Details for: SLC2A2

Gene ID: 6514

Symbol: SLC2A2

Ensembl ID: ENSG00000163581

Description: solute carrier family 2 member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: precursor cell (CL0011115)
    Fold Change: 5.3752
    Cell Significance Index: 40.7600
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 2.6308
    Cell Significance Index: 6.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.6020
    Cell Significance Index: 516.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.3082
    Cell Significance Index: 439.2700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.9225
    Cell Significance Index: 32.3900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2812
    Cell Significance Index: 76.9200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2667
    Cell Significance Index: 36.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1858
    Cell Significance Index: 37.9800
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.1563
    Cell Significance Index: 4.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8739
    Cell Significance Index: 789.1000
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.8327
    Cell Significance Index: 4.8000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8166
    Cell Significance Index: 88.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6931
    Cell Significance Index: 80.7700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.5481
    Cell Significance Index: 8.0900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5399
    Cell Significance Index: 37.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4533
    Cell Significance Index: 73.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3808
    Cell Significance Index: 8.2500
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.2751
    Cell Significance Index: 1.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.2416
    Cell Significance Index: 24.6800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2300
    Cell Significance Index: 22.7600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2214
    Cell Significance Index: 3.1700
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.2129
    Cell Significance Index: 2.1000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.1667
    Cell Significance Index: 2.4300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1254
    Cell Significance Index: 1.5900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.0941
    Cell Significance Index: 0.8000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0932
    Cell Significance Index: 1.5400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0876
    Cell Significance Index: 1.3200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0768
    Cell Significance Index: 0.8000
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.0687
    Cell Significance Index: 0.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0568
    Cell Significance Index: 1.2100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0356
    Cell Significance Index: 0.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0268
    Cell Significance Index: 0.9400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0165
    Cell Significance Index: 11.4000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0113
    Cell Significance Index: 0.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0027
    Cell Significance Index: 0.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0023
    Cell Significance Index: 1.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0014
    Cell Significance Index: 2.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0000
    Cell Significance Index: -0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0009
    Cell Significance Index: -0.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0014
    Cell Significance Index: -2.1200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0016
    Cell Significance Index: -0.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0023
    Cell Significance Index: -3.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0039
    Cell Significance Index: -0.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0055
    Cell Significance Index: -1.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0083
    Cell Significance Index: -1.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0091
    Cell Significance Index: -6.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0091
    Cell Significance Index: -3.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0108
    Cell Significance Index: -6.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0115
    Cell Significance Index: -5.2100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0124
    Cell Significance Index: -1.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0160
    Cell Significance Index: -0.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0192
    Cell Significance Index: -5.5200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0194
    Cell Significance Index: -0.4800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0200
    Cell Significance Index: -0.3900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0202
    Cell Significance Index: -0.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0221
    Cell Significance Index: -1.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0224
    Cell Significance Index: -0.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0239
    Cell Significance Index: -0.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0348
    Cell Significance Index: -6.2700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0399
    Cell Significance Index: -4.1500
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0419
    Cell Significance Index: -0.2600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0424
    Cell Significance Index: -0.5900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0440
    Cell Significance Index: -0.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0452
