Details for: PAFAH1B3
Gene ID: 5050
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PAFAH1B3
Ensembl ID: ENSG00000079462
Description: platelet activating factor acetylhydrolase 1b catalytic subunit 3
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 42rCSI 57.23%PRS 60.36
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CSI 31.03rCSI 39.82%PRS 65.54
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CSI 22.15rCSI 20.01%PRS 66.18
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CSI 21.46rCSI 25.76%PRS 67.17
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CSI 20.41rCSI 16.13%PRS 56.07
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CSI 20.24rCSI 16.78%PRS 68.77
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CSI 19.91rCSI 39.98%PRS 58.13
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CSI 17.81rCSI 24.67%PRS 68.57
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CSI 17.3rCSI 16.65%PRS 68.7
-
CSI 17.27rCSI 19.94%PRS 61.52
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CSI 17.13rCSI 25.18%PRS 61.94
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CSI 16.91rCSI 54.26%PRS 72.77
-
CSI 15.47rCSI 19.83%PRS 73.28
-
CSI 15.19rCSI 44.85%PRS 71.18
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CSI 14.05rCSI 31.88%PRS 71.22
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CSI 14.04rCSI 28.84%PRS 57.89
-
CSI 13.11rCSI 15.4%PRS 71.11
-
CSI 12.07rCSI 12.59%PRS 68.86
-
CSI 11.63rCSI 33.46%PRS 71.68
-
CSI 11.12rCSI 37.24%PRS 53.38
-
CSI 10.6rCSI 15.13%PRS 70.79
-
CSI 10.11rCSI 10.59%PRS 72.42
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CSI 9.74rCSI 6.47%PRS 71.83
-
CSI 8.96rCSI 8.64%PRS 60.45
-
CSI 8.9rCSI 17.31%PRS 72.06
-
CSI 8.86rCSI 12.3%PRS 67.41
-
CSI 8.75rCSI 68.54%PRS 77.63
-
CSI 7.9rCSI 8.26%PRS 66.7
-
CSI 6.94rCSI 8.71%PRS 79.16
-
CSI 6.83rCSI 36.85%PRS 78.82
-
CSI 6.82rCSI 10%PRS 64.03
-
CSI 6.61rCSI 5.2%PRS 75.39
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CSI 6.57rCSI 8.73%PRS 75.2
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CSI 6.38rCSI 4.44%PRS 83.83
-
CSI 6.37rCSI 4.43%PRS 80.32
-
CSI 6.25rCSI 5.41%PRS 73.67
-
CSI 6.23rCSI 5.04%PRS 70.72
-
CSI 5.72rCSI 5.41%PRS 68.03
-
CSI 5.69rCSI 9.17%PRS 70.77
-
CSI 5.63rCSI 12.58%PRS 76.73
-
CSI 5.43rCSI 8.66%PRS 60.71
-
CSI 5.36rCSI 4.08%PRS 81.9
-
CSI 5.3rCSI 4.39%PRS 71.37
-
CSI 5.22rCSI 5.37%PRS 83.8
-
CSI 5.15rCSI 5.89%PRS 84.53
-
CSI 4.96rCSI 4.88%PRS 71.45
-
CSI 4.84rCSI 7.7%PRS 61.5
-
CSI 4.84rCSI 4.29%PRS 66.68
-
CSI 4.8rCSI 3.57%PRS 81.76
-
CSI 4.69rCSI 7.21%PRS 61.81
-
CSI 4.64rCSI 4.07%PRS 74.27
