Details for: PHGDH
Gene ID: 26227
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PHGDH
Ensembl ID: ENSG00000092621
Description: phosphoglycerate dehydrogenase
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 26.25rCSI 27.43%PRS 85.89
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CSI 21.81rCSI 18.28%PRS 89.28
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CSI 17.34rCSI 16.69%PRS 87.04
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CSI 15.6rCSI 15.04%PRS 83.66
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CSI 14.88rCSI 15.41%PRS 90.27
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CSI 11.75rCSI 9.74%PRS 89.28
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CSI 11.04rCSI 35.81%PRS 86.31
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CSI 11.01rCSI 35.32%PRS 88.36
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CSI 9.94rCSI 11.93%PRS 87.03
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CSI 9.91rCSI 24.54%PRS 88.55
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CSI 9.07rCSI 9.5%PRS 85.76
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CSI 7.62rCSI 12.35%PRS 82.65
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CSI 6.93rCSI 5.74%PRS 90.13
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CSI 6.05rCSI 4.78%PRS 80.16
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CSI 6.03rCSI 11.73%PRS 90
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CSI 5.86rCSI 8.96%PRS 92.21
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CSI 5.61rCSI 4.42%PRS 91.07
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CSI 5.57rCSI 8.89%PRS 80.5
-
CSI 5.42rCSI 31.51%PRS 90.16
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CSI 5.2rCSI 6.91%PRS 91.65
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CSI 5.1rCSI 7.07%PRS 84.81
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CSI 5.03rCSI 7.77%PRS 86.83
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CSI 4.94rCSI 4.35%PRS 79.12
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CSI 4.93rCSI 3.65%PRS 83.8
-
CSI 4.83rCSI 5.17%PRS 89.93
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CSI 4.68rCSI 5.41%PRS 81.01
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CSI 4.63rCSI 4.11%PRS 85.74
-
CSI 4.36rCSI 8.76%PRS 81.38
-
CSI 4.18rCSI 2.78%PRS 90.09
-
CSI 4.16rCSI 11.86%PRS 89.92
-
CSI 3.99rCSI 5.54%PRS 86.73
-
CSI 3.91rCSI 3.64%PRS 89.3
-
CSI 3.88rCSI 6.95%PRS 87.23
-
CSI 3.7rCSI 3.25%PRS 91.94
-
CSI 3.46rCSI 4.28%PRS 86.75
-
CSI 3.39rCSI 3.06%PRS 87.08
-
CSI 3.34rCSI 4.25%PRS 92.27
-
CSI 3.26rCSI 2.81%PRS 87.8
-
CSI 3.24rCSI 14.27%PRS 77.24
-
