Details for: TSPAN6

Gene ID: 7105

Symbol: TSPAN6

Ensembl ID: ENSG00000000003

Description: tetraspanin 6

Associated with

  • Extracellular exosome
    (GO:0070062)
  • Negative regulation of canonical nf-kappab signal transduction
    (GO:0043124)
  • Negative regulation of cytoplasmic pattern recognition receptor signaling pathway
    (GO:0039532)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of canonical nf-kappab signal transduction
    (GO:0043123)
  • Protein binding
    (GO:0005515)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 300.5557
    Cell Significance Index: -46.7500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 185.1813
    Cell Significance Index: -46.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 89.9554
    Cell Significance Index: -42.4700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 86.6372
    Cell Significance Index: -35.6900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 63.3213
    Cell Significance Index: -42.4900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.0549
    Cell Significance Index: -46.9200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.2513
    Cell Significance Index: -43.5400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.8828
    Cell Significance Index: -46.8900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 5.3204
    Cell Significance Index: 139.9000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 4.5815
    Cell Significance Index: 36.5800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.9756
    Cell Significance Index: 36.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.6684
    Cell Significance Index: 190.5600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 3.1737
    Cell Significance Index: 516.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.5495
    Cell Significance Index: 297.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.5085
    Cell Significance Index: 116.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.8476
    Cell Significance Index: 83.7500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.8466
    Cell Significance Index: 64.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2302
    Cell Significance Index: 221.7600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.1838
    Cell Significance Index: 15.1600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1540
    Cell Significance Index: 86.0100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.1210
    Cell Significance Index: 23.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9103
    Cell Significance Index: 497.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7923
    Cell Significance Index: 97.4300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.7497
    Cell Significance Index: 8.1500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6867
    Cell Significance Index: 10.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6442
    Cell Significance Index: 44.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4546
    Cell Significance Index: 62.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4039
    Cell Significance Index: 39.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3244
    Cell Significance Index: 64.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3018
    Cell Significance Index: 57.4300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2695
    Cell Significance Index: 34.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1931
    Cell Significance Index: 85.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1717
    Cell Significance Index: 22.1900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1637
    Cell Significance Index: 1.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1215
    Cell Significance Index: 3.8900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0385
    Cell Significance Index: 28.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0182
    Cell Significance Index: 0.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0015
    Cell Significance Index: -0.4500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0038
    Cell Significance Index: -3.4600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0186
    Cell Significance Index: -35.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0416
    Cell Significance Index: -76.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0462
    Cell Significance Index: -71.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0463
    Cell Significance Index: -35.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0525
    Cell Significance Index: -33.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0551
    Cell Significance Index: -3.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0556
    Cell Significance Index: -75.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0701
    Cell Significance Index: -51.9300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0860
    Cell Significance Index: -53.7400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0922
    Cell Significance Index: -52.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0992
    Cell Significance Index: -45.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1052
    Cell Significance Index: -2.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1109
    Cell Significance Index: -18.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1168
    Cell Significance Index: -41.9100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1422
    Cell Significance Index: -3.8700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1440
    Cell Significance Index: -3.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1540
    Cell Significance Index: -15.7300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1642
    Cell Significance Index: -1.7000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1712
    Cell Significance Index: -3.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1842
    Cell Significance Index: -4.9400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1846
    Cell Significance Index: -10.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1886
    Cell Significance Index: -8.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1961
    Cell Significance Index: -39.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2097
    Cell Significance Index: -30.4900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2329
    Cell Significance Index: -3.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2525
    Cell Significance Index: -28.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2646
    Cell Significance Index: -55.7300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2967
    Cell Significance Index: -17.8100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3044
    Cell Significance Index: -15.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3078
    Cell Significance Index: -4.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3454
    Cell Significance Index: -5.7800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3488
    Cell Significance Index: -14.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3506
    Cell Significance Index: -41.3500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4370
    Cell Significance Index: -34.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4498
    Cell Significance Index: -46.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4635
    Cell Significance Index: -28.4200
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.4768
    Cell Significance Index: -3.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4921
    Cell Significance Index: -13.1400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5374
    Cell Significance Index: -15.8300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.5497
    Cell Significance Index: -5.2300
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.6043
    Cell Significance Index: -4.5000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6085
    Cell Significance Index: -38.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6101
    Cell Significance Index: -37.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6239
    Cell Significance Index: -40.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6401
    Cell Significance Index: -49.1200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6513
    Cell Significance Index: -13.8700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6839
    Cell Significance Index: -17.5800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.6848
    Cell Significance Index: -4.6400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6913
    Cell Significance Index: -46.4800
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.7051
    Cell Significance Index: -5.5300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.7857
    Cell Significance Index: -13.8900
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.8276
    Cell Significance Index: -5.1200
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.9061
    Cell Significance Index: -5.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9068
    Cell Significance Index: -47.6100
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.9739
    Cell Significance Index: -5.1000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9807
    Cell Significance Index: -36.0000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.0230
    Cell Significance Index: -24.7800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.0453
    Cell Significance Index: -24.1500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.1100
    Cell Significance Index: -31.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.1321
    Cell Significance Index: -50.0800
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -1.1821
    Cell Significance Index: -7.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Tetraspanin structure:** TSPAN6 is a type II transmembrane protein, consisting of four tandem repeats of a 46-amino acid sequence, with two extracellular loops and two intracellular loops. 2. **Expression pattern:** TSPAN6 is highly expressed in various tissues and cell types, including ciliated columnar cells of the tracheobronchial tree, epithelial cells of the nephron, squamous epithelial cells, and kidney collecting duct principal cells. 3. **Protein binding capabilities:** TSPAN6 interacts with various proteins, including other tetraspanins, integrins, and immune receptors, modulating their activity and function. **Pathways and Functions:** 1. **Negative regulation of NF-κB signaling:** TSPAN6 negatively regulates the canonical NF-κB signaling pathway, which is crucial for immune response and inflammation. 2. **Negative regulation of cytoplasmic pattern recognition receptor signaling:** TSPAN6 also negatively regulates the signaling pathways of cytoplasmic pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs) and NOD-like receptors (NLRs), which are essential for innate immune response. 3. **Positive regulation of NF-κB signaling:** In contrast, TSPAN6 can positively regulate the canonical NF-κB signaling pathway under certain conditions, suggesting a context-dependent role for TSPAN6 in immune response. 4. **Exosome-mediated regulation:** TSPAN6 is involved in the formation and regulation of exosomes, which are small extracellular vesicles that carry proteins and lipids from cells to other cells, influencing immune response and cellular signaling. **Clinical Significance:** 1. **Inflammation and immune response:** TSPAN6's role in regulating NF-κB signaling and PRR signaling pathways makes it a potential target for the treatment of inflammatory and autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, and Crohn's disease. 2. **Cancer and metastasis:** TSPAN6's involvement in exosome-mediated regulation of cell signaling and adhesion suggests its potential role in cancer progression and metastasis. 3. **Respiratory diseases:** TSPAN6's expression in ciliated columnar cells of the tracheobronchial tree and its involvement in regulating immune response make it a potential target for the treatment of respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and asthma. In conclusion, TSPAN6 is a multifaceted protein that regulates various cellular processes, including immune response, cell signaling, and adhesion. Its clinical significance extends to the treatment of inflammatory and autoimmune diseases, cancer, and respiratory diseases, highlighting the importance of further research into the functions and mechanisms of TSPAN6.

