Details for: TOP2A

Gene ID: 7153

Symbol: TOP2A

Ensembl ID: ENSG00000131747

Description: DNA topoisomerase II alpha

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.16
    Marker Score: 2031
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.92
    Marker Score: 5224
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.86
    Marker Score: 2249
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.79
    Marker Score: 2576
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169181
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.42
    Marker Score: 1517
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.32
    Marker Score: 3918
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.19
    Marker Score: 392
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.12
    Marker Score: 702
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.1
    Marker Score: 617
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.05
    Marker Score: 1476
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71803
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48028
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1
    Marker Score: 492
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.99
    Marker Score: 1880
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.99
    Marker Score: 1684
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 498
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5330
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.92
    Marker Score: 1921
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.92
    Marker Score: 959
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2732
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.91
    Marker Score: 250
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.88
    Marker Score: 660
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.88
    Marker Score: 1099
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.87
    Marker Score: 875
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.86
    Marker Score: 3582.5
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.84
    Marker Score: 561
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.83
    Marker Score: 456
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.81
    Marker Score: 1074
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.81
    Marker Score: 429
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.81
    Marker Score: 1668
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1273
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.76
    Marker Score: 1795
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.76
    Marker Score: 11911
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 303
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 386
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 568
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.74
    Marker Score: 233
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 651
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2963
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.7
    Marker Score: 202
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7
    Marker Score: 24115
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.7
    Marker Score: 736
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.69
    Marker Score: 778
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.68
    Marker Score: 1853
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.68
    Marker Score: 8941
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.66
    Marker Score: 624
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.63
    Marker Score: 2481
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.63
    Marker Score: 331
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.62
    Marker Score: 373
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.62
    Marker Score: 253
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.6
    Marker Score: 440
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.6
    Marker Score: 1216
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.6
    Marker Score: 220
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.59
    Marker Score: 296
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.59
    Marker Score: 1390.5
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.58
    Marker Score: 261
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.58
    Marker Score: 578
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.58
    Marker Score: 817
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.57
    Marker Score: 464
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.56
    Marker Score: 488
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.56
    Marker Score: 270
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.55
    Marker Score: 317
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.54
    Marker Score: 160
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.51
    Marker Score: 1900
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.51
    Marker Score: 242
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.5
    Marker Score: 1949
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.5
    Marker Score: 162
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.5
    Marker Score: 175
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.49
    Marker Score: 1158
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.49
    Marker Score: 1999
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.47
    Marker Score: 2813.5
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.47
    Marker Score: 1540
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.47
    Marker Score: 162
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.46
    Marker Score: 122
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.46
    Marker Score: 484
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.45
    Marker Score: 127
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.45
    Marker Score: 120
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.45
    Marker Score: 270
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.45
    Marker Score: 140
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.45
    Marker Score: 283
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.44
    Marker Score: 124
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.44
    Marker Score: 273
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.44
    Marker Score: 201
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.44
    Marker Score: 108
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.43
    Marker Score: 285
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.43
    Marker Score: 209
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.42
    Marker Score: 464
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.41
    Marker Score: 141
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.41
    Marker Score: 169
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.4
    Marker Score: 152
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.4
    Marker Score: 306
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.39
    Marker Score: 278