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CSI 4.63rCSI 3.23%PRS 71.93
-
CSI 4.59rCSI 7.01%PRS 78.07
-
CSI 4.53rCSI 4.45%PRS 83.85
-
CSI 4.51rCSI 41.72%PRS 75.74
-
CSI 4.41rCSI 28.22%PRS 68.83
-
CSI 4.39rCSI 3.32%PRS 82.15
-
CSI 4.34rCSI 4.42%PRS 80.38
-
CSI 4.32rCSI 3.35%PRS 71.91
-
CSI 4.31rCSI 5.24%PRS 76.27
-
CSI 4.3rCSI 6.97%PRS 64.79
-
CSI 4.29rCSI 5.87%PRS 69.89
-
CSI 4.2rCSI 3.52%PRS 72.42
-
CSI 4.11rCSI 6.08%PRS 73.97
-
CSI 3.75rCSI 8.28%PRS 54.74
-
CSI 3.71rCSI 5.67%PRS 73.28
-
CSI 3.68rCSI 5.31%PRS 77.08
-
CSI 3.67rCSI 4.91%PRS 68.81
-
CSI 3.54rCSI 5.47%PRS 67.52
-
CSI 3.48rCSI 4.43%PRS 74.95
-
CSI 3.44rCSI 8.73%PRS 62.7
-
CSI 3.43rCSI 12.2%PRS 92.95
-
CSI 3.42rCSI 3.41%PRS 62.35
-
CSI 3.36rCSI 4.96%PRS 82.75
-
CSI 3.26rCSI 48.27%PRS 80.36
-
CSI 3.26rCSI 4.21%PRS 51.44
-
CSI 3.25rCSI 8.61%PRS 78.23
-
CSI 3.24rCSI 5.61%PRS 59.3
-
CSI 3.24rCSI 5.31%PRS 57.96
-
CSI 3.14rCSI 4.61%PRS 80.08
-
CSI 3.13rCSI 12.09%PRS 81.19
-
CSI 3.12rCSI 17.86%PRS 76.91
-
CSI 3.11rCSI 7.18%PRS 57.12
-
CSI 3.05rCSI 39.92%PRS 82.33
-
CSI 3.03rCSI 18.66%PRS 80.03
-
CSI 2.98rCSI 8.39%PRS 65.07
-
CSI 2.96rCSI 5.07%PRS 77.01
-
CSI 2.86rCSI 4.26%PRS 69.78
-
CSI 2.83rCSI 3.79%PRS 87.16
-
CSI 2.83rCSI 2.61%PRS 70.69
-
CSI 2.77rCSI 2.95%PRS 77.23
-
CSI 2.72rCSI 17.5%PRS 83.36
-
CSI 2.58rCSI 9.04%PRS 79.9
-
CSI 2.5rCSI 4.47%PRS 80.91
-
CSI 2.46rCSI 2.29%PRS 69.65
-
CSI 2.42rCSI 2.79%PRS 59.74
-
CSI 2.4rCSI 9.04%PRS 53.31
-
CSI 2.37rCSI 6.75%PRS 78.44
-
CSI 2.33rCSI 3.19%PRS 61.3
-
CSI 2.3rCSI 10.11%PRS 58.24
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CSI 0.3rCSI 1.4%PRS 81.1%
-
CSI 0.3rCSI 3.0%PRS 81.2%
-
CSI 0.5rCSI 3.7%PRS 82.7%
-
CSI 0.5rCSI 2.4%PRS 79.7%
-
CSI 0.6rCSI 2.4%PRS 79.4%
-
CSI 0.6rCSI 2.2%PRS 75.8%
-
CSI 0.7rCSI 1.5%PRS 67.3%
-
CSI 0.8rCSI 1.3%PRS 58.3%
-
CSI 0.9rCSI 3.9%PRS 81.2%
-
CSI 1.0rCSI 5.3%PRS 92.8%
-
CSI 1.1rCSI 4.1%PRS 87.2%
-
CSI 1.1rCSI 6.9%PRS 91.2%
-
CSI 1.1rCSI 3.3%PRS 58.2%
-
CSI 1.2rCSI 2.9%PRS 67.6%
-
CSI 1.2rCSI 1.9%PRS 52.0%
-
CSI 1.2rCSI 1.8%PRS 73.8%
-
CSI 1.3rCSI 3.0%PRS 76.5%
-
CSI 1.3rCSI 2.2%PRS 49.2%
-
CSI 1.3rCSI 2.2%PRS 50.1%
-
CSI 1.3rCSI 1.8%PRS 73.8%
-
CSI 1.5rCSI 7.4%PRS 81.4%
-
CSI 1.5rCSI 3.2%PRS 78.3%
-
CSI 1.6rCSI 3.7%PRS 69.8%
-
CSI 1.6rCSI 2.4%PRS 69.5%
-
CSI 1.6rCSI 1.7%PRS 65.8%
-
CSI 1.6rCSI 3.9%PRS 85.1%
-
CSI 1.6rCSI 3.5%PRS 65.9%
-
CSI 1.7rCSI 1.6%PRS 87.6%
-
CSI 1.7rCSI 2.4%PRS 78.2%
-
CSI 1.7rCSI 2.5%PRS 73.9%
-
CSI 1.7rCSI 3.2%PRS 86.0%
-
CSI 1.7rCSI 5.4%PRS 51.8%
-
CSI 1.8rCSI 2.1%PRS 49.9%
-
CSI 1.8rCSI 54.0%PRS 85.3%
-
CSI 1.8rCSI 3.3%PRS 61.9%
-
CSI 1.8rCSI 17.4%PRS 93.3%
