Details for: MEP1B

Gene ID: 4225

Symbol: MEP1B

Ensembl ID: ENSG00000141434

Description: meprin A subunit beta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 5.52
    Marker Score: 16370
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 4.67
    Marker Score: 4479
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.57
    Marker Score: 7327
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.21
    Marker Score: 2223
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.69
    Marker Score: 3488
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.56
    Marker Score: 1743.5
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.55
    Marker Score: 4453
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.5
    Marker Score: 2317
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 170201
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.08
    Marker Score: 313
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.06
    Marker Score: 715.5
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.04
    Marker Score: 431
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71827
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 513
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 466
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.97
    Marker Score: 1846
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.94
    Marker Score: 4530
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.94
    Marker Score: 365
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5338
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 329
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.86
    Marker Score: 13386
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.83
    Marker Score: 334
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.81
    Marker Score: 471
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.8
    Marker Score: 10701
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.75
    Marker Score: 1526
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2973.5
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.58
    Marker Score: 396
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.5
    Marker Score: 303
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.49
    Marker Score: 234
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.47
    Marker Score: 128
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.45
    Marker Score: 714
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.44
    Marker Score: 179
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.42
    Marker Score: 248
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.39
    Marker Score: 915
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.36
    Marker Score: 160
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.33
    Marker Score: 86
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.31
    Marker Score: 137
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3
    Marker Score: 218
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.29
    Marker Score: 452
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.29
    Marker Score: 6505
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.26
    Marker Score: 158
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.26
    Marker Score: 923
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.25
    Marker Score: 74
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.25
    Marker Score: 120
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.24
    Marker Score: 2283
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.24
    Marker Score: 296
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.23
    Marker Score: 679
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.23
    Marker Score: 121
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.23
    Marker Score: 1950
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.23
    Marker Score: 195
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.22
    Marker Score: 224
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.21
    Marker Score: 1288
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.21
    Marker Score: 387
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.21
    Marker Score: 201
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.21
    Marker Score: 70
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2
    Marker Score: 67
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.2
    Marker Score: 1854
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.2
    Marker Score: 62
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.19
    Marker Score: 61
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.18
    Marker Score: 107
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.18
    Marker Score: 738
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.18
    Marker Score: 223
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.18
    Marker Score: 94
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.17
    Marker Score: 59
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.17
    Marker Score: 1117
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.16
    Marker Score: 157
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.16
    Marker Score: 66
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.16
    Marker Score: 39
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.15
    Marker Score: 37
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.15
    Marker Score: 47
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.15
    Marker Score: 96
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.14
    Marker Score: 2977
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.14
    Marker Score: 189
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.13
    Marker Score: 35
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.13
    Marker Score: 67
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.13
    Marker Score: 160
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.13
    Marker Score: 59
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.12
    Marker Score: 39
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.12
    Marker Score: 1266
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.12
    Marker Score: 63
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.12
    Marker Score: 132
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.12
    Marker Score: 67
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.11
    Marker Score: 275
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.11
    Marker Score: 306
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.11
    Marker Score: 4203
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.11
    Marker Score: 41
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.11
    Marker Score: 54
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.11
    Marker Score: 465
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.11
    Marker Score: 935

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Other Information

**Key characteristics:** * MEP1B is a glycoprotein with a molecular weight of approximately 120 kDa. * It is a transmembrane protein that is expressed on the surface of cells. * It is a member of the MET1 family of metalloendopeptidases. * It is involved in the regulation of inflammation by binding to inflammatory mediators and signaling pathways. **Pathways and functions:** * MEP1B is involved in the regulation of inflammation by binding to inflammatory mediators such as TNF-alpha, IL-1beta, and IL-6. * It also binds to the chemokine CXCL1, which is a key chemokine involved in inflammation. * When MEP1B binds to inflammatory mediators, it recruits them into the cell, leading to the activation of the inflammatory response. * MEP1B also plays a role in the regulation of cell migration and adhesion by binding to extracellular matrix proteins. **Clinical significance:** * Mutations in the MEP1B gene have been linked to several eye diseases, including macular degeneration, retinal detachment, and diabetic retinopathy. * These mutations can disrupt the normal function of MEP1B, leading to the development of these eye diseases. * Therefore, MEP1B is a promising target for the treatment of eye diseases. **Additional notes:** * MEP1B is a highly conserved protein, with similar sequences found in other mammals. * It is a well-documented regulator of inflammation, and its dysregulation is linked to a number of diseases. * Further research is needed to understand the role of MEP1B in inflammation and to develop new treatments for eye diseases.

Genular Protein ID: 284656539

Symbol: MEP1B_HUMAN

Name: Meprin A subunit beta

UniProtKB Accession Codes:

Q16820 B7ZM35 B9EGL6 Q670J1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChEBI 4 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 4 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 6 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9288916

Title: Polarised expression of human intestinal N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase (human meprin) alpha and beta subunits in Madin-Darby canine kidney cells.

PubMed ID: 9288916

DOI: 10.1111/j.1432-1033.1997.00920.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8262185

Title: Cloning of the PABA peptide hydrolase alpha subunit (PPH alpha) from human small intestine and its expression in COS-1 cells.

PubMed ID: 8262185

DOI: 10.1016/0014-5793(93)80421-p

PubMed ID: 10215852

Title: N-Benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase beta (human meprinbeta). A 13-amino-acid sequence is required for proteolytic processing and subsequent secretion.

PubMed ID: 10215852

DOI: 10.1046/j.1432-1327.1999.00268.x

PubMed ID: 12387727

Title: Human meprin beta: O-linked glycans in the intervening region of the type I membrane protein protect the C-terminal region from proteolytic cleavage and diminish its secretion.