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Other Information

**Key Characteristics:** 1. **DNA topoisomerase activity**: TOP2A is a type II topoisomerase that catalyzes the transient unwinding and re-ligation of DNA, enabling the covalent binding of proteins to DNA and facilitating the regulation of chromosomal processes. 2. **Cell cycle regulation**: TOP2A is involved in the control of cell cycle progression, particularly during the G1/S transition and mitosis, where it regulates DNA replication and segregation. 3. **Apoptosis regulation**: TOP2A has been shown to modulate apoptosis by regulating the expression of pro-apoptotic and anti-apoptotic genes, as well as interacting with key apoptosis regulators, such as p53 and Bcl-2. 4. **Chromatin binding**: TOP2A exhibits a high affinity for chromatin, allowing it to interact with transcription factors and other chromatin-associated proteins, influencing gene expression and chromatin structure. 5. **Sumoylation and ubiquitination**: TOP2A is a substrate for sumoylation and ubiquitination, which regulate its activity, localization, and interaction with other proteins. **Pathways and Functions:** 1. **Apoptotic chromosome condensation**: TOP2A regulates the condensation of apoptotic chromosomes, ensuring proper segregation of DNA during mitosis. 2. **DNA damage response**: TOP2A participates in the DNA damage response by regulating the expression of genes involved in DNA repair and apoptosis. 3. **Cell cycle regulation**: TOP2A modulates cell cycle progression by regulating the expression of cyclin-dependent kinases and the activity of the cyclin-dependent kinase inhibitor, p21. 4. **Transcriptional regulation**: TOP2A interacts with transcription factors, such as NF-κB and p53, to regulate the expression of genes involved in cell growth, differentiation, and survival. 5. **Chromatin remodeling**: TOP2A contributes to chromatin remodeling by regulating the activity of chromatin-associated proteins, such as histone deacetylases and chromatin-modifying enzymes. **Clinical Significance:** 1. **Cancer therapy**: TOP2A is a target for cancer therapy, as its inhibition has been shown to induce apoptosis in various cancer cell lines, including those with mutated p53. 2. **Neurodegenerative diseases**: TOP2A has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's, where it may contribute to the regulation of chromatin structure and gene expression. 3. **Immune system disorders**: TOP2A is expressed in immune cells, and its dysregulation has been linked to immune system disorders, such as rheumatoid arthritis and multiple sclerosis. 4. **Developmental disorders**: TOP2A is essential for embryonic development, and its dysregulation has been implicated in developmental disorders, such as neural tube defects and congenital heart disease. In conclusion, DNA topoisomerase II alpha is a multifunctional protein that plays a critical role in maintaining genomic stability, regulating cell cycle progression, and modulating apoptosis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of TOP2A and its potential as a therapeutic target.

Genular Protein ID: 2528300018

Symbol: TOP2A_HUMAN

Name: DNA topoisomerase 2-alpha

UniProtKB Accession Codes:

P11388 B2RTS1 Q71UN1 Q71UQ5 Q9HB24 Q9HB25 Q9HB26 Q9UP44 Q9UQP9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CORUM 1 CPTAC 1 CTD 1 CarbonylDB 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 37 DrugCentral 1 EC 1 EMBL 37 EMDB 5 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 38 Gene3D 7 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 17 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 10 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2845399

Title: Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22.

PubMed ID: 2845399

DOI: 10.1073/pnas.85.19.7177

PubMed ID: 8393377

Title: Use of yeast in the study of anticancer drugs targeting DNA topoisomerases: expression of a functional recombinant human DNA topoisomerase II alpha in yeast.

PubMed ID: 8393377

PubMed ID: 9795238

Title: Structural organization of the human TOP2A and TOP2B genes.

PubMed ID: 9795238

DOI: 10.1016/s0378-1119(98)00468-5

PubMed ID: 10095062

Title: Molecular cloning and characterization of the human topoisomerase IIalpha and IIbeta genes: evidence for isoform evolution through gene duplication.

PubMed ID: 10095062

DOI: 10.1016/s0167-4781(99)00020-2

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8299728

Title: Discrete localization of different DNA topoisomerases in HeLa and K562 cell nuclei and subnuclear fractions.

PubMed ID: 8299728

DOI: 10.1006/excr.1994.1046

PubMed ID: 9155056

Title: The distribution and expression of the two isoforms of DNA topoisomerase II in normal and neoplastic human tissues.

PubMed ID: 9155056

DOI: 10.1038/bjc.1997.227

PubMed ID: 10942766

Title: Mitotic phosphorylation of DNA topoisomerase II alpha by protein kinase CK2 creates the MPM-2 phosphoepitope on Ser-1469.

PubMed ID: 10942766

DOI: 10.1074/jbc.m005179200

PubMed ID: 12821127

Title: Identification of functional nuclear export sequences in human topoisomerase IIalpha and beta.

