KPNA2 | ENSG00000182481 | NCBI 3838

Details for: KPNA2

Gene ID: 3838

Symbol: KPNA2

Ensembl ID: ENSG00000182481

Description: karyopherin subunit alpha 2

Associated with

Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Ca-dependent events
(R-HSA-111996)
Calmodulin induced events
(R-HSA-111933)
Camk iv-mediated phosphorylation of creb
(R-HSA-111932)
Cam pathway
(R-HSA-111997)
Creb1 phosphorylation through the activation of camkii/camkk/camkiv cascasde
(R-HSA-442729)
Cytokine signaling in immune system
(R-HSA-1280215)
Dag and ip3 signaling
(R-HSA-1489509)
Disease
(R-HSA-1643685)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna repair
(R-HSA-73894)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
G-protein mediated events
(R-HSA-112040)
G alpha (i) signalling events
(R-HSA-418594)
Gpcr downstream signalling
(R-HSA-388396)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Interferon signaling
(R-HSA-913531)
Intracellular signaling by second messengers
(R-HSA-9006925)
Isg15 antiviral mechanism
(R-HSA-1169408)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Ns1 mediated effects on host pathways
(R-HSA-168276)
Opioid signalling
(R-HSA-111885)
Plc beta mediated events
(R-HSA-112043)
Post nmda receptor activation events
(R-HSA-438064)
Sars-cov-1 activates/modulates innate immune responses
(R-HSA-9692916)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Sensing of dna double strand breaks
(R-HSA-5693548)
Signaling by gpcr
(R-HSA-372790)
Signaling by nuclear receptors
(R-HSA-9006931)
Signal transduction
(R-HSA-162582)
Transmission across chemical synapses
(R-HSA-112315)
Viral infection pathways
(R-HSA-9824446)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna metabolic process
(GO:0006259)
Endoplasmic reticulum membrane
(GO:0005789)
Entry of viral genome into host nucleus through nuclear pore complex via importin
(GO:0075506)
Golgi membrane
(GO:0000139)
Histone deacetylase binding
(GO:0042826)
Host cell
(GO:0043657)
Membrane
(GO:0016020)
Nls-bearing protein import into nucleus
(GO:0006607)
Nls-dependent protein nuclear import complex
(GO:0042564)
Nuclear import signal receptor activity
(GO:0061608)
Nuclear localization sequence binding
(GO:0008139)
Nuclear membrane
(GO:0031965)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of type i interferon production
(GO:0032481)
Positive regulation of viral life cycle
(GO:1903902)
Protein binding
(GO:0005515)
Protein import into nucleus
(GO:0006606)
Regulation of dna recombination
(GO:0000018)
Rna binding
(GO:0003723)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 116.4036
Cell Significance Index: -29.5300
Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 109.6787
Cell Significance Index: -17.0600
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 81.8308
Cell Significance Index: -33.7100
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 73.8791
Cell Significance Index: -34.8800
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 65.3207
Cell Significance Index: -33.6000
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 30.3537
Cell Significance Index: -28.9800
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 25.7511
Cell Significance Index: -31.7500
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 10.7770
Cell Significance Index: -28.8700
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 8.4616
Cell Significance Index: -33.3900
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 5.6748
Cell Significance Index: -17.4300
Cell Name: germ cell (CL0000586)
Fold Change: 5.0241
Cell Significance Index: 37.9400
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 4.6843
Cell Significance Index: 49.7700
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 3.3172
Cell Significance Index: -7.2600
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 3.2121
Cell Significance Index: 34.9200
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 2.0485
Cell Significance Index: 238.7300
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.8322
Cell Significance Index: 38.3500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.6637
Cell Significance Index: 78.1900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.3879
Cell Significance Index: 163.6800
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.3304
Cell Significance Index: 46.2300
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.2440
Cell Significance Index: 32.7100
Cell Name: sensory neuron (CL0000101)
Fold Change: 1.1048
Cell Significance Index: 6.2800
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.9252
Cell Significance Index: 505.2700
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.8471
Cell Significance Index: 63.1300
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.8324
Cell Significance Index: 90.5400
Cell Name: lactocyte (CL0002325)
Fold Change: 0.8274
Cell Significance Index: 106.9000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.7863
Cell Significance Index: 77.7900
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.7360
Cell Significance Index: 47.4900
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.6743
Cell Significance Index: 11.9200
Cell Name: odontoblast (CL0000060)
Fold Change: 0.6359
Cell Significance Index: 81.5200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6250
Cell Significance Index: 101.6500
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.6182
Cell Significance Index: 122.6900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5420
Cell Significance Index: 15.6200
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.5222
Cell Significance Index: 14.9700
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.4946
Cell Significance Index: 60.8100
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 0.4463
Cell Significance Index: 3.8400
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3891
Cell Significance Index: 172.0400
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3843
Cell Significance Index: 23.0700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.3742
Cell Significance Index: 10.0100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3289
Cell Significance Index: 59.2900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3251
Cell Significance Index: 65.2200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3028
Cell Significance Index: 41.5800
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2968
Cell Significance Index: 6.4300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.2885
Cell Significance Index: 9.2400
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2390
Cell Significance Index: 6.6800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2314
Cell Significance Index: 10.4900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2154
Cell Significance Index: 11.1900
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.1967
Cell Significance Index: 11.0400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1434
Cell Significance Index: 5.0400
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1253
Cell Significance Index: 8.8600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1024
Cell Significance Index: 19.4900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0961
Cell Significance Index: 34.4900
