Details for: HELLS

Gene ID: 3070

Symbol: HELLS

Ensembl ID: ENSG00000119969

Description: helicase, lymphoid specific

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 87.8844
    Cell Significance Index: -13.6700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 56.2601
    Cell Significance Index: -14.2700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 48.2828
    Cell Significance Index: -19.8900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 43.4454
    Cell Significance Index: -17.6500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.6647
    Cell Significance Index: -17.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.6210
    Cell Significance Index: -19.2600
  • Cell Name: germ cell (CL0000586)
    Fold Change: 5.1863
    Cell Significance Index: 39.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.1343
    Cell Significance Index: -20.2600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.8153
    Cell Significance Index: -14.7900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 3.0782
    Cell Significance Index: 82.3400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.5998
    Cell Significance Index: -5.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.5872
    Cell Significance Index: 145.1800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.1787
    Cell Significance Index: 215.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7476
    Cell Significance Index: 346.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.6245
    Cell Significance Index: 45.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.5268
    Cell Significance Index: 91.6600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.5200
    Cell Significance Index: 177.1400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.3376
    Cell Significance Index: 46.4800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2659
    Cell Significance Index: 137.7000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2336
    Cell Significance Index: 200.6300
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 1.1435
    Cell Significance Index: 6.5000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.1177
    Cell Significance Index: 131.8200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0628
    Cell Significance Index: 14.5000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.7626
    Cell Significance Index: 8.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7110
    Cell Significance Index: 20.4900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6115
    Cell Significance Index: 12.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5529
    Cell Significance Index: 28.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5009
    Cell Significance Index: 61.5900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4020
    Cell Significance Index: 10.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4013
    Cell Significance Index: 219.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4010
    Cell Significance Index: 177.3000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3622
    Cell Significance Index: 250.4800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3488
    Cell Significance Index: 9.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3385
    Cell Significance Index: 64.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2925
    Cell Significance Index: 52.7300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2796
    Cell Significance Index: 18.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2716
    Cell Significance Index: 6.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2418
    Cell Significance Index: 86.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2416
    Cell Significance Index: 218.1300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2126
    Cell Significance Index: 3.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1924
    Cell Significance Index: 38.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1761
    Cell Significance Index: 24.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1650
    Cell Significance Index: 11.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1060
    Cell Significance Index: 3.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0965
    Cell Significance Index: 2.0900
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0469
    Cell Significance Index: 0.5500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0469
    Cell Significance Index: 2.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0415
    Cell Significance Index: 1.4600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0033
    Cell Significance Index: 0.0600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0028
    Cell Significance Index: 0.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0021
    Cell Significance Index: 3.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0018
    Cell Significance Index: -3.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0020
    Cell Significance Index: -3.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0069
    Cell Significance Index: -0.8800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.0089
    Cell Significance Index: -0.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0097
    Cell Significance Index: -0.4400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0106
    Cell Significance Index: -0.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0140
    Cell Significance Index: -19.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0152
    Cell Significance Index: -11.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0172
    Cell Significance Index: -10.9000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0181
    Cell Significance Index: -13.2500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0192
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0268
    Cell Significance Index: -19.8300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0369
    Cell Significance Index: -20.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0372
    Cell Significance Index: -23.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0379