-
CSI 1.9rCSI 3.4%PRS 82.5%
-
CSI 2.0rCSI 13.1%PRS 91.2%
-
CSI 2.1rCSI 3.1%PRS 65.2%
-
CSI 2.1rCSI 2.1%PRS 74.6%
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CSI 2.1rCSI 1.8%PRS 56.9%
-
CSI 2.1rCSI 2.3%PRS 69.2%
-
CSI 2.1rCSI 23.3%PRS 78.8%
-
CSI 2.2rCSI 3.3%PRS 80.9%
-
CSI 2.3rCSI 10.1%PRS 58.2%
-
CSI 2.3rCSI 3.2%PRS 61.3%
-
CSI 2.4rCSI 6.8%PRS 78.4%
-
CSI 2.4rCSI 9.0%PRS 53.3%
-
CSI 2.4rCSI 2.8%PRS 59.7%
-
CSI 2.5rCSI 2.3%PRS 69.7%
-
CSI 2.5rCSI 4.5%PRS 80.9%
-
CSI 2.6rCSI 9.0%PRS 79.9%
-
CSI 2.7rCSI 17.5%PRS 83.4%
-
CSI 2.8rCSI 3.0%PRS 77.2%
-
CSI 2.8rCSI 2.6%PRS 70.7%
-
CSI 2.8rCSI 3.8%PRS 87.2%
-
CSI 2.9rCSI 4.3%PRS 69.8%
-
CSI 3.0rCSI 5.1%PRS 77.0%
-
CSI 3.0rCSI 8.4%PRS 65.1%
-
CSI 3.0rCSI 18.7%PRS 80.0%
-
CSI 3.1rCSI 39.9%PRS 82.3%
-
CSI 3.1rCSI 7.2%PRS 57.1%
-
CSI 3.1rCSI 17.9%PRS 76.9%
-
CSI 3.1rCSI 12.1%PRS 81.2%
-
CSI 3.1rCSI 4.6%PRS 80.1%
-
CSI 3.2rCSI 5.3%PRS 58.0%
-
CSI 3.2rCSI 5.6%PRS 59.3%
-
CSI 3.3rCSI 8.6%PRS 78.2%
-
CSI 3.3rCSI 4.2%PRS 51.4%
-
CSI 3.3rCSI 48.3%PRS 80.4%
-
CSI 3.4rCSI 5.0%PRS 82.8%
-
CSI 3.4rCSI 3.4%PRS 62.4%
-
CSI 3.4rCSI 12.2%PRS 93.0%
-
CSI 3.4rCSI 8.7%PRS 62.7%
-
CSI 3.5rCSI 4.4%PRS 75.0%
-
CSI 3.5rCSI 5.5%PRS 67.5%
-
CSI 3.7rCSI 4.9%PRS 68.8%
-
CSI 3.7rCSI 5.3%PRS 77.1%
-
CSI 3.7rCSI 5.7%PRS 73.3%
-
CSI 3.8rCSI 8.3%PRS 54.7%
-
CSI 4.1rCSI 6.1%PRS 74.0%
-
CSI 4.2rCSI 3.5%PRS 72.4%
-
CSI 4.3rCSI 5.9%PRS 69.9%
-
CSI 4.3rCSI 7.0%PRS 64.8%
-
CSI 4.3rCSI 5.2%PRS 76.3%
-
CSI 4.3rCSI 3.4%PRS 71.9%
-
CSI 4.3rCSI 4.4%PRS 80.4%
-
CSI 4.4rCSI 3.3%PRS 82.2%
-
CSI 4.4rCSI 28.2%PRS 68.8%
-
CSI 4.5rCSI 41.7%PRS 75.7%
-
CSI 4.5rCSI 4.5%PRS 83.9%
-
CSI 4.6rCSI 7.0%PRS 78.1%
-
CSI 4.6rCSI 3.2%PRS 71.9%
-
CSI 4.6rCSI 4.1%PRS 74.3%
-
CSI 4.7rCSI 7.2%PRS 61.8%
-
CSI 4.8rCSI 3.6%PRS 81.8%
-
CSI 4.8rCSI 4.3%PRS 66.7%
-
CSI 4.8rCSI 7.7%PRS 61.5%
-
CSI 5.0rCSI 4.9%PRS 71.5%
-
CSI 5.2rCSI 5.9%PRS 84.5%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3019884131
Symbol: PA1B3_HUMAN
Name: PAF acetylhydrolase 29 kDa subunit
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7669037
Title: cDNA cloning of human cytosolic platelet-activating factor acetylhydrolase gamma-subunit and its mRNA expression in human tissues.
PubMed ID: 7669037
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 231
- Mass: 25734
- Checksum: 58A4CB8E7076AE23
- Sequence:
MSGEENPASK PTPVQDVQGD GRWMSLHHRF VADSKDKEPE VVFIGDSLVQ LMHQCEIWRE LFSPLHALNF GIGGDGTQHV LWRLENGELE HIRPKIVVVW VGTNNHGHTA EQVTGGIKAI VQLVNERQPQ ARVVVLGLLP RGQHPNPLRE KNRQVNELVR AALAGHPRAH FLDADPGFVH SDGTISHHDM YDYLHLSRLG YTPVCRALHS LLLRLLAQDQ GQGAPLLEPA P