Details for: MPST

Gene ID: 4357

Symbol: MPST

Ensembl ID: ENSG00000128309

Description: mercaptopyruvate sulfurtransferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 127.4870
    Cell Significance Index: -19.8300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 105.5419
    Cell Significance Index: -26.7700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 81.3136
    Cell Significance Index: -38.3900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 77.9063
    Cell Significance Index: -31.6500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 74.6814
    Cell Significance Index: -38.4200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 57.0622
    Cell Significance Index: -38.2900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.9044
    Cell Significance Index: -32.3700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.7568
    Cell Significance Index: -32.9900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.1256
    Cell Significance Index: -27.1300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.1516
    Cell Significance Index: -36.1100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.4020
    Cell Significance Index: -22.7400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.5104
    Cell Significance Index: -12.0600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.9925
    Cell Significance Index: 23.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.5221
    Cell Significance Index: 174.4200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.4257
    Cell Significance Index: 2190.2700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.3852
    Cell Significance Index: 25.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.3279
    Cell Significance Index: 62.2700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.2978
    Cell Significance Index: 34.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.2187
    Cell Significance Index: 58.3400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9883
    Cell Significance Index: 54.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.9876
    Cell Significance Index: 43.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.9362
    Cell Significance Index: 90.2800
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.8984
    Cell Significance Index: 4.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.7949
    Cell Significance Index: 980.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.7942
    Cell Significance Index: 177.4900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.7733
    Cell Significance Index: 40.9700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.5641
    Cell Significance Index: 214.8000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.5541
    Cell Significance Index: 32.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.5537
    Cell Significance Index: 53.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5306
    Cell Significance Index: 79.5100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3746
    Cell Significance Index: 18.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3097
    Cell Significance Index: 84.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2759
    Cell Significance Index: 36.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2531
    Cell Significance Index: 154.0800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.2152
    Cell Significance Index: 11.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1073
    Cell Significance Index: 219.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0871
    Cell Significance Index: 195.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9287
    Cell Significance Index: 119.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9006
    Cell Significance Index: 40.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7388
    Cell Significance Index: 34.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6503
    Cell Significance Index: 287.5300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6408
    Cell Significance Index: 18.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6121
    Cell Significance Index: 116.4900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5877
    Cell Significance Index: 35.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5817
    Cell Significance Index: 43.3600
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.5140
    Cell Significance Index: 3.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4532
    Cell Significance Index: 73.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4441
    Cell Significance Index: 14.2300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3688
    Cell Significance Index: 47.2800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3393
    Cell Significance Index: 24.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3216
    Cell Significance Index: 11.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2318
    Cell Significance Index: 27.3400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1348
    Cell Significance Index: 2.2700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1288
    Cell Significance Index: 1.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1181
    Cell Significance Index: 89.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1099
    Cell Significance Index: 3.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1078
    Cell Significance Index: 18.4000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0605
    Cell Significance Index: 0.4100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0551
    Cell Significance Index: 2.8700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0376
    Cell Significance Index: 0.6300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0171
    Cell Significance Index: 0.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0072
    Cell Significance Index: 5.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0044
    Cell Significance Index: -0.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0108
    Cell Significance Index: -20.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0215
    Cell Significance Index: -39.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0236
    Cell Significance Index: -2.4100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0254
    Cell Significance Index: -0.6500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0255
    Cell Significance Index: -39.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0309
    Cell Significance Index: -41.9900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0356
    Cell Significance Index: -22.6300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0412
    Cell Significance Index: -28.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0465
    Cell Significance Index: -16.6900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0526
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0555
    Cell Significance Index: -41.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0646
    Cell Significance Index: -36.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0693
    Cell Significance Index: -1.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0706
    Cell Significance Index: -44.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0768
    Cell Significance Index: -34.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1027
    Cell Significance Index: -20.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1104
    Cell Significance Index: -31.7600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1340
    Cell Significance Index: -3.3500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1394
    Cell Significance Index: -15.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1401
    Cell Significance Index: -20.3700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1545
    Cell Significance Index: -2.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1617
    Cell Significance Index: -18.8500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1893
    Cell Significance Index: -2.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2128
    Cell Significance Index: -44.8300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2867
    Cell Significance Index: -22.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3410
    Cell Significance Index: -35.5100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3775
    Cell Significance Index: -11.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4150
    Cell Significance Index: -21.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4181
    Cell Significance Index: -25.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4226
    Cell Significance Index: -25.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4582
    Cell Significance Index: -25.7100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5090
    Cell Significance Index: -14.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5803
    Cell Significance Index: -39.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5987
    Cell Significance Index: -26.4800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6293
    Cell Significance Index: -39.6600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6806
    Cell Significance Index: -12.5800
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.7012
    Cell Significance Index: -4.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** * MPST is a thioltransferase enzyme that catalyzes the transfer of a sulfur atom from mercaptopyruvate to a sulfur-containing compound. * The enzyme is highly specific, with a high affinity for sulfur-containing substrates. * MPST is involved in the degradation of cysteine and homocysteine, as well as the biosynthesis of hydrogen sulfide. * The enzyme is also involved in the regulation of immune responses, particularly in the context of inflammation and oxidative stress. **Pathways and Functions:** MPST is involved in several key metabolic pathways, including: * Sulfur amino acid catabolic process: MPST catalyzes the degradation of cysteine and homocysteine, releasing sulfur-containing compounds that can be reused by the body. * Hydrogen sulfide biosynthetic process: MPST is involved in the production of hydrogen sulfide, a potent antioxidant that plays a crucial role in maintaining cellular homeostasis. * Thioltransferase activity: MPST catalyzes the transfer of a sulfur atom from mercaptopyruvate to a thiol group, facilitating the formation of disulfide bonds and the regulation of cellular redox state. MPST also plays a crucial role in immune function, particularly in the context of inflammation and oxidative stress. The enzyme is involved in the regulation of immune responses, including: * Response to toxic substance: MPST helps to detoxify sulfur-containing compounds that can be toxic to cells. * Sulfur amino acid metabolism: MPST is involved in the regulation of sulfur amino acid metabolism, including the degradation of cysteine and homocysteine. * Transsulfuration: MPST is involved in the transfer of sulfur atoms between molecules, facilitating the formation of sulfur-containing compounds. **Clinical Significance:** Dysregulation of MPST has been implicated in various diseases, including: * Cancer: MPST has been shown to be overexpressed in certain types of cancer, including lung and breast cancer. * Diabetes: MPST has been implicated in the regulation of glucose metabolism and insulin signaling. * Neurodegenerative disorders: MPST has been shown to be involved in the regulation of oxidative stress and inflammation in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, MPST is a crucial enzyme involved in the metabolism of sulfur-containing amino acids and the regulation of immune function. The dysregulation of MPST has been implicated in various diseases, highlighting the importance of this enzyme in maintaining cellular homeostasis and preventing disease. Further research is needed to fully understand the role of MPST in human health and disease.

