Details for: NR2F1

Gene ID: 7025

Symbol: NR2F1

Ensembl ID: ENSG00000175745

Description: nuclear receptor subfamily 2 group F member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.88
    Marker Score: 3311
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.69
    Marker Score: 5619
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.28
    Marker Score: 666
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.26
    Marker Score: 4346
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.25
    Marker Score: 2141
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.21
    Marker Score: 3754
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.18
    Marker Score: 1549
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.04
    Marker Score: 43442
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 2.03
    Marker Score: 492
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.96
    Marker Score: 7584
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.93
    Marker Score: 8088
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.86
    Marker Score: 27810.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.8
    Marker Score: 20295
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.76
    Marker Score: 4614
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.75
    Marker Score: 59531
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.67
    Marker Score: 63396.5
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.67
    Marker Score: 12782
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.66
    Marker Score: 1106
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1154
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.58
    Marker Score: 13610.5
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.57
    Marker Score: 872
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.56
    Marker Score: 1921
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.56
    Marker Score: 95678
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.52
    Marker Score: 480
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.49
    Marker Score: 1571
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.36
    Marker Score: 45915
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.36
    Marker Score: 1866
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.35
    Marker Score: 857
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.35
    Marker Score: 560
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.34
    Marker Score: 2931
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.28
    Marker Score: 632
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.27
    Marker Score: 1081.5
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.2
    Marker Score: 5535
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.19
    Marker Score: 1035
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4779
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.1
    Marker Score: 1066
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.09
    Marker Score: 256
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.09
    Marker Score: 10325
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.07
    Marker Score: 274
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.04
    Marker Score: 684
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.04
    Marker Score: 703
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.03
    Marker Score: 5556
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 785
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.02
    Marker Score: 3632
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.01
    Marker Score: 263
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1
    Marker Score: 37055
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71777
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48001
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1
    Marker Score: 383
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.99
    Marker Score: 405
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.98
    Marker Score: 19532.5
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.98
    Marker Score: 612
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.95
    Marker Score: 4990
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5335
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.93
    Marker Score: 524
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.92
    Marker Score: 425
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 368
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.92
    Marker Score: 201
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.91
    Marker Score: 210
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2731
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.91
    Marker Score: 3053
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.89
    Marker Score: 3143.5
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.88
    Marker Score: 943
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.86
    Marker Score: 793
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.84
    Marker Score: 208
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.84
    Marker Score: 1298
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.82
    Marker Score: 184
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.82
    Marker Score: 774
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.82
    Marker Score: 204
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.81
    Marker Score: 204
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.81
    Marker Score: 10710
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.78
    Marker Score: 835
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.78
    Marker Score: 943
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.78
    Marker Score: 492
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1254
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.77
    Marker Score: 1189
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 701
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.76
    Marker Score: 287
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.76
    Marker Score: 259
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.76
    Marker Score: 713
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.74
    Marker Score: 233
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.74
    Marker Score: 637
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.72
    Marker Score: 183
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.69
    Marker Score: 278
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.68
    Marker Score: 1195
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.68
    Marker Score: 158
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.67
    Marker Score: 278.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.66
    Marker Score: 2671
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.65
    Marker Score: 1499
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.64
    Marker Score: 403
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.63
    Marker Score: 368
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.63
    Marker Score: 1191.5