    Cell Significance Index: -6.5700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0466
    Cell Significance Index: -0.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0573
    Cell Significance Index: -7.0500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0604
    Cell Significance Index: -1.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0648
    Cell Significance Index: -4.9700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0651
    Cell Significance Index: -1.1000
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0684
    Cell Significance Index: -0.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0726
    Cell Significance Index: -4.8800
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0750
    Cell Significance Index: -0.8700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0790
    Cell Significance Index: -6.2600
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0818
    Cell Significance Index: -0.7300
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0834
    Cell Significance Index: -0.8400
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0849
    Cell Significance Index: -1.0000
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0864
    Cell Significance Index: -0.7500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0916
    Cell Significance Index: -1.2700
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.0969
    Cell Significance Index: -1.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0989
    Cell Significance Index: -5.5500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1016
    Cell Significance Index: -0.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1042
    Cell Significance Index: -4.6100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1073
    Cell Significance Index: -3.7600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1100
    Cell Significance Index: -3.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1123
    Cell Significance Index: -6.9000
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.1179
    Cell Significance Index: -1.2200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1183
    Cell Significance Index: -4.4800
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1197
    Cell Significance Index: -1.2600
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.1201
    Cell Significance Index: -1.1500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1212
    Cell Significance Index: -3.8600
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1215
    Cell Significance Index: -1.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1235
    Cell Significance Index: -3.3100
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.1269
    Cell Significance Index: -1.2400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1289
    Cell Significance Index: -1.7400
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.1321
    Cell Significance Index: -1.1800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1327
    Cell Significance Index: -1.4000
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.1384
    Cell Significance Index: -0.9600
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.1418
    Cell Significance Index: -0.8700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1432
    Cell Significance Index: -3.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The SLC2A2 gene is a member of the solute carrier family 2 (SLC2A) and encodes for a transmembrane protein with 12 transmembrane domains. The protein is primarily expressed in enterocytes, hepatocytes, retinal ganglion cells, kidney epithelial cells, and goblet cells. It is involved in the transport of glucose, fructose, galactose, and dehydroascorbic acid across cell membranes. The protein's structure and function are characterized by its ability to bind and transport glucose molecules, as well as its role in regulating insulin secretion and cellular metabolism. **Pathways and Functions** The SLC2A2 protein is involved in various cellular processes, including: 1. **Glucose homeostasis**: The protein plays a crucial role in regulating glucose uptake and storage in cells, particularly in the liver and muscles. 2. **Insulin secretion**: The protein is involved in regulating insulin secretion in response to glucose stimuli, and its dysfunction can lead to impaired glucose regulation and insulin resistance. 3. **Cellular metabolism**: The protein is involved in the transport of glucose and other hexoses, which is essential for cellular energy metabolism. 4. **Dehydroascorbic acid transport**: The protein is also involved in the transport of dehydroascorbic acid, a precursor to ascorbic acid (vitamin C). 5. **Regulation of gene expression**: The protein is involved in regulating gene expression in beta cells, which are responsible for insulin production. **Clinical Significance** Mutations in the SLC2A2 gene have been associated with Fanconi-Bickel syndrome (FBS), a rare genetic disorder characterized by: 1. **Impaired glucose uptake and storage**: FBS patients exhibit impaired glucose uptake and storage in cells, leading to hyperglycemia and insulin resistance. 2. **Renal tubular dysfunction**: FBS patients often develop renal tubular dysfunction, leading to impaired glucose reabsorption and excessive glucose excretion in the urine. 3. **Increased risk of diabetes and cardiovascular disease**: FBS patients are at increased risk of developing diabetes and cardiovascular disease due to impaired glucose regulation and insulin resistance. In conclusion, the SLC2A2 gene plays a crucial role in glucose homeostasis, insulin secretion, and cellular metabolism. Mutations in this gene can lead to Fanconi-Bickel syndrome, a rare genetic disorder characterized by impaired glucose uptake and storage, renal tubular dysfunction, and increased risk of diabetes and cardiovascular disease. Further research is needed to fully understand the mechanisms underlying SLC2A2-mediated glucose transport and its clinical significance.

