Details for: NUSAP1

Gene ID: 51203

Symbol: NUSAP1

Ensembl ID: ENSG00000137804

Description: nucleolar and spindle associated protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 39.7014
    Cell Significance Index: -10.0700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 32.3828
    Cell Significance Index: -13.3400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 28.6026
    Cell Significance Index: -11.6200
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 23.5833
    Cell Significance Index: 10.7400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.2179
    Cell Significance Index: -11.6700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.9159
    Cell Significance Index: -9.7600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.8901
    Cell Significance Index: -13.1000
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 3.1333
    Cell Significance Index: 17.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.0461
    Cell Significance Index: -12.0200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.2113
    Cell Significance Index: 24.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.8650
    Cell Significance Index: 219.9400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.7329
    Cell Significance Index: 46.3600
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.7066
    Cell Significance Index: 8.3000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.6406
    Cell Significance Index: 57.0100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.4027
    Cell Significance Index: -3.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.3813
    Cell Significance Index: 77.5100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.2601
    Cell Significance Index: 37.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1141
    Cell Significance Index: 121.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.0362
    Cell Significance Index: 21.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0203
    Cell Significance Index: 100.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.0180
    Cell Significance Index: 118.6400
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.8026
    Cell Significance Index: 2.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7985
    Cell Significance Index: 21.4000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.7739
    Cell Significance Index: 6.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7402
    Cell Significance Index: 146.8900
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.7112
    Cell Significance Index: 5.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5974
    Cell Significance Index: 16.7000
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.5117
    Cell Significance Index: 2.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5052
    Cell Significance Index: 16.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4258
    Cell Significance Index: 29.4500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4208
    Cell Significance Index: 12.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3978
    Cell Significance Index: 359.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3302
    Cell Significance Index: 180.3400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2789
    Cell Significance Index: 16.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2723
    Cell Significance Index: 7.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2172
    Cell Significance Index: 5.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2126
    Cell Significance Index: 4.6100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.1992
    Cell Significance Index: 2.0100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.1982
    Cell Significance Index: 2.7800
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.1965
    Cell Significance Index: 2.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1873
    Cell Significance Index: 82.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1641
    Cell Significance Index: 22.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1442
    Cell Significance Index: 3.8500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1384
    Cell Significance Index: 7.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1128
    Cell Significance Index: 3.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0869
    Cell Significance Index: 5.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0854
    Cell Significance Index: 17.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0760
    Cell Significance Index: 9.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0678
    Cell Significance Index: 11.0300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0665
    Cell Significance Index: 12.6600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0578
    Cell Significance Index: 2.6200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0544
    Cell Significance Index: 0.9100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0461
    Cell Significance Index: 16.5500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0455
    Cell Significance Index: 0.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0319
    Cell Significance Index: 9.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0236
    Cell Significance Index: 4.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0037
    Cell Significance Index: -2.7400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0043
    Cell Significance Index: -2.6800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0049
    Cell Significance Index: -0.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0063
    Cell Significance Index: -11.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0064
    Cell Significance Index: -3.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0092
    Cell Significance Index: -16.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0110
    Cell Significance Index: -8.3600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0123
    Cell Significance Index: -16.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0138
    Cell Significance Index: -2.9100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0153
    Cell Significance Index: -0.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0171
    Cell Significance Index: -12.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0171
    Cell Significance Index: -2.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0177
    Cell Significance Index: -1.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0188
    Cell Significance Index: -1.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0311
    Cell Significance Index: -14.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0366
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0410
    Cell Significance Index: -4.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0474
    Cell Significance Index: -6.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0476
    Cell Significance Index: -6.1500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0560
    Cell Significance Index: -3.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0587
    Cell Significance Index: -2.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0660
    Cell Significance Index: -7.5600
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0759
    Cell Significance Index: -0.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0885
    Cell Significance Index: -12.8700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1018
    Cell Significance Index: -6.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1036
    Cell Significance Index: -2.8200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1147
    Cell Significance Index: -7.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1154
    Cell Significance Index: -12.0200
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.1155
    Cell Significance Index: -0.8400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1264
    Cell Significance Index: -1.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1385
    Cell Significance Index: -10.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1428
    Cell Significance Index: -7.4400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1480
    Cell Significance Index: -2.2300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1484
    Cell Significance Index: -3.7000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1512
    Cell Significance Index: -2.3400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1542
    Cell Significance Index: -9.7200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1636
    Cell Significance Index: -12.9600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1700
    Cell Significance Index: -2.3200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1843
    Cell Significance Index: -2.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1900
    Cell Significance Index: -12.7800
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.2145
    Cell Significance Index: -1.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2194
    Cell Significance Index: -9.7100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2238
    Cell Significance Index: -11.7500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2318
    Cell Significance Index: -2.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Microtubule binding**: NUSAP1 interacts with microtubules, which are essential components of the mitotic spindle, to regulate its organization and stability. 2. **Nucleolar localization**: NUSAP1 is localized to the nucleolus, a region involved in ribosome biogenesis and RNA processing. 3. **Mitotic spindle organization**: NUSAP1 contributes to the establishment of the mitotic spindle, ensuring proper chromosome segregation and cytokinesis. 4. **RNA binding**: NUSAP1 binds to RNA molecules, which may influence its function in regulating mitotic nuclear division. **Pathways and Functions:** 1. **Establishment of mitotic spindle localization**: NUSAP1 interacts with microtubules to regulate their organization and stability, ensuring proper spindle formation. 2. **Mitotic chromosome condensation**: NUSAP1 contributes to the condensation of chromosomes, which is essential for proper segregation during mitosis. 3. **Mitotic cytokinesis**: NUSAP1 regulates the separation of sister chromatids, ensuring proper cytokinesis. 4. **Positive regulation of mitotic nuclear division**: NUSAP1 promotes the progression of mitotic nuclear division, ensuring proper cell cycle progression. **Clinical Significance:** 1. **Cancer research**: Altered expression of NUSAP1 has been observed in various cancers, including leukemia and lymphoma. Understanding its role in cancer development and progression may lead to the identification of new therapeutic targets. 2. **Neurological disorders**: NUSAP1 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Further research is needed to understand its role in these conditions. 3. **Developmental biology**: NUSAP1 plays a critical role in the development and maintenance of stem cells and embryonic tissues. Understanding its function in these contexts may provide insights into regenerative medicine and tissue engineering. In conclusion, NUSAP1 is a critical protein involved in the regulation of mitotic nuclear division, and its dysregulation has been implicated in various diseases. Further research is needed to fully elucidate its role in these conditions and to explore its potential as a therapeutic target.

