Details for: MCM7

Gene ID: 4176

Symbol: MCM7

Ensembl ID: ENSG00000166508

Description: minichromosome maintenance complex component 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 59.8620
    Cell Significance Index: -24.6600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 52.8676
    Cell Significance Index: -24.9600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 52.2329
    Cell Significance Index: -21.2200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 50.6617
    Cell Significance Index: -12.8500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 48.0574
    Cell Significance Index: -24.7200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 37.2268
    Cell Significance Index: -24.9800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.4563
    Cell Significance Index: -21.4400
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 21.4314
    Cell Significance Index: 9.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.7362
    Cell Significance Index: -20.6400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.4551
    Cell Significance Index: -22.6500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.2670
    Cell Significance Index: -24.7300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.1507
    Cell Significance Index: -15.8200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.7466
    Cell Significance Index: 40.7300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.3629
    Cell Significance Index: -7.3600
  • Cell Name: germ cell (CL0000586)
    Fold Change: 3.2169
    Cell Significance Index: 24.2900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 3.1092
    Cell Significance Index: 83.1700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.9992
    Cell Significance Index: 104.2200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.8989
    Cell Significance Index: 223.9400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.7210
    Cell Significance Index: 187.1900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6264
    Cell Significance Index: 97.6400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0148
    Cell Significance Index: 65.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0023
    Cell Significance Index: 28.0100
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.9729
    Cell Significance Index: 5.5300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.9275
    Cell Significance Index: 7.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8289
    Cell Significance Index: 17.3500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6588
    Cell Significance Index: 17.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6562
    Cell Significance Index: 130.2400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.6472
    Cell Significance Index: 9.8300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.6469
    Cell Significance Index: 20.7200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6453
    Cell Significance Index: 44.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5768
    Cell Significance Index: 16.6200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5669
    Cell Significance Index: 7.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5559
    Cell Significance Index: 303.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5439
    Cell Significance Index: 30.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5180
    Cell Significance Index: 23.4800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4979
    Cell Significance Index: 220.1400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4628
    Cell Significance Index: 12.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4012
    Cell Significance Index: 39.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3795
    Cell Significance Index: 52.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.2896
    Cell Significance Index: 29.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2853
    Cell Significance Index: 35.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2754
    Cell Significance Index: 19.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2700
    Cell Significance Index: 12.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2234
    Cell Significance Index: 40.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2223
    Cell Significance Index: 4.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1961
    Cell Significance Index: 25.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1758
    Cell Significance Index: 22.5400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1715
    Cell Significance Index: 27.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1634
    Cell Significance Index: 3.4800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1350
    Cell Significance Index: 7.0300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1193
    Cell Significance Index: 3.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1114
    Cell Significance Index: 3.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0911
    Cell Significance Index: 6.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0710
    Cell Significance Index: 64.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0695
    Cell Significance Index: 1.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0660
    Cell Significance Index: 12.5700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0293
    Cell Significance Index: 0.4900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0256
    Cell Significance Index: 0.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0250
    Cell Significance Index: 1.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0193
    Cell Significance Index: 0.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0035
    Cell Significance Index: 1.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0007
    Cell Significance Index: 0.1500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0067
    Cell Significance Index: -0.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0086
    Cell Significance Index: -16.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0118
    Cell Significance Index: -8.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0156
    Cell Significance Index: -28.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0169
    Cell Significance Index: -25.9800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0188
    Cell Significance Index: -12.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0217
    Cell Significance Index: -0.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0223
    Cell Significance Index: -30.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0248
    Cell Significance Index: -18.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0267
    Cell Significance Index: -4.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0275
    Cell Significance Index: -17.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0350
    Cell Significance Index: -25.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0401
    Cell Significance Index: -2.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0446
    Cell Significance Index: -27.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0447
    Cell Significance Index: -25.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0508
    Cell Significance Index: -23.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0623
    Cell Significance Index: -17.9300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0908
    Cell Significance Index: -10.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0911
    Cell Significance Index: -5.6000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1088
    Cell Significance Index: -5.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1383
    Cell Significance Index: -29.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1401
    Cell Significance Index: -20.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1516
    Cell Significance Index: -17.3700
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.1628
    Cell Significance Index: -1.0800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1780
    Cell Significance Index: -2.2800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1996
    Cell Significance Index: -2.8000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2097
    Cell Significance Index: -6.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2364
    Cell Significance Index: -24.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2403
    Cell Significance Index: -18.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2775
    Cell Significance Index: -21.9800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3086
    Cell Significance Index: -4.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3477
    Cell Significance Index: -23.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3482
    Cell Significance Index: -21.3500
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.3540
    Cell Significance Index: -2.2600
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.3647
    Cell Significance Index: -2.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4051
    Cell Significance Index: -6.9400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4154
    Cell Significance Index: -11.1300
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.4169
    Cell Significance Index: -3.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** MCM7 is widely expressed in various cell types, including erythroid progenitor cells, migratory enteric neural crest cells, oogonial cells, and epithelial cells of the nephron. 2. **Function:** MCM7 is a component of the MCM complex, which is responsible for the assembly and activation of the pre-replicative complex. This complex is essential for the initiation of DNA replication. 3. **Cell Cycle Regulation:** MCM7 is involved in the regulation of cell cycle progression, particularly during the G1/S transition and the G2/M checkpoint. 4. **DNA Replication:** MCM7 is required for the synthesis of DNA and the unwinding of DNA during replication. **Pathways and Functions:** 1. **Activation of the Pre-replicative Complex:** MCM7 is involved in the assembly and activation of the pre-replicative complex, which is essential for the initiation of DNA replication. 2. **DNA Replication Initiation:** MCM7 is required for the initiation of DNA replication, which involves the unwinding of DNA and the synthesis of new strands. 3. **Cell Cycle Progression:** MCM7 is involved in the regulation of cell cycle progression, particularly during the G1/S transition and the G2/M checkpoint. 4. **DNA Damage Response:** MCM7 is also involved in the response to DNA damage, particularly during the repair of double-strand breaks via break-induced replication. **Clinical Significance:** Dysregulation of MCM7 has been implicated in various diseases, including: 1. **Cancer:** Overexpression or mutations in MCM7 have been associated with various types of cancer, including breast, lung, and colon cancer. 2. **Genetic Disorders:** Mutations in MCM7 have been linked to genetic disorders, such as X-linked mental retardation and growth restriction. 3. **Reproductive Disorders:** MCM7 is also involved in the regulation of meiosis, and dysregulation of this gene has been implicated in reproductive disorders, such as infertility and premature ovarian failure. In conclusion, MCM7 is a critical gene that plays a central role in the regulation of DNA replication and cell cycle progression. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in human health and disease. Further research is needed to fully understand the mechanisms by which MCM7 regulates DNA replication and cell cycle progression, and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 1856893416