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key Characteristics** NR2F1 is a nuclear receptor subfamily 2 group F member 1, which belongs to the COUP (Corticosteroid-Responsive Enhancer-Binding Protein) family of transcription factors. It is a ligand-activated transcription factor that binds to specific DNA sequences, known as COUP response elements (CRE), and modulates gene expression. NR2F1 is a transcriptional repressor, meaning it typically inhibits the expression of target genes. However, it can also act as a transcriptional activator in certain contexts. The protein is highly conserved across species, suggesting its importance in fundamental biological processes. **Pathways and Functions** NR2F1 is involved in several biological pathways, including: 1. **Anatomical structure development**: NR2F1 regulates the expression of genes involved in the development of various tissues, including the nervous system, kidney, and vascular system. 2. **Cell differentiation**: NR2F1 influences the differentiation of cells, particularly in the context of neural development and kidney formation. 3. **Gene expression (transcription)**: NR2F1 modulates the expression of target genes by binding to specific DNA sequences and recruiting co-regulatory proteins. 4. **Intracellular receptor signaling pathway**: NR2F1 is a ligand-activated transcription factor that responds to specific ligands, such as retinoic acid, and modulates gene expression accordingly. 5. **Negative regulation of transcription by RNA polymerase II**: NR2F1 can inhibit the expression of target genes by interacting with RNA polymerase II and suppressing its activity. **Clinical Significance** NR2F1 has been implicated in various diseases and disorders, including: 1. **Neurological disorders**: NR2F1 has been linked to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia, as well as neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Kidney disease**: NR2F1 has been implicated in kidney development and function, and its dysregulation has been linked to kidney disease, including nephrotic syndrome and chronic kidney disease. 3. **Vascular disease**: NR2F1 has been shown to regulate the expression of genes involved in vascular development and function, and its dysregulation has been linked to vascular diseases, including atherosclerosis and hypertension. In summary, NR2F1 is a transcription factor that plays a critical role in various cellular processes, including gene expression, cell differentiation, and development. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of NR2F1 in maintaining tissue homeostasis and overall health.

Genular Protein ID: 1143386972

Symbol: COT1_HUMAN

Name: COUP transcription factor 1

UniProtKB Accession Codes:

P10589

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 4 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 3 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2739739

Title: COUP transcription factor is a member of the steroid receptor superfamily.

PubMed ID: 2739739

DOI: 10.1038/340163a0

PubMed ID: 2905047

Title: Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other.

PubMed ID: 2905047

DOI: 10.1093/nar/16.23.11057

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1517211

Title: Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II).

PubMed ID: 1517211

DOI: 10.1016/s0021-9258(19)37087-5

PubMed ID: 10207062

Title: Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily.

PubMed ID: 10207062

DOI: 10.1128/mcb.19.5.3383

PubMed ID: 10644740

Title: Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor.

PubMed ID: 10644740

DOI: 10.1074/jbc.275.4.2763

PubMed ID: 11682620

Title: EAR2 and EAR3/COUP-TFI regulate transcription of the rat LH receptor.

PubMed ID: 11682620

DOI: 10.1210/mend.15.11.0720

PubMed ID: 24462372

Title: NR2F1 mutations cause optic atrophy with intellectual disability.

PubMed ID: 24462372

DOI: 10.1016/j.ajhg.2014.01.002

PubMed ID: 26138355

Title: Whole-exome sequencing improves the diagnosis yield in sporadic infantile spasm syndrome.

PubMed ID: 26138355

DOI: 10.1111/cge.12636

Sequence Information:

  • Length: 423
  • Mass: 46156
  • Checksum: 6EE634BE96242731
  • Sequence:
    • MAMVVSSWRD PQDDVAGGNP GGPNPAAQAA RGGGGGAGEQ QQQAGSGAPH TPQTPGQPGA 
PATPGTAGDK GQGPPGSGQS QQHIECVVCG DKSSGKHYGQ FTCEGCKSFF KRSVRRNLTY 
TCRANRNCPI DQHHRNQCQY CRLKKCLKVG MRREAVQRGR MPPTQPNPGQ YALTNGDPLN 
GHCYLSGYIS LLLRAEPYPT SRYGSQCMQP NNIMGIENIC ELAARLLFSA VEWARNIPFF 
PDLQITDQVS LLRLTWSELF VLNAAQCSMP LHVAPLLAAA GLHASPMSAD RVVAFMDHIR 
IFQEQVEKLK ALHVDSAEYS CLKAIVLFTS DACGLSDAAH IESLQEKSQC ALEEYVRSQY 
PNQPSRFGKL LLRLPSLRTV SSSVIEQLFF VRLVGKTPIE TLIRDMLLSG SSFNWPYMSI 
QCS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.