Details for: PCNA

Gene ID: 5111

Symbol: PCNA

Ensembl ID: ENSG00000132646

Description: proliferating cell nuclear antigen

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 93.1623
    Cell Significance Index: -23.6300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 81.9036
    Cell Significance Index: -33.7400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 71.0832
    Cell Significance Index: -33.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 70.0049
    Cell Significance Index: -28.4400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 49.9984
    Cell Significance Index: -33.5500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 30.1023
    Cell Significance Index: -28.7400
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 25.6694
    Cell Significance Index: 11.6900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.8881
    Cell Significance Index: -28.2200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.2539
    Cell Significance Index: -24.7900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.5224
    Cell Significance Index: -33.6300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.6972
    Cell Significance Index: -20.5700
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 6.3004
    Cell Significance Index: -0.9800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 3.0109
    Cell Significance Index: 80.5400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.7572
    Cell Significance Index: 95.8100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.6471
    Cell Significance Index: 158.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.0469
    Cell Significance Index: 238.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.0396
    Cell Significance Index: 128.5500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.8195
    Cell Significance Index: 19.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5582
    Cell Significance Index: 253.4200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.5184
    Cell Significance Index: 18.1000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.5124
    Cell Significance Index: -3.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.5087
    Cell Significance Index: 177.9200
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.3628
    Cell Significance Index: 10.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9379
    Cell Significance Index: 414.6900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8838
    Cell Significance Index: 18.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7586
    Cell Significance Index: 93.2800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7135
    Cell Significance Index: 50.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6564
    Cell Significance Index: 358.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6055
    Cell Significance Index: 31.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5941
    Cell Significance Index: 76.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5899
    Cell Significance Index: 532.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5629
    Cell Significance Index: 111.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5449
    Cell Significance Index: 98.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5092
    Cell Significance Index: 32.8500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5080
    Cell Significance Index: 16.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4969
    Cell Significance Index: 68.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4837
    Cell Significance Index: 27.1500
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.4763
    Cell Significance Index: 3.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.4719
    Cell Significance Index: 48.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3888
    Cell Significance Index: 18.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3854
    Cell Significance Index: 10.4900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3689
    Cell Significance Index: 9.8500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3341
    Cell Significance Index: 8.7900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.2979
    Cell Significance Index: 2.5600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2960
    Cell Significance Index: 4.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2469
    Cell Significance Index: 11.1900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2429
    Cell Significance Index: 24.0300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2414
    Cell Significance Index: 5.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2125
    Cell Significance Index: 11.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1954
    Cell Significance Index: 5.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1903
    Cell Significance Index: 36.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1413
    Cell Significance Index: 7.3600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1205
    Cell Significance Index: 13.1100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0975
    Cell Significance Index: 2.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0771
    Cell Significance Index: 13.1700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0526
    Cell Significance Index: 0.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0372
    Cell Significance Index: 7.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0313
    Cell Significance Index: 11.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0310
    Cell Significance Index: 0.6600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0296
    Cell Significance Index: 0.8700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0190
    Cell Significance Index: 14.4000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0009
    Cell Significance Index: 0.1100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0008
    Cell Significance Index: 0.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0045
    Cell Significance Index: -0.2100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0059
