Details for: ZNF22

Gene ID: 7570

Symbol: ZNF22

Ensembl ID: ENSG00000165512

Description: zinc finger protein 22

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 193.7057
    Cell Significance Index: -30.1300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 84.2826
    Cell Significance Index: -34.7200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 76.9927
    Cell Significance Index: -36.3500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 75.1002
    Cell Significance Index: -30.5100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 55.9447
    Cell Significance Index: -14.1900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 54.3052
    Cell Significance Index: -36.4400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 32.5795
    Cell Significance Index: -31.1100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.8518
    Cell Significance Index: -34.3400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.1461
    Cell Significance Index: -27.1800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.0331
    Cell Significance Index: -35.6500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.2018
    Cell Significance Index: -22.1200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.1099
    Cell Significance Index: 24.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.0418
    Cell Significance Index: 105.7000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.7727
    Cell Significance Index: 23.2900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.6929
    Cell Significance Index: 29.2800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.5311
    Cell Significance Index: 32.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.3367
    Cell Significance Index: 48.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.1822
    Cell Significance Index: 254.3100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.7517
    Cell Significance Index: 91.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.7286
    Cell Significance Index: 47.0500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.6848
    Cell Significance Index: 1521.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4826
    Cell Significance Index: 95.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3546
    Cell Significance Index: 186.0300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.1960
    Cell Significance Index: 31.4500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.9824
    Cell Significance Index: 11.1600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8606
    Cell Significance Index: 110.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8225
    Cell Significance Index: 56.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7003
    Cell Significance Index: 49.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6683
    Cell Significance Index: 66.1100
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.6352
    Cell Significance Index: 3.9300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5832
    Cell Significance Index: 30.6200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5829
    Cell Significance Index: 43.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5695
    Cell Significance Index: 26.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5619
    Cell Significance Index: 26.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5573
    Cell Significance Index: 246.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5410
    Cell Significance Index: 295.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4785
    Cell Significance Index: 91.0600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4731
    Cell Significance Index: 10.9300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4407
    Cell Significance Index: 51.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4327
    Cell Significance Index: 55.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3519
    Cell Significance Index: 60.0900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3486
    Cell Significance Index: 21.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2993
    Cell Significance Index: 53.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1957
    Cell Significance Index: 4.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1810
    Cell Significance Index: 5.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1761
    Cell Significance Index: 35.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1708
    Cell Significance Index: 21.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1003
    Cell Significance Index: 35.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0956
    Cell Significance Index: 5.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0915
    Cell Significance Index: 2.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0884
    Cell Significance Index: 5.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0680
    Cell Significance Index: 13.5000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0675
    Cell Significance Index: 1.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0423
    Cell Significance Index: 1.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0303
    Cell Significance Index: 0.8700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0281
    Cell Significance Index: 0.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0268
    Cell Significance Index: 0.9400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0165
    Cell Significance Index: 12.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0145
    Cell Significance Index: 10.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0002
    Cell Significance Index: 0.3000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0011
    Cell Significance Index: -0.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0035
    Cell Significance Index: -2.5600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0084
    Cell Significance Index: -5.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0107
    Cell Significance Index: -20.0800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0125
    Cell Significance Index: -0.3200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0211
    Cell Significance Index: -0.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0236
    Cell Significance Index: -36.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0241
    Cell Significance Index: -44.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0291
    Cell Significance Index: -2.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0398
    Cell Significance Index: -25.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0409
    Cell Significance Index: -23.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0516
    Cell Significance Index: -2.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0604
    Cell Significance Index: -3.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0649
    Cell Significance Index: -29.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0695
    Cell Significance Index: -14.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0706
    Cell Significance Index: -20.3200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0798
    Cell Significance Index: -1.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0867
    Cell Significance Index: -9.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1197
    Cell Significance Index: -2.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1707
    Cell Significance Index: -24.8100
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: -0.1707
    Cell Significance Index: -0.9700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2598
    Cell Significance Index: -29.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3032
    Cell Significance Index: -23.2700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3172
    Cell Significance Index: -25.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3413
    Cell Significance Index: -35.5400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4047
    Cell Significance Index: -11.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4057
    Cell Significance Index: -27.2800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4318
    Cell Significance Index: -7.4000
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.4953
    Cell Significance Index: -3.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5091
    Cell Significance Index: -31.2100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6266
    Cell Significance Index: -16.7600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6317
    Cell Significance Index: -15.7900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6540
    Cell Significance Index: -6.7700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.6609
    Cell Significance Index: -9.2700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6829
    Cell Significance Index: -8.1400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7007
    Cell Significance Index: -20.6400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7167
    Cell Significance Index: -31.7000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7710
    Cell Significance Index: -20.6600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8049
    Cell Significance Index: -20.6900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.8131
    Cell Significance Index: -19.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNF22 is a transcription factor that belongs to the zinc finger protein family, which is characterized by its unique DNA-binding domain. The protein's structure consists of a C-terminal zinc finger motif, which interacts with specific DNA sequences to regulate gene expression. ZNF22's expression is tightly regulated, with significant fluctuations observed across different cell types and developmental stages. This dynamic expression pattern suggests that ZNF22 plays a critical role in cellular differentiation and development. **Pathways and Functions:** ZNF22's signaling pathways are multifaceted, with involvement in several critical cellular processes: 1. **Odontogenesis**: ZNF22 is involved in tooth development, where it regulates the expression of genes involved in enamel and dentin formation. 2. **Regulation of DNA-templated transcription**: ZNF22 acts as a transcriptional regulator, influencing the expression of genes involved in cell growth, differentiation, and survival. 3. **DNA binding**: ZNF22's zinc finger motif enables it to interact with specific DNA sequences, modulating gene expression in response to environmental cues. 4. **Protein binding**: ZNF22 interacts with various proteins, including other transcription factors, co-repressors, and histone modifiers, to regulate gene expression. **Clinical Significance:** ZNF22's involvement in various cellular processes has significant implications for human health and disease: 1. **Immune system dysfunction**: Alterations in ZNF22 expression have been linked to immune system disorders, such as autoimmune diseases and cancer. 2. **Neurological disorders**: ZNF22's role in neural crest cell development suggests its involvement in neurodevelopmental disorders, such as autism and schizophrenia. 3. **Cancer**: ZNF22's regulatory functions in cell growth and differentiation make it a potential target for cancer therapy. 4. **Developmental disorders**: ZNF22's involvement in odontogenesis and other developmental processes highlights its potential role in congenital disorders, such as tooth agenesis. In conclusion, ZNF22 is a multifunctional transcription factor that plays a critical role in various cellular processes, including development, differentiation, and immune function. Further research is needed to fully elucidate the mechanisms underlying ZNF22's regulatory functions and its clinical significance in human disease.

