Details for: PXMP2

Gene ID: 5827

Symbol: PXMP2

Ensembl ID: ENSG00000176894

Description: peroxisomal membrane protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 126.1369
    Cell Significance Index: -19.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 81.5318
    Cell Significance Index: -20.6800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 38.8065
    Cell Significance Index: -26.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.1004
    Cell Significance Index: -23.5500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.8424
    Cell Significance Index: -23.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.1631
    Cell Significance Index: -24.3200
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 3.5398
    Cell Significance Index: 21.9000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.0130
    Cell Significance Index: 69.9500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.6962
    Cell Significance Index: 18.4400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.4710
    Cell Significance Index: 23.6000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4544
    Cell Significance Index: 1313.2000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.4504
    Cell Significance Index: 30.3600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4263
    Cell Significance Index: 85.6300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.4017
    Cell Significance Index: 96.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3358
    Cell Significance Index: 28.9400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.1488
    Cell Significance Index: 30.7300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.9337
    Cell Significance Index: 13.9900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8528
    Cell Significance Index: 22.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7706
    Cell Significance Index: 35.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7139
    Cell Significance Index: 20.5700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6589
    Cell Significance Index: 16.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.6338
    Cell Significance Index: 20.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6292
    Cell Significance Index: 17.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5923
    Cell Significance Index: 26.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5821
    Cell Significance Index: 41.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5534
    Cell Significance Index: 76.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5163
    Cell Significance Index: 51.0700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4855
    Cell Significance Index: 10.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4312
    Cell Significance Index: 22.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3918
    Cell Significance Index: 48.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3505
    Cell Significance Index: 41.3300
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.3472
    Cell Significance Index: 2.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3466
    Cell Significance Index: 62.4800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3311
    Cell Significance Index: 146.3700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.3014
    Cell Significance Index: 5.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2921
    Cell Significance Index: 159.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2320
    Cell Significance Index: 46.5400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2258
    Cell Significance Index: 156.1400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2253
    Cell Significance Index: 2.5600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2194
    Cell Significance Index: 35.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1947
    Cell Significance Index: 24.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1532
    Cell Significance Index: 11.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1510
    Cell Significance Index: 54.1600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1484
    Cell Significance Index: 19.1800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1040
    Cell Significance Index: 19.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0814
    Cell Significance Index: 16.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0799
    Cell Significance Index: 58.6200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0517
    Cell Significance Index: 0.7100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0391
    Cell Significance Index: 0.6600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0084
    Cell Significance Index: 0.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0017
    Cell Significance Index: -0.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0075
    Cell Significance Index: -5.6400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0110
    Cell Significance Index: -20.6500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0119
    Cell Significance Index: -18.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0135
    Cell Significance Index: -24.8100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0204
    Cell Significance Index: -0.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0218
    Cell Significance Index: -29.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0329
    Cell Significance Index: -20.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0356
    Cell Significance Index: -3.6400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0375
    Cell Significance Index: -27.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0421
    Cell Significance Index: -1.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0429
    Cell Significance Index: -7.3200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0436
    Cell Significance Index: -3.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0465
    Cell Significance Index: -3.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0494
    Cell Significance Index: -27.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0533
    Cell Significance Index: -6.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0562
    Cell Significance Index: -25.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0618
    Cell Significance Index: -3.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0711
    Cell Significance Index: -4.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0750
    Cell Significance Index: -21.5700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0933
    Cell Significance Index: -2.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0998
    Cell Significance Index: -11.6300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1174
    Cell Significance Index: -1.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1217
    Cell Significance Index: -3.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1590
    Cell Significance Index: -23.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1609
    Cell Significance Index: -33.8900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1779
    Cell Significance Index: -7.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1926
    Cell Significance Index: -12.9500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2026
    Cell Significance Index: -4.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2047
    Cell Significance Index: -12.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2326
    Cell Significance Index: -14.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2366
    Cell Significance Index: -24.6400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2467
    Cell Significance Index: -1.9700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2654
    Cell Significance Index: -1.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2777
    Cell Significance Index: -14.5800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3558
    Cell Significance Index: -7.3800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3587
    Cell Significance Index: -9.2200
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.3770
    Cell Significance Index: -2.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3801
    Cell Significance Index: -19.8000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4072
    Cell Significance Index: -3.4200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.4302
    Cell Significance Index: -4.3400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.4416
    Cell Significance Index: -4.5700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4549
    Cell Significance Index: -6.8600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5013
    Cell Significance Index: -17.5600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5083
    Cell Significance Index: -6.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5256
    Cell Significance Index: -23.2500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5301
    Cell Significance Index: -8.9300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5395
    Cell Significance Index: -15.8900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5678
    Cell Significance Index: -21.5000
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.5792
    Cell Significance Index: -3.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PXMP2 is a peroxisomal membrane protein, specifically classified as a Class I peroxisomal membrane protein import. Its primary function involves regulating the movement of proteins across the peroxisomal membrane, thereby influencing the metabolic processes that occur within peroxisomes. PXMP2 is significantly expressed in various cell types, including pulmonary interstitial fibroblasts, enterocytes, and stem cells, underscoring its importance in tissue development and maintenance. **Pathways and Functions:** PXMP2 is intricately involved in several metabolic pathways, including glyoxylate metabolism and glycine degradation. These pathways are essential for the breakdown of amino acids and their derivatives, which is critical for maintaining cellular homeostasis. PXMP2's role in protein localization is also noteworthy, as it regulates the movement of proteins across the peroxisomal membrane, thereby influencing cellular differentiation and development. PXMP2's involvement in the following pathways is well-documented: 1. **Glyoxylate metabolism and glycine degradation**: These pathways are crucial for the breakdown of amino acids and their derivatives. PXMP2's regulation of protein movement across the peroxisomal membrane is essential for this process. 2. **Peroxisomal membrane**: PXMP2's role in regulating protein movement across the peroxisomal membrane is critical for maintaining peroxisomal function and integrity. 3. **Cytoplasm and cytosol**: PXMP2's involvement in these pathways highlights its importance in regulating protein localization and movement within the cell. 4. **Metabolism of amino acids and derivatives**: PXMP2's role in glyoxylate metabolism and glycine degradation underscores its significance in amino acid metabolism. **Clinical Significance:** Dysregulation of PXMP2 has been implicated in various diseases, including: 1. **Neurological disorders**: Mutations in PXMP2 have been linked to neurological disorders, such as autism spectrum disorder and schizophrenia. 2. **Metabolic disorders**: PXMP2's role in glyoxylate metabolism and glycine degradation highlights its importance in maintaining metabolic homeostasis. Dysregulation of PXMP2 has been implicated in metabolic disorders, such as type 2 diabetes and metabolic syndrome. 3. **Cancer**: PXMP2's involvement in protein localization and movement across the peroxisomal membrane suggests its potential role in cancer development and progression. In conclusion, PXMP2 is a critical component of the peroxisomal membrane, playing a vital role in various cellular processes. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms underlying PXMP2's functions and the clinical significance of its dysregulation.

