Details for: H1 0

Gene ID: 3005

Symbol: H1 0

Ensembl ID: ENSG00000189060

Description: H1.0 linker histone

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 148.0425
    Cell Significance Index: -37.5500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 110.8822
    Cell Significance Index: -52.3500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 104.0228
    Cell Significance Index: -42.2600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 100.2362
    Cell Significance Index: -51.5600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 78.1494
    Cell Significance Index: -52.4400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 44.4570
    Cell Significance Index: -42.4500
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 42.1742
    Cell Significance Index: -6.5600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 28.3222
    Cell Significance Index: -34.9200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.5036
    Cell Significance Index: -49.3400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 6.6806
    Cell Significance Index: 53.3400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 6.0687
    Cell Significance Index: 77.7200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.5378
    Cell Significance Index: -12.1200
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 4.9372
    Cell Significance Index: 30.5500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 4.9051
    Cell Significance Index: 53.3300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.8510
    Cell Significance Index: 101.5400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.6309
    Cell Significance Index: 22.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.1597
    Cell Significance Index: 83.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.6226
    Cell Significance Index: 195.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.3767
    Cell Significance Index: 107.7300
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.1137
    Cell Significance Index: 10.2800
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.9162
    Cell Significance Index: 4.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.6409
    Cell Significance Index: 57.0200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6117
    Cell Significance Index: 21.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.4869
    Cell Significance Index: 204.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4808
    Cell Significance Index: 191.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2241
    Cell Significance Index: 35.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.2054
    Cell Significance Index: 56.2000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1853
    Cell Significance Index: 25.6800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1832
    Cell Significance Index: 145.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.0548
    Cell Significance Index: 55.3800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.9593
    Cell Significance Index: 13.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9471
    Cell Significance Index: 93.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8910
    Cell Significance Index: 114.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8753
    Cell Significance Index: 157.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8752
    Cell Significance Index: 41.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8730
    Cell Significance Index: 476.7400
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.8713
    Cell Significance Index: 4.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7987
    Cell Significance Index: 158.5000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6467
    Cell Significance Index: 14.9400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5170
    Cell Significance Index: 35.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5135
    Cell Significance Index: 227.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5055
    Cell Significance Index: 26.2600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4091
    Cell Significance Index: 6.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4014
    Cell Significance Index: 28.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3848
    Cell Significance Index: 65.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.3550
    Cell Significance Index: 40.6800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2832
    Cell Significance Index: 17.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2201
    Cell Significance Index: 35.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2136
    Cell Significance Index: 40.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1950
    Cell Significance Index: 69.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1521
    Cell Significance Index: 30.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1046
    Cell Significance Index: 79.1700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0457
    Cell Significance Index: 0.7700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0286
    Cell Significance Index: 53.7900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0204
    Cell Significance Index: 1.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0103
    Cell Significance Index: 0.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0101
    Cell Significance Index: 9.1200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0009
    Cell Significance Index: 0.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0067
    Cell Significance Index: -4.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0077
    Cell Significance Index: -10.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0088
    Cell Significance Index: -0.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0208
    Cell Significance Index: -32.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0209
    Cell Significance Index: -2.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0247
    Cell Significance Index: -45.6400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0261
    Cell Significance Index: -0.7300
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0338
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0609
    Cell Significance Index: -45.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0619
    Cell Significance Index: -39.3000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0677
    Cell Significance Index: -2.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0844
    Cell Significance Index: -38.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0844
    Cell Significance Index: -47.6100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1054
    Cell Significance Index: -65.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1127
    Cell Significance Index: -5.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1405
    Cell Significance Index: -40.4400
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: -0.1589
    Cell Significance Index: -1.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1613
    Cell Significance Index: -4.3900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1717
    Cell Significance Index: -1.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2028
    Cell Significance Index: -11.3800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2473
    Cell Significance Index: -2.8100
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.2492
    Cell Significance Index: -1.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2768
    Cell Significance Index: -40.2400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2940
    Cell Significance Index: -4.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2970
    Cell Significance Index: -62.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3006
    Cell Significance Index: -23.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3270
    Cell Significance Index: -38.5600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3797
    Cell Significance Index: -39.5400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4204
    Cell Significance Index: -12.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4595
    Cell Significance Index: -29.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4782
    Cell Significance Index: -37.8700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.5357
    Cell Significance Index: -4.5000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5897
    Cell Significance Index: -6.1100
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.6609
    Cell Significance Index: -4.1500
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.6916
    Cell Significance Index: -4.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7080
    Cell Significance Index: -43.4100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.7131
    Cell Significance Index: -12.2200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7417
    Cell Significance Index: -18.5400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.7485
    Cell Significance Index: -4.8800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.8016
    Cell Significance Index: -8.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8526
    Cell Significance Index: -53.7400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.8712
    Cell Significance Index: -5.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Chromatin binding**: H1.0 linker histone binds to linker DNA, which is the non-histone DNA segment between nucleosomes, thereby stabilizing chromatin structure and preventing DNA compaction. 2. **Transcriptional regulation**: H1.0 acts as a transcriptional repressor by binding to specific DNA sequences, thereby inhibiting gene expression and maintaining chromatin compaction. 3. **DNA damage response**: H1.0 plays a role in DNA damage response by interacting with histones and other proteins to facilitate DNA repair and genome stability. 4. **Cellular differentiation**: H1.0 is involved in cellular differentiation processes, particularly in the development of skeletal muscle and pancreatic acinar cells. **Pathways and Functions:** 1. **Apoptosis regulation**: H1.0 interacts with BCL-2 family proteins to regulate apoptosis, a process essential for maintaining genome stability and preventing cancer. 2. **Chromatin remodeling**: H1.0 linker histone participates in chromatin remodeling, a process that regulates gene expression by altering chromatin structure and accessibility. 3. **Cellular senescence**: H1.0 is involved in the regulation of cellular senescence, a process that prevents cancer by inhibiting cell proliferation and promoting cell cycle arrest. 4. **DNA repair**: H1.0 interacts with DNA repair proteins to facilitate DNA repair and maintain genome stability. **Clinical Significance:** 1. **Cancer research**: Abnormal expression of H1.0 has been observed in various cancers, including pancreatic cancer, suggesting its potential as a biomarker for cancer diagnosis and prognosis. 2. **Neurological disorders**: H1.0 has been implicated in neurological disorders, such as Alzheimer's disease, where it may contribute to chromatin instability and disease progression. 3. **Regenerative medicine**: H1.0 plays a role in cellular differentiation and regeneration, making it a potential target for therapeutic interventions in regenerative medicine. In conclusion, H1.0 linker histone is a critical protein component of chromatin that regulates gene expression, DNA replication, and cell cycle progression. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its role in human health and disease.

