Details for: UGT2B17

Gene ID: 7367

Symbol: UGT2B17

Ensembl ID: ENSG00000197888

Description: UDP glucuronosyltransferase family 2 member B17

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: precursor cell (CL0011115)
    Fold Change: 15.7477
    Cell Significance Index: 119.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 7.2514
    Cell Significance Index: 328.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 7.1942
    Cell Significance Index: 155.8600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 6.5067
    Cell Significance Index: 1238.2500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 6.4208
    Cell Significance Index: 96.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 3.4592
    Cell Significance Index: 3123.3500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.2924
    Cell Significance Index: -8.8200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.1195
    Cell Significance Index: 89.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.5184
    Cell Significance Index: 249.1300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.4903
    Cell Significance Index: 79.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.8476
    Cell Significance Index: 127.7700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5139
    Cell Significance Index: 246.2300
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.3059
    Cell Significance Index: 9.1900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1.2785
    Cell Significance Index: 13.2400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2699
    Cell Significance Index: 76.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.8431
    Cell Significance Index: 17.9600
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.6662
    Cell Significance Index: 7.2200
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.2945
    Cell Significance Index: 1.8200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.1563
    Cell Significance Index: 3.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1309
    Cell Significance Index: 4.6000
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.1241
    Cell Significance Index: 0.7700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0239
    Cell Significance Index: 0.3400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0147
    Cell Significance Index: 0.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0077
    Cell Significance Index: 4.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0020
    Cell Significance Index: -0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0043
    Cell Significance Index: -8.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0071
    Cell Significance Index: -13.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0085
    Cell Significance Index: -13.1100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0090
    Cell Significance Index: -0.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0097
    Cell Significance Index: -13.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0098
    Cell Significance Index: -0.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0103
    Cell Significance Index: -7.6600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0104
    Cell Significance Index: -0.4200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0123
    Cell Significance Index: -9.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0148
    Cell Significance Index: -8.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0172
    Cell Significance Index: -10.9100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0173
    Cell Significance Index: -0.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0226
    Cell Significance Index: -2.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0245
    Cell Significance Index: -11.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0259
    Cell Significance Index: -9.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0287
    Cell Significance Index: -4.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0312
    Cell Significance Index: -8.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0345
    Cell Significance Index: -6.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0384
    Cell Significance Index: -7.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0384
    Cell Significance Index: -4.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0394
    Cell Significance Index: -7.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0435
    Cell Significance Index: -9.1600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0444
    Cell Significance Index: -0.9200
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0482
    Cell Significance Index: -0.3500
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0611
    Cell Significance Index: -0.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0624
    Cell Significance Index: -8.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0677
    Cell Significance Index: -8.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0725
    Cell Significance Index: -10.5500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0791
    Cell Significance Index: -4.8500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0897
    Cell Significance Index: -10.5800
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.1137
    Cell Significance Index: -1.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1201
    Cell Significance Index: -12.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1422
    Cell Significance Index: -9.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1602
    Cell Significance Index: -11.9400
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.1650
    Cell Significance Index: -1.5800
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.1692
    Cell Significance Index: -1.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1811
    Cell Significance Index: -11.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1857
    Cell Significance Index: -10.4200
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.1946
    Cell Significance Index: -1.7600
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.1965
    Cell Significance Index: -1.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2065
    Cell Significance Index: -9.6300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2190
    Cell Significance Index: -2.3100
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.2215
    Cell Significance Index: -1.3000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2281
    Cell Significance Index: -10.0900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2285
    Cell Significance Index: -4.4600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2326
    Cell Significance Index: -8.1500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2644
    Cell Significance Index: -8.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2683
    Cell Significance Index: -10.1600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2731
    Cell Significance Index: -6.8200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2768
    Cell Significance Index: -8.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2845
    Cell Significance Index: -13.3700
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: -0.2913
    Cell Significance Index: -1.7100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2973
    Cell Significance Index: -4.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3004
    Cell Significance Index: -8.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3139
    Cell Significance Index: -8.4100
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.3407
    Cell Significance Index: -1.6300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3410
    Cell Significance Index: -9.7300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3417
    Cell Significance Index: -8.7300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3544
    Cell Significance Index: -8.8400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3592
    Cell Significance Index: -6.1400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3637
    Cell Significance Index: -4.5900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3650
    Cell Significance Index: -9.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3681
    Cell Significance Index: -10.0200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3743
    Cell Significance Index: -9.3400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3856
    Cell Significance Index: -7.5400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.4040
    Cell Significance Index: -5.5400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4144
    Cell Significance Index: -6.9700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4193
    Cell Significance Index: -9.0600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.4215
    Cell Significance Index: -13.3300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4269
    Cell Significance Index: -12.5800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4323
    Cell Significance Index: -9.1800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.4445
    Cell Significance Index: -7.2000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4456
    Cell Significance Index: -9.3000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4499
    Cell Significance Index: -7.7100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4623
    Cell Significance Index: -11.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** UGT2B17 exhibits glucuronidation activity, a Phase II conjugation reaction that involves the transfer of glucuronic acid to a substrate molecule, resulting in the formation of a water-soluble conjugate that can be easily excreted from the body. 2. **Steroid-Specificity:** UGT2B17 is specifically involved in the glucuronidation of C19-steroids, which are a subclass of steroids that include estrogens, progestins, and androgens. 3. **Expression Pattern:** The expression of UGT2B17 is predominantly found in enterocytes of the colon, colon epithelial cells, and intestinal stem cells, highlighting its role in gut-associated metabolic processes. 4. **Pathway Involvement:** UGT2B17 is involved in various metabolic pathways, including aspirin adme, biological oxidations, cellular glucuronidation, drug adme, and xenobiotic metabolic process. **Pathways and Functions:** 1. **Glucuronidation:** UGT2B17 plays a crucial role in the glucuronidation of various compounds, including steroids, estrogens, and xenobiotics, facilitating their excretion from the body. 2. **Steroid Metabolic Process:** UGT2B17 is specifically involved in the glucuronidation of C19-steroids, which are a subclass of steroids that include estrogens, progestins, and androgens. 3. **Cellular Glucuronidation:** UGT2B17 is involved in the cellular glucuronidation of various compounds, including steroids, estrogens, and xenobiotics. 4. **Xenobiotic Metabolic Process:** UGT2B17 plays a role in the metabolism of xenobiotics, including drugs and environmental toxins. **Clinical Significance:** 1. **Dysregulation of Glucuronidation:** Alterations in UGT2B17 expression or activity may lead to dysregulation of glucuronidation, potentially contributing to various diseases, including cancer, metabolic disorders, and drug toxicity. 2. **Cancer Association:** The overexpression of UGT2B17 has been associated with various types of cancer, including colon, breast, and prostate cancer. 3. **Pharmacokinetic Variability:** Variations in UGT2B17 expression or activity may influence the pharmacokinetics of drugs, including the efficacy and toxicity of these medications. 4. **Nutritional and Environmental Factors:** The expression of UGT2B17 may be influenced by nutritional and environmental factors, such as diet and exposure to environmental toxins, which can impact metabolic processes and disease risk. In conclusion, UGT2B17 is a crucial enzyme involved in glucuronidation and metabolic processes, with significant implications for our understanding of various diseases and pharmacokinetic variability. Further research is needed to elucidate the mechanisms of UGT2B17 and its role in human health and disease.

