Details for: NR2F1

Gene ID: 7025

Symbol: NR2F1

Ensembl ID: ENSG00000175745

Description: nuclear receptor subfamily 2 group F member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 97.0087
    Cell Significance Index: -45.8000
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 5.4447
    Cell Significance Index: 33.6900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 4.7044
    Cell Significance Index: 163.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.3592
    Cell Significance Index: 323.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.1041
    Cell Significance Index: 129.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.9016
    Cell Significance Index: 54.5100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.8005
    Cell Significance Index: 43.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.7589
    Cell Significance Index: 630.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3128
    Cell Significance Index: 263.3500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.1786
    Cell Significance Index: 9.4100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.1270
    Cell Significance Index: 24.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0082
    Cell Significance Index: 200.0800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.9207
    Cell Significance Index: 19.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.7180
    Cell Significance Index: 23.0000
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.6193
    Cell Significance Index: 3.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4808
    Cell Significance Index: 26.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3791
    Cell Significance Index: 240.7400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2679
    Cell Significance Index: 504.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2158
    Cell Significance Index: 117.8400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1176
    Cell Significance Index: 1.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0843
    Cell Significance Index: 13.7100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0710
    Cell Significance Index: 49.1000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0577
    Cell Significance Index: 0.9100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0385
    Cell Significance Index: 0.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0346
    Cell Significance Index: 15.7300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0155
    Cell Significance Index: 0.2600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0232
    Cell Significance Index: -2.9700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0290
    Cell Significance Index: -53.5600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0356
    Cell Significance Index: -26.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0378
    Cell Significance Index: -58.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0441
    Cell Significance Index: -60.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0644
    Cell Significance Index: -48.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0645
    Cell Significance Index: -47.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0830
    Cell Significance Index: -51.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0864
    Cell Significance Index: -12.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0881
    Cell Significance Index: -49.7100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1005
    Cell Significance Index: -1.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.1143
    Cell Significance Index: -21.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1460
    Cell Significance Index: -42.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1476
    Cell Significance Index: -26.6100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1722
    Cell Significance Index: -3.7700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.2259
    Cell Significance Index: -22.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2295
    Cell Significance Index: -48.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2314
    Cell Significance Index: -24.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2889
    Cell Significance Index: -33.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.3022
    Cell Significance Index: -51.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.3034
    Cell Significance Index: -37.3100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.3070
    Cell Significance Index: -33.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3398
    Cell Significance Index: -43.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3726
    Cell Significance Index: -38.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3941
    Cell Significance Index: -23.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4007
    Cell Significance Index: -26.9400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4089
    Cell Significance Index: -21.4700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4094
    Cell Significance Index: -8.5700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.4342
    Cell Significance Index: -30.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4619
    Cell Significance Index: -52.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5164
    Cell Significance Index: -40.9000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.5192
    Cell Significance Index: -7.2600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.5466
    Cell Significance Index: -13.2400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.5510
    Cell Significance Index: -3.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5947
    Cell Significance Index: -44.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.6301
    Cell Significance Index: -28.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6311
    Cell Significance Index: -29.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6553
    Cell Significance Index: -50.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.6886
    Cell Significance Index: -19.8400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7351
    Cell Significance Index: -38.2900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7437
    Cell Significance Index: -14.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7710
    Cell Significance Index: -48.6000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.7818
    Cell Significance Index: -21.8500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7859
    Cell Significance Index: -25.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.8011
    Cell Significance Index: -17.3600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8674
    Cell Significance Index: -25.5500
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.8792
    Cell Significance Index: -5.7200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.9375
    Cell Significance Index: -21.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.9485
    Cell Significance Index: -49.2700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.9487
    Cell Significance Index: -5.6300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.9855
    Cell Significance Index: -17.0400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9872
    Cell Significance Index: -31.4400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.9963
    Cell Significance Index: -4.6000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0162
    Cell Significance Index: -26.1200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.0197
    Cell Significance Index: -22.0300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.0616
    Cell Significance Index: -30.3000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.0993
    Cell Significance Index: -27.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.1003
    Cell Significance Index: -48.6700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.1037
    Cell Significance Index: -23.5100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.1133
    Cell Significance Index: -39.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.1243
    Cell Significance Index: -52.4200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.2107
    Cell Significance Index: -32.4400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.2114
    Cell Significance Index: -25.7100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.2795
    Cell Significance Index: -48.4500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.3139
    Cell Significance Index: -25.9800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.3277
    Cell Significance Index: -48.7400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.4071
    Cell Significance Index: -71.1100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -1.4786
    Cell Significance Index: -16.9200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.4928
    Cell Significance Index: -39.8600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -1.5155
    Cell Significance Index: -17.6800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -1.5319
    Cell Significance Index: -13.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.5379
    Cell Significance Index: -54.0400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -1.5415
    Cell Significance Index: -38.4400
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.5487
    Cell Significance Index: -14.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NR2F1 is a nuclear receptor subfamily 2 group F member 1, which belongs to the COUP (Corticosteroid-Responsive Enhancer-Binding Protein) family of transcription factors. It is a ligand-activated transcription factor that binds to specific DNA sequences, known as COUP response elements (CRE), and modulates gene expression. NR2F1 is a transcriptional repressor, meaning it typically inhibits the expression of target genes. However, it can also act as a transcriptional activator in certain contexts. The protein is highly conserved across species, suggesting its importance in fundamental biological processes. **Pathways and Functions** NR2F1 is involved in several biological pathways, including: 1. **Anatomical structure development**: NR2F1 regulates the expression of genes involved in the development of various tissues, including the nervous system, kidney, and vascular system. 2. **Cell differentiation**: NR2F1 influences the differentiation of cells, particularly in the context of neural development and kidney formation. 3. **Gene expression (transcription)**: NR2F1 modulates the expression of target genes by binding to specific DNA sequences and recruiting co-regulatory proteins. 4. **Intracellular receptor signaling pathway**: NR2F1 is a ligand-activated transcription factor that responds to specific ligands, such as retinoic acid, and modulates gene expression accordingly. 5. **Negative regulation of transcription by RNA polymerase II**: NR2F1 can inhibit the expression of target genes by interacting with RNA polymerase II and suppressing its activity. **Clinical Significance** NR2F1 has been implicated in various diseases and disorders, including: 1. **Neurological disorders**: NR2F1 has been linked to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia, as well as neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Kidney disease**: NR2F1 has been implicated in kidney development and function, and its dysregulation has been linked to kidney disease, including nephrotic syndrome and chronic kidney disease. 3. **Vascular disease**: NR2F1 has been shown to regulate the expression of genes involved in vascular development and function, and its dysregulation has been linked to vascular diseases, including atherosclerosis and hypertension. In summary, NR2F1 is a transcription factor that plays a critical role in various cellular processes, including gene expression, cell differentiation, and development. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of NR2F1 in maintaining tissue homeostasis and overall health.

