Details for: MEP1B

Gene ID: 4225

Symbol: MEP1B

Ensembl ID: ENSG00000141434

Description: meprin A subunit beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.1500
    Cell Significance Index: 61.9500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2843
    Cell Significance Index: 31.1100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9128
    Cell Significance Index: 54.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7680
    Cell Significance Index: 693.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6470
    Cell Significance Index: 64.0000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6241
    Cell Significance Index: 67.8800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5261
    Cell Significance Index: 100.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4243
    Cell Significance Index: 29.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3838
    Cell Significance Index: 62.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3743
    Cell Significance Index: 8.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3254
    Cell Significance Index: 4.4400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2516
    Cell Significance Index: 6.2900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.2289
    Cell Significance Index: 3.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2097
    Cell Significance Index: 7.3700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1993
    Cell Significance Index: 4.2500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1561
    Cell Significance Index: 4.0100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1214
    Cell Significance Index: 2.0800
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.0884
    Cell Significance Index: 0.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0666
    Cell Significance Index: 3.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0565
    Cell Significance Index: 11.3300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0450
    Cell Significance Index: 3.4600
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.0432
    Cell Significance Index: 0.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0130
    Cell Significance Index: 4.6800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0104
    Cell Significance Index: 7.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0067
    Cell Significance Index: 1.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0061
    Cell Significance Index: 8.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0045
    Cell Significance Index: 0.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0040
    Cell Significance Index: 7.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0040
    Cell Significance Index: 7.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0016
    Cell Significance Index: 2.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0029
    Cell Significance Index: -0.8300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0035
    Cell Significance Index: -0.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0039
    Cell Significance Index: -2.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0046
    Cell Significance Index: -3.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0052
    Cell Significance Index: -2.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0059
    Cell Significance Index: -3.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0062
    Cell Significance Index: -3.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0066
    Cell Significance Index: -1.3100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0115
    Cell Significance Index: -0.1700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0126
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0138
    Cell Significance Index: -2.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0152
    Cell Significance Index: -2.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0153
    Cell Significance Index: -2.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0163
    Cell Significance Index: -2.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0257
    Cell Significance Index: -3.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0263
    Cell Significance Index: -1.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0272
    Cell Significance Index: -1.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0289
    Cell Significance Index: -3.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0292
    Cell Significance Index: -3.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0298
    Cell Significance Index: -1.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0298
    Cell Significance Index: -1.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0331
    Cell Significance Index: -3.4500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0348
    Cell Significance Index: -0.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0364
    Cell Significance Index: -2.0400
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0371
    Cell Significance Index: -0.2300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0372
    Cell Significance Index: -1.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0378
    Cell Significance Index: -1.6700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0407
    Cell Significance Index: -0.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0447
    Cell Significance Index: -2.8200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0459
    Cell Significance Index: -1.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0490
    Cell Significance Index: -1.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0500
    Cell Significance Index: -5.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0603
    Cell Significance Index: -1.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0677
    Cell Significance Index: -2.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0736
    Cell Significance Index: -2.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0742
    Cell Significance Index: -3.7500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0748
    Cell Significance Index: -2.6200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0750
    Cell Significance Index: -1.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0768
    Cell Significance Index: -3.6100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0783
    Cell Significance Index: -2.2400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0808
    Cell Significance Index: -0.9800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0822
    Cell Significance Index: -1.8000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0825
    Cell Significance Index: -2.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0861
    Cell Significance Index: -2.3000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0885
    Cell Significance Index: -1.1200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0922
    Cell Significance Index: -2.5100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0934
    Cell Significance Index: -2.2400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0938
    Cell Significance Index: -2.3400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0942
    Cell Significance Index: -2.0000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1029
    Cell Significance Index: -2.5700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1084
    Cell Significance Index: -1.3900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1085
    Cell Significance Index: -2.2500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1087
    Cell Significance Index: -1.0300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1176
    Cell Significance Index: -2.3600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1183
    Cell Significance Index: -2.3400
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.1222
    Cell Significance Index: -0.7600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1238
    Cell Significance Index: -2.1400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1277
    Cell Significance Index: -2.7600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1304
    Cell Significance Index: -1.5600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1331
    Cell Significance Index: -1.3800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1361
    Cell Significance Index: -2.8400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1401
    Cell Significance Index: -5.7400
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1413
    Cell Significance Index: -2.0100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1439
    Cell Significance Index: -1.9400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1441
    Cell Significance Index: -4.1300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1471
    Cell Significance Index: -2.0400
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.1509
    Cell Significance Index: -2.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1510
    Cell Significance Index: -3.9700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1523
    Cell Significance Index: -3.8900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1533
    Cell Significance Index: -3.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit structure:** Meprin A is a heterodimer composed of two subunits, alpha and beta, with MEP1B encoding the beta subunit. 2. **Metalloendopeptidase activity:** Meprin A exhibits zinc-dependent metalloendopeptidase activity, cleaving a diverse range of substrates. 3. **Cellular localization:** MEP1B is expressed in various cell types, including OFF-bipolar cells, retina horizontal cells, retinal rod cells, blood vessel endothelial cells, kidney proximal convoluted tubule epithelial cells, plasma cells, retinal cone cells, enterocytes of colon, mural cells, and enterocytes of epithelium proper of ileum. 4. **Protein binding:** Meprin A interacts with various proteins, including other enzymes, receptors, and signaling molecules. **Pathways and Functions:** 1. **Extracellular matrix remodeling:** Meprin A participates in the degradation of extracellular matrix components, influencing tissue remodeling and repair. 2. **Inflammatory response:** Meprin A is involved in the regulation of inflammatory responses by cleaving pro-inflammatory cytokines and chemokines. 3. **Cellular signaling:** Meprin A modulates cellular signaling pathways, including those involved in cell proliferation, differentiation, and survival. 4. **Proteolysis:** Meprin A is a key enzyme in the degradation of various proteins, peptides, and molecules, influencing protein homeostasis and cellular function. **Clinical Significance:** 1. **Diseases associated with meprin A dysfunction:** Meprin A dysregulation has been implicated in various diseases, including inflammatory bowel disease, cancer, and neurodegenerative disorders. 2. **Immunological disorders:** Impaired meprin A function has been linked to immune system dysregulation, leading to conditions such as autoimmune diseases and immunodeficiency disorders. 3. **Cancer:** Meprin A has been shown to play a role in cancer progression and metastasis, highlighting its potential as a therapeutic target. 4. **Neurological disorders:** Meprin A involvement in neurodegenerative diseases, such as Alzheimer's and Parkinson's, underscores its importance in maintaining neuronal function and homeostasis. In conclusion, the MEP1B gene and its encoded protein, meprin A, are critical components of the immune system and cellular regulation. Their dysregulation has significant implications for various diseases, emphasizing the need for further research into the mechanisms and therapeutic potential of meprin A.