Genular Protein ID: 2784202357

Symbol: PXMP2_HUMAN

Name: Peroxisomal membrane protein 2

UniProtKB Accession Codes:

Q9NR77

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 5 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 STRING 1 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11590176

Title: Two different targeting signals direct human peroxisomal membrane protein 22 to peroxisomes.

PubMed ID: 11590176

DOI: 10.1074/jbc.m108155200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10704444

Title: PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.

PubMed ID: 10704444

DOI: 10.1083/jcb.148.5.931

PubMed ID: 16683188

Title: The zinc containing pro-apoptotic protein siva interacts with the peroxisomal membrane protein pmp22.

PubMed ID: 16683188

DOI: 10.1007/s11010-005-9082-6

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 195
  • Mass: 22253
  • Checksum: 9CA7FD67F8391E94
  • Sequence:
    • MAPAASRLRA EAGLGALPRR ALAQYLLFLR LYPVLTKAAT SGILSALGNF LAQMIEKKRK 
KENSRSLDVG GPLRYAVYGF FFTGPLSHFF YFFMEHWIPP EVPLAGLRRL LLDRLVFAPA 
FLMLFFLIMN FLEGKDASAF AAKMRGGFWP ALRMNWRVWT PLQFININYV PLKFRVLFAN 
LAALFWYAYL ASLGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.