Details for: NME4

Gene ID: 4833

Symbol: NME4

Ensembl ID: ENSG00000103202

Description: NME/NM23 nucleoside diphosphate kinase 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3
    Marker Score: 39563
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.67
    Marker Score: 17353
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.55
    Marker Score: 2656.5
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.27
    Marker Score: 2421
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.25
    Marker Score: 5285.5
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.2
    Marker Score: 2333
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.16
    Marker Score: 2031
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.15
    Marker Score: 857
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.14
    Marker Score: 4875
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.13
    Marker Score: 1337
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.12
    Marker Score: 23920
  • Cell Name: neural cell (CL0002319)
    Fold Change: 2.12
    Marker Score: 1023
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.09
    Marker Score: 5677
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.05
    Marker Score: 8831
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.05
    Marker Score: 774
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.04
    Marker Score: 579
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 2.03
    Marker Score: 1377
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.92
    Marker Score: 1394
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.92
    Marker Score: 4014
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.92
    Marker Score: 7095
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.91
    Marker Score: 7815
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.83
    Marker Score: 1972
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.79
    Marker Score: 18049.5
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.77
    Marker Score: 569
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.72
    Marker Score: 945
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.71
    Marker Score: 1610
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.67
    Marker Score: 1112.5
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.66
    Marker Score: 547
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.66
    Marker Score: 2814
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.64
    Marker Score: 905
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.64
    Marker Score: 1654
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.63
    Marker Score: 1727
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.63
    Marker Score: 813
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.61
    Marker Score: 1208
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.61
    Marker Score: 516
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.59
    Marker Score: 4260.5
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.56
    Marker Score: 9223.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.54
    Marker Score: 2270
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.53
    Marker Score: 536
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.52
    Marker Score: 1710
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.51
    Marker Score: 882
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.5
    Marker Score: 1069
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.5
    Marker Score: 2066
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.48
    Marker Score: 5717
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.45
    Marker Score: 684.5
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.43
    Marker Score: 482
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.43
    Marker Score: 1792.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.43
    Marker Score: 2343
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.43
    Marker Score: 699
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.42
    Marker Score: 334
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.41
    Marker Score: 728
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.4
    Marker Score: 486
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.39
    Marker Score: 1721
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.39
    Marker Score: 393
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.38
    Marker Score: 489
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.38
    Marker Score: 2437
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.37
    Marker Score: 308
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.37
    Marker Score: 2102
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.35
    Marker Score: 667
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.35
    Marker Score: 3197
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 1.33
    Marker Score: 1004
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.33
    Marker Score: 875
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.32
    Marker Score: 2190
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.32
    Marker Score: 2473
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.32
    Marker Score: 537
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.3
    Marker Score: 3272
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.29
    Marker Score: 3388
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.29
    Marker Score: 5064
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.29
    Marker Score: 763
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.27
    Marker Score: 531
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.24
    Marker Score: 1317
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.24
    Marker Score: 2815
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.23
    Marker Score: 657
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.23
    Marker Score: 781
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.2
    Marker Score: 6309
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2
    Marker Score: 2928
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.18
    Marker Score: 742
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.17
    Marker Score: 1190
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.17
    Marker Score: 1875
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.16
    Marker Score: 466
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.15
    Marker Score: 364
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 1.14
    Marker Score: 418
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.13
    Marker Score: 20074
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.12
    Marker Score: 641
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.12
    Marker Score: 1784
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.12
    Marker Score: 523
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.11
    Marker Score: 1299
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.09
    Marker Score: 406
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.09
    Marker Score: 928
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1.09
    Marker Score: 584
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.08
    Marker Score: 1126
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.07
    Marker Score: 765
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.06
    Marker Score: 1008
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.05
    Marker Score: 36533
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.05
    Marker Score: 654.5
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.05
    Marker Score: 696
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.04
    Marker Score: 1470
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.02
    Marker Score: 2039
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.01
    Marker Score: 1320
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.01
    Marker Score: 245