PubMed ID: 12387727

DOI: 10.1042/bj20021398

PubMed ID: 12888571

Title: Critical amino acids in the active site of meprin metalloproteinases for substrate and peptide bond specificity.

PubMed ID: 12888571

DOI: 10.1074/jbc.m303718200

PubMed ID: 18786924

Title: Prointerleukin-18 is activated by meprin beta in vitro and in vivo in intestinal inflammation.

PubMed ID: 18786924

DOI: 10.1074/jbc.m802814200

PubMed ID: 18478055

Title: The metalloprotease meprinbeta processes E-cadherin and weakens intercellular adhesion.

PubMed ID: 18478055

DOI: 10.1371/journal.pone.0002153

PubMed ID: 20806899

Title: Fetuin-A and cystatin C are endogenous inhibitors of human meprin metalloproteases.

PubMed ID: 20806899

DOI: 10.1021/bi1004238

PubMed ID: 19748582

Title: Specific processing of tenascin-C by the metalloprotease meprinbeta neutralizes its inhibition of cell spreading.

PubMed ID: 19748582

DOI: 10.1016/j.matbio.2009.08.007

PubMed ID: 21693781

Title: Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates.

PubMed ID: 21693781

DOI: 10.1074/mcp.m111.009233

PubMed ID: 22940918

Title: The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin beta and ADAM10.

PubMed ID: 22940918

DOI: 10.1007/s00018-012-1106-2

PubMed ID: 22988105

Title: Structural basis for the sheddase function of human meprin beta metalloproteinase at the plasma membrane.

PubMed ID: 22988105

DOI: 10.1073/pnas.1211076109

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

Sequence Information:

  • Length: 701
  • Mass: 79571
  • Checksum: 4733DBF018A4F3CD
  • Sequence:
    • MDLWNLSWFL FLDALLVISG LATPENFDVD GGMDQDIFDI NEGLGLDLFE GDIRLDRAQI 
RNSIIGEKYR WPHTIPYVLE DSLEMNAKGV ILNAFERYRL KTCIDFKPWA GETNYISVFK 
GSGCWSSVGN RRVGKQELSI GANCDRIATV QHEFLHALGF WHEQSRSDRD DYVRIMWDRI 
LSGREHNFNT YSDDISDSLN VPYDYTSVMH YSKTAFQNGT EPTIVTRISD FEDVIGQRMD 
FSDSDLLKLN QLYNCSSSLS FMDSCSFELE NVCGMIQSSG DNADWQRVSQ VPRGPESDHS 
NMGQCQGSGF FMHFDSSSVN VGATAVLESR TLYPKRGFQC LQFYLYNSGS ESDQLNIYIR 
EYSADNVDGN LTLVEEIKEI PTGSWQLYHV TLKVTKKFRV VFEGRKGSGA SLGGLSIDDI 
NLSETRCPHH IWHIRNFTQF IGSPNGTLYS PPFYSSKGYA FQIYLNLAHV TNAGIYFHLI 
SGANDDQLQW PCPWQQATMT LLDQNPDIRQ RMSNQRSITT DPFMTTDNGN YFWDRPSKVG 
TVALFSNGTQ FRRGGGYGTS AFITHERLKS RDFIKGDDVY ILLTVEDISH LNSTQIQLTP 
APSVQDLCSK TTCKNDGVCT VRDGKAECRC QSGEDWWYMG ERCEKRGSTR DTIVIAVSST 
VAVFALMLII TLVSVYCTRK KYRERMSSNR PNLTPQNQHA F

Genular Protein ID: 2138660991

Symbol: J3QKX5_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3QKX5

Database IDs:

ARBA 9 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 5 DNASU 1 EMBL 4 Ensembl 2 GO 4 Gene3D 3 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 11 MEROPS 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 2 PRINTS 2 PROSITE 9 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 3 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

Sequence Information:

  • Length: 700
  • Mass: 79443
  • Checksum: F7C7D728A4F3CD32
  • Sequence:
    • MDLWNLSWFL FLDALLVISG LATPENFDVD GGMDQDIFDI NEGLGLDLFE GDIRLDRAQI 
RNSIIGEKYR WPHTIPYVLE DSLEMNAKGV ILNAFERYRL KTCIDFKPWA GETNYISVFK 
GSGCWSSVGN RRVGKQELSI GANCDRIATV QHEFLHALGF WHEQSRSDRD DYVRIMWDRI 
LSGREHNFNT YSDDISDSLN VPYDYTSVMH YSKTAFQNGT EPTIVTRISD FEDVIGQRMD 
FSDSDLLKLN QLYNCSSSLS FMDSCSFELE NVCGMIQSSG DNADWQRVSQ VPRGPESDHS 
NMGQCQGSGF FMHFDSSSVN VGATAVLESR TLYPKRGFQC LQFYLYNSGS ESDQLNIYIR 
EYSADNVDGN LTLVEEIKEI PTGSWQLYHV TLKVTKKFRV VFEGRKGSGA SLGGLSIDDI 
NLSETRCPHH IWHIRNFTQF IGSPNGTLYS PPFYSSKGYA FQIYLNLAHV TNAGIYFHLI 
SGANDDQLQW PCPWQQATMT LLDQNPDIRQ RMSNQRSITT DPFMTTDNGN YFWDRPSKVG 
TVALFSNGTQ FRRGGGYGTS AFITHERLKS RDFIKGDDVY ILLTVEDISH LNSTQIQLTP 
APSVQDLCSK TTCKNDGVCT VRDGKAECRC QSGEDWWYMG ERCEKRGSTR DTIVIAVSST 
VAVFALMLII TLVSVYCTRK KYRERMSSNR PNLTPQNHAF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.