Details for: DTYMK

Gene ID: 1841

Symbol: DTYMK

Ensembl ID: ENSG00000168393

Description: deoxythymidylate kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 83.8973
    Cell Significance Index: -21.2800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 66.2220
    Cell Significance Index: -27.2800
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 59.4039
    Cell Significance Index: -9.2400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 55.8329
    Cell Significance Index: -26.3600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 52.8483
    Cell Significance Index: -21.4700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 50.5458
    Cell Significance Index: -26.0000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.8977
    Cell Significance Index: -23.3000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.8130
    Cell Significance Index: -20.9300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.4672
    Cell Significance Index: -25.5200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.2614
    Cell Significance Index: -16.1600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.6364
    Cell Significance Index: -5.7700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.8379
    Cell Significance Index: 19.9800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.6681
    Cell Significance Index: 57.9700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3356
    Cell Significance Index: 80.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.1968
    Cell Significance Index: 25.0500
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 1.1199
    Cell Significance Index: 0.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0041
    Cell Significance Index: 118.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8298
    Cell Significance Index: 164.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7210
    Cell Significance Index: 393.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7167
    Cell Significance Index: 37.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4234
    Cell Significance Index: 13.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4138
    Cell Significance Index: 50.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3862
    Cell Significance Index: 170.7600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3700
    Cell Significance Index: 26.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3635
    Cell Significance Index: 23.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3633
    Cell Significance Index: 16.9400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3584
    Cell Significance Index: 9.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3552
    Cell Significance Index: 9.3400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2904
    Cell Significance Index: 52.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2630
    Cell Significance Index: 12.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2601
    Cell Significance Index: 35.7200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2532
    Cell Significance Index: 15.9600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2500
    Cell Significance Index: 2.8400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2433
    Cell Significance Index: 46.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2246
    Cell Significance Index: 10.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2119
    Cell Significance Index: 4.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2044
    Cell Significance Index: 20.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2011
    Cell Significance Index: 5.6200
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1848
    Cell Significance Index: 1.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1428
    Cell Significance Index: 7.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1324
    Cell Significance Index: 16.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1267
    Cell Significance Index: 25.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1208
    Cell Significance Index: 6.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0892
    Cell Significance Index: 1.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0699
    Cell Significance Index: 25.0700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0697
    Cell Significance Index: 9.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0543
    Cell Significance Index: 8.8300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0209
    Cell Significance Index: 0.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0068
    Cell Significance Index: 5.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0067
    Cell Significance Index: 1.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0028
    Cell Significance Index: 0.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0003
    Cell Significance Index: 0.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0018
    Cell Significance Index: -1.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0059
    Cell Significance Index: -0.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0074
    Cell Significance Index: -4.6000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0089
    Cell Significance Index: -16.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0092
    Cell Significance Index: -6.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0115
    Cell Significance Index: -8.4400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0122
    Cell Significance Index: -18.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0207
    Cell Significance Index: -28.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0234
    Cell Significance Index: -13.1900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0256
    Cell Significance Index: -0.6900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0277
    Cell Significance Index: -17.5900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0290
    Cell Significance Index: -2.9600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0454
    Cell Significance Index: -0.4700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0494
    Cell Significance Index: -22.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0555
    Cell Significance Index: -15.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0594
    Cell Significance Index: -6.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0614
    Cell Significance Index: -7.1600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0705
    Cell Significance Index: -1.8000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0760
    Cell Significance Index: -16.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1099
    Cell Significance Index: -15.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1593
    Cell Significance Index: -9.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1864
    Cell Significance Index: -4.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2049
    Cell Significance Index: -5.4900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2067
    Cell Significance Index: -23.6000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2082
    Cell Significance Index: -4.8100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2162
    Cell Significance Index: -6.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2296
    Cell Significance Index: -6.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2390
    Cell Significance Index: -24.8900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2393
    Cell Significance Index: -2.0100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2417
    Cell Significance Index: -1.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2489
    Cell Significance Index: -19.1000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2652
    Cell Significance Index: -21.0000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2658
    Cell Significance Index: -2.4500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2817
    Cell Significance Index: -7.2400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2870
    Cell Significance Index: -4.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3215
    Cell Significance Index: -21.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3396
    Cell Significance Index: -20.8200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3796
    Cell Significance Index: -11.1800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3978
    Cell Significance Index: -20.7200
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: -0.4187
    Cell Significance Index: -2.3800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.5072
    Cell Significance Index: -3.0100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5200
    Cell Significance Index: -4.2400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.5414
    Cell Significance Index: -3.4000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.5547
    Cell Significance Index: -7.7800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5688
    Cell Significance Index: -7.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5783
    Cell Significance Index: -25.5800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5914
    Cell Significance Index: -7.0500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.5988
    Cell Significance Index: -1.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Function:** DTYMK is a nucleoside diphosphate kinase, which means it facilitates the interconversion of nucleotide di- and triphosphates. Specifically, it catalyzes the conversion of dTMP to dTDP, a crucial step in DNA synthesis and repair. 2. **Cellular Expression:** DTYMK is highly expressed in various cell types, including erythroid progenitor cells, migratory enteric neural crest cells, and epithelial cells of the nephron. This widespread expression suggests a critical role in maintaining cellular homeostasis. 3. **Pathway Involvement:** DTYMK is implicated in multiple cellular pathways, including ATP binding, cellular response to growth factor stimulus, and response to estrogen. These pathways highlight the enzyme's involvement in regulating cellular growth, differentiation, and survival. **Pathways and Functions:** 1. **Nucleotide Biosynthesis:** DTYMK plays a central role in nucleotide biosynthesis, facilitating the conversion of dTMP to dTDP. This reaction is essential for DNA synthesis and repair, highlighting the enzyme's importance in maintaining genomic integrity. 2. **Immune Regulation:** Recent studies have demonstrated the involvement of DTYMK in immune regulation, suggesting its potential as a therapeutic target in diseases characterized by impaired immune function. Specifically, DTYMK has been shown to regulate the activity of T-cells and B-cells, highlighting its role in immune cell development and function. 3. **Cytoskeleton Dynamics:** DTYMK has been implicated in regulating cytoskeleton dynamics, particularly in the context of cell migration and differentiation. This suggests that the enzyme plays a role in maintaining cellular structure and function. **Clinical Significance:** 1. **Cancer Therapy:** DTYMK has been identified as a potential therapeutic target in cancer treatment. The enzyme's role in nucleotide biosynthesis and immune regulation makes it an attractive target for cancer therapy. 2. **Immunodeficiency Diseases:** DTYMK's involvement in immune regulation highlights its potential as a therapeutic target in immunodeficiency diseases, such as HIV/AIDS and autoimmune disorders. 3. **Neurological Disorders:** The enzyme's role in cytoskeleton dynamics and cellular differentiation suggests its potential involvement in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, DTYMK is a critical enzyme involved in nucleotide biosynthesis, immune regulation, and cellular differentiation. Its potential as a therapeutic target in various diseases makes it an exciting area of research for immunologists and clinicians. Further studies are needed to fully elucidate the role of DTYMK in human health and disease.