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Other Information

**Key Characteristics:** 1. **Nucleoside Diphosphate Kinase Activity:** NME4 is a nucleoside diphosphate kinase (NDK) enzyme, which means it catalyzes the transfer of phosphate groups between nucleotides, playing a critical role in maintaining cellular energy homeostasis. 2. **Expression in Various Cell Types:** NME4 is expressed in a wide range of cell types, including mesodermal cells, interstitial cells of the ovary, erythroid progenitor cells, and neural crest cells, suggesting its importance in various physiological processes. 3. **Involvement in Metabolic Pathways:** NME4 is involved in multiple metabolic pathways, including the metabolism of nucleotides, lipids, and proteins, highlighting its role in maintaining cellular energy homeostasis. **Pathways and Functions:** 1. **Interconversion of Nucleotide Di- and Triphosphates:** NME4 catalyzes the interconversion of nucleotide di- and triphosphates, playing a critical role in maintaining cellular energy homeostasis. 2. **Metabolism of Nucleotides:** NME4 is involved in the metabolism of nucleotides, including the synthesis and degradation of nucleotides. 3. **Lipid Transport:** NME4 is involved in lipid transport, suggesting its role in maintaining cellular lipid homeostasis. 4. **Protein Binding:** NME4 interacts with various proteins, including those involved in energy metabolism and lipid transport. 5. **Cardiolipin Binding:** NME4 binds to cardiolipin, a critical phospholipid component of the inner mitochondrial membrane, suggesting its role in maintaining mitochondrial function. **Clinical Significance:** 1. **Cancer:** NME4 has been implicated in cancer development and progression, with its expression altered in various types of cancer, including breast, lung, and colon cancer. 2. **Neurological Disorders:** NME4 has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease, where its expression is altered. 3. **Metabolic Disorders:** NME4 has been implicated in metabolic disorders, including type 2 diabetes and obesity, where its expression is altered. 4. **Mitochondrial Function:** NME4 plays a critical role in maintaining mitochondrial function, and its dysfunction has been linked to various diseases, including neurodegenerative disorders. In conclusion, NME4 is a critical regulator of cellular metabolism and energy homeostasis, with its expression altered in various diseases, including cancer, neurological disorders, and metabolic disorders. Further research is needed to fully understand the role of NME4 in human health and disease.

Genular Protein ID: 1235635070

Symbol: NDKM_HUMAN

Name: Nucleoside diphosphate kinase D

UniProtKB Accession Codes:

O00746 A2IDD0 Q5U0M9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 16 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 9 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 7 Rhea 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9099850

Title: nm23-H4, a new member of the family of human nm23/nucleoside diphosphate kinase genes localised on chromosome 16p13.

PubMed ID: 9099850

DOI: 10.1007/s004390050405

PubMed ID: 11157797

Title: Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.

PubMed ID: 11157797

DOI: 10.1093/hmg/10.4.339

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17028143

Title: Novel lipid transfer property of two mitochondrial proteins that bridge the inner and outer membranes.

PubMed ID: 17028143

DOI: 10.1529/biophysj.106.092353

PubMed ID: 18635542

Title: The nucleoside diphosphate kinase D (NM23-H4) binds the inner mitochondrial membrane with high affinity to cardiolipin and couples nucleotide transfer with respiration.

PubMed ID: 18635542

DOI: 10.1074/jbc.m803132200

PubMed ID: 23150663

Title: Dual function of mitochondrial Nm23-H4 protein in phosphotransfer and intermembrane lipid transfer: a cardiolipin-dependent switch.

PubMed ID: 23150663

DOI: 10.1074/jbc.m112.408633

PubMed ID: 24970086

Title: Membrane trafficking. Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling.

PubMed ID: 24970086

DOI: 10.1126/science.1253768

PubMed ID: 10799505

Title: The human nm23-H4 gene product is a mitochondrial nucleoside diphosphate kinase.

PubMed ID: 10799505

DOI: 10.1074/jbc.275.19.14264

Sequence Information:

  • Length: 187
  • Mass: 20659
  • Checksum: A56FEF18A7D712D4
  • Sequence:
    • MGGLFWRSAL RGLRCGPRAP GPSLLVRHGS GGPSWTRERT LVAVKPDGVQ RRLVGDVIQR 
FERRGFTLVG MKMLQAPESV LAEHYQDLRR KPFYPALIRY MSSGPVVAMV WEGYNVVRAS 
RAMIGHTDSA EAAPGTIRGD FSVHISRNVI HASDSVEGAQ REIQLWFQSS ELVSWADGGQ 
HSSIHPA

Genular Protein ID: 688508084

Symbol: A0A087WVT9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WVT9

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 9 ChiTaRS 1 DNASU 1 EC 2 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 Rhea 2 RuleBase 1 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

Sequence Information:

  • Length: 153
  • Mass: 16783
  • Checksum: BC83941C555B35DB
  • Sequence:
    • MGGLFWRSAL RGLRCGPRAP GPSLLVRHGS GGPSWTRERT LVAVKPDGVQ RRLVGDVIQR 
FERRGFTLVG MKMLQVWEGY NVVRASRAMI GHTDSAEAAP GTIRGDFSVH ISRNVIHASD 
SVEGAQREIQ LWFQSSELVS WADGGQHSSI HPA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.