CSI 3.22rCSI 3.04%PRS 86.13
-
CSI 3.15rCSI 4.3%PRS 87.04
-
CSI 3.09rCSI 3.16%PRS 91.25
-
CSI 3.08rCSI 4.73%PRS 76.82
-
CSI 3.02rCSI 4.29%PRS 85.67
-
CSI 3.02rCSI 2.44%PRS 89.94
-
CSI 3.01rCSI 4.12%PRS 80.25
-
CSI 3.01rCSI 4.12%PRS 91.58
-
CSI 2.89rCSI 4.59%PRS 93.32
-
CSI 2.74rCSI 6.69%PRS 81.27
-
CSI 2.73rCSI 3.43%PRS 93.85
-
CSI 2.72rCSI 3.49%PRS 84.77
-
CSI 2.71rCSI 5.13%PRS 94.15
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CSI 2.71rCSI 3.7%PRS 81.58
-
CSI 2.68rCSI 2.18%PRS 87.6
-
CSI 2.65rCSI 4.18%PRS 89.07
-
CSI 2.63rCSI 2.28%PRS 90.8
-
CSI 2.63rCSI 3.79%PRS 91.66
-
CSI 2.63rCSI 4.31%PRS 80.23
-
CSI 2.6rCSI 3.81%PRS 94.07
-
CSI 2.56rCSI 2.68%PRS 90.38
-
CSI 2.49rCSI 6.3%PRS 91.25
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CSI 2.48rCSI 7.06%PRS 84.28
-
CSI 2.47rCSI 2.51%PRS 94.03
-
CSI 2.46rCSI 3.75%PRS 87.53
-
CSI 2.4rCSI 3.42%PRS 88.62
-
CSI 2.39rCSI 2.54%PRS 90.72
-
CSI 2.38rCSI 5.69%PRS 90.63
-
CSI 2.26rCSI 5.07%PRS 74.44
-
CSI 2.24rCSI 2.99%PRS 85.59
-
CSI 2.14rCSI 3.13%PRS 91.94
-
CSI 2.13rCSI 3.87%PRS 81.36
-
CSI 2.12rCSI 4.06%PRS 95.77
-
CSI 2.1rCSI 5.91%PRS 83.99
-
CSI 2.08rCSI 2.4%PRS 82.22
-
CSI 2.05rCSI 4.06%PRS 84.44
-
CSI 2rCSI 3.19%PRS 83.04
-
CSI 1.94rCSI 7.53%PRS 85.8
-
CSI 1.89rCSI 2.16%PRS 93.61
-
CSI 1.81rCSI 31.56%PRS 92.41
-
CSI 1.81rCSI 2.92%PRS 85.41
-
CSI 1.76rCSI 1.76%PRS 82.55
-
CSI 1.76rCSI 4.22%PRS 89.54
-
CSI 1.7rCSI 2.46%PRS 91.29
-
CSI 1.64rCSI 1.97%PRS 93.39
-
CSI 1.59rCSI 2.72%PRS 91.2
-
CSI 1.56rCSI 3.97%PRS 82.85
-
CSI 1.54rCSI 5.4%PRS 92.83
-
CSI 1.53rCSI 2.24%PRS 83.5
-
CSI 1.52rCSI 5.77%PRS 81.07
-
CSI 1.51rCSI 45.3%PRS 93.84
-
CSI 1.34rCSI 2.37%PRS 73.32
-
CSI 1.14rCSI 26.48%PRS 94.48
-
CSI 1.09rCSI 4.25%PRS 97.04
-
CSI 1.06rCSI 3.16%PRS 93.07
-
CSI 1rCSI 9.45%PRS 97.23
-
CSI 0.95rCSI 5.1%PRS 92.84
-
CSI 0.94rCSI 4.05%PRS 91.49
-
CSI 0.92rCSI 2.65%PRS 90.48
-
CSI 0.87rCSI 4.48%PRS 96.7
-
CSI 0.84rCSI 1.92%PRS 81.37
-
CSI 0.2rCSI 5.9%PRS 92.3%
-
CSI 0.3rCSI 3.4%PRS 93.4%
-
CSI 0.4rCSI 3.9%PRS 88.7%
-
CSI 0.8rCSI 8.3%PRS 90.7%
-
CSI 0.8rCSI 2.2%PRS 91.9%
-
CSI 0.8rCSI 1.9%PRS 81.4%
-
CSI 0.9rCSI 4.5%PRS 96.7%
-
CSI 0.9rCSI 2.7%PRS 90.5%
-
CSI 0.9rCSI 4.1%PRS 91.5%
-
CSI 1.0rCSI 5.1%PRS 92.8%
-
CSI 1.0rCSI 9.5%PRS 97.2%
-
CSI 1.1rCSI 3.2%PRS 93.1%
-
CSI 1.1rCSI 4.3%PRS 97.0%
-
CSI 1.1rCSI 26.5%PRS 94.5%
-
CSI 1.3rCSI 2.4%PRS 73.3%
-
CSI 1.5rCSI 45.3%PRS 93.8%
-
CSI 1.5rCSI 5.8%PRS 81.1%
-
CSI 1.5rCSI 2.2%PRS 83.5%
-
CSI 1.5rCSI 5.4%PRS 92.8%
-
CSI 1.6rCSI 4.0%PRS 82.9%
-
CSI 1.6rCSI 2.7%PRS 91.2%
-
CSI 1.6rCSI 2.0%PRS 93.4%
-
CSI 1.7rCSI 2.5%PRS 91.3%
-
CSI 1.8rCSI 4.2%PRS 89.5%
-
CSI 1.8rCSI 1.8%PRS 82.6%
-
CSI 1.8rCSI 2.9%PRS 85.4%
