Details for: H1 0

Gene ID: 3005

Symbol: H1 0

Ensembl ID: ENSG00000189060

Description: H1.0 linker histone

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.53
    Marker Score: 7460
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 3.48
    Marker Score: 2331
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.16
    Marker Score: 41647
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.12
    Marker Score: 2786
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 2.96
    Marker Score: 1573
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.79
    Marker Score: 1755
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 2.76
    Marker Score: 2208
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.62
    Marker Score: 8240
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.57
    Marker Score: 5373
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.56
    Marker Score: 16654
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.52
    Marker Score: 2689
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.49
    Marker Score: 33407
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.41
    Marker Score: 9321
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.39
    Marker Score: 2678
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.37
    Marker Score: 2226.5
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.35
    Marker Score: 23647
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.32
    Marker Score: 1578
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.31
    Marker Score: 4097
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.29
    Marker Score: 1360
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.25
    Marker Score: 8685
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.23
    Marker Score: 6082
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.18
    Marker Score: 12936.5
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.16
    Marker Score: 1442
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.13
    Marker Score: 1007
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.1
    Marker Score: 4259
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.03
    Marker Score: 510
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.01
    Marker Score: 2433
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2
    Marker Score: 1919
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.98
    Marker Score: 4670
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.97
    Marker Score: 2088
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.95
    Marker Score: 1841
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.92
    Marker Score: 645
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.87
    Marker Score: 1030
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.87
    Marker Score: 3001
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.86
    Marker Score: 1752
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.84
    Marker Score: 1536
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.84
    Marker Score: 653
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.82
    Marker Score: 690
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.81
    Marker Score: 1913
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.77
    Marker Score: 11315
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.77
    Marker Score: 13186
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.73
    Marker Score: 705
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.71
    Marker Score: 996
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.7
    Marker Score: 11096
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.7
    Marker Score: 585
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.65
    Marker Score: 388
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.65
    Marker Score: 2705
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.64
    Marker Score: 14160
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.62
    Marker Score: 2966
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.61
    Marker Score: 7703
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.59
    Marker Score: 774
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.55
    Marker Score: 2391
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.55
    Marker Score: 8147
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.55
    Marker Score: 6668
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.51
    Marker Score: 781
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.48
    Marker Score: 514
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.48
    Marker Score: 290
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.47
    Marker Score: 831
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.47
    Marker Score: 11449
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.46
    Marker Score: 3474
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.46
    Marker Score: 2319
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167187
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.45
    Marker Score: 371
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.43
    Marker Score: 669
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.42
    Marker Score: 750
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.42
    Marker Score: 15974.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.41
    Marker Score: 3215
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.4
    Marker Score: 3182
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.4
    Marker Score: 397
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.4
    Marker Score: 1247
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.39
    Marker Score: 931
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.39
    Marker Score: 441
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.36
    Marker Score: 835.5
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.36
    Marker Score: 392
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.35
    Marker Score: 46791
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.35
    Marker Score: 3292.5
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.34
    Marker Score: 2525
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.34
    Marker Score: 736
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.34
    Marker Score: 1387
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 1.33
    Marker Score: 372
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.31
    Marker Score: 524
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.29
    Marker Score: 855
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.28
    Marker Score: 1272
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.27
    Marker Score: 6239.5
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.27
    Marker Score: 473
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.27
    Marker Score: 1497
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.27
    Marker Score: 1564
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.24
    Marker Score: 1715
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.22
    Marker Score: 459
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.19
    Marker Score: 479
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.18
    Marker Score: 1742
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.18
    Marker Score: 617.5
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.18
    Marker Score: 1295
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.17
    Marker Score: 1266
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.16
    Marker Score: 915
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.15
    Marker Score: 280
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.14
    Marker Score: 479
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.14
    Marker Score: 1567
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.13
    Marker Score: 281
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.13
    Marker Score: 3889

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Other Information

**Key characteristics**: - H1.0 is a basic histone that is present in all eukaryotic cells. - It is a highly conserved protein with a predicted molecular weight of 100 kDa. - It is a key component of chromatin and plays a role in the packaging and organization of DNA. - H1.0 is involved in the regulation of gene expression by interacting with DNA-binding proteins and facilitating their access to specific DNA sequences. **Pathways and functions**: - H1.0 is involved in a variety of cellular processes, including apoptosis, cell cycle regulation, DNA repair, and development. - In apoptosis, H1.0 is essential for the activation of caspases, which are enzymes that are responsible for the execution of apoptosis. - In cell cycle regulation, H1.0 is involved in the regulation of cell cycle checkpoints and the maintenance of genomic integrity. - In DNA repair, H1.0 is involved in the repair of DNA damage and the maintenance of genomic stability. **Clinical significance**: - Mutations in H1.0 have been linked to a number of human diseases, including cancer and developmental disorders. - In cancer, mutations in H1.0 are often associated with the inactivation of tumor suppressor genes and the activation of oncogenes. - Targeting H1.0 has been explored as a therapeutic strategy for cancer.

Genular Protein ID: 883517988

Symbol: H10_HUMAN

Name: Histone H1.0

UniProtKB Accession Codes:

P07305 B2R6I0 B4DRD6 Q6FG88 Q8N6R3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 ELM 1 EMBL 9 EMDB 3 EPD 1 Ensembl 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 12 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3084796

Title: Differential distribution of lysine and arginine residues in the closely related histones H1 and H5. Analysis of a human H1 gene.

PubMed ID: 3084796

DOI: 10.1016/0022-2836(86)90446-8

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18993075

Title: Evidence for insertional RNA editing in humans.

PubMed ID: 18993075

DOI: 10.1016/j.cub.2008.09.059

PubMed ID: 9582379

Title: The microheterogeneity of the mammalian H1(0) histone. Evidence for an age-dependent deamidation.

PubMed ID: 9582379

DOI: 10.1074/jbc.273.21.13324

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 27723750

Title: Serine is a new target residue for endogenous ADP-ribosylation on histones.

PubMed ID: 27723750

DOI: 10.1038/nchembio.2180

Sequence Information:

  • Length: 194
  • Mass: 20863
  • Checksum: 03ED6F01919F8BE1
  • Sequence:
    • MTENSTSAPA AKPKRAKASK KSTDHPKYSD MIVAAIQAEK NRAGSSRQSI QKYIKSHYKV 
GENADSQIKL SIKRLVTTGV LKQTKGVGAS GSFRLAKSDE PKKSVAFKKT KKEIKKVATP 
KKASKPKKAA SKAPTKKPKA TPVKKAKKKL AATPKKAKKP KTVKAKPVKA SKPKKAKPVK 
PKAKSSAKRA GKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.