Genular Protein ID: 1102028723

Symbol: ZNF22_HUMAN

Name: Zinc finger protein 22

UniProtKB Accession Codes:

P17026 Q5T741 Q96FM4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1421376

Title: Isolation of a cDNA clone encoding a zinc finger protein highly expressed in T-leukemia lines.

PubMed ID: 1421376

PubMed ID: 14630903

Title: The human KROX-26/ZNF22 gene is expressed at sites of tooth formation and maps to the locus for permanent tooth agenesis (He-Zhao deficiency).

PubMed ID: 14630903

DOI: 10.1177/154405910308201213

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1946370

Title: Characterization and mapping of human genes encoding zinc finger proteins.

PubMed ID: 1946370

DOI: 10.1073/pnas.88.21.9563

PubMed ID: 2288909

Title: Multiple genes encoding zinc finger domains are expressed in human T cells.

PubMed ID: 2288909

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 224
  • Mass: 25915
  • Checksum: 61BE158D2CEAEE19
  • Sequence:
    • MRLAKPKAGI SRSSSQGKAY ENKRKTGRQR QKWGMTIRFD SSFSRLRRSL DDKPYKCTEC 
EKSFSQSSTL FQHQKIHTGK KSHKCADCGK SFFQSSNLIQ HRRIHTGEKP YKCDECGESF 
KQSSNLIQHQ RIHTGEKPYQ CDECGRCFSQ SSHLIQHQRT HTGEKPYQCS ECGKCFSQSS 
HLRQHMKVHK EEKPRKTRGK NIRVKTHLPS WKAGTGRKSV AGLR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.