PubMed ID: 12821127

DOI: 10.1016/s0006-291x(03)01077-5

PubMed ID: 12711669

Title: RNA helicase A interacts with dsDNA and topoisomerase IIalpha.

PubMed ID: 12711669

DOI: 10.1093/nar/gkg328

PubMed ID: 15126503

Title: Interaction between glucose-regulated destruction domain of DNA topoisomerase IIalpha and MPN domain of Jab1/CSN5.

PubMed ID: 15126503

DOI: 10.1074/jbc.m401411200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 17567603

Title: Nuclear interactions of topoisomerase II alpha and beta with phospholipid scramblase 1.

PubMed ID: 17567603

DOI: 10.1093/nar/gkm434

PubMed ID: 18062778

Title: Plk3 phosphorylates topoisomerase IIalpha at Thr(1342), a site that is not recognized by Plk1.

PubMed ID: 18062778

DOI: 10.1042/bj20071394

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18790802

Title: The SET and transposase domain protein Metnase enhances chromosome decatenation: regulation by automethylation.

PubMed ID: 18790802

DOI: 10.1093/nar/gkn560

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19222228

Title: Use of divalent metal ions in the DNA cleavage reaction of human type II topoisomerases.

PubMed ID: 19222228

DOI: 10.1021/bi8023256

PubMed ID: 19697956

Title: Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha.

PubMed ID: 19697956

DOI: 10.1021/bi900875c

PubMed ID: 19043076

Title: Casein kinase I delta/epsilon phosphorylates topoisomerase IIalpha at serine-1106 and modulates DNA cleavage activity.

PubMed ID: 19043076

DOI: 10.1093/nar/gkn934

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20457750

Title: Metnase promotes restart and repair of stalled and collapsed replication forks.

PubMed ID: 20457750

DOI: 10.1093/nar/gkq339

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23022727

Title: Structure of a topoisomerase II-DNA-nucleotide complex reveals a new control mechanism for ATPase activity.

PubMed ID: 23022727

DOI: 10.1038/nsmb.2388

PubMed ID: 22013166

Title: RECQL5 cooperates with Topoisomerase II alpha in DNA decatenation and cell cycle progression.

PubMed ID: 22013166

DOI: 10.1093/nar/gkr844

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 22323612

Title: DNA cleavage and opening reactions of human topoisomerase IIalpha are regulated via Mg2+-mediated dynamic bending of gate-DNA.

PubMed ID: 22323612

DOI: 10.1073/pnas.1115704109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23652018

Title: GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy.

PubMed ID: 23652018

DOI: 10.1038/ncomms2823

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 26030138

Title: Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

PubMed ID: 26030138

DOI: 10.1371/journal.pone.0128558

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 34543352

Title: The Epstein-Barr virus deubiquitinating enzyme BPLF1 regulates the activity of topoisomerase II during productive infection.

PubMed ID: 34543352

DOI: 10.1371/journal.ppat.1009954

PubMed ID: 16100112

Title: Nucleotide-dependent domain movement in the ATPase domain of a human type IIA DNA topoisomerase.

PubMed ID: 16100112

DOI: 10.1074/jbc.m506520200

PubMed ID: 22841979

Title: The structure of DNA-bound human topoisomerase II alpha: conformational mechanisms for coordinating inter-subunit interactions with DNA cleavage.

PubMed ID: 22841979

DOI: 10.1016/j.jmb.2012.07.014

PubMed ID: 25202966

Title: Structure of the N-terminal Gyrase B fragment in complex with ADPPi reveals rigid-body motion induced by ATP hydrolysis.

PubMed ID: 25202966

DOI: 10.1371/journal.pone.0107289

PubMed ID: 1651812

Title: Identification of a point mutation in the topoisomerase II gene from a human leukemia cell line containing an amsacrine-resistant form of topoisomerase II.

PubMed ID: 1651812

PubMed ID: 1652758

Title: Expression of a mutant DNA topoisomerase II in CCRF-CEM human leukemic cells selected for resistance to teniposide.

