Gene H2AX - ENSG00000188486 | NCBI Gene ID: 3014

Details for: H2AX

Gene ID: 3014

Symbol: H2AX

Ensembl ID: ENSG00000188486

Description: H2A.X variant histone

Associated with

Activated pkn1 stimulates transcription of ar (androgen receptor) regulated genes klk2 and klk3
(R-HSA-5625886)
Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Cleavage of the damaged purine
(R-HSA-110331)
Cleavage of the damaged pyrimidine
(R-HSA-110329)
Condensation of prophase chromosomes
(R-HSA-2299718)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation of gene expression
(R-HSA-212165)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Processing of dna double-strand break ends
(R-HSA-5693607)
Recognition and association of dna glycosylase with site containing an affected purine
(R-HSA-110330)
Recognition and association of dna glycosylase with site containing an affected pyrimidine
(R-HSA-110328)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Damaged dna binding
(GO:0003684)
Dna binding
(GO:0003677)
Enzyme binding
(GO:0019899)
Protein binding
(GO:0005515)
Structural constituent of chromatin
(GO:0030527)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 2.85
Marker Score: 1910
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 2.35
Marker Score: 2098
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 2.05
Marker Score: 1925
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.7
Marker Score: 5055
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.67
Marker Score: 4532.5
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 1.59
Marker Score: 1559
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 1.47
Marker Score: 640
Cell Name: neural crest cell (CL0011012)
Fold Change: 1.45
Marker Score: 1545
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.44
Marker Score: 980
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.37
Marker Score: 5085
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.31
Marker Score: 873
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.3
Marker Score: 8488
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.3
Marker Score: 3529
Cell Name: neural cell (CL0002319)
Fold Change: 1.28
Marker Score: 616
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.25
Marker Score: 12531.5
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 1.22
Marker Score: 3432
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 1.2
Marker Score: 755
Cell Name: Unknown (CL0002371)
Fold Change: 1.19
Marker Score: 1262
Cell Name: Unknown (CL0000548)
Fold Change: 1.16
Marker Score: 844
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.16
Marker Score: 637
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.15
Marker Score: 4538
Cell Name: type I NK T cell (CL0000921)
Fold Change: 1.15
Marker Score: 901
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 1.14
Marker Score: 1423
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.12
Marker Score: 1197
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.11
Marker Score: 38505
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.06
Marker Score: 1118.5
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.06
Marker Score: 635
Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.05
Marker Score: 603
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.03
Marker Score: 1688.5
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.03
Marker Score: 1035
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 1.03
Marker Score: 875
Cell Name: oogonial cell (CL0000024)
Fold Change: 1.02
Marker Score: 1467
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 1.01
Marker Score: 760.5
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 1.01
Marker Score: 2800
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 1.01
Marker Score: 1429
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1
Marker Score: 33942
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71662
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47886
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.99
Marker Score: 991
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.98
Marker Score: 293
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.98
Marker Score: 505
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30384
Cell Name: Leydig cell (CL0000178)
Fold Change: 0.98
Marker Score: 1052
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.94
Marker Score: 1390
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2387
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.93
Marker Score: 1577
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.92
Marker Score: 474
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.92
Marker Score: 1913
Cell Name: stem cell (CL0000034)
Fold Change: 0.91
Marker Score: 2170
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.91
Marker Score: 431
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.91
Marker Score: 282
Cell Name: leukocyte (CL0000738)
Fold Change: 0.91
Marker Score: 522
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 0.91
Marker Score: 655
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5169
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.89
Marker Score: 10065
Cell Name: mature T cell (CL0002419)
Fold Change: 0.89
Marker Score: 8839
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.89
Marker Score: 267
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.89
Marker Score: 5253
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.88
Marker Score: 848
Cell Name: enteric neuron (CL0007011)
Fold Change: 0.88
Marker Score: 467
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.87
Marker Score: 638
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 0.86
Marker Score: 358
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.86
Marker Score: 5201
Cell Name: plasmablast (CL0000980)
Fold Change: 0.86
Marker Score: 1137
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.85
Marker Score: 307
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.85
Marker Score: 11169
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.85
Marker Score: 796
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.84
Marker Score: 3254
Cell Name: T-helper 1 cell (CL0000545)
Fold Change: 0.84
Marker Score: 327
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.84
Marker Score: 912
Cell Name: vasa recta ascending limb cell (CL1001131)
Fold Change: 0.84
Marker Score: 221
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.83
Marker Score: 8440
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.83
Marker Score: 1344
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.83
Marker Score: 3384
Cell Name: malignant cell (CL0001064)
Fold Change: 0.82
Marker Score: 11033
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.82
Marker Score: 339
Cell Name: keratocyte (CL0002363)
Fold Change: 0.81
Marker Score: 187
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.81
Marker Score: 1912
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 0.81
Marker Score: 266
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.81
Marker Score: 1012
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.8
Marker Score: 1109
Cell Name: Schwann cell (CL0002573)
Fold Change: 0.8
Marker Score: 276
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.79
Marker Score: 1401
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: 0.78
Marker Score: 389
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.78
Marker Score: 379
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.77
Marker Score: 592
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.77
Marker Score: 1627
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 0.77
Marker Score: 349
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.75
Marker Score: 216
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.75
Marker Score: 344
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.75
Marker Score: 630
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.75
Marker Score: 151
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 0.74
Marker Score: 158
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.74
Marker Score: 297
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.74
Marker Score: 176
Cell Name: mucous neck cell (CL0000651)
Fold Change: 0.74
Marker Score: 1669
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 469
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.73
Marker Score: 6374
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.72
Marker Score: 270

