Details for: H1 0
Gene ID: 3005
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: H1 0
Ensembl ID: ENSG00000189060
Description: H1.0 linker histone
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 27.41rCSI 48.33%PRS 70.58
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CSI 27.11rCSI 36.94%PRS 54.27
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CSI 25.57rCSI 30.7%PRS 60.56
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CSI 25.02rCSI 35.7%PRS 64.75
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CSI 22.88rCSI 30.4%PRS 68.98
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CSI 22.62rCSI 46.93%PRS 59.55
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CSI 22.4rCSI 19.88%PRS 60.31
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CSI 21.01rCSI 52.65%PRS 85.24
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CSI 20.97rCSI 21.96%PRS 58.89
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CSI 20.74rCSI 49.22%PRS 66.09
-
CSI 20.15rCSI 44.36%PRS 66.78
-
CSI 18.89rCSI 12.55%PRS 65.6
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CSI 18.15rCSI 20.96%PRS 55.52
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CSI 18.13rCSI 43.09%PRS 71.24
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CSI 17.74rCSI 19.01%PRS 62.05
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CSI 16.56rCSI 22.54%PRS 74.09
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CSI 15.82rCSI 45.79%PRS 63.75
-
CSI 14.68rCSI 17.02%PRS 70.04
-
CSI 14.31rCSI 13.78%PRS 62.52
-
CSI 14.26rCSI 18.3%PRS 59.64
-
CSI 14.23rCSI 22.88%PRS 46.14
-
CSI 13.53rCSI 18.8%PRS 60.99
-
CSI 13.02rCSI 41.77%PRS 67.47
-
CSI 12.9rCSI 25.09%PRS 65.47
-
CSI 12.8rCSI 10.61%PRS 61.84
-
CSI 12.18rCSI 12.42%PRS 75.2
-
CSI 12.11rCSI 17.92%PRS 67.75
-
CSI 12.01rCSI 16.63%PRS 63.39
-
CSI 11.99rCSI 38.89%PRS 62.7
-
CSI 11.89rCSI 52.33%PRS 52.7
-
CSI 11.77rCSI 17.22%PRS 67.27
-
CSI 11.61rCSI 11.58%PRS 55.8
-
CSI 11.48rCSI 25.07%PRS 75.85
-
CSI 11.46rCSI 9.49%PRS 64.68
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CSI 11.01rCSI 17.39%PRS 64.72
-
CSI 10.86rCSI 17.59%PRS 59.05
-
CSI 10.67rCSI 9.63%PRS 59.37
-
CSI 10.54rCSI 8.57%PRS 62.89
-
CSI 10.46rCSI 9.73%PRS 62.99
-
CSI 8.92rCSI 55.07%PRS 88.48
-
CSI 8.72rCSI 23.03%PRS 71.24
-
CSI 8.59rCSI 16.22%PRS 72.83
-
CSI 8.37rCSI 45.17%PRS 74.66
-
CSI 8.21rCSI 11.84%PRS 72
-
CSI 8.18rCSI 8.96%PRS 66.19
-
CSI 8.17rCSI 6.34%PRS 64.45
-
CSI 8.07rCSI 11.83%PRS 58.47
-
CSI 7.8rCSI 16.61%PRS 73.49
-
CSI 7.73rCSI 8.06%PRS 62.73
-
CSI 7.64rCSI 8%PRS 66.12
-
CSI 7.61rCSI 13.49%PRS 36.71
-
CSI 7.57rCSI 9.63%PRS 68.93
-
CSI 7.54rCSI 16.83%PRS 70.28
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CSI 7.47rCSI 26.5%PRS 71.05
-
CSI 7.46rCSI 7.05%PRS 61.91
-
CSI 7.32rCSI 6.75%PRS 63.85
-