PubMed ID: 1652758

DOI: 10.1073/pnas.88.17.7654

Sequence Information:

  • Length: 1531
  • Mass: 174385
  • Checksum: 3DF40BC9E84789DC
  • Sequence:
    • MEVSPLQPVN ENMQVNKIKK NEDAKKRLSV ERIYQKKTQL EHILLRPDTY IGSVELVTQQ 
MWVYDEDVGI NYREVTFVPG LYKIFDEILV NAADNKQRDP KMSCIRVTID PENNLISIWN 
NGKGIPVVEH KVEKMYVPAL IFGQLLTSSN YDDDEKKVTG GRNGYGAKLC NIFSTKFTVE 
TASREYKKMF KQTWMDNMGR AGEMELKPFN GEDYTCITFQ PDLSKFKMQS LDKDIVALMV 
RRAYDIAGST KDVKVFLNGN KLPVKGFRSY VDMYLKDKLD ETGNSLKVIH EQVNHRWEVC 
LTMSEKGFQQ ISFVNSIATS KGGRHVDYVA DQIVTKLVDV VKKKNKGGVA VKAHQVKNHM 
WIFVNALIEN PTFDSQTKEN MTLQPKSFGS TCQLSEKFIK AAIGCGIVES ILNWVKFKAQ 
VQLNKKCSAV KHNRIKGIPK LDDANDAGGR NSTECTLILT EGDSAKTLAV SGLGVVGRDK 
YGVFPLRGKI LNVREASHKQ IMENAEINNI IKIVGLQYKK NYEDEDSLKT LRYGKIMIMT 
DQDQDGSHIK GLLINFIHHN WPSLLRHRFL EEFITPIVKV SKNKQEMAFY SLPEFEEWKS 
STPNHKKWKV KYYKGLGTST SKEAKEYFAD MKRHRIQFKY SGPEDDAAIS LAFSKKQIDD 
RKEWLTNFME DRRQRKLLGL PEDYLYGQTT TYLTYNDFIN KELILFSNSD NERSIPSMVD 
GLKPGQRKVL FTCFKRNDKR EVKVAQLAGS VAEMSSYHHG EMSLMMTIIN LAQNFVGSNN 
LNLLQPIGQF GTRLHGGKDS ASPRYIFTML SSLARLLFPP KDDHTLKFLY DDNQRVEPEW 
YIPIIPMVLI NGAEGIGTGW SCKIPNFDVR EIVNNIRRLM DGEEPLPMLP SYKNFKGTIE 
ELAPNQYVIS GEVAILNSTT IEISELPVRT WTQTYKEQVL EPMLNGTEKT PPLITDYREY 
HTDTTVKFVV KMTEEKLAEA ERVGLHKVFK LQTSLTCNSM VLFDHVGCLK KYDTVLDILR 
DFFELRLKYY GLRKEWLLGM LGAESAKLNN QARFILEKID GKIIIENKPK KELIKVLIQR 
GYDSDPVKAW KEAQQKVPDE EENEESDNEK ETEKSDSVTD SGPTFNYLLD MPLWYLTKEK 
KDELCRLRNE KEQELDTLKR KSPSDLWKED LATFIEELEA VEAKEKQDEQ VGLPGKGGKA 
KGKKTQMAEV LPSPRGQRVI PRITIEMKAE AEKKNKKKIK NENTEGSPQE DGVELEGLKQ 
RLEKKQKREP GTKTKKQTTL AFKPIKKGKK RNPWSDSESD RSSDESNFDV PPRETEPRRA 
ATKTKFTMDL DSDEDFSDFD EKTDDEDFVP SDASPPKTKT SPKLSNKELK PQKSVVSDLE 
ADDVKGSVPL SSSPPATHFP DETEITNPVP KKNVTVKKTA AKSQSSTSTT GAKKRAAPKG 
TKRDPALNSG VSQKPDPAKT KNRRKRKPST SDDSDSNFEK IVSKAVTSKK SKGESDDFHM 
DFDSAVAPRA KSVRAKKPIK YLEESDEDDL F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.