Details for: DHFR

Gene ID: 1719

Symbol: DHFR

Ensembl ID: ENSG00000228716

Description: dihydrofolate reductase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 70.0590
    Cell Significance Index: -17.7700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.9742
    Cell Significance Index: -20.0300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.6210
    Cell Significance Index: -19.2600
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 11.8294
    Cell Significance Index: -1.8400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.1117
    Cell Significance Index: -21.7300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.2120
    Cell Significance Index: -19.0800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.4307
    Cell Significance Index: -21.4300
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 4.9846
    Cell Significance Index: 2.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.3915
    Cell Significance Index: 673.0600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.0842
    Cell Significance Index: -6.7500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.7637
    Cell Significance Index: 46.5600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.5318
    Cell Significance Index: 72.2500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 2.0759
    Cell Significance Index: 4.6800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.9253
    Cell Significance Index: 190.4600
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.8964
    Cell Significance Index: 11.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4749
    Cell Significance Index: 173.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.4049
    Cell Significance Index: 37.5800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3916
    Cell Significance Index: 83.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.2140
    Cell Significance Index: 53.7000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0696
    Cell Significance Index: 116.3500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0658
    Cell Significance Index: 40.3600
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.9897
    Cell Significance Index: 13.8400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9201
    Cell Significance Index: 149.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8708
    Cell Significance Index: 58.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8479
    Cell Significance Index: 22.6400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7830
    Cell Significance Index: 27.2100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.7171
    Cell Significance Index: 9.3000
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.7100
    Cell Significance Index: 4.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4772
    Cell Significance Index: 13.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4314
    Cell Significance Index: 24.2100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.4213
    Cell Significance Index: 4.2500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4104
    Cell Significance Index: 13.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3653
    Cell Significance Index: 23.5700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3547
    Cell Significance Index: 4.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3407
    Cell Significance Index: 68.3400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.3058
    Cell Significance Index: 1.9000
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.3032
    Cell Significance Index: 3.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2866
    Cell Significance Index: 14.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2790
    Cell Significance Index: 6.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2727
    Cell Significance Index: 148.9500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2477
    Cell Significance Index: 223.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2403
    Cell Significance Index: 5.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2107
    Cell Significance Index: 25.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1889
    Cell Significance Index: 34.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1864
    Cell Significance Index: 53.6500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1711
    Cell Significance Index: 3.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1649
    Cell Significance Index: 31.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1621
    Cell Significance Index: 11.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1607
    Cell Significance Index: 4.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1505
    Cell Significance Index: 6.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1357
    Cell Significance Index: 48.6600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1341
    Cell Significance Index: 59.2700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1142
    Cell Significance Index: 0.6900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0858
    Cell Significance Index: 0.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0643
    Cell Significance Index: 8.2400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0506
    Cell Significance Index: 0.5500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0357
    Cell Significance Index: 0.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0180
    Cell Significance Index: 2.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0128
    Cell Significance Index: 0.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0065
    Cell Significance Index: 12.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0045
    Cell Significance Index: 0.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0061
    Cell Significance Index: -9.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0064
    Cell Significance Index: -11.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0109
    Cell Significance Index: -8.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0147
    Cell Significance Index: -10.8600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0148
    Cell Significance Index: -10.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0151
    Cell Significance Index: -20.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0160
    Cell Significance Index: -9.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0171
    Cell Significance Index: -10.8900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0242
    Cell Significance Index: -13.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0254
    Cell Significance Index: -11.5100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0466
    Cell Significance Index: -1.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0520
    Cell Significance Index: -8.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0527
    Cell Significance Index: -3.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0528
    Cell Significance Index: -5.3900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0569
    Cell Significance Index: -0.8400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0657
    Cell Significance Index: -1.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0661
    Cell Significance Index: -8.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0700
    Cell Significance Index: -14.7400
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0752
    Cell Significance Index: -0.4800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0754
    Cell Significance Index: -0.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0757
    Cell Significance Index: -11.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0765
    Cell Significance Index: -8.9200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0853
    Cell Significance Index: -1.2600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1226
    Cell Significance Index: -13.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1289
    Cell Significance Index: -14.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1342
    Cell Significance Index: -10.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1889
    Cell Significance Index: -14.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1982
    Cell Significance Index: -20.6400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2151
    Cell Significance Index: -5.6600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2261
    Cell Significance Index: -6.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2310
    Cell Significance Index: -14.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2412
    Cell Significance Index: -19.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2479
    Cell Significance Index: -15.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2494
    Cell Significance Index: -15.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2569
    Cell Significance Index: -6.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2745
    Cell Significance Index: -14.4100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2787
    Cell Significance Index: -4.2000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2847
    Cell Significance Index: -5.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2862
    Cell Significance Index: -13.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cofactor-dependent enzyme:** DHFR requires THF as a cofactor to catalyze its enzymatic activity, making it a crucial component of the one-carbon metabolic pathway. 2. **Regulatory role in cell cycle:** DHFR has been shown to modulate cell cycle progression, particularly in the G1/S transition, by influencing the activity of cyclin-dependent kinases and the expression of cell cycle regulatory genes. 3. **Apoptosis regulation:** DHFR has been implicated in the regulation of apoptosis, with alterations in its expression and activity contributing to the development of various diseases, including cancer. 4. **Therapeutic target:** DHFR has been recognized as a potential therapeutic target for the treatment of diseases, such as leukemia and cancer, where methotrexate, a DHFR inhibitor, is used to induce apoptosis. **Pathways and Functions:** 1. **One-carbon metabolic pathway:** DHFR plays a central role in the one-carbon metabolic pathway, which is essential for the synthesis of nucleic acids, amino acids, and other biomolecules. 2. **Cell cycle regulation:** DHFR modulates cell cycle progression by influencing the activity of cyclin-dependent kinases and the expression of cell cycle regulatory genes. 3. **Apoptosis regulation:** DHFR has been implicated in the regulation of apoptosis, with alterations in its expression and activity contributing to the development of various diseases. 4. **Response to methotrexate:** DHFR is a target of methotrexate, a widely used therapeutic agent that inhibits DHFR activity, leading to the induction of apoptosis in cancer cells. **Clinical Significance:** 1. **Leukemia and cancer treatment:** DHFR has been recognized as a potential therapeutic target for the treatment of leukemia and cancer, where methotrexate is used to induce apoptosis. 2. **Folate deficiency disorders:** DHFR deficiency can lead to folate deficiency disorders, such as megaloblastic anemia, which can be treated with folate supplementation. 3. **Neurological disorders:** DHFR has been implicated in the pathogenesis of various neurological disorders, including Alzheimer's disease and Parkinson's disease, where alterations in its expression and activity contribute to disease progression. 4. **Regulation of cell growth and differentiation:** DHFR plays a crucial role in regulating cell growth and differentiation, particularly in the development of the nervous system and the hematopoietic system. In conclusion, DHFR is a multifunctional enzyme that plays a critical role in various cellular processes, including one-carbon metabolism, cell cycle regulation, apoptosis, and response to therapeutic agents. Its clinical significance extends beyond its role in folate metabolism, with implications for the treatment of leukemia, cancer, and other diseases. Further research is necessary to fully elucidate the complexities of DHFR and its role in maintaining cellular homeostasis.

