Details for: PAFAH1B3

Gene ID: 5050

Symbol: PAFAH1B3

Ensembl ID: ENSG00000079462

Description: platelet activating factor acetylhydrolase 1b catalytic subunit 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 139.8629
    Cell Significance Index: -21.7600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 78.6265
    Cell Significance Index: -32.3900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 74.5141
    Cell Significance Index: -18.9000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 67.7404
    Cell Significance Index: -27.5200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 48.0312
    Cell Significance Index: -32.2300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.0026
    Cell Significance Index: -27.6900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.8225
    Cell Significance Index: -30.6100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.2021
    Cell Significance Index: -27.3300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.3248
    Cell Significance Index: -32.8500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.9613
    Cell Significance Index: -18.3100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 4.4938
    Cell Significance Index: 35.8800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.4853
    Cell Significance Index: 37.8900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.3705
    Cell Significance Index: 70.5500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.3661
    Cell Significance Index: 116.9700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.0609
    Cell Significance Index: 39.2000
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.3799
    Cell Significance Index: 17.9700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.3577
    Cell Significance Index: -5.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.1753
    Cell Significance Index: 130.5900
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 2.0267
    Cell Significance Index: 11.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.7844
    Cell Significance Index: 46.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6914
    Cell Significance Index: 275.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4907
    Cell Significance Index: 77.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2626
    Cell Significance Index: 689.5100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.0705
    Cell Significance Index: 75.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.9134
    Cell Significance Index: 56.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.9123
    Cell Significance Index: 47.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9004
    Cell Significance Index: 812.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8446
    Cell Significance Index: 103.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8184
    Cell Significance Index: 42.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8125
    Cell Significance Index: 359.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8111
    Cell Significance Index: 146.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6705
    Cell Significance Index: 42.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6387
    Cell Significance Index: 75.3200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6195
    Cell Significance Index: 5.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6171
    Cell Significance Index: 27.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6080
    Cell Significance Index: 39.2300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5385
    Cell Significance Index: 15.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5078
    Cell Significance Index: 65.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4385
    Cell Significance Index: 20.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4320
    Cell Significance Index: 32.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4184
    Cell Significance Index: 12.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.3901
    Cell Significance Index: 112.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3595
    Cell Significance Index: 16.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3439
    Cell Significance Index: 7.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3404
    Cell Significance Index: 46.7400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3218
    Cell Significance Index: 4.3900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3019
    Cell Significance Index: 3.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2346
    Cell Significance Index: 46.5500
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.1789
    Cell Significance Index: 1.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1631
    Cell Significance Index: 5.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1427
    Cell Significance Index: 8.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1291
    Cell Significance Index: 25.9000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1165
    Cell Significance Index: 2.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1152
    Cell Significance Index: 3.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1097
    Cell Significance Index: 39.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1002
    Cell Significance Index: 2.1400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0834
    Cell Significance Index: 1.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0669
    Cell Significance Index: 2.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0520
    Cell Significance Index: 6.6700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0239
    Cell Significance Index: 0.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0168
    Cell Significance Index: 3.1900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0128
    Cell Significance Index: 0.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0055
    Cell Significance Index: 4.1300
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.0015
    Cell Significance Index: 0.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0010
    Cell Significance Index: 0.7400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0106
    Cell Significance Index: -0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0135
    Cell Significance Index: -25.4500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0215
    Cell Significance Index: -0.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0221