Genular Protein ID: 284656539

Symbol: MEP1B_HUMAN

Name: Meprin A subunit beta

UniProtKB Accession Codes:

Q16820 B7ZM35 B9EGL6 Q670J1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChEBI 4 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 4 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9288916

Title: Polarised expression of human intestinal N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase (human meprin) alpha and beta subunits in Madin-Darby canine kidney cells.

PubMed ID: 9288916

DOI: 10.1111/j.1432-1033.1997.00920.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8262185

Title: Cloning of the PABA peptide hydrolase alpha subunit (PPH alpha) from human small intestine and its expression in COS-1 cells.

PubMed ID: 8262185

DOI: 10.1016/0014-5793(93)80421-p

PubMed ID: 10215852

Title: N-Benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase beta (human meprinbeta). A 13-amino-acid sequence is required for proteolytic processing and subsequent secretion.

PubMed ID: 10215852

DOI: 10.1046/j.1432-1327.1999.00268.x

PubMed ID: 12387727

Title: Human meprin beta: O-linked glycans in the intervening region of the type I membrane protein protect the C-terminal region from proteolytic cleavage and diminish its secretion.

PubMed ID: 12387727

DOI: 10.1042/bj20021398

PubMed ID: 12888571

Title: Critical amino acids in the active site of meprin metalloproteinases for substrate and peptide bond specificity.

PubMed ID: 12888571

DOI: 10.1074/jbc.m303718200

PubMed ID: 18786924

Title: Prointerleukin-18 is activated by meprin beta in vitro and in vivo in intestinal inflammation.

PubMed ID: 18786924

DOI: 10.1074/jbc.m802814200

PubMed ID: 18478055

Title: The metalloprotease meprinbeta processes E-cadherin and weakens intercellular adhesion.

PubMed ID: 18478055

DOI: 10.1371/journal.pone.0002153

PubMed ID: 20806899

Title: Fetuin-A and cystatin C are endogenous inhibitors of human meprin metalloproteases.

PubMed ID: 20806899

DOI: 10.1021/bi1004238

PubMed ID: 19748582

Title: Specific processing of tenascin-C by the metalloprotease meprinbeta neutralizes its inhibition of cell spreading.

PubMed ID: 19748582

DOI: 10.1016/j.matbio.2009.08.007

PubMed ID: 21693781

Title: Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates.

PubMed ID: 21693781

DOI: 10.1074/mcp.m111.009233

PubMed ID: 22940918

Title: The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin beta and ADAM10.