Genular Protein ID: 1111452852

Symbol: THTM_HUMAN

Name: 3-mercaptopyruvate sulfurtransferase

UniProtKB Accession Codes:

P25325 A8MZ34 B3KP52 J3KPV7 O75750 Q6FHN9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 6 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 12 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1953758

Title: Cloning and sequence analysis of the human liver rhodanese: comparison with the bovine and chicken enzymes.

PubMed ID: 1953758

DOI: 10.1016/s0006-291x(05)81148-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 4973015

Title: Mental deficiency and a new aminoaciduria.

PubMed ID: 4973015

DOI: 10.1001/archpedi.1969.02100030068007

PubMed ID: 4690911

Title: beta-Mercaptolactate cysteine disulfiduria in two normal sisters. Isolation and characterization of beta-mercaptolactate cysteine disulfide.

PubMed ID: 4690911

DOI: 10.1016/0009-8981(73)90480-4

PubMed ID: 6945862

Title: 3-mercaptolactate cysteine disulfiduria: biochemical studies on affected and unaffected members of a family.

PubMed ID: 6945862

DOI: 10.1016/0006-2944(81)90035-1

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 297
  • Mass: 33178
  • Checksum: 2313CC15A47A42EA
  • Sequence:
    • MASPQLCRAL VSAQWVAEAL RAPRAGQPLQ LLDASWYLPK LGRDARREFE ERHIPGAAFF 
DIDQCSDRTS PYDHMLPGAE HFAEYAGRLG VGAATHVVIY DASDQGLYSA PRVWWMFRAF 
GHHAVSLLDG GLRHWLRQNL PLSSGKSQPA PAEFRAQLDP AFIKTYEDIK ENLESRRFQV 
VDSRATGRFR GTEPEPRDGI EPGHIPGTVN IPFTDFLSQE GLEKSPEEIR HLFQEKKVDL 
SKPLVATCGS GVTACHVALG AYLCGKPDVP IYDGSWVEWY MRARPEDVIS EGRGKTH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.