    Cell Significance Index: -40.6900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0260
    Cell Significance Index: -17.9700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0267
    Cell Significance Index: -41.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0308
    Cell Significance Index: -22.8300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0316
    Cell Significance Index: -0.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0318
    Cell Significance Index: -43.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0328
    Cell Significance Index: -3.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0414
    Cell Significance Index: -26.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0500
    Cell Significance Index: -28.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0570
    Cell Significance Index: -35.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0584
    Cell Significance Index: -5.9700
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.0592
    Cell Significance Index: -0.4900
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.0617
    Cell Significance Index: -0.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0716
    Cell Significance Index: -32.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0826
    Cell Significance Index: -14.1000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1122
    Cell Significance Index: -2.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1455
    Cell Significance Index: -16.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1555
    Cell Significance Index: -17.8100
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1561
    Cell Significance Index: -0.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1607
    Cell Significance Index: -4.3800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1611
    Cell Significance Index: -1.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1741
    Cell Significance Index: -36.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1775
    Cell Significance Index: -25.8100
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.2027
    Cell Significance Index: -1.1900
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.2486
    Cell Significance Index: -2.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3085
    Cell Significance Index: -24.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3145
    Cell Significance Index: -32.7500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3190
    Cell Significance Index: -7.3700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3441
    Cell Significance Index: -23.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3711
    Cell Significance Index: -9.9100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3731
    Cell Significance Index: -5.2300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3888
    Cell Significance Index: -10.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** PAFAH1B3 is an esterase enzyme that hydrolyzes platelet-activating factor acetylcholine, a potent phospholipid mediator involved in various physiological and pathological processes. 2. **Subcellular Localization:** The gene product is predominantly found in the cytosol and Golgi apparatus, suggesting its involvement in lipid metabolism and protein complex formation. 3. **Cellular Expression:** PAFAH1B3 is highly expressed in peripheral nervous system neurons, mesenchymal cells, and neural crest cells, underscoring its role in neural development and maintenance. 4. **Protein Interactions:** The gene product interacts with various proteins, including platelet-activating factor acetyltransferase, suggesting its involvement in complex signaling pathways. **Pathways and Functions:** 1. **Lipid Metabolism:** PAFAH1B3 is involved in the hydrolysis of platelet-activating factor acetylcholine, regulating its levels and activity in lipid metabolism pathways. 2. **Neuronal Development:** The gene product plays a critical role in the development and maintenance of the peripheral nervous system, particularly in the formation and function of neural crest cells. 3. **Golgi-to-Erythrocyte Retrograde Transport:** PAFAH1B3 is involved in the regulation of Golgi-to-erythrocyte retrograde transport, ensuring the proper trafficking of proteins and lipids within the cell. 4. **Spermatogenesis:** The gene product is also expressed in testicular cells, suggesting its involvement in the regulation of spermatogenesis. **Clinical Significance:** Dysregulation of PAFAH1B3 has been implicated in various neurological disorders, including autism spectrum disorder, schizophrenia, and Alzheimer's disease. Mutations in the gene have been associated with impaired lipid metabolism, leading to abnormal platelet-activating factor acetylcholine levels and altered signaling pathways. Furthermore, the gene's involvement in neuronal development and maintenance highlights its potential as a therapeutic target for neurodegenerative diseases. Further research is necessary to fully elucidate the functional significance of PAFAH1B3 and its potential applications in human disease. In conclusion, PAFAH1B3 is a multifunctional gene that plays a crucial role in lipid metabolism, neuronal development, and maintenance. Its unique enzymatic activity and interactions with various proteins underscore its significance in regulating complex signaling pathways. Further research is necessary to fully understand the functional significance of PAFAH1B3 and its potential applications in human disease.

Genular Protein ID: 3019884131

Symbol: PA1B3_HUMAN

Name: PAF acetylhydrolase 29 kDa subunit

UniProtKB Accession Codes:

Q15102 Q53X88

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 6 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7669037

Title: cDNA cloning of human cytosolic platelet-activating factor acetylhydrolase gamma-subunit and its mRNA expression in human tissues.

PubMed ID: 7669037

DOI: 10.1006/bbrc.1995.2272

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 231
  • Mass: 25734
  • Checksum: 58A4CB8E7076AE23
  • Sequence:
    • MSGEENPASK PTPVQDVQGD GRWMSLHHRF VADSKDKEPE VVFIGDSLVQ LMHQCEIWRE 
LFSPLHALNF GIGGDGTQHV LWRLENGELE HIRPKIVVVW VGTNNHGHTA EQVTGGIKAI 
VQLVNERQPQ ARVVVLGLLP RGQHPNPLRE KNRQVNELVR AALAGHPRAH FLDADPGFVH 
SDGTISHHDM YDYLHLSRLG YTPVCRALHS LLLRLLAQDQ GQGAPLLEPA P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.