Hover over a box to see details here...

**Key characteristics:** * H2AX is a member of the H2A family of histone proteins. * It is found in the nucleus of eukaryotic cells. * It is involved in the regulation of gene expression by interacting with other histone proteins. * H2AX is a key regulator of cell cycle progression, DNA repair, and differentiation. **Pathways and functions:** * H2AX interacts with the transcription factor Sox1 and recruits it to the Hox gene promoter, promoting the expression of hox genes. * It is involved in cell cycle regulation by binding to DNA sequences involved in cell cycle checkpoints. * H2AX is a stress sensor that responds to DNA damage. It forms a complex with the DNA damage sensor MRE1 and activates the transcription factor p53, promoting cell cycle arrest or apoptosis. * It is also involved in chromatin remodeling by forming complexes with other histone proteins and remodeling chromatin structure. **Clinical significance:** * Mutations in H2AX genes have been linked to a number of human cancers, including breast cancer, lung cancer, and leukemia. * Targeting H2AX has emerged as a promising therapeutic strategy for these malignancies. * H2AX inhibitors are currently being investigated as potential treatments for cancer and other diseases characterized by abnormal chromatin remodeling. **Other notable facts:** * H2AX is a highly conserved protein with homologs in other species. * It is a large protein with a molecular weight of approximately 140 kDa. * It is found in a variety of cell types, including skeletal muscle satellite cells, germ cells, and cancer cells.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Histone H2AX

Genular Protein ID: 576387282

Symbol: H2AX_HUMAN

Name: Histone H2AX

UniProtKB Accession Codes:

P16104 Q4ZGJ7 Q6IAS5

Database IDs:

Citations:

PubMed ID: 2587254

Title: H2A.X. a histone isoprotein with a conserved C-terminal sequence, is encoded by a novel mRNA with both DNA replication type and polyA 3' processing signals.

PubMed ID: 2587254

DOI: 10.1093/nar/17.22.9113

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9488723

Title: DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139.

PubMed ID: 9488723

DOI: 10.1074/jbc.273.10.5858

PubMed ID: 10477747

Title: Megabase chromatin domains involved in DNA double-strand breaks in vivo.

PubMed ID: 10477747

DOI: 10.1083/jcb.146.5.905

PubMed ID: 10959836

Title: A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.