Genular Protein ID: 284718848

Symbol: UDB17_HUMAN

Name: C19-steroid-specific UDP-glucuronosyltransferase

UniProtKB Accession Codes:

O75795

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CDD 1 CTD 1 ChEBI 30 ChEMBL 1 DNASU 1 DisGeNET 1 DrugBank 11 EC 1 EMBL 1 Ensembl 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 2 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 12 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8798464

Title: Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids.

PubMed ID: 8798464

DOI: 10.1074/jbc.271.37.22855

PubMed ID: 9364925

Title: Chromosomal localization, structure, and regulation of the UGT2B17 gene, encoding a C19 steroid metabolizing enzyme.

PubMed ID: 9364925

DOI: 10.1089/dna.1997.16.1143

PubMed ID: 16595710

Title: Human UDP-glucuronosyltransferase, UGT1A8, glucuronidates dihydrotestosterone to a monoglucuronide and further to a structurally novel diglucuronide.

PubMed ID: 16595710

DOI: 10.1124/dmd.106.009621

PubMed ID: 18719240

Title: The configuration of the 17-hydroxy group variably influences the glucuronidation of beta-estradiol and epiestradiol by human UDP-glucuronosyltransferases.

PubMed ID: 18719240

DOI: 10.1124/dmd.108.022731

PubMed ID: 18992858

Title: Genome-wide copy-number-variation study identified a susceptibility gene, UGT2B17, for osteoporosis.

PubMed ID: 18992858

DOI: 10.1016/j.ajhg.2008.10.006

PubMed ID: 19022937

Title: UDP-glucuronosyltransferases (UGTs) 2B7 and UGT2B17 display converse specificity in testosterone and epitestosterone glucuronidation, whereas UGT2A1 conjugates both androgens similarly.

PubMed ID: 19022937

DOI: 10.1124/dmd.108.024844

PubMed ID: 23288867

Title: Regiospecificity and stereospecificity of human UDP-glucuronosyltransferases in the glucuronidation of estriol, 16-epiestriol, 17-epiestriol, and 13-epiestradiol.

PubMed ID: 23288867

DOI: 10.1124/dmd.112.049072

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 530
  • Mass: 61095
  • Checksum: 8E59EBC43CF43760
  • Sequence:
    • MSLKWMSVFL LMQLSCYFSS GSCGKVLVWP TEYSHWINMK TILEELVQRG HEVIVLTSSA 
SILVNASKSS AIKLEVYPTS LTKNDLEDFF MKMFDRWTYS ISKNTFWSYF SQLQELCWEY 
SDYNIKLCED AVLNKKLMRK LQESKFDVLL ADAVNPCGEL LAELLNIPFL YSLRFSVGYT 
VEKNGGGFLF PPSYVPVVMS ELSDQMIFME RIKNMIYMLY FDFWFQAYDL KKWDQFYSEV 
LGRPTTLFET MGKAEMWLIR TYWDFEFPRP FLPNVDFVGG LHCKPAKPLP KEMEEFVQSS 
GENGIVVFSL GSMISNMSEE SANMIASALA QIPQKVLWRF DGKKPNTLGS NTRLYKWLPQ 
NDLLGHPKTK AFITHGGTNG IYEAIYHGIP MVGIPLFADQ HDNIAHMKAK GAALSVDIRT 
MSSRDLLNAL KSVINDPIYK ENIMKLSRIH HDQPVKPLDR AVFWIEFVMR HKGAKHLRVA 
AHNLTWIQYH SLDVIAFLLA CVATMIFMIT KCCLFCFRKL AKTGKKKKRD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.