Details for: NME4

Gene ID: 4833

Symbol: NME4

Ensembl ID: ENSG00000103202

Description: NME/NM23 nucleoside diphosphate kinase 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 90.7179
    Cell Significance Index: -23.0100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 82.1282
    Cell Significance Index: -33.8300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 79.6191
    Cell Significance Index: -37.5900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 77.0202
    Cell Significance Index: -31.2900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 70.9585
    Cell Significance Index: -36.5000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 32.8570
    Cell Significance Index: -31.3700
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 27.6456
    Cell Significance Index: 12.5900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.6853
    Cell Significance Index: -27.9700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.4442
    Cell Significance Index: -36.0200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.9995
    Cell Significance Index: -35.5100
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 7.9720
    Cell Significance Index: -1.2400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 7.3009
    Cell Significance Index: 79.3700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 6.2389
    Cell Significance Index: 79.9000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 5.2968
    Cell Significance Index: 110.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.3529
    Cell Significance Index: 507.2800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 4.0928
    Cell Significance Index: 109.4800
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 3.6896
    Cell Significance Index: 19.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.1459
    Cell Significance Index: 82.7200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.0659
    Cell Significance Index: -6.7100
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.9394
    Cell Significance Index: 18.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.7546
    Cell Significance Index: 128.4300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.6765
    Cell Significance Index: 21.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.5917
    Cell Significance Index: 421.5200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.1523
    Cell Significance Index: 19.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.1466
    Cell Significance Index: 294.7900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.0056
    Cell Significance Index: 53.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.9417
    Cell Significance Index: 116.5700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.3173
    Cell Significance Index: 45.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.2430
    Cell Significance Index: 159.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2413
    Cell Significance Index: 64.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0334
    Cell Significance Index: 77.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0300
    Cell Significance Index: 48.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0020
    Cell Significance Index: 129.4500
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.9962
    Cell Significance Index: 4.8500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.9047
    Cell Significance Index: 5.5700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8453
    Cell Significance Index: 58.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8152
    Cell Significance Index: 161.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6585
    Cell Significance Index: 359.6000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6467
    Cell Significance Index: 45.7400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6295
    Cell Significance Index: 568.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5679
    Cell Significance Index: 36.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5548
    Cell Significance Index: 68.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5174
    Cell Significance Index: 93.2700
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.5032
    Cell Significance Index: 2.8600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.4998
    Cell Significance Index: 7.0100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4824
    Cell Significance Index: 5.4800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4694
    Cell Significance Index: 207.5500
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.4429
    Cell Significance Index: 2.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3459
    Cell Significance Index: 69.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3423
    Cell Significance Index: 65.1400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.3305
    Cell Significance Index: 3.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3093
    Cell Significance Index: 6.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1704
    Cell Significance Index: 61.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1673
    Cell Significance Index: 16.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1646
    Cell Significance Index: 4.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1591
    Cell Significance Index: 27.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1558
    Cell Significance Index: 7.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0857
    Cell Significance Index: 62.8500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0684
    Cell Significance Index: 1.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0365
    Cell Significance Index: 27.6600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0347
    Cell Significance Index: 23.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0111
    Cell Significance Index: 0.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0044
    Cell Significance Index: 8.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0001
    Cell Significance Index: -0.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0105
    Cell Significance Index: -1.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0188
    Cell Significance Index: -34.6700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0193
    Cell Significance Index: -12.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0212
    Cell Significance Index: -32.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0295
    Cell Significance Index: -1.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0301
    Cell Significance Index: -40.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0336
    Cell Significance Index: -21.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0382
    Cell Significance Index: -4.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0387
    Cell Significance Index: -21.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0445
    Cell Significance Index: -20.2100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0468
    Cell Significance Index: -1.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0482
    Cell Significance Index: -2.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0547
    Cell Significance Index: -1.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0668
    Cell Significance Index: -14.0700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0861
    Cell Significance Index: -2.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1077
    Cell Significance Index: -30.9800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1091
    Cell Significance Index: -0.8900
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.1120
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1444
    Cell Significance Index: -16.5400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1569
    Cell Significance Index: -12.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1721
    Cell Significance Index: -4.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1924
    Cell Significance Index: -27.9700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2228
    Cell Significance Index: -3.0400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2293
    Cell Significance Index: -26.1700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2345
    Cell Significance Index: -1.9700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2880
    Cell Significance Index: -8.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3044
    Cell Significance Index: -18.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3281
    Cell Significance Index: -34.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3509
    Cell Significance Index: -11.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3571
    Cell Significance Index: -27.4100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3608
    Cell Significance Index: -3.7400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3696
    Cell Significance Index: -8.5400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3956
    Cell Significance Index: -26.6000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4018
    Cell Significance Index: -11.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4041
    Cell Significance Index: -25.4700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4294
    Cell Significance Index: -9.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Nucleoside Diphosphate Kinase Activity:** NME4 is a nucleoside diphosphate kinase (NDK) enzyme, which means it catalyzes the transfer of phosphate groups between nucleotides, playing a critical role in maintaining cellular energy homeostasis. 2. **Expression in Various Cell Types:** NME4 is expressed in a wide range of cell types, including mesodermal cells, interstitial cells of the ovary, erythroid progenitor cells, and neural crest cells, suggesting its importance in various physiological processes. 3. **Involvement in Metabolic Pathways:** NME4 is involved in multiple metabolic pathways, including the metabolism of nucleotides, lipids, and proteins, highlighting its role in maintaining cellular energy homeostasis. **Pathways and Functions:** 1. **Interconversion of Nucleotide Di- and Triphosphates:** NME4 catalyzes the interconversion of nucleotide di- and triphosphates, playing a critical role in maintaining cellular energy homeostasis. 2. **Metabolism of Nucleotides:** NME4 is involved in the metabolism of nucleotides, including the synthesis and degradation of nucleotides. 3. **Lipid Transport:** NME4 is involved in lipid transport, suggesting its role in maintaining cellular lipid homeostasis. 4. **Protein Binding:** NME4 interacts with various proteins, including those involved in energy metabolism and lipid transport. 5. **Cardiolipin Binding:** NME4 binds to cardiolipin, a critical phospholipid component of the inner mitochondrial membrane, suggesting its role in maintaining mitochondrial function. **Clinical Significance:** 1. **Cancer:** NME4 has been implicated in cancer development and progression, with its expression altered in various types of cancer, including breast, lung, and colon cancer. 2. **Neurological Disorders:** NME4 has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease, where its expression is altered. 3. **Metabolic Disorders:** NME4 has been implicated in metabolic disorders, including type 2 diabetes and obesity, where its expression is altered. 4. **Mitochondrial Function:** NME4 plays a critical role in maintaining mitochondrial function, and its dysfunction has been linked to various diseases, including neurodegenerative disorders. In conclusion, NME4 is a critical regulator of cellular metabolism and energy homeostasis, with its expression altered in various diseases, including cancer, neurological disorders, and metabolic disorders. Further research is needed to fully understand the role of NME4 in human health and disease.