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0640
Cell Significance Index: 1.7100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0428
Cell Significance Index: 2.7000
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0325
Cell Significance Index: 2.2500
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0155
Cell Significance Index: 0.2600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0057
Cell Significance Index: -4.2000
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0112
Cell Significance Index: -7.0100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0117
Cell Significance Index: -22.0800
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0154
Cell Significance Index: -28.4900
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0180
Cell Significance Index: -27.7000
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0213
Cell Significance Index: -0.2200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0233
Cell Significance Index: -13.1500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0235
Cell Significance Index: -4.0100
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0243
Cell Significance Index: -33.1000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0257
Cell Significance Index: -19.4700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0286
Cell Significance Index: -18.1700
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0358
Cell Significance Index: -26.2700
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.0384
Cell Significance Index: -1.1300
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0405
Cell Significance Index: -0.4600
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0475
Cell Significance Index: -4.8500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0564
Cell Significance Index: -0.7700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0676
Cell Significance Index: -7.7500
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0677
Cell Significance Index: -30.7200
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0762
Cell Significance Index: -16.0500
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: -0.0825
Cell Significance Index: -0.7500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1071
Cell Significance Index: -2.2800
Cell Name: ventricular cardiac muscle cell (CL2000046)
Fold Change: -0.1084
Cell Significance Index: -0.4800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1476
Cell Significance Index: -21.4600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1559
Cell Significance Index: -7.2700
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1804
Cell Significance Index: -20.5900
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2169
Cell Significance Index: -5.5400
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2242
Cell Significance Index: -11.7700
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.2712
Cell Significance Index: -6.7800
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3008
Cell Significance Index: -18.4900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3201
Cell Significance Index: -33.3300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.3423
Cell Significance Index: -26.2700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3670
Cell Significance Index: -22.5000
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3865
Cell Significance Index: -25.9900
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3883
Cell Significance Index: -30.7500
Cell Name: theca cell (CL0000503)
Fold Change: -0.3915
Cell Significance Index: -2.3000
Cell Name: kidney cell (CL1000497)
Fold Change: -0.4183
Cell Significance Index: -3.3400
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.4443
Cell Significance Index: -12.6800
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.4713
Cell Significance Index: -6.6100
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.4870
Cell Significance Index: -5.8100
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.5313
Cell Significance Index: -15.6500
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.5357
Cell Significance Index: -14.5800
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.5493
Cell Significance Index: -28.6100
Cell Name: radial glial cell (CL0000681)
Fold Change: -0.5814
Cell Significance Index: -3.4500
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.6108
Cell Significance Index: -15.7000
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.6372
Cell Significance Index: -3.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** KPNA2 is a nuclear pore complex (NPC) subunit that facilitates the transport of proteins and RNA into and out of the nucleus. It is a karyopherin subunit alpha (KAP alpha) protein, which is characterized by its ability to bind to nuclear localization signals (NLS) and interact with importin proteins. KPNA2 has a unique structure, consisting of two alpha-helical domains and a conserved motif that interacts with other NPC components. This protein is highly abundant in cells and has been shown to be essential for various cellular processes, including DNA repair, transcriptional regulation, and immune responses. **Pathways and Functions** KPNA2 is involved in several cellular pathways, including: 1. **DNA repair**: KPNA2 plays a crucial role in the repair of DNA double-strand breaks by facilitating the transport of proteins involved in this process. 2. **Transcriptional regulation**: KPNA2 regulates gene expression by controlling the transport of transcription factors and RNA into and out of the nucleus. 3. **Immune responses**: KPNA2 is involved in the regulation of immune responses, including the activation of immune cells and the production of cytokines. 4. **Nuclear export**: KPNA2 regulates the export of proteins and RNA from the nucleus, which is essential for various cellular processes, including cell growth and differentiation. 5. **Cytokine signaling**: KPNA2 interacts with cytokine receptors and regulates the signaling pathways involved in immune responses. **Clinical Significance** Dysregulation of KPNA2 has been implicated in various diseases, including: 1. **Cancer**: KPNA2 is overexpressed in certain types of cancer, including breast cancer and lung cancer, and is associated with poor prognosis. 2. **Neurodegenerative disorders**: KPNA2 has been implicated in neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. 3. **Infectious diseases**: KPNA2 is involved in the regulation of immune responses to viral infections, including influenza and SARS-CoV-2. 4. **Birth defects**: KPNA2 mutations have been associated with birth defects, including neural tube defects and cardiac anomalies. In conclusion, KPNA2 is a critical gene that plays a central role in various cellular processes, including DNA repair, transcriptional regulation, and immune responses. Its dysregulation has been linked to various diseases, highlighting the importance of this gene in human health and disease. Further research is needed to fully understand the mechanisms by which KPNA2 regulates cellular processes and to develop therapeutic strategies to target this gene in disease prevention and treatment.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Karyopherin subunit alpha-2