    Cell Significance Index: -17.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0527
    Cell Significance Index: -15.1500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0528
    Cell Significance Index: -0.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0633
    Cell Significance Index: -4.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0643
    Cell Significance Index: -9.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0743
    Cell Significance Index: -9.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0748
    Cell Significance Index: -7.6400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0810
    Cell Significance Index: -2.1300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0814
    Cell Significance Index: -1.0100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0846
    Cell Significance Index: -2.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0973
    Cell Significance Index: -5.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1117
    Cell Significance Index: -7.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1126
    Cell Significance Index: -23.7100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1137
    Cell Significance Index: -19.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1265
    Cell Significance Index: -14.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1436
    Cell Significance Index: -6.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1555
    Cell Significance Index: -7.3100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1625
    Cell Significance Index: -10.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1857
    Cell Significance Index: -9.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1862
    Cell Significance Index: -19.3900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1987
    Cell Significance Index: -4.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2089
    Cell Significance Index: -7.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2298
    Cell Significance Index: -17.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2308
    Cell Significance Index: -17.7100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2309
    Cell Significance Index: -3.4800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2408
    Cell Significance Index: -19.0800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2662
    Cell Significance Index: -6.3900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2697
    Cell Significance Index: -7.9200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2765
    Cell Significance Index: -12.8900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2877
    Cell Significance Index: -7.8300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.3207
    Cell Significance Index: -4.4500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3293
    Cell Significance Index: -6.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3507
    Cell Significance Index: -21.5000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3872
    Cell Significance Index: -19.5700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3931
    Cell Significance Index: -5.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HELLS is a lymphoid-specific helicase that exhibits the following key characteristics: 1. **Helicase activity:** HELLS possesses helicase activity, which enables it to unwind DNA double helices and regulate DNA replication and transcription. 2. **ATP-dependent chromatin remodeler activity:** The protein also exhibits ATP-dependent chromatin remodeler activity, allowing it to reorganize chromatin structure and regulate gene expression. 3. **Lymphoid-specific expression:** HELLS is specifically expressed in lymphoid cells, including oogonial cells, taste receptor cells, and large pre-B-II cells, indicating its critical role in immune cell development. 4. **Regulation of gene expression:** HELLS regulates gene expression by modulating chromatin structure and DNA replication, thereby influencing the development and function of lymphoid cells. **Pathways and Functions:** HELLS is involved in several key pathways and functions, including: 1. **Apoptotic process:** HELLS regulates the apoptotic process by modulating chromatin structure and DNA replication, thereby influencing the development and function of lymphoid cells. 2. **Cell cycle:** The protein regulates the cell cycle by controlling DNA replication and transcription, ensuring proper cell division and growth. 3. **Chromatin binding:** HELLS exhibits chromatin-binding activity, allowing it to regulate chromatin structure and gene expression. 4. **DNA methylation:** The protein regulates DNA methylation by modulating chromatin structure and DNA replication, thereby influencing gene expression and cellular development. **Clinical Significance:** HELLS has significant clinical implications, particularly in the context of immune-related disorders. Dysregulation of the HELLS gene has been implicated in various diseases, including: 1. **Immunodeficiency disorders:** Mutations in the HELLS gene can lead to immunodeficiency disorders, such as severe combined immunodeficiency (SCID), characterized by impaired lymphoid cell development and function. 2. **Lymphoma:** HELLS has been implicated in the development of lymphoma, a type of cancer that affects the immune system. 3. **Autoimmune diseases:** Dysregulation of the HELLS gene has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, characterized by impaired immune regulation and tissue damage. In conclusion, the HELLS gene plays a critical role in lymphoid cell development and function, regulating gene expression and DNA replication through its helicase and ATP-dependent chromatin remodeler activities. Dysregulation of the HELLS gene has significant clinical implications, particularly in the context of immune-related disorders. Further research is necessary to fully elucidate the mechanisms by which HELLS regulates lymphoid cell development and function, with implications for the development of novel therapeutic strategies for immune-related diseases.

