Details for: TSPAN6

Gene ID: 7105

Symbol: TSPAN6

Ensembl ID: ENSG00000000003

Description: tetraspanin 6

Associated with

  • Extracellular exosome
    (GO:0070062)
  • Membrane
    (GO:0016020)
  • Negative regulation of canonical nf-kappab signal transduction
    (GO:0043124)
  • Negative regulation of cytoplasmic pattern recognition receptor signaling pathway
    (GO:0039532)
  • Positive regulation of canonical nf-kappab signal transduction
    (GO:0043123)
  • Protein binding
    (GO:0005515)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.4
    Marker Score: 20891
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.33
    Marker Score: 4860
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.27
    Marker Score: 1546
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.22
    Marker Score: 5063
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.13
    Marker Score: 7332
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.06
    Marker Score: 5193
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.06
    Marker Score: 1374
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.96
    Marker Score: 2884.5
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.92
    Marker Score: 2036
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.88
    Marker Score: 1034.5
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.85
    Marker Score: 5801
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.84
    Marker Score: 11941
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.81
    Marker Score: 3445
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.81
    Marker Score: 18191
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.8
    Marker Score: 839
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.78
    Marker Score: 4775.5
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.73
    Marker Score: 405
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.72
    Marker Score: 2467
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.71
    Marker Score: 1428
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.68
    Marker Score: 4565
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.64
    Marker Score: 21569
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.59
    Marker Score: 311
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.59
    Marker Score: 633
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.55
    Marker Score: 5974
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.54
    Marker Score: 13278
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.49
    Marker Score: 422.5
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.48
    Marker Score: 360
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.48
    Marker Score: 2089
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.46
    Marker Score: 1831
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.46
    Marker Score: 976
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.46
    Marker Score: 19551
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.45
    Marker Score: 1530
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.43
    Marker Score: 49472
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.43
    Marker Score: 10615
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.4
    Marker Score: 1319
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.4
    Marker Score: 443
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.39
    Marker Score: 1241
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.37
    Marker Score: 2274
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.35
    Marker Score: 3216
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.35
    Marker Score: 389
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.33
    Marker Score: 1423
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.32
    Marker Score: 1403
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.32
    Marker Score: 1137
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.28
    Marker Score: 805
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.27
    Marker Score: 1315
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.25
    Marker Score: 360
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.23
    Marker Score: 313
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.22
    Marker Score: 1310
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.2
    Marker Score: 4452.5
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2
    Marker Score: 1191.5
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.15
    Marker Score: 548
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.12
    Marker Score: 884
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.1
    Marker Score: 1113
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.09
    Marker Score: 1931
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.09
    Marker Score: 1272
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.08
    Marker Score: 1775
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.07
    Marker Score: 2431
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.06
    Marker Score: 616
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251758
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.03
    Marker Score: 1883
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71776
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1
    Marker Score: 492
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48000.5
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1
    Marker Score: 417
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.98
    Marker Score: 243
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.98
    Marker Score: 690
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.97
    Marker Score: 246
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.96
    Marker Score: 3422
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.96
    Marker Score: 1014
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.95
    Marker Score: 5620
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5308
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.92
    Marker Score: 345
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2727
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.9
    Marker Score: 2111
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.88
    Marker Score: 4214
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.87
    Marker Score: 1836.5
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.87
    Marker Score: 505
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.86
    Marker Score: 237
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.86
    Marker Score: 619
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.85
    Marker Score: 311
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.85
    Marker Score: 185
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 633.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.82
    Marker Score: 330
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.82
    Marker Score: 775
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.81
    Marker Score: 6327
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.81
    Marker Score: 350
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.8
    Marker Score: 491
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.79
    Marker Score: 1097
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.79
    Marker Score: 3092
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.77
    Marker Score: 4050
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.77
    Marker Score: 660
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.76
    Marker Score: 1169
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392