PubMed ID: 10959836

DOI: 10.1016/s0960-9822(00)00610-2

PubMed ID: 10734083

Title: Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139.

PubMed ID: 10734083

DOI: 10.1074/jbc.275.13.9390

PubMed ID: 11673449

Title: Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress.

PubMed ID: 11673449

DOI: 10.1074/jbc.c100569200

PubMed ID: 12419185

Title: NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain.

PubMed ID: 12419185

DOI: 10.1016/s0960-9822(02)01259-9

PubMed ID: 12697768

Title: Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX.

PubMed ID: 12697768

DOI: 10.1074/jbc.c300117200

PubMed ID: 12660252

Title: Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.

PubMed ID: 12660252

DOI: 10.1074/jbc.m300198200

PubMed ID: 12607005

Title: MDC1 is a mediator of the mammalian DNA damage checkpoint.

PubMed ID: 12607005

DOI: 10.1038/nature01446

PubMed ID: 14627815

Title: DNA-PK is activated by nucleosomes and phosphorylates H2AX within the nucleosomes in an acetylation-dependent manner.

PubMed ID: 14627815

DOI: 10.1093/nar/gkg921

PubMed ID: 15059890

Title: ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation.

PubMed ID: 15059890

DOI: 10.1158/0008-5472.can-03-3207

PubMed ID: 15201865

Title: Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention.

PubMed ID: 15201865

DOI: 10.1038/sj.emboj.7600269

PubMed ID: 15489221

Title: Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species.

PubMed ID: 15489221

DOI: 10.1074/jbc.m406879200

PubMed ID: 15613478

Title: Actinomycin D induces histone gamma-H2AX foci and complex formation of gamma-H2AX with Ku70 and nuclear DNA helicase II.

PubMed ID: 15613478

DOI: 10.1074/jbc.m411444200

PubMed ID: 16310392

Title: gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair.

PubMed ID: 16310392

DOI: 10.1016/j.molcel.2005.10.003

PubMed ID: 16820410

Title: Novel function of beta-arrestin2 in the nucleus of mature spermatozoa.

PubMed ID: 16820410

DOI: 10.1242/jcs.03046

PubMed ID: 18001824

Title: RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.

PubMed ID: 18001824

DOI: 10.1016/j.cell.2007.09.040

PubMed ID: 18001825

Title: RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.

PubMed ID: 18001825

DOI: 10.1016/j.cell.2007.09.041

PubMed ID: 17709392

Title: DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics.

PubMed ID: 17709392

DOI: 10.1128/mcb.00579-07

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19203578

Title: The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.

PubMed ID: 19203578

DOI: 10.1016/j.cell.2008.12.042

PubMed ID: 19203579

Title: RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.

PubMed ID: 19203579

DOI: 10.1016/j.cell.2008.12.041

PubMed ID: 19092802

Title: WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity.

PubMed ID: 19092802

DOI: 10.1038/nature07668

PubMed ID: 19234442

Title: Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions.

PubMed ID: 19234442

DOI: 10.1038/nature07849

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22980979

Title: RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA Damage signaling.

PubMed ID: 22980979

DOI: 10.1016/j.cell.2012.08.005

PubMed ID: 24429368

Title: Epstein-Barr virus essential antigen EBNA3C attenuates H2AX expression.

PubMed ID: 24429368

DOI: 10.1128/jvi.03568-13

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 26438602

Title: Acetylation of histone H2AX at Lys 5 by the TIP60 histone acetyltransferase complex is essential for the dynamic binding of NBS1 to damaged chromatin.

PubMed ID: 26438602

DOI: 10.1128/mcb.00757-15

PubMed ID: 26734725

Title: The proximity ligation assay reveals that at DNA double-strand breaks WRAP53beta associates with gammaH2AX and controls interactions between RNF8 and MDC1.

PubMed ID: 26734725

DOI: 10.1080/19491034.2015.1106675

PubMed ID: 26721387

Title: Hepatoma-derived growth factor-related protein 2 promotes DNA repair by homologous recombination.