Genular Protein ID: 4053884756

Symbol: DYR_HUMAN

Name: Dihydrofolate reductase

UniProtKB Accession Codes:

P00374 B4DDD2 Q14130 Q6IRW8

Database IDs:

AGR 2 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 32 DrugCentral 1 EC 2 EMBL 19 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MoonProt 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 88 PDBsum 88 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 Rhea 1 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6323448

Title: The functional human dihydrofolate reductase gene.

PubMed ID: 6323448

DOI: 10.1016/s0021-9258(17)43186-3

PubMed ID: 6687716

Title: The nucleotide sequence of the cDNA coding for the human dihydrofolic acid reductase.

PubMed ID: 6687716

DOI: 10.1016/0378-1119(83)90147-6

PubMed ID: 6235374

Title: Human dihydrofolate reductase gene organization. Extensive conservation of the G + C-rich 5' non-coding sequence and strong intron size divergence from homologous mammalian genes.

PubMed ID: 6235374

DOI: 10.1016/0022-2836(84)90419-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21310276

Title: Identification and characterization of an inborn error of metabolism caused by dihydrofolate reductase deficiency.

PubMed ID: 21310276

DOI: 10.1016/j.ajhg.2011.01.004

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21876184

Title: The former annotated human pseudogene dihydrofolate reductase-like 1 (DHFRL1) is expressed and functional.

PubMed ID: 21876184

DOI: 10.1073/pnas.1103605108

PubMed ID: 21876188

Title: Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria.

PubMed ID: 21876188

DOI: 10.1073/pnas.1103623108

PubMed ID: 3383852

Title: Crystal structure of human dihydrofolate reductase complexed with folate.