Symbol: MCM7_HUMAN

Name: DNA replication licensing factor MCM7

UniProtKB Accession Codes:

P33993 A4D2A1 A4D2A2 E9PGN9 Q15076 Q96D34 Q96GL1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 11 EMDB 6 Ensembl 2 ExpressionAtlas 1 GO 22 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 6 RefSeq 3 Rhea 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8626784

Title: hCDC47, a human member of the MCM family. Dissociation of the nucleus-bound form during S phase.

PubMed ID: 8626784

DOI: 10.1074/jbc.271.8.4349

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7842741

Title: Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication.

PubMed ID: 7842741

DOI: 10.1159/000133918

PubMed ID: 8265339

Title: The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins.

PubMed ID: 8265339

DOI: 10.1093/nar/21.23.5289-a

PubMed ID: 9305914

Title: A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.

PubMed ID: 9305914

DOI: 10.1074/jbc.272.39.24508

PubMed ID: 15538388

Title: Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling.

PubMed ID: 15538388

DOI: 10.1038/sj.emboj.7600463

PubMed ID: 15210935

Title: Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases.

PubMed ID: 15210935

DOI: 10.1073/pnas.0403410101

PubMed ID: 16899510

Title: Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells.

PubMed ID: 16899510

DOI: 10.1091/mbc.e06-03-0241

PubMed ID: 17116885

Title: Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function.