    Cell Significance Index: -4.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0071
    Cell Significance Index: -4.4600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0100
    Cell Significance Index: -6.9200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0110
    Cell Significance Index: -20.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0164
    Cell Significance Index: -12.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0205
    Cell Significance Index: -37.8700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0249
    Cell Significance Index: -38.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0295
    Cell Significance Index: -40.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0367
    Cell Significance Index: -20.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0392
    Cell Significance Index: -24.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0610
    Cell Significance Index: -4.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0663
    Cell Significance Index: -30.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0717
    Cell Significance Index: -20.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0757
    Cell Significance Index: -15.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0998
    Cell Significance Index: -2.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1006
    Cell Significance Index: -3.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1010
    Cell Significance Index: -11.5700
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1577
    Cell Significance Index: -0.9900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1679
    Cell Significance Index: -2.3600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1949
    Cell Significance Index: -22.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1961
    Cell Significance Index: -28.5100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2476
    Cell Significance Index: -5.7200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2514
    Cell Significance Index: -3.4300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2813
    Cell Significance Index: -2.5900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2818
    Cell Significance Index: -2.2500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3024
    Cell Significance Index: -23.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3198
    Cell Significance Index: -33.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3648
    Cell Significance Index: -22.4200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3806
    Cell Significance Index: -29.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4521
    Cell Significance Index: -30.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5400
    Cell Significance Index: -33.1100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5419
    Cell Significance Index: -15.9600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6110
    Cell Significance Index: -6.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6119
    Cell Significance Index: -17.5400
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.6283
    Cell Significance Index: -3.2900
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.6422
    Cell Significance Index: -4.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PCNA is a 36-kDa protein that is highly expressed in proliferating cells, particularly in the S phase of the cell cycle. It is a component of the replication complex, where it binds to DNA polymerases and other enzymes to facilitate DNA synthesis. PCNA is also involved in the recognition of DNA damage and the recruitment of repair enzymes to damaged sites. The protein has multiple binding domains, including the C-terminal domain, which interacts with DNA polymerases, and the N-terminal domain, which interacts with other proteins involved in DNA repair. **Pathways and Functions:** PCNA is involved in various DNA repair pathways, including base excision repair (BER), nucleotide excision repair (NER), and homologous recombination repair (HRR). It also plays a critical role in DNA replication, particularly in the synthesis of the lagging strand. PCNA-dependent long patch base excision repair is a specialized pathway that involves the removal of oxidized bases from DNA. Additionally, PCNA is involved in the regulation of transcription, particularly in the transcription of cell cycle genes. **Clinical Significance:** Dysregulation of PCNA has been implicated in various diseases, including cancer, where it is often overexpressed. Mutations in the PCNA gene have also been associated with certain types of cancer, such as breast and ovarian cancer. Furthermore, PCNA is involved in the regulation of cell cycle checkpoints, which are critical for maintaining genome stability. Abnormalities in PCNA expression have been linked to various types of cancer, including leukemia, lymphoma, and solid tumors. **Clinical Implications:** 1. **Cancer Therapy:** PCNA is a potential target for cancer therapy, as its overexpression is often associated with tumor progression. Inhibitors of PCNA have been developed as potential anticancer agents. 2. **Genetic Disorders:** Mutations in the PCNA gene have been associated with certain genetic disorders, such as Fanconi anemia, a rare genetic disorder characterized by bone marrow failure and increased risk of cancer. 3. **Aging and Telomere Maintenance:** PCNA is involved in the maintenance of telomeres, which are essential for cellular aging. Abnormalities in PCNA expression have been linked to premature aging and telomere shortening. 4. **Neurological Disorders:** PCNA has been implicated in the pathogenesis of certain neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it is involved in the clearance of toxic proteins. In conclusion, PCNA is a critical protein involved in DNA replication and repair, and its dysregulation has been implicated in various diseases, including cancer and genetic disorders. Further research is needed to fully understand the role of PCNA in human disease and to develop effective therapeutic strategies targeting this protein.