PubMed ID: 26721387

DOI: 10.1093/nar/gkv1526

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 27715493

Title: Phosphorylation of the Cajal body protein WRAP53beta by ATM promotes its involvement in the DNA damage response.

PubMed ID: 27715493

DOI: 10.1080/15476286.2016.1243647

PubMed ID: 35849344

Title: LncRNA CTBP1-DT-encoded microprotein DDUP sustains DNA damage response signalling to trigger dual DNA repair mechanisms.

PubMed ID: 35849344

DOI: 10.1mw093/nar/gkac611

PubMed ID: 22154951

Title: Specific recognition of phosphorylated tail of H2AX by the tandem BRCT domains of MCPH1 revealed by complex structure.

PubMed ID: 22154951

DOI: 10.1016/j.jsb.2011.11.022

Sequence Information:

Length: 143
Mass: 15145
Checksum: D4683775C2E6C3A9
Sequence:

MSGRGKTGGK ARAKAKSRSS RAGLQFPVGR VHRLLRKGHY AERVGAGAPV YLAAVLEYLT 
AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGG VTIAQGGVLP NIQAVLLPKK 
TSATVGPKAP SGGKKATQAS QEY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: H2AX

Associated with

Cells (max top 100)

Other Information

H2A.X. a histone isoprotein with a conserved C-terminal sequence, is encoded by a novel mRNA with both DNA replication type and polyA 3' processing signals. PubMed ID: 2587254

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. PubMed ID: 9488723

Megabase chromatin domains involved in DNA double-strand breaks in vivo. PubMed ID: 10477747

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. PubMed ID: 10959836

Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139. PubMed ID: 10734083

Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. PubMed ID: 11673449

NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain. PubMed ID: 12419185

Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX. PubMed ID: 12697768

Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes. PubMed ID: 12660252

MDC1 is a mediator of the mammalian DNA damage checkpoint. PubMed ID: 12607005

DNA-PK is activated by nucleosomes and phosphorylates H2AX within the nucleosomes in an acetylation-dependent manner. PubMed ID: 14627815

ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. PubMed ID: 15059890

Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention. PubMed ID: 15201865

Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species. PubMed ID: 15489221

Actinomycin D induces histone gamma-H2AX foci and complex formation of gamma-H2AX with Ku70 and nuclear DNA helicase II. PubMed ID: 15613478

gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair. PubMed ID: 16310392

Novel function of beta-arrestin2 in the nucleus of mature spermatozoa. PubMed ID: 16820410

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. PubMed ID: 18001824

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. PubMed ID: 18001825

DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics. PubMed ID: 17709392

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage. PubMed ID: 19203578

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. PubMed ID: 19203579

WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. PubMed ID: 19092802

Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. PubMed ID: 19234442

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA Damage signaling. PubMed ID: 22980979

Epstein-Barr virus essential antigen EBNA3C attenuates H2AX expression. PubMed ID: 24429368

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

Acetylation of histone H2AX at Lys 5 by the TIP60 histone acetyltransferase complex is essential for the dynamic binding of NBS1 to damaged chromatin. PubMed ID: 26438602

The proximity ligation assay reveals that at DNA double-strand breaks WRAP53beta associates with gammaH2AX and controls interactions between RNF8 and MDC1. PubMed ID: 26734725

Hepatoma-derived growth factor-related protein 2 promotes DNA repair by homologous recombination. PubMed ID: 26721387

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Phosphorylation of the Cajal body protein WRAP53beta by ATM promotes its involvement in the DNA damage response. PubMed ID: 27715493

LncRNA CTBP1-DT-encoded microprotein DDUP sustains DNA damage response signalling to trigger dual DNA repair mechanisms. PubMed ID: 35849344

Specific recognition of phosphorylated tail of H2AX by the tandem BRCT domains of MCPH1 revealed by complex structure. PubMed ID: 22154951