Genular Protein ID: 1653149281

Symbol: IMA1_HUMAN

Name: Karyopherin subunit alpha-2

UniProtKB Accession Codes:

P52292 B9EJD6 Q53YE3 Q6NVW7 Q9BRU5

Database IDs:

Citations:

PubMed ID: 7754385

Title: Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences.

PubMed ID: 7754385

DOI: 10.1126/science.7754385

PubMed ID: 11735022

Title: Genomic structure of karyopherin alpha2 (KPNA2) within a low-copy repeat on chromosome 17q23-q24 and mutation analysis in patients with Russell-Silver syndrome.

PubMed ID: 11735022

DOI: 10.1007/s004390100605

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8016130

Title: Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein.

PubMed ID: 8016130

DOI: 10.1073/pnas.91.13.6156

PubMed ID: 7604027

Title: Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins.

PubMed ID: 7604027

DOI: 10.1073/pnas.92.14.6532

PubMed ID: 8617227

Title: The conserved amino-terminal domain of hSRP1 alpha is essential for nuclear protein import.

PubMed ID: 8617227

DOI: 10.1002/j.1460-2075.1996.tb00531.x

PubMed ID: 9323134

Title: Export of importin-alpha from the nucleus is mediated by a specific nuclear transport factor.

PubMed ID: 9323134

DOI: 10.1016/s0092-8674(00)80372-4

PubMed ID: 9020106

Title: Epstein-Barr virus nuclear antigen 1 forms a complex with the nuclear transporter karyopherin alpha2.

PubMed ID: 9020106

DOI: 10.1074/jbc.272.7.3999

PubMed ID: 9463369

Title: Viral protein R regulates nuclear import of the HIV-1 pre-integration complex.

PubMed ID: 9463369

DOI: 10.1093/emboj/17.4.909

PubMed ID: 9786944

Title: Determination of the functional domain organization of the importin alpha nuclear import factor.