Genular Protein ID: 3131872620

Symbol: PCNA_HUMAN

Name: Proliferating cell nuclear antigen

UniProtKB Accession Codes:

P12004 B2R897 D3DW02

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 9 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 ELM 1 EMBL 10 EMDB 21 Ensembl 2 EvolutionaryTrace 1 GO 50 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 71 PDBsum 71 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 26 RefSeq 2 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2882507

Title: Cloning and sequence of the human nuclear protein cyclin: homology with DNA-binding proteins.

PubMed ID: 2882507

DOI: 10.1073/pnas.84.6.1575

PubMed ID: 2565339

Title: Structure of the human gene for the proliferating cell nuclear antigen.

PubMed ID: 2565339

DOI: 10.1016/s0021-9258(18)83257-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2882422

Title: The cell-cycle regulated proliferating cell nuclear antigen is required for SV40 DNA replication in vitro.

PubMed ID: 2882422

DOI: 10.1038/326471a0

PubMed ID: 9305916

Title: The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21.

PubMed ID: 9305916

DOI: 10.1074/jbc.272.39.24522

PubMed ID: 9302295

Title: Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1.

PubMed ID: 9302295

DOI: 10.1126/science.277.5334.1996

PubMed ID: 9566895

Title: Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase.

PubMed ID: 9566895

DOI: 10.1128/mcb.18.5.2758

PubMed ID: 11595739

Title: Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta.

PubMed ID: 11595739

DOI: 10.1074/jbc.m106990200

PubMed ID: 11376153

Title: Human APE2 protein is mostly localized in the nuclei and to some extent in the mitochondria, while nuclear APE2 is partly associated with proliferating cell nuclear antigen.

PubMed ID: 11376153

DOI: 10.1093/nar/29.11.2349

PubMed ID: 11784855

Title: Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA.

PubMed ID: 11784855

DOI: 10.1128/mcb.22.3.784-791.2002

PubMed ID: 12786946

Title: Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone.

PubMed ID: 12786946

DOI: 10.1046/j.1365-2443.2003.00656.x

PubMed ID: 12522211

Title: Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen.

PubMed ID: 12522211

DOI: 10.1074/jbc.m208694200

PubMed ID: 15225546

Title: A defined human system that supports bidirectional mismatch-provoked excision.

PubMed ID: 15225546

DOI: 10.1016/j.molcel.2004.06.016

PubMed ID: 15149598

Title: Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage.

PubMed ID: 15149598

DOI: 10.1016/s1097-2765(04)00259-x

PubMed ID: 15543136

Title: The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci.

PubMed ID: 15543136

DOI: 10.1038/ncb1196

PubMed ID: 16510448

Title: Functional roles of p12, the fourth subunit of human DNA polymerase delta.

PubMed ID: 16510448

DOI: 10.1074/jbc.m600322200

PubMed ID: 17130289

Title: Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination.

PubMed ID: 17130289

DOI: 10.1083/jcb.200606145

PubMed ID: 16949367

Title: A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.

PubMed ID: 16949367

DOI: 10.1016/j.molcel.2006.08.010

PubMed ID: 17115032

Title: Tyrosine phosphorylation controls PCNA function through protein stability.

PubMed ID: 17115032

DOI: 10.1038/ncb1501

PubMed ID: 17108083

Title: Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen.

PubMed ID: 17108083

DOI: 10.1073/pnas.0608595103

PubMed ID: 18948756

Title: PCNA is ubiquitinated by RNF8.

PubMed ID: 18948756

DOI: 10.4161/cc.7.21.6949

PubMed ID: 18794347

Title: PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.

PubMed ID: 18794347

DOI: 10.1101/gad.1676108

PubMed ID: 19336415

Title: Human DNA polymerase beta polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity.

PubMed ID: 19336415

DOI: 10.1093/nar/gkp201

PubMed ID: 18499658

Title: Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1.

PubMed ID: 18499658

DOI: 10.1074/jbc.m802696200

PubMed ID: 18703516

Title: CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation.

PubMed ID: 18703516

DOI: 10.1074/jbc.m806045200

PubMed ID: 19443450

Title: Role of PCNA-dependent stimulation of 3'-phosphodiesterase and 3'-5' exonuclease activities of human Ape2 in repair of oxidative DNA damage.

PubMed ID: 19443450

DOI: 10.1093/nar/gkp357

PubMed ID: 18316726

Title: Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination.

PubMed ID: 18316726

DOI: 10.1073/pnas.0800563105

PubMed ID: 18719106

Title: Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks.

PubMed ID: 18719106

DOI: 10.1073/pnas.0805685105

PubMed ID: 19419956

Title: Proliferating cell nuclear antigen is protected from degradation by forming a complex with MutT Homolog2.