CSI 7.15rCSI 17.71%PRS 60.89
-
CSI 7.14rCSI 9.36%PRS 76.04
-
CSI 7.09rCSI 18.01%PRS 56.63
-
CSI 6.96rCSI 16.07%PRS 51.48
-
CSI 6.92rCSI 28.72%PRS 65.62
-
CSI 6.89rCSI 16.46%PRS 70.9
-
CSI 6.82rCSI 9.11%PRS 82.69
-
CSI 6.74rCSI 5.19%PRS 62.98
-
CSI 6.72rCSI 73.57%PRS 74.65
-
CSI 6.61rCSI 10.52%PRS 54.79
-
CSI 6.55rCSI 6.85%PRS 60.46
-
CSI 6.51rCSI 10.39%PRS 54.93
-
CSI 6.36rCSI 5.59%PRS 68.04
-
CSI 6.36rCSI 7.98%PRS 72.87
-
CSI 6.19rCSI 8.27%PRS 62.75
-
CSI 6.15rCSI 18.14%PRS 65.57
-
CSI 6.05rCSI 9.66%PRS 66.57
-
CSI 5.98rCSI 9.13%PRS 63.11
-
CSI 5.94rCSI 9.58%PRS 66.02
-
CSI 5.92rCSI 9.04%PRS 66.67
-
CSI 5.88rCSI 4.35%PRS 54.96
-
CSI 5.8rCSI 5.1%PRS 50.35
-
CSI 5.78rCSI 9.99%PRS 52.54
-
CSI 5.69rCSI 28.62%PRS 63.16
-
CSI 5.6rCSI 36%PRS 79.72
-
CSI 5.54rCSI 8.47%PRS 71.84
-
CSI 5.53rCSI 7.56%PRS 64.15
-
CSI 5.52rCSI 6.87%PRS 42.21
-
CSI 5.47rCSI 5.67%PRS 68.2
-
CSI 5.4rCSI 14.02%PRS 65.92
-
CSI 5.4rCSI 4.67%PRS 67.49
-
CSI 5.38rCSI 11.78%PRS 70.41
-
CSI 5.37rCSI 12.18%PRS 66.39
-
CSI 5.36rCSI 5.27%PRS 65.13
-
CSI 5.31rCSI 6.81%PRS 67.34
-
CSI 5.28rCSI 9.6%PRS 77.45
-
CSI 5.09rCSI 4.27%PRS 66.85
-
CSI 5.08rCSI 8.91%PRS 54.25
-
CSI 4.97rCSI 9.84%PRS 78.71
-
CSI 4.87rCSI 7.45%PRS 75.66
-
CSI 4.72rCSI 17.97%PRS 53.17
-
CSI 4.7rCSI 5.91%PRS 74.39
-
CSI 4.61rCSI 9.81%PRS 61.62
-
CSI 4.58rCSI 34.43%PRS 78.24
-
CSI 0.2rCSI 4.4%PRS 78.9%
-
CSI 0.2rCSI 1.6%PRS 73.8%
-
CSI 0.2rCSI 4.6%PRS 89.6%
-
CSI 0.2rCSI 5.4%PRS 80.9%
-
CSI 0.3rCSI 3.0%PRS 79.2%
-
CSI 0.3rCSI 7.4%PRS 94.1%
-
CSI 0.4rCSI 3.4%PRS 80.4%
-
CSI 0.4rCSI 10.6%PRS 88.8%
-
CSI 0.5rCSI 2.8%PRS 71.7%
-
CSI 0.5rCSI 4.9%PRS 91.9%
-
CSI 0.5rCSI 2.3%PRS 75.0%
-
CSI 0.5rCSI 2.1%PRS 77.9%
-
CSI 0.6rCSI 1.7%PRS 73.6%
-
CSI 0.6rCSI 3.3%PRS 77.8%
-
CSI 0.6rCSI 2.9%PRS 78.8%
-
CSI 0.7rCSI 3.7%PRS 67.5%
-
CSI 0.7rCSI 3.7%PRS 83.8%
-
CSI 0.8rCSI 3.5%PRS 78.8%
-
CSI 0.8rCSI 2.5%PRS 48.3%
-
CSI 0.8rCSI 3.7%PRS 76.8%
-
CSI 0.9rCSI 2.0%PRS 60.4%
-
CSI 0.9rCSI 3.7%PRS 74.8%
-
CSI 1.0rCSI 2.2%PRS 58.8%
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CSI 1.0rCSI 10.6%PRS 77.0%
-
CSI 1.0rCSI 2.7%PRS 74.9%
-
CSI 1.0rCSI 3.9%PRS 76.7%
-
CSI 1.1rCSI 2.8%PRS 57.4%
-
CSI 1.1rCSI 3.8%PRS 75.0%
-
CSI 1.1rCSI 4.3%PRS 82.2%
-
CSI 1.1rCSI 12.6%PRS 82.4%
-
CSI 1.2rCSI 6.2%PRS 74.6%
-
CSI 1.2rCSI 1.4%PRS 80.7%
-
CSI 1.2rCSI 3.5%PRS 75.6%
-
CSI 1.3rCSI 2.8%PRS 48.6%
-
CSI 1.3rCSI 2.0%PRS 66.7%
-
CSI 1.4rCSI 4.2%PRS 74.5%
-
CSI 1.5rCSI 2.0%PRS 69.2%
-
CSI 1.5rCSI 2.1%PRS 58.7%
-
CSI 1.5rCSI 2.5%PRS 67.7%
-
CSI 1.5rCSI 3.3%PRS 79.8%
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CSI 1.6rCSI 4.2%PRS 80.4%
-
CSI 1.6rCSI 42.5%PRS 83.0%
-
CSI 1.6rCSI 5.5%PRS 47.6%
-
CSI 1.6rCSI 4.0%PRS 69.7%
-
CSI 1.7rCSI 2.6%PRS 58.7%
-
CSI 1.7rCSI 3.8%PRS 74.9%
-
CSI 1.8rCSI 2.9%PRS 51.7%
-
CSI 1.8rCSI 5.0%PRS 59.0%