Genular Protein ID: 883517988

Symbol: H10_HUMAN

Name: Histone H1.0

UniProtKB Accession Codes:

P07305 B2R6I0 B4DRD6 Q6FG88 Q8N6R3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugCentral 1 ELM 1 EMBL 9 EMDB 3 Ensembl 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3084796

Title: Differential distribution of lysine and arginine residues in the closely related histones H1 and H5. Analysis of a human H1 gene.

PubMed ID: 3084796

DOI: 10.1016/0022-2836(86)90446-8

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18993075

Title: Evidence for insertional RNA editing in humans.

PubMed ID: 18993075

DOI: 10.1016/j.cub.2008.09.059

PubMed ID: 9582379

Title: The microheterogeneity of the mammalian H1(0) histone. Evidence for an age-dependent deamidation.

PubMed ID: 9582379

DOI: 10.1074/jbc.273.21.13324

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 27723750

Title: Serine is a new target residue for endogenous ADP-ribosylation on histones.

PubMed ID: 27723750

DOI: 10.1038/nchembio.2180

Sequence Information:

  • Length: 194
  • Mass: 20863
  • Checksum: 03ED6F01919F8BE1
  • Sequence:
    • MTENSTSAPA AKPKRAKASK KSTDHPKYSD MIVAAIQAEK NRAGSSRQSI QKYIKSHYKV 
GENADSQIKL SIKRLVTTGV LKQTKGVGAS GSFRLAKSDE PKKSVAFKKT KKEIKKVATP 
KKASKPKKAA SKAPTKKPKA TPVKKAKKKL AATPKKAKKP KTVKAKPVKA SKPKKAKPVK 
PKAKSSAKRA GKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.