-
CSI 1.8rCSI 31.6%PRS 92.4%
-
CSI 1.9rCSI 2.2%PRS 93.6%
-
CSI 1.9rCSI 7.5%PRS 85.8%
-
CSI 2.0rCSI 3.2%PRS 83.0%
-
CSI 2.1rCSI 4.1%PRS 84.4%
-
CSI 2.1rCSI 2.4%PRS 82.2%
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CSI 2.1rCSI 5.9%PRS 84.0%
-
CSI 2.1rCSI 4.1%PRS 95.8%
-
CSI 2.1rCSI 3.9%PRS 81.4%
-
CSI 2.1rCSI 3.1%PRS 91.9%
-
CSI 2.2rCSI 3.0%PRS 85.6%
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CSI 2.3rCSI 5.1%PRS 74.4%
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CSI 2.4rCSI 5.7%PRS 90.6%
-
CSI 2.4rCSI 2.5%PRS 90.7%
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CSI 2.4rCSI 3.4%PRS 88.6%
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CSI 2.5rCSI 3.8%PRS 87.5%
-
CSI 2.5rCSI 2.5%PRS 94.0%
-
CSI 2.5rCSI 7.1%PRS 84.3%
-
CSI 2.5rCSI 6.3%PRS 91.3%
-
CSI 2.6rCSI 2.7%PRS 90.4%
-
CSI 2.6rCSI 3.8%PRS 94.1%
-
CSI 2.6rCSI 4.3%PRS 80.2%
-
CSI 2.6rCSI 3.8%PRS 91.7%
-
CSI 2.6rCSI 2.3%PRS 90.8%
-
CSI 2.7rCSI 4.2%PRS 89.1%
-
CSI 2.7rCSI 2.2%PRS 87.6%
-
CSI 2.7rCSI 3.7%PRS 81.6%
-
CSI 2.7rCSI 5.1%PRS 94.2%
-
CSI 2.7rCSI 3.5%PRS 84.8%
-
CSI 2.7rCSI 3.4%PRS 93.9%
-
CSI 2.7rCSI 6.7%PRS 81.3%
-
CSI 2.9rCSI 4.6%PRS 93.3%
-
CSI 3.0rCSI 4.1%PRS 91.6%
-
CSI 3.0rCSI 4.1%PRS 80.3%
-
CSI 3.0rCSI 2.4%PRS 89.9%
-
CSI 3.0rCSI 4.3%PRS 85.7%
-
CSI 3.1rCSI 4.7%PRS 76.8%
-
CSI 3.1rCSI 3.2%PRS 91.3%
-
CSI 3.2rCSI 4.3%PRS 87.0%
-
CSI 3.2rCSI 3.0%PRS 86.1%
-
CSI 3.2rCSI 14.3%PRS 77.2%
-
CSI 3.3rCSI 2.8%PRS 87.8%
-
CSI 3.3rCSI 4.3%PRS 92.3%
-
CSI 3.4rCSI 3.1%PRS 87.1%
-
CSI 3.5rCSI 4.3%PRS 86.8%
-
CSI 3.7rCSI 3.3%PRS 91.9%
-
CSI 3.9rCSI 7.0%PRS 87.2%
-
CSI 3.9rCSI 3.6%PRS 89.3%
-
CSI 4.0rCSI 5.5%PRS 86.7%
-
CSI 4.2rCSI 11.9%PRS 89.9%
-
CSI 4.2rCSI 2.8%PRS 90.1%
-
CSI 4.4rCSI 8.8%PRS 81.4%
-
CSI 4.6rCSI 4.1%PRS 85.7%
-
CSI 4.7rCSI 5.4%PRS 81.0%
-
CSI 4.8rCSI 5.2%PRS 89.9%
-
CSI 4.9rCSI 3.7%PRS 83.8%
-
CSI 4.9rCSI 4.4%PRS 79.1%
-
CSI 5.0rCSI 7.8%PRS 86.8%
-
CSI 5.1rCSI 7.1%PRS 84.8%
-
CSI 5.2rCSI 6.9%PRS 91.7%
-
CSI 5.4rCSI 31.5%PRS 90.2%
-
CSI 5.6rCSI 8.9%PRS 80.5%
-
CSI 5.6rCSI 4.4%PRS 91.1%
-
CSI 5.9rCSI 9.0%PRS 92.2%
-
CSI 6.0rCSI 11.7%PRS 90.0%
-
CSI 6.1rCSI 4.8%PRS 80.2%
-
CSI 6.9rCSI 5.7%PRS 90.1%
-
CSI 7.6rCSI 12.4%PRS 82.7%
-
CSI 9.1rCSI 9.5%PRS 85.8%
-
CSI 9.9rCSI 24.5%PRS 88.6%
-
CSI 9.9rCSI 11.9%PRS 87.0%
-
CSI 11.0rCSI 35.3%PRS 88.4%
-
CSI 11.0rCSI 35.8%PRS 86.3%
-
CSI 11.8rCSI 9.7%PRS 89.3%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3790902606
Symbol: SERA_HUMAN
Name: D-3-phosphoglycerate dehydrogenase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10713460
Title: Nucleotide sequence and differential expression of the human 3-phosphoglycerate dehydrogenase gene.