PubMed ID: 19419956

DOI: 10.1074/jbc.m109.015289

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20147293

Title: Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1.

PubMed ID: 20147293

DOI: 10.1074/jbc.m109.092544

PubMed ID: 20733054

Title: A chromatin-bound kinase, ERK8, protects genomic integrity by inhibiting HDM2-mediated degradation of the DNA clamp PCNA.

PubMed ID: 20733054

DOI: 10.1083/jcb.201002124

PubMed ID: 20129063

Title: CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis.

PubMed ID: 20129063

DOI: 10.1016/j.molcel.2009.12.018

PubMed ID: 20227374

Title: Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells.

PubMed ID: 20227374

DOI: 10.1016/j.molcel.2010.02.009

PubMed ID: 19995904

Title: DNA polymerase POLN participates in cross-link repair and homologous recombination.

PubMed ID: 19995904

DOI: 10.1128/mcb.01124-09

PubMed ID: 20457750

Title: Metnase promotes restart and repair of stalled and collapsed replication forks.

PubMed ID: 20457750

DOI: 10.1093/nar/gkq339

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21549307

Title: Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.

PubMed ID: 21549307

DOI: 10.1016/j.molcel.2011.02.036

PubMed ID: 21628590

Title: Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate.

PubMed ID: 21628590

DOI: 10.1073/pnas.1106136108

PubMed ID: 22148433

Title: Phosphorylation of the p68 subunit of Pol delta acts as a molecular switch to regulate its interaction with PCNA.

PubMed ID: 22148433

DOI: 10.1021/bi201638e

PubMed ID: 22153967

Title: Inhibition of homologous recombination by the PCNA-interacting protein PARI.

PubMed ID: 22153967

DOI: 10.1016/j.molcel.2011.11.010

PubMed ID: 22681887

Title: Spartan/C1orf124, a reader of PCNA ubiquitylation and a regulator of UV-induced DNA damage response.

PubMed ID: 22681887

DOI: 10.1016/j.molcel.2012.05.020

PubMed ID: 22759634

Title: ZRANB3 is a structure-specific ATP-dependent endonuclease involved in replication stress response.

PubMed ID: 22759634

DOI: 10.1101/gad.193516.112

PubMed ID: 22705370

Title: The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress.

PubMed ID: 22705370

DOI: 10.1016/j.molcel.2012.05.025

PubMed ID: 23000965

Title: Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.

PubMed ID: 23000965

DOI: 10.1038/ncb2579

PubMed ID: 22704558

Title: Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress.

PubMed ID: 22704558

DOI: 10.1016/j.molcel.2012.05.024

PubMed ID: 22634751

Title: Mutations in the PCNA-binding domain of CDKN1C cause IMAGe syndrome.

PubMed ID: 22634751

DOI: 10.1038/ng.2275

PubMed ID: 23711367

Title: A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses.

PubMed ID: 23711367

DOI: 10.1016/j.febslet.2013.05.037

PubMed ID: 23677613

Title: The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)-mediated proteolysis in human cells.

PubMed ID: 23677613

DOI: 10.1093/nar/gkt397

PubMed ID: 24115439

Title: RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication.

PubMed ID: 24115439

DOI: 10.1126/science.1241779

PubMed ID: 24695737

Title: The ADP-ribosyltransferase PARP10/ARTD10 interacts with proliferating cell nuclear antigen (PCNA) and is required for DNA damage tolerance.

PubMed ID: 24695737

DOI: 10.1074/jbc.m114.556340

PubMed ID: 24911150

Title: Hypomorphic PCNA mutation underlies a human DNA repair disorder.

PubMed ID: 24911150

DOI: 10.1172/jci74593

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24561620

Title: Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components.

PubMed ID: 24561620

DOI: 10.1038/ncb2918

PubMed ID: 24939902

Title: CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis.

PubMed ID: 24939902

DOI: 10.1093/nar/gku533

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25732820

Title: Human C6orf211 encodes Armt1, a protein carboxyl methyltransferase that targets PCNA and is linked to the DNA damage response.