Genular Protein ID: 1361080485

Symbol: HELLS_HUMAN

Name: Lymphoid-specific helicase

UniProtKB Accession Codes:

Q9NRZ9 B2RB41 Q3LID1 Q6I7N7 Q76H76 Q76H77 Q76H78 Q76H79 Q76H80 Q76H81 Q7Z397 Q7Z5X2 Q8N6P4 Q9H4P5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 2 CTD 1 ChEBI 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 18 Ensembl 8 ExpressionAtlas 1 GO 18 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 9 Pumba 1 RNAct 1 Reactome 1 RefSeq 10 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10910076

Title: Proliferation-associated SNF2-like gene (PASG): a SNF2 family member altered in leukemia.

PubMed ID: 10910076

PubMed ID: 15305370

Title: Tumor-specific exon creation of the HELLS/SMARCA6 gene in non-small cell lung cancer.

PubMed ID: 15305370

DOI: 10.1002/ijc.20407

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12880961

Title: Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma.

PubMed ID: 12880961

DOI: 10.1016/s0304-3835(03)00085-5

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26216346

Title: Mutations in CDCA7 and HELLS cause immunodeficiency-centromeric instability-facial anomalies syndrome.

PubMed ID: 26216346

DOI: 10.1038/ncomms8870

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

Sequence Information:

  • Length: 838
  • Mass: 97074
  • Checksum: FE8C644C23F2526E
  • Sequence:
    • MPAERPAGSG GSEAPAMVEQ LDTAVITPAM LEEEEQLEAA GLERERKMLE KARMSWDRES 
TEIRYRRLQH LLEKSNIYSK FLLTKMEQQQ LEEQKKKEKL ERKKESLKVK KGKNSIDASE 
EKPVMRKKRG REDESYNISE VMSKEEILSV AKKNKKENED ENSSSTNLCV EDLQKNKDSN 
SIIKDRLSET VRQNTKFFFD PVRKCNGQPV PFQQPKHFTG GVMRWYQVEG MEWLRMLWEN 
GINGILADEM GLGKTVQCIA TIALMIQRGV PGPFLVCGPL STLPNWMAEF KRFTPDIPTM 
LYHGTQEERQ KLVRNIYKRK GTLQIHPVVI TSFEIAMRDR NALQHCYWKY LIVDEGHRIK 
NMKCRLIREL KRFNADNKLL LTGTPLQNNL SELWSLLNFL LPDVFDDLKS FESWFDITSL 
SETAEDIIAK EREQNVLHML HQILTPFLLR RLKSDVALEV PPKREVVVYA PLSKKQEIFY 
TAIVNRTIAN MFGSSEKETI ELSPTGRPKR RTRKSINYSK IDDFPNELEK LISQIQPEVD 
RERAVVEVNI PVESEVNLKL QNIMMLLRKC CNHPYLIEYP IDPVTQEFKI DEELVTNSGK 
FLILDRMLPE LKKRGHKVLL FSQMTSMLDI LMDYCHLRDF NFSRLDGSMS YSEREKNMHS 
FNTDPEVFIF LVSTRAGGLG INLTAADTVI IYDSDWNPQS DLQAQDRCHR IGQTKPVVVY 
RLVTANTIDQ KIVERAAAKR KLEKLIIHKN HFKGGQSGLN LSKNFLDPKE LMELLKSRDY 
EREIKGSREK VISDKDLELL LDRSDLIDQM NASGPIKEKM GIFKILENSE DSSPECLF

Genular Protein ID: 3784979962

Symbol: Q76H82_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q76H82

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 1 GeneTree 1 HGNC 1 HOGENOM 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 97
  • Mass: 11210
  • Checksum: 0DB80077AA17A3FE
  • Sequence:
    • MPAERPAGSG GSEAPAMVEQ LDTAVITPAM LEEEEQLEAA GLERERKMLE KARMSWDRES 
TEIRYRRLQH LLEKSNIYSK FLLTKMEQQQ LETVMKI

Genular Protein ID: 1494177214

Symbol: Q0VGL2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q0VGL2

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 RefSeq 8 SAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 97
  • Mass: 11292
  • Checksum: 8CD805C6488F87FB
  • Sequence:
    • MPAERPAGSG GSEAPAMVEQ LDTAVITPAM LEEEEQLEAA GLERERKMLE KARMSWDRES 
TEIRYRRLQH LLEKSNIYSK FLLTKMEQQK KKKKKKK

Genular Protein ID: 3374547472

Symbol: A0A0B4J1V9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0B4J1V9

Database IDs:

