK 
RKASQLVGIE KKFHPDV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.