Genular Protein ID: 2776596054

Symbol: NUSAP_HUMAN

Name: Nucleolar and spindle-associated protein 1

UniProtKB Accession Codes:

Q9BXS6 B4DDF1 E7ERR5 J3KN21 Q53GW2 Q8TBT4 Q96E58 Q96FJ1 Q9GZM9 Q9NZ85 Q9UI70

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 7 ExpressionAtlas 1 GO 13 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 RefSeq 7 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11483580

Title: Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs.

PubMed ID: 11483580

DOI: 10.1101/gr.175501

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12963707

Title: NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization.

PubMed ID: 12963707

DOI: 10.1083/jcb.200302129

PubMed ID: 17618083

Title: NuSAP is degraded by APC/C-Cdh1 and its overexpression results in mitotic arrest dependent of its microtubules' affinity.

PubMed ID: 17618083

DOI: 10.1016/j.cellsig.2007.05.017

PubMed ID: 17276916

Title: A role for NuSAP in linking microtubules to mitotic chromosomes.

PubMed ID: 17276916

DOI: 10.1016/j.cub.2006.11.050

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21130744

Title: ATM-mediated NuSAP phosphorylation induces mitotic arrest.

PubMed ID: 21130744

DOI: 10.1016/j.bbrc.2010.11.135

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 441
  • Mass: 49452
  • Checksum: 1400E1B9F3FB727F
  • Sequence:
    • MIIPSLEELD SLKYSDLQNL AKSLGLRANL RATKLLKALK GYIKHEARKG NENQDESQTS 
ASSCDETEIQ ISNQEEAERQ PLGHVTKTRR RCKTVRVDPD SQQNHSEIKI SNPTEFQNHE 
KQESQDLRAT AKVPSPPDEH QEAENAVSSG NRDSKVPSEG KKSLYTDESS KPGKNKRTAI 
TTPNFKKLHE AHFKEMESID QYIERKKKHF EEHNSMNELK QQPINKGGVR TPVPPRGRLS 
VASTPISQRR SQGRSCGPAS QSTLGLKGSL KRSAISAAKT GVRFSAATKD NEHKRSLTKT 
PARKSAHVTV SGGTPKGEAV LGTHKLKTIT GNSAAVITPF KLTTEATQTP VSNKKPVFDL 
KASLSRPLNY EPHKGKLKPW GQSKENNYLN QHVNRINFYK KTYKQPHLQT KEEQRKKREQ 
ERKEKKAKVL GMRRGLILAE D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.