PubMed ID: 9786944

DOI: 10.1083/jcb.143.2.309

PubMed ID: 10612665

Title: Epstein-barr virus nuclear antigen-1 binds to nuclear transporter karyopherin alpha1/NPI-1 in addition to karyopherin alpha2/Rch1.

PubMed ID: 10612665

DOI: 10.1006/viro.1999.0054

PubMed ID: 10980193

Title: ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli.

PubMed ID: 10980193

DOI: 10.1074/jbc.m002470200

PubMed ID: 11882654

Title: Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal.

PubMed ID: 11882654

DOI: 10.1074/jbc.m112112200

PubMed ID: 11840567

Title: Cluster analysis of an extensive human breast cancer cell line protein expression map database.

PubMed ID: 11840567

DOI: 10.1002/1615-9861(200202)2:2<212::aid-prot212>3.0.co;2-h

PubMed ID: 16188882

Title: Importin KPNA2 is required for proper nuclear localization and multiple functions of NBS1.

PubMed ID: 16188882

DOI: 10.1074/jbc.m508425200

PubMed ID: 15942031

Title: Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1).

PubMed ID: 15942031

DOI: 10.1093/nar/gki641

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17596301

Title: Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane.

PubMed ID: 17596301

DOI: 10.1128/jvi.01012-07

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19386897

Title: Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors.

PubMed ID: 19386897

DOI: 10.1242/jcs.041749

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 20147401

Title: Venezuelan equine encephalitis virus capsid protein forms a tetrameric complex with CRM1 and importin alpha/beta that obstructs nuclear pore complex function.

PubMed ID: 20147401

DOI: 10.1128/jvi.02554-09

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21454664

Title: Importin alpha protein acts as a negative regulator for Snail protein nuclear import.

PubMed ID: 21454664

DOI: 10.1074/jbc.m110.213579

PubMed ID: 21385873

Title: CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31.

PubMed ID: 21385873

DOI: 10.1074/jbc.m110.208769

PubMed ID: 21699900

Title: Facioscapulohumeral muscular dystrophy region gene 1 is a dynamic RNA-associated and actin-bundling protein.

PubMed ID: 21699900

DOI: 10.1016/j.jmb.2011.06.014

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29042515

Title: Structural basis for regulation of the nucleo-cytoplasmic distribution of Bag6 by TRC35.

PubMed ID: 29042515

DOI: 10.1073/pnas.1702940114

PubMed ID: 30848123

Title: Zika Virus NS5 Forms Supramolecular Nuclear Bodies That Sequester Importin-alpha and Modulate the Host Immune and Pro-Inflammatory Response in Neuronal Cells.

PubMed ID: 30848123

DOI: 10.1021/acsinfecdis.8b00373

PubMed ID: 32979938

Title: Evasion of Type I Interferon by SARS-CoV-2.

PubMed ID: 32979938

DOI: 10.1016/j.celrep.2020.108234

PubMed ID: 32130408

Title: USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2.

PubMed ID: 32130408

DOI: 10.1084/jem.20191174

PubMed ID: 35446349

Title: Tumor suppressor BAP1 nuclear import is governed by transportin-1.

PubMed ID: 35446349

DOI: 10.1083/jcb.202201094

PubMed ID: 36647821

Title: Karyopherin alpha deficiency contributes to human preimplantation embryo arrest.

PubMed ID: 36647821

DOI: 10.1172/jci159951

PubMed ID: 10353244

Title: Structure of importin-beta bound to the IBB domain of importin-alpha.

PubMed ID: 10353244

DOI: 10.1038/20367

PubMed ID: 28991411

Title: Structural insights into the nuclear import of the histone acetyltransferase males-absent-on-the-first by importin alpha1.