-
CSI 1.8rCSI 2.7%PRS 78.0%
-
CSI 1.8rCSI 4.9%PRS 69.5%
-
CSI 1.8rCSI 2.9%PRS 73.5%
-
CSI 1.9rCSI 9.5%PRS 88.2%
-
CSI 1.9rCSI 3.6%PRS 82.1%
-
CSI 1.9rCSI 2.8%PRS 55.8%
-
CSI 2.0rCSI 9.8%PRS 73.5%
-
CSI 2.0rCSI 4.9%PRS 80.1%
-
CSI 2.1rCSI 13.5%PRS 87.9%
-
CSI 2.2rCSI 3.2%PRS 73.0%
-
CSI 2.2rCSI 1.6%PRS 65.3%
-
CSI 2.2rCSI 14.7%PRS 86.9%
-
CSI 2.3rCSI 1.8%PRS 49.3%
-
CSI 2.3rCSI 3.1%PRS 71.4%
-
CSI 2.5rCSI 3.7%PRS 63.8%
-
CSI 2.6rCSI 3.7%PRS 65.9%
-
CSI 2.6rCSI 2.4%PRS 71.4%
-
CSI 2.7rCSI 21.2%PRS 80.3%
-
CSI 2.7rCSI 12.6%PRS 79.4%
-
CSI 2.7rCSI 6.6%PRS 42.7%
-
CSI 2.8rCSI 4.7%PRS 84.8%
-
CSI 2.8rCSI 19.7%PRS 76.6%
-
CSI 2.8rCSI 7.1%PRS 70.4%
-
CSI 2.8rCSI 5.3%PRS 77.1%
-
CSI 2.9rCSI 12.4%PRS 74.7%
-
CSI 2.9rCSI 5.2%PRS 61.5%
-
CSI 2.9rCSI 23.9%PRS 55.7%
-
CSI 3.0rCSI 5.3%PRS 55.6%
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CSI 3.1rCSI 3.8%PRS 64.1%
-
CSI 3.1rCSI 16.4%PRS 71.9%
-
CSI 3.2rCSI 7.6%PRS 72.4%
-
CSI 3.2rCSI 3.7%PRS 52.6%
-
CSI 3.3rCSI 4.1%PRS 59.1%
-
CSI 3.4rCSI 4.1%PRS 70.0%
-
CSI 3.4rCSI 19.8%PRS 71.3%
-
CSI 3.4rCSI 5.9%PRS 71.3%
-
CSI 3.5rCSI 30.0%PRS 59.4%
-
CSI 3.5rCSI 4.8%PRS 68.6%
-
CSI 3.5rCSI 7.2%PRS 80.3%
-
CSI 3.6rCSI 2.9%PRS 63.9%
-
CSI 3.6rCSI 5.6%PRS 60.7%
-
CSI 3.7rCSI 4.4%PRS 71.4%
-
CSI 3.9rCSI 6.5%PRS 44.1%
-
CSI 4.0rCSI 10.5%PRS 73.6%
-
CSI 4.0rCSI 7.1%PRS 76.0%
-
CSI 4.0rCSI 9.3%PRS 79.8%
-
CSI 4.1rCSI 5.3%PRS 45.4%
-
CSI 4.2rCSI 3.6%PRS 67.9%
-
CSI 4.3rCSI 6.4%PRS 78.0%
-
CSI 4.4rCSI 23.3%PRS 52.7%
-
CSI 4.4rCSI 4.5%PRS 76.6%
-
CSI 4.5rCSI 31.9%PRS 62.5%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 883517988
Symbol: H10_HUMAN
Name: Histone H1.0
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3084796
Title: Differential distribution of lysine and arginine residues in the closely related histones H1 and H5. Analysis of a human H1 gene.
PubMed ID: 3084796
PubMed ID: 15461802
Title: A genome annotation-driven approach to cloning the human ORFeome.
PubMed ID: 15461802
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 10591208
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 18993075
Title: Evidence for insertional RNA editing in humans.
PubMed ID: 18993075
PubMed ID: 9582379
Title: The microheterogeneity of the mammalian H1(0) histone. Evidence for an age-dependent deamidation.
PubMed ID: 9582379
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 27723750
Title: Serine is a new target residue for endogenous ADP-ribosylation on histones.
PubMed ID: 27723750
Sequence Information:
- Length: 194
- Mass: 20863
- Checksum: 03ED6F01919F8BE1
- Sequence:
MTENSTSAPA AKPKRAKASK KSTDHPKYSD MIVAAIQAEK NRAGSSRQSI QKYIKSHYKV GENADSQIKL SIKRLVTTGV LKQTKGVGAS GSFRLAKSDE PKKSVAFKKT KKEIKKVATP KKASKPKKAA SKAPTKKPKA TPVKKAKKKL AATPKKAKKP KTVKAKPVKA SKPKKAKPVK PKAKSSAKRA GKKK