PubMed ID: 17116885

DOI: 10.1073/pnas.0609251103

PubMed ID: 17296731

Title: Identification and characterization of a novel component of the human minichromosome maintenance complex.

PubMed ID: 17296731

DOI: 10.1128/mcb.02384-06

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22967762

Title: Characterization of O-GlcNAc cycling and proteomic identification of differentially O-GlcNAcylated proteins during G1/S transition.

PubMed ID: 22967762

DOI: 10.1016/j.bbagen.2012.08.024

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23711367

Title: A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses.

PubMed ID: 23711367

DOI: 10.1016/j.febslet.2013.05.037

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25661590

Title: G364R mutation of MCM4 detected in human skin cancer cells affects DNA helicase activity of MCM4/6/7 complex.

PubMed ID: 25661590

DOI: 10.1093/jb/mvv015

PubMed ID: 28191891

Title: Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism.

PubMed ID: 28191891

DOI: 10.1038/ng.3790

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 35585232

Title: Fast and efficient DNA replication with purified human proteins.

PubMed ID: 35585232

DOI: 10.1038/s41586-022-04759-1

PubMed ID: 32453425

Title: CryoEM structures of human CMG-ATPgammaS-DNA and CMG-AND-1 complexes.

PubMed ID: 32453425

DOI: 10.1093/nar/gkaa429

PubMed ID: 34700328

Title: A conserved mechanism for regulating replisome disassembly in eukaryotes.

PubMed ID: 34700328

DOI: 10.1038/s41586-021-04145-3

PubMed ID: 34694004

Title: Structure of a human replisome shows the organisation and interactions of a DNA replication machine.

PubMed ID: 34694004

DOI: 10.15252/embj.2021108819

Sequence Information:

  • Length: 719
  • Mass: 81308
  • Checksum: 330A1DEFAEFBFB88
  • Sequence:
    • MALKDYALEK EKVKKFLQEF YQDDELGKKQ FKYGNQLVRL AHREQVALYV DLDDVAEDDP 
ELVDSICENA RRYAKLFADA VQELLPQYKE REVVNKDVLD VYIEHRLMME QRSRDPGMVR 
SPQNQYPAEL MRRFELYFQG PSSNKPRVIR EVRADSVGKL VTVRGIVTRV SEVKPKMVVA 
TYTCDQCGAE TYQPIQSPTF MPLIMCPSQE CQTNRSGGRL YLQTRGSRFI KFQEMKMQEH 
SDQVPVGNIP RSITVLVEGE NTRIAQPGDH VSVTGIFLPI LRTGFRQVVQ GLLSETYLEA 
HRIVKMNKSE DDESGAGELT REELRQIAEE DFYEKLAASI APEIYGHEDV KKALLLLLVG 
GVDQSPRGMK IRGNINICLM GDPGVAKSQL LSYIDRLAPR SQYTTGRGSS GVGLTAAVLR 
DSVSGELTLE GGALVLADQG VCCIDEFDKM AEADRTAIHE VMEQQTISIA KAGILTTLNA 
RCSILAAANP AYGRYNPRRS LEQNIQLPAA LLSRFDLLWL IQDRPDRDND LRLAQHITYV 
HQHSRQPPSQ FEPLDMKLMR RYIAMCREKQ PMVPESLADY ITAAYVEMRR EAWASKDATY 
TSARTLLAIL RLSTALARLR MVDVVEKEDV NEAIRLMEMS KDSLLGDKGQ TARTQRPADV 
IFATVRELVS GGRSVRFSEA EQRCVSRGFT PAQFQAALDE YEELNVWQVN ASRTRITFV

Genular Protein ID: 2879306113

Symbol: C6EMX8_HUMAN

Name: N/A

UniProtKB Accession Codes:

C6EMX8

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 11 Gene3D 4 InterPro 10 KEGG 1 MetOSite 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 PeptideAtlas 1 Pfam 4 RefSeq 2 Rhea 2 RuleBase 2 SMART 2 SUPFAM 2

Citations:

PubMed ID: 9223437

Title: Expression, nuclear localization and interactions of human MCM/P1 proteins.