PubMed ID: 3383852

DOI: 10.1111/j.1432-1033.1988.tb14108.x

PubMed ID: 2248959

Title: Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate.

PubMed ID: 2248959

DOI: 10.1021/bi00492a021

PubMed ID: 1731871

Title: Sequence-specific 1H and 15N resonance assignments for human dihydrofolate reductase in solution.

PubMed ID: 1731871

DOI: 10.1021/bi00116a031

PubMed ID: 7890613

Title: Methotrexate-resistant variants of human dihydrofolate reductase with substitutions of leucine 22. Kinetics, crystallography, and potential as selectable markers.

PubMed ID: 7890613

DOI: 10.1074/jbc.270.10.5057

PubMed ID: 9374868

Title: Comparison of two independent crystal structures of human dihydrofolate reductase ternary complexes reduced with nicotinamide adenine dinucleotide phosphate and the very tight-binding inhibitor PT523.

PubMed ID: 9374868

DOI: 10.1021/bi971711l

PubMed ID: 9719595

Title: Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents.

PubMed ID: 9719595

DOI: 10.1021/jm980081y

PubMed ID: 12096917

Title: Atomic structures of human dihydrofolate reductase complexed with NADPH and two lipophilic antifolates at 1.09 A and 1.05 A resolution.

PubMed ID: 12096917

DOI: 10.1016/s0022-2836(02)00469-2

PubMed ID: 12657784

Title: Analysis of two polymorphic forms of a pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolate binary complex with human dihydrofolate reductase.

PubMed ID: 12657784

DOI: 10.1107/s0907444903001951

PubMed ID: 12925791

Title: Analysis of three crystal structure determinations of a 5-methyl-6-N-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase.

PubMed ID: 12925791

DOI: 10.1107/s0907444903014963

PubMed ID: 15039552

Title: Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry.

PubMed ID: 15039552

DOI: 10.1107/s0907444904002094

PubMed ID: 15681865

Title: Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH.

PubMed ID: 15681865

DOI: 10.1107/s0907444904030422

PubMed ID: 16222560

Title: Solution structure of human dihydrofolate reductase in its complex with trimethoprim and NADPH.

PubMed ID: 16222560

DOI: 10.1007/s10858-005-1475-z

PubMed ID: 17569517

Title: Novel boron-containing, nonclassical antifolates: synthesis and preliminary biological and structural evaluation.

PubMed ID: 17569517

DOI: 10.1021/jm0701977

PubMed ID: 19196009

Title: Correlations of inhibitor kinetics for Pneumocystis jirovecii and human dihydrofolate reductase with structural data for human active site mutant enzyme complexes.

PubMed ID: 19196009

DOI: 10.1021/bi801960h

PubMed ID: 19478082

Title: Multiple conformers in active site of human dihydrofolate reductase F31R/Q35E double mutant suggest structural basis for methotrexate resistance.

PubMed ID: 19478082

DOI: 10.1074/jbc.m109.018010

PubMed ID: 19719239

Title: Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents.

PubMed ID: 19719239

DOI: 10.1021/jm900490a

PubMed ID: 21310277

Title: Dihydrofolate reductase deficiency due to a homozygous DHFR mutation causes megaloblastic anemia and cerebral folate deficiency leading to severe neurologic disease.

PubMed ID: 21310277

DOI: 10.1016/j.ajhg.2011.01.007

Sequence Information:

  • Length: 187
  • Mass: 21453
  • Checksum: EBDF3D1EC73E1566
  • Sequence:
    • MVGSLNCIVA VSQNMGIGKN GDLPWPPLRN EFRYFQRMTT TSSVEGKQNL VIMGKKTWFS 
IPEKNRPLKG RINLVLSREL KEPPQGAHFL SRSLDDALKL TEQPELANKV DMVWIVGGSS 
VYKEAMNHPG HLKLFVTRIM QDFESDTFFP EIDLEKYKLL PEYPGVLSDV QEEKGIKYKF 
EVYEKND

Genular Protein ID: 3716210371

Symbol: B4DM58_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DM58

Database IDs:

ARBA 7 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 6 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SUPFAM 1 UCSC 1 UniPathway 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 129
  • Mass: 14500
  • Checksum: A86D545B3347CB61
  • Sequence:
    • MVGSLNCIVA VSQNMGIGKN GDLPWPPLRN EFRYFQRMTT TSSVEGKQNL VIMGKKTWFS 
IPEKNRPLKG RINLVLSREL KEPPQGAHFL SRSLDDALKL TEQPELANKV DMVWIVGGSS 
VYKIPRCSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.