Genular Protein ID: 1235635070

Symbol: NDKM_HUMAN

Name: Nucleoside diphosphate kinase D

UniProtKB Accession Codes:

O00746 A2IDD0 Q5U0M9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 16 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 9 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 7 Rhea 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9099850

Title: nm23-H4, a new member of the family of human nm23/nucleoside diphosphate kinase genes localised on chromosome 16p13.

PubMed ID: 9099850

DOI: 10.1007/s004390050405

PubMed ID: 11157797

Title: Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.

PubMed ID: 11157797

DOI: 10.1093/hmg/10.4.339

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17028143

Title: Novel lipid transfer property of two mitochondrial proteins that bridge the inner and outer membranes.

PubMed ID: 17028143

DOI: 10.1529/biophysj.106.092353

PubMed ID: 18635542

Title: The nucleoside diphosphate kinase D (NM23-H4) binds the inner mitochondrial membrane with high affinity to cardiolipin and couples nucleotide transfer with respiration.

PubMed ID: 18635542

DOI: 10.1074/jbc.m803132200

PubMed ID: 23150663

Title: Dual function of mitochondrial Nm23-H4 protein in phosphotransfer and intermembrane lipid transfer: a cardiolipin-dependent switch.

PubMed ID: 23150663

DOI: 10.1074/jbc.m112.408633

PubMed ID: 24970086

Title: Membrane trafficking. Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling.

PubMed ID: 24970086

DOI: 10.1126/science.1253768

PubMed ID: 10799505

Title: The human nm23-H4 gene product is a mitochondrial nucleoside diphosphate kinase.

PubMed ID: 10799505

DOI: 10.1074/jbc.275.19.14264

Sequence Information:

  • Length: 187
  • Mass: 20659
  • Checksum: A56FEF18A7D712D4
  • Sequence:
    • MGGLFWRSAL RGLRCGPRAP GPSLLVRHGS GGPSWTRERT LVAVKPDGVQ RRLVGDVIQR 
FERRGFTLVG MKMLQAPESV LAEHYQDLRR KPFYPALIRY MSSGPVVAMV WEGYNVVRAS 
RAMIGHTDSA EAAPGTIRGD FSVHISRNVI HASDSVEGAQ REIQLWFQSS ELVSWADGGQ 
HSSIHPA

Genular Protein ID: 688508084

Symbol: A0A087WVT9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WVT9

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 1 RuleBase 1 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

Sequence Information:

  • Length: 153
  • Mass: 16783
  • Checksum: BC83941C555B35DB
  • Sequence:
    • MGGLFWRSAL RGLRCGPRAP GPSLLVRHGS GGPSWTRERT LVAVKPDGVQ RRLVGDVIQR 
FERRGFTLVG MKMLQVWEGY NVVRASRAMI GHTDSAEAAP GTIRGDFSVH ISRNVIHASD 
SVEGAQREIQ LWFQSSELVS WADGGQHSSI HPA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.