Genular Protein ID: 1143386972

Symbol: COT1_HUMAN

Name: COUP transcription factor 1

UniProtKB Accession Codes:

P10589

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 4 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 3 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2739739

Title: COUP transcription factor is a member of the steroid receptor superfamily.

PubMed ID: 2739739

DOI: 10.1038/340163a0

PubMed ID: 2905047

Title: Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other.

PubMed ID: 2905047

DOI: 10.1093/nar/16.23.11057

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1517211

Title: Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II).

PubMed ID: 1517211

DOI: 10.1016/s0021-9258(19)37087-5

PubMed ID: 10207062

Title: Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily.

PubMed ID: 10207062

DOI: 10.1128/mcb.19.5.3383

PubMed ID: 10644740

Title: Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor.

PubMed ID: 10644740

DOI: 10.1074/jbc.275.4.2763

PubMed ID: 11682620

Title: EAR2 and EAR3/COUP-TFI regulate transcription of the rat LH receptor.

PubMed ID: 11682620

DOI: 10.1210/mend.15.11.0720

PubMed ID: 24462372

Title: NR2F1 mutations cause optic atrophy with intellectual disability.

PubMed ID: 24462372

DOI: 10.1016/j.ajhg.2014.01.002

PubMed ID: 26138355

Title: Whole-exome sequencing improves the diagnosis yield in sporadic infantile spasm syndrome.

PubMed ID: 26138355

DOI: 10.1111/cge.12636

Sequence Information:

  • Length: 423
  • Mass: 46156
  • Checksum: 6EE634BE96242731
  • Sequence:
    • MAMVVSSWRD PQDDVAGGNP GGPNPAAQAA RGGGGGAGEQ QQQAGSGAPH TPQTPGQPGA 
PATPGTAGDK GQGPPGSGQS QQHIECVVCG DKSSGKHYGQ FTCEGCKSFF KRSVRRNLTY 
TCRANRNCPI DQHHRNQCQY CRLKKCLKVG MRREAVQRGR MPPTQPNPGQ YALTNGDPLN 
GHCYLSGYIS LLLRAEPYPT SRYGSQCMQP NNIMGIENIC ELAARLLFSA VEWARNIPFF 
PDLQITDQVS LLRLTWSELF VLNAAQCSMP LHVAPLLAAA GLHASPMSAD RVVAFMDHIR 
IFQEQVEKLK ALHVDSAEYS CLKAIVLFTS DACGLSDAAH IESLQEKSQC ALEEYVRSQY 
PNQPSRFGKL LLRLPSLRTV SSSVIEQLFF VRLVGKTPIE TLIRDMLLSG SSFNWPYMSI 
QCS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.