ARBA 3 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 4 Gene3D 2 GeneTree 1 HGNC 1 IntAct 1 InterPro 7 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 2 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 884
  • Mass: 102715
  • Checksum: 35FE7D7294C66283
  • Sequence:
    • MPAERPAGSG GSEAPAMVEQ LDTAVITPAM LEEEEQLEAA GLERERKMLE KARMSWDRES 
TEIRYRRLQH LLEKSNIYSK FLLTKMEQQQ LEEQKKKEKL ERKKESLKVK KGKNSIDASE 
EKPVMRKKRG REDESYNISE VMSKEEILSV AKKNKKENED ENSSSTNLCV EDLQKNKDSN 
SIIKDRLSET VRQNTKFFFD PVRKCNGQPV PFQQPKHFTG GVMRWYQVEG MEWLRMLWEN 
GINGILADEM GLGKTVQCIA TIALMIQRGV PGPFLVCGPL STLPNWMAEF KRFTPDIPTM 
LYHGTQEERQ KLVRNIYKRK GTLQIHPVVI TSFEIAMRDR NALQHCYWKY LIVDEGHRIK 
NMKCRLIREL KRFNADNKLL LTGTPLQNNL SELWSLLNFL LPDVFDDLKS FESWFDITSL 
SETAEDIIAK EREQNVLHML HQERIPRMYV SEFTDEGFFE GKLPSRKDLY DIRPYENTYL 
LKLHTNFEIL TPFLLRRLKS DVALEVPPKR EVVVYAPLSK KQEIFYTAIV NRTIANMFGS 
SEKETIELSP TGRPKRRTRK SINYSKIDDF PNELEKLISQ IQPEVDRERA VVEVNIPVES 
EVNLKLQNIM MLLRKCCNHP YLIEYPIDPV TQEFKIDEEL VTNSGKFLIL DRMLPELKKR 
GHKVLLFSQM TSMLDILMDY CHLRDFNFSR LDGSMSYSER EKNMHSFNTD PEVFIFLVST 
RAGGLGINLT AADTVIIYDS DWNPQSDLQA QDRCHRIGQT KPVVVYRLVT ANTIDQKIVE 
RAAAKRKLEK LIIHKNHFKG GQSGLNLSKN FLDPKELMEL LKSRDYEREI KGSREKVISD 
KDLELLLDRS DLIDQMNASG PIKEKMGIFK ILENSEDSSP ECLF

Genular Protein ID: 3860705216

Symbol: A0A087WSW7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WSW7

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 2 HGNC 1 HOGENOM 1 InterPro 7 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 700
  • Mass: 81036
  • Checksum: AEE7C610A32B3161
  • Sequence:
    • MQVKRSQEIL SVAKKNKKEN EDENSSSTNL CVEDLQKNKD SNSIIKDRLS ETVRQNTKFF 
FDPVRKCNGQ PVPFQQPKHF TGGVMRWYQV EGMEWLRMLW ENGINGILAD EMGLGKTVQC 
IATIALMIQR GVPGPFLVCG PLSTLPNWMA EFKRFTPDIP TMLYHGTQEE RQKLVRNIYK 
RKGTLQIHPV VITSFEIAMR DRNALQHCYW KYLIVDEGHR IKNMKCRLIR ELKRFNADNK 
LLLTGTPLQN NLSELWSLLN FLLPDVFDDL KSFESWFDIT SLSETAEDII AKEREQNVLH 
MLHQILTPFL LRRLKSDVAL EVPPKREVVV YAPLSKKQEI FYTAIVNRTI ANMFGSSEKE 
TIELSPTGRP KRRTRKSINY SKIDDFPNEL EKLISQIQPE VDRERAVVEV NIPVESEVNL 
KLQNIMMLLR KCCNHPYLIE YPIDPVTQEF KIDEELVTNS GKFLILDRML PELKKRGHKV 
LLFSQMTSML DILMDYCHLR DFNFSRLDGS MSYSEREKNM HSFNTDPEVF IFLVSTRAGG 
LGINLTAADT VIIYDSDWNP QSDLQAQDRC HRIGQTKPVV VYRLVTANTI DQKIVERAAA 
KRKLEKLIIH KNHFKGGQSG LNLSKNFLDP KELMELLKSR DYEREIKGSR EKVISDKDLE 
LLLDRSDLID QMNASGPIKE KMGIFKILEN SEDSSPECLF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.