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Other Information

**Key Characteristics:** 1. **Tetraspanin structure:** TSPAN6 is a type II transmembrane protein, consisting of four tandem repeats of a 46-amino acid sequence, with two extracellular loops and two intracellular loops. 2. **Expression pattern:** TSPAN6 is highly expressed in various tissues and cell types, including ciliated columnar cells of the tracheobronchial tree, epithelial cells of the nephron, squamous epithelial cells, and kidney collecting duct principal cells. 3. **Protein binding capabilities:** TSPAN6 interacts with various proteins, including other tetraspanins, integrins, and immune receptors, modulating their activity and function. **Pathways and Functions:** 1. **Negative regulation of NF-κB signaling:** TSPAN6 negatively regulates the canonical NF-κB signaling pathway, which is crucial for immune response and inflammation. 2. **Negative regulation of cytoplasmic pattern recognition receptor signaling:** TSPAN6 also negatively regulates the signaling pathways of cytoplasmic pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs) and NOD-like receptors (NLRs), which are essential for innate immune response. 3. **Positive regulation of NF-κB signaling:** In contrast, TSPAN6 can positively regulate the canonical NF-κB signaling pathway under certain conditions, suggesting a context-dependent role for TSPAN6 in immune response. 4. **Exosome-mediated regulation:** TSPAN6 is involved in the formation and regulation of exosomes, which are small extracellular vesicles that carry proteins and lipids from cells to other cells, influencing immune response and cellular signaling. **Clinical Significance:** 1. **Inflammation and immune response:** TSPAN6's role in regulating NF-κB signaling and PRR signaling pathways makes it a potential target for the treatment of inflammatory and autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, and Crohn's disease. 2. **Cancer and metastasis:** TSPAN6's involvement in exosome-mediated regulation of cell signaling and adhesion suggests its potential role in cancer progression and metastasis. 3. **Respiratory diseases:** TSPAN6's expression in ciliated columnar cells of the tracheobronchial tree and its involvement in regulating immune response make it a potential target for the treatment of respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and asthma. In conclusion, TSPAN6 is a multifaceted protein that regulates various cellular processes, including immune response, cell signaling, and adhesion. Its clinical significance extends to the treatment of inflammatory and autoimmune diseases, cancer, and respiratory diseases, highlighting the importance of further research into the functions and mechanisms of TSPAN6.

Genular Protein ID: 3783405662

Symbol: TSN6_HUMAN

Name: Tetraspanin-6

UniProtKB Accession Codes:

O43657 Q54A42 Q6IAN9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 11 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9714763

Title: Sequences and expression of six new members of the tetraspanin/TM4SF family.

PubMed ID: 9714763

DOI: 10.1016/s0167-4781(98)00087-6

PubMed ID: 9782095

Title: Cloning and characterization of a novel human gene, TM4SF6, encoding a protein belonging to the transmembrane 4 superfamily, and mapped to Xq22.

PubMed ID: 9782095

DOI: 10.1006/geno.1998.5415

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 12761501

Title: Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.

PubMed ID: 12761501

DOI: 10.1038/sj.onc.1206406

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 245
  • Mass: 27563
  • Checksum: 811FAB19C2805BE2
  • Sequence:
    • MASPSRRLQT KPVITCFKSV LLIYTFIFWI TGVILLAVGI WGKVSLENYF SLLNEKATNV 
PFVLIATGTV IILLGTFGCF ATCRASAWML KLYAMFLTLV FLVELVAAIV GFVFRHEIKN 
SFKNNYEKAL KQYNSTGDYR SHAVDKIQNT LHCCGVTDYR DWTDTNYYSE KGFPKSCCKL 
EDCTPQRDAD KVNNEGCFIK VMTIIESEMG VVAGISFGVA CFQLIGIFLA YCLSRAITNN 
QYEIV

Genular Protein ID: 3875297590

Symbol: A0A087WYV6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WYV6

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 2 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 129
  • Mass: 14958
  • Checksum: A91152BDA837BB74
  • Sequence:
    • MLKLYAMFLT LVFLVELVAA IVGFVFRHEI KNSFKNNYEK ALKQYNSTGD YRSHAVDKIQ 
NTLHCCGVTD YRDWTDTNYY SEKGFPKSCC KLEDCTPQRD ADKVNNELIG IFLAYCLSRA 
ITNNQYEIV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.