Genular Protein ID: 3783405662

Symbol: TSN6_HUMAN

Name: Tetraspanin-6

UniProtKB Accession Codes:

O43657 Q54A42 Q6IAN9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9714763

Title: Sequences and expression of six new members of the tetraspanin/TM4SF family.

PubMed ID: 9714763

DOI: 10.1016/s0167-4781(98)00087-6

PubMed ID: 9782095

Title: Cloning and characterization of a novel human gene, TM4SF6, encoding a protein belonging to the transmembrane 4 superfamily, and mapped to Xq22.

PubMed ID: 9782095

DOI: 10.1006/geno.1998.5415

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 12761501

Title: Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.

PubMed ID: 12761501

DOI: 10.1038/sj.onc.1206406

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 245
  • Mass: 27563
  • Checksum: 811FAB19C2805BE2
  • Sequence:
    • MASPSRRLQT KPVITCFKSV LLIYTFIFWI TGVILLAVGI WGKVSLENYF SLLNEKATNV 
PFVLIATGTV IILLGTFGCF ATCRASAWML KLYAMFLTLV FLVELVAAIV GFVFRHEIKN 
SFKNNYEKAL KQYNSTGDYR SHAVDKIQNT LHCCGVTDYR DWTDTNYYSE KGFPKSCCKL 
EDCTPQRDAD KVNNEGCFIK VMTIIESEMG VVAGISFGVA CFQLIGIFLA YCLSRAITNN 
QYEIV

Genular Protein ID: 3875297590

Symbol: A0A087WYV6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WYV6

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 HGNC 1 InterPro 2 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 129
  • Mass: 14958
  • Checksum: A91152BDA837BB74
  • Sequence:
    • MLKLYAMFLT LVFLVELVAA IVGFVFRHEI KNSFKNNYEK ALKQYNSTGD YRSHAVDKIQ 
NTLHCCGVTD YRDWTDTNYY SEKGFPKSCC KLEDCTPQRD ADKVNNELIG IFLAYCLSRA 
ITNNQYEIV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.