Genular Protein ID: 779889152

Symbol: GTR2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3399500

Title: Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein.

PubMed ID: 3399500

DOI: 10.1073/pnas.85.15.5434

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 7593414

Title: Sequence variations of the pancreatic islet/liver glucose transporter (GLUT2) gene in Japanese subjects with noninsulin dependent diabetes mellitus.

PubMed ID: 7593414

DOI: 10.1210/jcem.80.11.7593414

PubMed ID: 8457197

Title: Kinetic analysis of the liver-type (GLUT2) and brain-type (GLUT3) glucose transporters in Xenopus oocytes: substrate specificities and effects of transport inhibitors.

PubMed ID: 8457197

DOI: 10.1042/bj2900701

PubMed ID: 16186102

Title: Identification of a hydrophobic residue as a key determinant of fructose transport by the facilitative hexose transporter SLC2A7 (GLUT7).

PubMed ID: 16186102

DOI: 10.1074/jbc.m508678200

PubMed ID: 23396969

Title: Intestinal dehydroascorbic acid (DHA) transport mediated by the facilitative sugar transporters, GLUT2 and GLUT8.

PubMed ID: 23396969

DOI: 10.1074/jbc.m112.436790

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28083649

Title: Reassessment of GLUT7 and GLUT9 as putative fructose and glucose transporters.

PubMed ID: 28083649

DOI: 10.1007/s00232-016-9945-7

PubMed ID: 29548810

Title: Differential patterns of inhibition of the sugar transporters GLUT2, GLUT5 and GLUT7 by flavonoids.

PubMed ID: 29548810

DOI: 10.1016/j.bcp.2018.03.011

PubMed ID: 8063045

Title: Variability of the pancreatic islet beta cell/liver (GLUT 2) glucose transporter gene in NIDDM patients.

PubMed ID: 8063045

DOI: 10.1007/bf00408481

PubMed ID: 8027028

Title: A mutation in the Glut2 glucose transporter gene of a diabetic patient abolishes transport activity.

PubMed ID: 8027028

DOI: 10.1016/s0021-9258(17)32372-4

PubMed ID: 10987651

Title: A mutation in GLUT2, not in phosphorylase kinase subunits, in hepato-renal glycogenosis with Fanconi syndrome and low phosphorylase kinase activity.

PubMed ID: 10987651

DOI: 10.1007/s004390051095

PubMed ID: 11044475

Title: Mutation analysis of the GLUT2 gene in patients with Fanconi-Bickel syndrome.

PubMed ID: 11044475

DOI: 10.1203/00006450-200011000-00005

Sequence Information:

  • Length: 524
  • Mass: 57490
  • Checksum: DA600577207EC083
  • Sequence:
  • MTEDKVTGTL VFTVITAVLG SFQFGYDIGV INAPQQVIIS HYRHVLGVPL DDRKAINNYV 
    INSTDELPTI SYSMNPKPTP WAEEETVAAA QLITMLWSLS VSSFAVGGMT ASFFGGWLGD 
    TLGRIKAMLV ANILSLVGAL LMGFSKLGPS HILIIAGRSI SGLYCGLISG LVPMYIGEIA 
    PTALRGALGT FHQLAIVTGI LISQIIGLEF ILGNYDLWHI LLGLSGVRAI LQSLLLFFCP 
    ESPRYLYIKL DEEVKAKQSL KRLRGYDDVT KDINEMRKER EEASSEQKVS IIQLFTNSSY 
    RQPILVALML HVAQQFSGIN GIFYYSTSIF QTAGISKPVY ATIGVGAVNM VFTAVSVFLV 
    EKAGRRSLFL IGMSGMFVCA IFMSVGLVLL NKFSWMSYVS MIAIFLFVSF FEIGPGPIPW 
    FMVAEFFSQG PRPAALAIAA FSNWTCNFIV ALCFQYIADF CGPYVFFLFA GVLLAFTLFT 
    FFKVPETKGK SFEEIAAEFQ KKSGSAHRPK AAVEMKFLGA TETV

Genular Protein ID: 1405102200

Symbol: Q6PAU8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 351
  • Mass: 39089
  • Checksum: CBF67D0FE18C6098
  • Sequence:
  • MYIGEIAPTA LRGALGTFHQ LAIVTGILIS QIIGLEFILG NYDLWHILLG LSGVRAILQS 
    LLLFFCPESP RYLYIKLDEE VKAKQSLKRL RGYDDVTKDI NEMRKEREEA SSEQKVSIIQ 
    LFTNSSYRQP ILVALMLHVA QQFSGINGIF YYSTSIFQTA GISKPVYATI GVGAVNMVFT 
    AVSVFLVEKA GRRSLFLIGM SGMFVCAIFM SVGLVLLNKF SWMSYVSMIA IFLFVSFFEI 
    GPGPIPWFMV AEFFSQGPRP AALAIAAFSN WTCNFIVALC FQYIADFCGP YVFFLFAGVL 
    LAFTLFTFFK VPETKGKSFE EIAAEFQKKS GSAHRPKAAV EMKFLGATET V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.