PubMed ID: 10713460
PubMed ID: 11055895
Title: Molecular characterization of 3-phosphoglycerate dehydrogenase deficiency -- a neurometabolic disorder associated with reduced L-serine biosynthesis.
PubMed ID: 11055895
DOI: 10.1086/316886
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11751922
Title: V490M, a common mutation in 3-phosphoglycerate dehydrogenase deficiency, causes enzyme deficiency by decreasing the yield of mature enzyme.
PubMed ID: 11751922
PubMed ID: 14654843
Title: Proteomic characterization of the human centrosome by protein correlation profiling.
PubMed ID: 14654843
DOI: 10.1038/nature02166
PubMed ID: 16949628
Title: Identification of novel proteins induced by estradiol, 4-hydroxytamoxifen and acolbifene in T47D breast cancer cells.
PubMed ID: 16949628
PubMed ID: 18378410
Title: Positive regulation of promoter activity of human 3-phosphoglycerate dehydrogenase (PHGDH) gene is mediated by transcription factors Sp1 and NF-Y.
PubMed ID: 18378410
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25114211
Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
PubMed ID: 25114211
PubMed ID: 25406093
Title: Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate.
PubMed ID: 25406093
DOI: 10.1021/cb500683c
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 19235232
Title: Novel mutations in 3-phosphoglycerate dehydrogenase (PHGDH) are distributed throughout the protein and result in altered enzyme kinetics.
PubMed ID: 19235232
DOI: 10.1002/humu.20934
PubMed ID: 24836451
Title: Neu-Laxova syndrome, an inborn error of serine metabolism, is caused by mutations in PHGDH.
PubMed ID: 24836451
Sequence Information:
- Length: 533
- Mass: 56651
- Checksum: C58EB72275C45B35
- Sequence:
MAFANLRKVL ISDSLDPCCR KILQDGGLQV VEKQNLSKEE LIAELQDCEG LIVRSATKVT ADVINAAEKL QVVGRAGTGV DNVDLEAATR KGILVMNTPN GNSLSAAELT CGMIMCLARQ IPQATASMKD GKWERKKFMG TELNGKTLGI LGLGRIGREV ATRMQSFGMK TIGYDPIISP EVSASFGVQQ LPLEEIWPLC DFITVHTPLL PSTTGLLNDN TFAQCKKGVR VVNCARGGIV DEGALLRALQ SGQCAGAALD VFTEEPPRDR ALVDHENVIS CPHLGASTKE AQSRCGEEIA VQFVDMVKGK SLTGVVNAQA LTSAFSPHTK PWIGLAEALG TLMRAWAGSP KGTIQVITQG TSLKNAGNCL SPAVIVGLLK EASKQADVNL VNAKLLVKEA GLNVTTSHSP AAPGEQGFGE CLLAVALAGA PYQAVGLVQG TTPVLQGLNG AVFRPEVPLR RDLPLLLFRT QTSDPAMLPT MIGLLAEAGV RLLSYQTSLV SDGETWHVMG ISSLLPSLEA WKQHVTEAFQ FHF