Genular Protein ID: 4233649751

Symbol: KTHY_HUMAN

Name: Thymidylate kinase

UniProtKB Accession Codes:

P23919 B7ZW70 Q6FGX1 Q9BUX4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 9 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EC 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 21 PDBsum 21 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 1 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2017365

Title: Molecular cloning and expression of the human deoxythymidylate kinase gene in yeast.

PubMed ID: 2017365

DOI: 10.1093/nar/19.4.823

PubMed ID: 8024690

Title: Human dTMP kinase: gene expression and enzymatic activity coinciding with cell cycle progression and cell growth.

PubMed ID: 8024690

DOI: 10.1089/dna.1994.13.461

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18469

Title: Human thymidylate kinase. Purification, characterization, and kinetic behavior of the thymidylate kinase derived from chronic myelocytic leukemia.

PubMed ID: 18469

DOI: 10.1016/s0021-9258(17)40077-9

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 12614151

Title: Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds.

PubMed ID: 12614151

DOI: 10.1021/bi027302t

PubMed ID: 31271740

Title: Deoxythymidylate kinase, DTYMK, is a novel gene for mitochondrial DNA depletion syndrome.

PubMed ID: 31271740

DOI: 10.1016/j.cca.2019.06.028

PubMed ID: 34918187

Title: DTYMK is essential for genome integrity and neuronal survival.

PubMed ID: 34918187

DOI: 10.1007/s00401-021-02394-0

Sequence Information:

  • Length: 212
  • Mass: 23819
  • Checksum: A52876625B3621B1
  • Sequence:
    • MAARRGALIV LEGVDRAGKS TQSRKLVEAL CAAGHRAELL RFPERSTEIG KLLSSYLQKK 
SDVEDHSVHL LFSANRWEQV PLIKEKLSQG VTLVVDRYAF SGVAFTGAKE NFSLDWCKQP 
DVGLPKPDLV LFLQLQLADA AKRGAFGHER YENGAFQERA LRCFHQLMKD TTLNWKMVDA 
SKSIEAVHED IRVLSEDAIR TATEKPLGEL WK

Genular Protein ID: 3039768894

Symbol: Q53F55_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53F55

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 9 Gene3D 1 HAMAP 1 InterPro 4 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 5 SMR 1 SUPFAM 1

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 212
  • Mass: 23761
  • Checksum: B5D4473D58F83C60
  • Sequence:
    • MAARRGALIV LEGVGRAGKS TQSRKLVEAL CAAGHRAELL RFPERSTEIG KLLSSYLQKK 
SDVEDHSVHL LFSANRWEQV PLIKEKLSQG VTLVVDRYAF SGVAFTGAKE NFSLDWCKQP 
DVGLPKPDLV LFLQLQLADA AKRGAFGHER YENGAFQERA LRCFHQLMKD TTLNWKMVDA 
SKSIEAVHED IRVLSEDAIR TATEKPLGEL WK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.