PubMed ID: 25732820

DOI: 10.1016/j.celrep.2015.01.054

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 26408825

Title: The interaction between ALKBH2 DNA repair enzyme and PCNA is direct, mediated by the hydrophobic pocket of PCNA and perturbed in naturally-occurring ALKBH2 variants.

PubMed ID: 26408825

DOI: 10.1016/j.dnarep.2015.09.008

PubMed ID: 26223641

Title: Bub1 in Complex with LANA Recruits PCNA To Regulate Kaposi's Sarcoma-Associated Herpesvirus Latent Replication and DNA Translesion Synthesis.

PubMed ID: 26223641

DOI: 10.1128/jvi.01524-15

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27462463

Title: TRAIP regulates replication fork recovery and progression via PCNA.

PubMed ID: 27462463

DOI: 10.1038/celldisc.2016.16

PubMed ID: 26760506

Title: R152C DNA Pol beta mutation impairs base excision repair and induces cellular transformation.

PubMed ID: 26760506

DOI: 10.18632/oncotarget.6849

PubMed ID: 27906959

Title: PCNA-dependent cleavage and degradation of SDE2 regulates response to replication stress.

PubMed ID: 27906959

DOI: 10.1371/journal.pgen.1006465

PubMed ID: 28191891

Title: Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism.

PubMed ID: 28191891

DOI: 10.1038/ng.3790

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29290612

Title: Removal of RTF2 from Stalled Replisomes Promotes Maintenance of Genome Integrity.

PubMed ID: 29290612

DOI: 10.1016/j.molcel.2017.11.035

PubMed ID: 30554877

Title: HMCES maintains genome integrity by shielding abasic sites in single-strand DNA.

PubMed ID: 30554877

DOI: 10.1016/j.cell.2018.10.055

PubMed ID: 35585232

Title: Fast and efficient DNA replication with purified human proteins.

PubMed ID: 35585232

DOI: 10.1038/s41586-022-04759-1

PubMed ID: 35849344

Title: LncRNA CTBP1-DT-encoded microprotein DDUP sustains DNA damage response signalling to trigger dual DNA repair mechanisms.

PubMed ID: 35849344

DOI: 10.1093/nar/gkac611

PubMed ID: 38459011

Title: GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer.

PubMed ID: 38459011

DOI: 10.1038/s41467-024-46283-y

PubMed ID: 8861913

Title: Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA.

PubMed ID: 8861913

DOI: 10.1016/s0092-8674(00)81347-1

PubMed ID: 15616578

Title: Structural basis for recruitment of human flap endonuclease 1 to PCNA.

PubMed ID: 15616578

DOI: 10.1038/sj.emboj.7600519

PubMed ID: 27084448

Title: Crystal structure of human PCNA in complex with the PIP box of DVC1.

PubMed ID: 27084448

DOI: 10.1016/j.bbrc.2016.04.053

PubMed ID: 26711499

Title: TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress.

PubMed ID: 26711499

DOI: 10.1083/jcb.201506071

PubMed ID: 28951215

Title: Structure insights into the molecular mechanism of the interaction between UHRF2 and PCNA.

PubMed ID: 28951215

DOI: 10.1016/j.bbrc.2017.09.102

Sequence Information:

  • Length: 261
  • Mass: 28769
  • Checksum: E6F08E7EDBC48B00
  • Sequence:
    • MFEARLVQGS ILKKVLEALK DLINEACWDI SSSGVNLQSM DSSHVSLVQL TLRSEGFDTY 
RCDRNLAMGV NLTSMSKILK CAGNEDIITL RAEDNADTLA LVFEAPNQEK VSDYEMKLMD 
LDVEQLGIPE QEYSCVVKMP SGEFARICRD LSHIGDAVVI SCAKDGVKFS ASGELGNGNI 
KLSQTSNVDK EEEAVTIEMN EPVQLTFALR YLNFFTKATP LSSTVTLSMS ADVPLVVEYK 
IADMGHLKYY LAPKIEDEEG S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.