PubMed ID: 9223437

DOI: 10.1006/bbrc.1997.6865

Sequence Information:

  • Length: 719
  • Mass: 81280
  • Checksum: 803EB7C0AA67904E
  • Sequence:
    • MALKDYALEK EKVKKFLQEF YQDDELGKKQ FKYGNQLVRL AHREQVALYV DLDDVAEDDP 
ELVDSICENA RRYANVFADA VQELLPQYKE REVVNKDVLD VYIEHRLMME QRSRDPGMVR 
SPQNQYPAEL MRRFELYFQG PSSNKPRVIR EVRADSVGKL VTVRGIVTRV SEVKPKMVVA 
TYTCDQCGAE TYQPIQSPTF MPLIMCPSQE CQTNRSGGRL YLQTRGSRFI KFQEMKMQEH 
SDQVPVGNIP RSITVLVEGE NTRIAQPGDH VSVTGIFLPI LRTGFRQVVQ GLLSETYLEA 
HRIVKMNKSE DDESGAGELT REELRQIAEE DFYEKLAASI APEIYGHEDV KKALLLLLVG 
GVDQSPRGMK IRGNINICLM GDPGVAKSQL LSYIDRLAPR SQYTTGRGSS GVGLTAAVLR 
DSVSGELTLE GGALVLADQG VCCIDEFDKM AEADRTAIHE VMEQQTISIA KAGILTTLNA 
RCSILAAANP AYGRYNPRRS LEQNIQLPAA LLSRFDLLWL IQDRPDRDND LRLAQHITYV 
HQHSRQPPSQ FEPLDMKLMR RYIAMCREKQ PMVPESLADY ITAAYVEMRR EAWASKDATY 
TSARTLLAIL RLSTALARLR MVDVVEKEDV NEAIRLMEMS KDSLLGDKGQ TARTQRPADV 
IFATVRELVS GGRSVRFSEA EQRCVSRGFT PAQFQAALDE YEELNVWQVN ASRTRITFV

Genular Protein ID: 2027837970

Symbol: C9J8M6_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9J8M6

Database IDs:

ARBA 10 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 EC 1 EMBL 1 Ensembl 4 GO 8 Gene3D 3 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 9 MetOSite 1 NCBI Taxonomy 1 OMA 1 PANTHER 2 PRINTS 2 PROSITE 3 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 2 Rhea 2 RuleBase 2 SMART 2 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 612
  • Mass: 68616
  • Checksum: ADB77D90963A2AE6
  • Sequence:
    • MMEQRSRDPG MVRSPQNQYP AELMRRFELY FQGPSSNKPR VIREVRADSV GKLVTVRGIV 
TRVSEVKPKM VVATYTCDQC GAETYQPIQS PTFMPLIMCP SQECQTNRSG GRLYLQTRGS 
RFIKFQEMKM QEHSDQVPVG NIPRSITVLV EGENTRIAQP GDHVSVTGIF LPILRTGFRQ 
VVQGLLSETY LEAHRIVKMN KSEDDESGAG ELTREELRQI AEEDFYEKLA ASIAPEIYGH 
EDVKKALLLL LVGGVDQSPR GMKIRGNINI CLMGDPGVAK SQLLSYIDRL APRSQYTTGR 
GSSGVGLTAA VLRDSVSGEL TLEGGALVLA DQGVCCIDEF DKMAEADRTA IHEVMEQQTI 
SIAKAGILTT LNARCSILAA ANPAYGRYNP RRSLEQNIQL PAALLSRFDL LWLIQDRPDR 
DNDLRLAQHI TYVHQHSRQP PSQFEPLDMK LMRRYIAMCR EKQPMVPESL ADYITAAYVE 
MRREAWASKD ATYTSARTLL AILRLSTALA RLRMVDVVEK EDVNEAIRLM EMSKDSLLGD 
KGQTARTQRP ADVIFATVRE LVSGGRSVRF SEAEQRCVSR GFTPAQFQAA LDEYEELNVW 
QVNASRTRIT FV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.