PubMed ID: 28991411

DOI: 10.1111/tra.12534

Sequence Information:

Length: 529
Mass: 57862
Checksum: B0F94A0475B80EED
Sequence:

MSTNENANTP AARLHRFKNK GKDSTEMRRR RIEVNVELRK AKKDDQMLKR RNVSSFPDDA 
TSPLQENRNN QGTVNWSVDD IVKGINSSNV ENQLQATQAA RKLLSREKQP PIDNIIRAGL 
IPKFVSFLGR TDCSPIQFES AWALTNIASG TSEQTKAVVD GGAIPAFISL LASPHAHISE 
QAVWALGNIA GDGSVFRDLV IKYGAVDPLL ALLAVPDMSS LACGYLRNLT WTLSNLCRNK 
NPAPPIDAVE QILPTLVRLL HHDDPEVLAD TCWAISYLTD GPNERIGMVV KTGVVPQLVK 
LLGASELPIV TPALRAIGNI VTGTDEQTQV VIDAGALAVF PSLLTNPKTN IQKEATWTMS 
NITAGRQDQI QQVVNHGLVP FLVSVLSKAD FKTQKEAVWA VTNYTSGGTV EQIVYLVHCG 
IIEPLMNLLT AKDTKIILVI LDAISNIFQA AEKLGETEKL SIMIEECGGL DKIEALQNHE 
NESVYKASLS LIEKYFSVEE EEDQNVVPET TSEGYTFQVQ DGAPGTFNF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: KPNA2

Associated with

Cells (max top 100)

Other Information

Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences. PubMed ID: 7754385

Genomic structure of karyopherin alpha2 (KPNA2) within a low-copy repeat on chromosome 17q23-q24 and mutation analysis in patients with Russell-Silver syndrome. PubMed ID: 11735022

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein. PubMed ID: 8016130

Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins. PubMed ID: 7604027

The conserved amino-terminal domain of hSRP1 alpha is essential for nuclear protein import. PubMed ID: 8617227

Export of importin-alpha from the nucleus is mediated by a specific nuclear transport factor. PubMed ID: 9323134

Epstein-Barr virus nuclear antigen 1 forms a complex with the nuclear transporter karyopherin alpha2. PubMed ID: 9020106

Viral protein R regulates nuclear import of the HIV-1 pre-integration complex. PubMed ID: 9463369

Determination of the functional domain organization of the importin alpha nuclear import factor. PubMed ID: 9786944

Epstein-barr virus nuclear antigen-1 binds to nuclear transporter karyopherin alpha1/NPI-1 in addition to karyopherin alpha2/Rch1. PubMed ID: 10612665

ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli. PubMed ID: 10980193

Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal. PubMed ID: 11882654

Cluster analysis of an extensive human breast cancer cell line protein expression map database. PubMed ID: 11840567

Importin KPNA2 is required for proper nuclear localization and multiple functions of NBS1. PubMed ID: 16188882

Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1). PubMed ID: 15942031

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane. PubMed ID: 17596301

Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. PubMed ID: 18220336

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors. PubMed ID: 19386897

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Venezuelan equine encephalitis virus capsid protein forms a tetrameric complex with CRM1 and importin alpha/beta that obstructs nuclear pore complex function. PubMed ID: 20147401

Initial characterization of the human central proteome. PubMed ID: 21269460

Importin alpha protein acts as a negative regulator for Snail protein nuclear import. PubMed ID: 21454664

CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31. PubMed ID: 21385873

Facioscapulohumeral muscular dystrophy region gene 1 is a dynamic RNA-associated and actin-bundling protein. PubMed ID: 21699900

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Structural basis for regulation of the nucleo-cytoplasmic distribution of Bag6 by TRC35. PubMed ID: 29042515

Zika Virus NS5 Forms Supramolecular Nuclear Bodies That Sequester Importin-alpha and Modulate the Host Immune and Pro-Inflammatory Response in Neuronal Cells. PubMed ID: 30848123

Evasion of Type I Interferon by SARS-CoV-2. PubMed ID: 32979938

USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2. PubMed ID: 32130408

Tumor suppressor BAP1 nuclear import is governed by transportin-1. PubMed ID: 35446349

Karyopherin alpha deficiency contributes to human preimplantation embryo arrest. PubMed ID: 36647821

Structure of importin-beta bound to the IBB domain of importin-alpha. PubMed ID: 10353244

Structural insights into the nuclear import of the histone acetyltransferase males-absent-on-the-first by importin alpha1. PubMed ID: 28991411