PubMed ID: 22940918

DOI: 10.1007/s00018-012-1106-2

PubMed ID: 27180357

Title: Tetraspanin 8 is an interactor of the metalloprotease meprin beta within tetraspanin-enriched microdomains.

PubMed ID: 27180357

DOI: 10.1515/hsz-20-2016-0126

PubMed ID: 34125978

Title: Phosphorylation of meprin beta controls its cell surface abundance and subsequently diminishes ectodomain shedding.

PubMed ID: 34125978

DOI: 10.1096/fj.202100271r

PubMed ID: 22988105

Title: Structural basis for the sheddase function of human meprin beta metalloproteinase at the plasma membrane.

PubMed ID: 22988105

DOI: 10.1073/pnas.1211076109

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

Sequence Information:

  • Length: 701
  • Mass: 79571
  • Checksum: 4733DBF018A4F3CD
  • Sequence:
    • MDLWNLSWFL FLDALLVISG LATPENFDVD GGMDQDIFDI NEGLGLDLFE GDIRLDRAQI 
RNSIIGEKYR WPHTIPYVLE DSLEMNAKGV ILNAFERYRL KTCIDFKPWA GETNYISVFK 
GSGCWSSVGN RRVGKQELSI GANCDRIATV QHEFLHALGF WHEQSRSDRD DYVRIMWDRI 
LSGREHNFNT YSDDISDSLN VPYDYTSVMH YSKTAFQNGT EPTIVTRISD FEDVIGQRMD 
FSDSDLLKLN QLYNCSSSLS FMDSCSFELE NVCGMIQSSG DNADWQRVSQ VPRGPESDHS 
NMGQCQGSGF FMHFDSSSVN VGATAVLESR TLYPKRGFQC LQFYLYNSGS ESDQLNIYIR 
EYSADNVDGN LTLVEEIKEI PTGSWQLYHV TLKVTKKFRV VFEGRKGSGA SLGGLSIDDI 
NLSETRCPHH IWHIRNFTQF IGSPNGTLYS PPFYSSKGYA FQIYLNLAHV TNAGIYFHLI 
SGANDDQLQW PCPWQQATMT LLDQNPDIRQ RMSNQRSITT DPFMTTDNGN YFWDRPSKVG 
TVALFSNGTQ FRRGGGYGTS AFITHERLKS RDFIKGDDVY ILLTVEDISH LNSTQIQLTP 
APSVQDLCSK TTCKNDGVCT VRDGKAECRC QSGEDWWYMG ERCEKRGSTR DTIVIAVSST 
VAVFALMLII TLVSVYCTRK KYRERMSSNR PNLTPQNQHA F

Genular Protein ID: 2138660991

Symbol: J3QKX5_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3QKX5

Database IDs:

ARBA 9 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 5 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 4 Gene3D 3 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 10 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 2 PRINTS 2 PROSITE 9 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 3 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

Sequence Information:

  • Length: 700
  • Mass: 79443
  • Checksum: F7C7D728A4F3CD32
  • Sequence:
    • MDLWNLSWFL FLDALLVISG LATPENFDVD GGMDQDIFDI NEGLGLDLFE GDIRLDRAQI 
RNSIIGEKYR WPHTIPYVLE DSLEMNAKGV ILNAFERYRL KTCIDFKPWA GETNYISVFK 
GSGCWSSVGN RRVGKQELSI GANCDRIATV QHEFLHALGF WHEQSRSDRD DYVRIMWDRI 
LSGREHNFNT YSDDISDSLN VPYDYTSVMH YSKTAFQNGT EPTIVTRISD FEDVIGQRMD 
FSDSDLLKLN QLYNCSSSLS FMDSCSFELE NVCGMIQSSG DNADWQRVSQ VPRGPESDHS 
NMGQCQGSGF FMHFDSSSVN VGATAVLESR TLYPKRGFQC LQFYLYNSGS ESDQLNIYIR 
EYSADNVDGN LTLVEEIKEI PTGSWQLYHV TLKVTKKFRV VFEGRKGSGA SLGGLSIDDI 
NLSETRCPHH IWHIRNFTQF IGSPNGTLYS PPFYSSKGYA FQIYLNLAHV TNAGIYFHLI 
SGANDDQLQW PCPWQQATMT LLDQNPDIRQ RMSNQRSITT DPFMTTDNGN YFWDRPSKVG 
TVALFSNGTQ FRRGGGYGTS AFITHERLKS RDFIKGDDVY ILLTVEDISH LNSTQIQLTP 
APSVQDLCSK TTCKNDGVCT VRDGKAECRC QSGEDWWYMG ERCEKRGSTR DTIVIAVSST 
VAVFALMLII TLVSVYCTRK KYRERMSSNR PNLTPQNHAF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.